Podcast
Questions and Answers
What is the purpose of using protease inhibitors in antiretroviral therapy?
What is the purpose of using protease inhibitors in antiretroviral therapy?
- To generate synthetic substrates for reverse transcriptase
- To target multiple stages of the HIV life cycle (correct)
- To induce a conformational change in the enzyme structure
- To competitively inhibit the incorporation of native nucleotides
What is the mechanism of action of Nucleos(t)ide Reverse Transcriptase Inhibitors (NRTIs)?
What is the mechanism of action of Nucleos(t)ide Reverse Transcriptase Inhibitors (NRTIs)?
- By lacking a 3′hydroxyl group to terminate DNA elongation
- By inducing a conformational change in the enzyme structure
- By competitively inhibiting the incorporation of native nucleotides (correct)
- By blocking replication of the viral genome by phosphorylation
How do NNRTIs act as inhibitors in HIV treatment?
How do NNRTIs act as inhibitors in HIV treatment?
- By binding to the active site to block enzyme function
- By inducing a conformational change in the enzyme structure (correct)
- By phosphorylation to generate synthetic substrates
- By competitively inhibiting reverse transcriptase activity
Why are Nucleos(t)ide Reverse Transcriptase Inhibitors important in HIV pharmacokinetics?
Why are Nucleos(t)ide Reverse Transcriptase Inhibitors important in HIV pharmacokinetics?
How do Nucleos(t)ide Reverse Transcriptase Inhibitors (NRTIs) exert their pharmacodynamic effect?
How do Nucleos(t)ide Reverse Transcriptase Inhibitors (NRTIs) exert their pharmacodynamic effect?
Which enzyme do Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) act on?
Which enzyme do Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) act on?
Why do NRTIs require intra-cytoplasmic activation via phosphorylation by cellular enzymes?
Why do NRTIs require intra-cytoplasmic activation via phosphorylation by cellular enzymes?
What is the mechanism of action of NNRTIs?
What is the mechanism of action of NNRTIs?
What is the selective toxicity of NRTIs based on?
What is the selective toxicity of NRTIs based on?
What adverse effect is commonly associated with Efavirenz use?
What adverse effect is commonly associated with Efavirenz use?
Which Nucleos(t)ide Reverse Transcriptase Inhibitor (NRTI) does not require triphosphorylation for activation?
Which Nucleos(t)ide Reverse Transcriptase Inhibitor (NRTI) does not require triphosphorylation for activation?
Which HIV strain are Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) active against?
Which HIV strain are Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) active against?
What is a common characteristic of Protease Inhibitors (PIs)?
What is a common characteristic of Protease Inhibitors (PIs)?
What is significant about the resistance development with Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)?
What is significant about the resistance development with Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)?
Where is the HBZ gene encoded in relation to the DNA strand?
Where is the HBZ gene encoded in relation to the DNA strand?
What is the characteristic of HBZ expression during infection?
What is the characteristic of HBZ expression during infection?
In ATL cells, what effects does Tax-independent cell proliferation lead to?
In ATL cells, what effects does Tax-independent cell proliferation lead to?
Which cellular transcription factors are constitutively expressed in aggressive ATL cells?
Which cellular transcription factors are constitutively expressed in aggressive ATL cells?
What is a genetic predisposition to Adult T-cell Leukemia (ATL) according to the text?
What is a genetic predisposition to Adult T-cell Leukemia (ATL) according to the text?
Which feature is characteristic of Adult T-cell Leukemia (ATL) at an advanced stage?
Which feature is characteristic of Adult T-cell Leukemia (ATL) at an advanced stage?
How is HTLV-1 infection diagnosed according to the text?
How is HTLV-1 infection diagnosed according to the text?
What is a cellular effect caused by the Tax protein of HTLV-1?
What is a cellular effect caused by the Tax protein of HTLV-1?
How does the HTLV-1 protein p12I contribute to down-modulation of MHC-I-restricted antigen presentation?
How does the HTLV-1 protein p12I contribute to down-modulation of MHC-I-restricted antigen presentation?
What is one of the effects of Tax-dependent cell proliferation of escape mutants?
What is one of the effects of Tax-dependent cell proliferation of escape mutants?
How does HBZ contribute to leukemogenesis in HTLV-1 infection?
How does HBZ contribute to leukemogenesis in HTLV-1 infection?
What characterizes the stage of low-grade ATL in HTLV-1 infection?
What characterizes the stage of low-grade ATL in HTLV-1 infection?
