Germ Cell Tumors in Pediatrics

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15 Questions

What is the primary treatment approach for intracranial germ cell tumors?

Radiotherapy

What is the characteristic feature of sacrococcygeal teratomas?

Contains derivatives of the three embryonic germ layers

What is the most common solid tumor in the neonate?

Sacrococcygeal teratoma

What is the location of sacrococcygeal teratomas?

Tip of the coccyx

When is a more toxic treatment regimen typically used?

For recurrent tumors

What is the primary goal of liver resection in the treatment of congenital tumors?

To completely remove the tumor and prevent recurrence

Which of the following tumors is known for its unpredictable behavior?

Neuroblastoma

In pediatric oncology, what is the primary indication for liver transplantation?

All of the above

What is the primary role of tumor markers in the diagnosis of congenital tumors?

To diagnose the tumor type

What is the primary treatment option for sacrococcygeal tumors?

Surgical resection

Which of the following procedures is NOT used for biopsy in neuroblastoma?

Mammography

What is the Greek origin of the word 'teratoma'?

Teratos meaning monster

What is a potential complication of neuroblastoma treatment?

Renal ischemia

Which of the following is a minimally invasive procedure used for biopsy in neuroblastoma?

Laparoscopy

What is a potential postsurgical complication of neuroblastoma treatment?

Chylous ascites

Study Notes

Germ Cell Tumors (GCTs)

  • A more toxic regimen is reserved for recurrence.
  • Radiotherapy is the mainstay for intracranial GCTs.

Sacrococygeal Teratomas (SCT)

  • A congenital tumor containing derivatives of the three embryonic germ layers.
  • Arises at the tip of the coccyx.
  • The most common solid tumor in the neonate.

Hepatoblastoma

  • Unresectable primary, multifocal tumors may be treated with:
    • Liver resection.
    • Liver transplantation.

Neuroblastoma

  • An enigmatic embryonal tumor arising from neuroblasts with somewhat unpredictable behavior.

Neuroblastoma Treatment

  • Biopsy methods:
    • Laparotomy or thoracotomy with classical open biopsy.
    • Laparoscopy or thoracoscopy with biopsy.
    • CT/USG-guided true-cut biopsy.
    • Fine needle aspiration.
  • Surgery may be performed.

Neuroblastoma Complications

  • Hemorrhage.
  • Renal ischemia.
  • Intestinal ischemia.
  • Prolonged ileus, bowel obstruction, intussusception.
  • Chylous ascites.
  • Vascular injuries with consequent morbidity.

Teratomas

  • Derived from the Greek words "teratos" meaning monster and "onkoma" meaning swelling.

This quiz covers the diagnosis and treatment of germ cell tumors in pediatrics, including sacrococygeal teratomas and intracranial GCTs.

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