Advanced Dosing MCPC 2

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What was the main objective of the NKF-ASN Taskforce formed in July 2020?

To compare different equations for estimating GFR

To evaluate the clinical consequences of GFR estimation approaches

To recommend immediate implementation of a new standard for estimating GFR (correct)

To analyze the standard body surface area for GFR estimation

Which variable did NOT play a significant role in the MDRD equation for estimating GFR?

Gender

Weight (correct)

Race

Age

What percentage of patients had African ancestry in the pooled data used for the original CKD-EPI with African Coefficient?

16%

6%

31% (correct)

12%

Which statement accurately describes the impact of using the CKD-EPI equation without the African coefficient for individuals with African ancestry?

It underestimates the true GFR. Signup and view all the answers

Which equation is accurate for estimating the true GFR in individuals with African ancestry?

CKD-EPIcys Signup and view all the answers

Which statement accurately describes the limitations of using cystatin C as a biomarker for estimating kidney function?

There are few laboratories capable of measuring cystatin C levels. Signup and view all the answers

Which equation is accurate for estimating the true GFR in people with African ancestry but NOT in people WITHOUT african ancestry

CKD-EPIcr-cysR Signup and view all the answers

The Cockcroft-Gault formula uses _____ instead of standard body surface area and is expressed in ml/min

Ideal body weight Signup and view all the answers

The MDRD equation becomes inaccurate at GFR higher than ____ ml/min/1.73^2 and it was not developed with medication dosing in mind

60 Signup and view all the answers

The MDRD used pooled data from 1638 different patients and ___% of them had African ancestry

12 Signup and view all the answers

The CKD-EPI without the African coefficient may make the GFR appear ________ than it really is

lower Signup and view all the answers

Blended CKD-EPI with African coefficient is adjusted based on the ________ of patients with African ancestry in the area served by the hospital

percentage Signup and view all the answers

CKD-EPI refit aims to maximize ________ in estimating GFR

justness Signup and view all the answers

______ is produced by all nucleated cells in the body and is not affected by race, gender, muscle mass, age, or disease

Cystatin C Signup and view all the answers

______ (B2M) is a biomarker for estimating kidney function but is not yet ready for clinical practice

practice Signup and view all the answers

NKF-ASN taskforce recommends using CKD-EPI Refit ____ the race variable

Without Signup and view all the answers

CKD-EPIcr with race variable ____ true GFR in black adults

Overestimates Signup and view all the answers

In patients with African Ancestry, the SCr concentration is likely to decrease as the percentage of African ancestry increases.

False Signup and view all the answers

The CKD-EPI with African coefficient weighted for demographics involves adjusting the coefficient based on genetic testing for each person.

False Signup and view all the answers

CKD-EPIcys (cystatin) is not accurate to the true GFR in black adults but is in non-black patients.

False Signup and view all the answers

CKD-EPIcr-cysNB (creatinine + cystatin.no race variable) underestimates true GFR in black adults and is accurate in non-black patients.

True Signup and view all the answers

CKD-EPIcr-cycR (refit.creatinine + cystatin) underestimates true GFR in black adults and overestimates in non-black patients.

False Signup and view all the answers

In two patients with identical age, gender, and SCr, the patient with African Ancestry likely has a measured GFR that is ____ than that of the patients without African ancestry.

higher Signup and view all the answers

in otherwise identical patients with the same measured GFR, the patient with African Ancestry will have a SCr value that is ____ than the patient who does not have African Ancestry

higher Signup and view all the answers

Standardizing to _____ compensates for patients of different body sizes.

body surface area Signup and view all the answers

If the package insert says use indexed MDRD, does Dr. Theilman think CKD-EPI Refit should be used and should it be de-indexed?

DONT use CKD-EPI Refit and DONT de-Index Signup and view all the answers

If the package insert specifically says use mL/min for GFR, Theilman think it is reasonable to use CKD-EPI Refit approach and de-index mL/min/1.73m2 to mL/min.

True Signup and view all the answers

A patient is 5'10 and a 150 pounds. Calculate their BSA

1.835 m^2 Signup and view all the answers

The Mindikoglu Equation and the GRAIL equation are both equations that can be used to calculate GFR in ____ disease

Liver Signup and view all the answers

Which process involves selectively filtering essential substances while retaining larger molecules and cells in the bloodstream?

Glomerular Filtration Signup and view all the answers

T/F: In liver disease, it is best to estimate GFR using equation that use cystatin alone

False Signup and view all the answers

Selective filtration of essential substances happens during tubular reabsorption in the kidney

True Signup and view all the answers

The CKD-EPI with African coefficient adjusts GFR accurately in black adults but not in non-black patients

False Signup and view all the answers

T/F: When using the Cock croft-Gault equation, you should use actual body weight if a patient is more than 130% their IBW

False Signup and view all the answers

a patient is 5'4 and 900 pounds. Calculate their IBW

54.7 kg Signup and view all the answers

a patient is 5'4 and 900 pounds. Calculate their ABW

196.5 kg Signup and view all the answers

Which biomarker for kidney function is endogenous?

Cystatin C Signup and view all the answers

T/F: If a patient is underweight, use their actual body weight in cockcroft-gault

True Signup and view all the answers

Advanced Dosing MCPC 2

Podcast Beta

Questions and Answers

What was the main objective of the NKF-ASN Taskforce formed in July 2020?

Which variable did NOT play a significant role in the MDRD equation for estimating GFR?

What percentage of patients had African ancestry in the pooled data used for the original CKD-EPI with African Coefficient?

Which statement accurately describes the impact of using the CKD-EPI equation without the African coefficient for individuals with African ancestry?

Which equation is accurate for estimating the true GFR in individuals with African ancestry?

Which statement accurately describes the limitations of using cystatin C as a biomarker for estimating kidney function?

Which equation is accurate for estimating the true GFR in people with African ancestry but NOT in people WITHOUT african ancestry

The Cockcroft-Gault formula uses _____ instead of standard body surface area and is expressed in ml/min

The MDRD equation becomes inaccurate at GFR higher than ____ ml/min/1.73^2 and it was not developed with medication dosing in mind

The MDRD used pooled data from 1638 different patients and ___% of them had African ancestry

The CKD-EPI without the African coefficient may make the GFR appear ________ than it really is

Blended CKD-EPI with African coefficient is adjusted based on the ________ of patients with African ancestry in the area served by the hospital

CKD-EPI refit aims to maximize ________ in estimating GFR

______ is produced by all nucleated cells in the body and is not affected by race, gender, muscle mass, age, or disease

______ (B2M) is a biomarker for estimating kidney function but is not yet ready for clinical practice

NKF-ASN taskforce recommends using CKD-EPI Refit ____ the race variable

CKD-EPIcr with race variable ____ true GFR in black adults

In patients with African Ancestry, the SCr concentration is likely to decrease as the percentage of African ancestry increases.

The CKD-EPI with African coefficient weighted for demographics involves adjusting the coefficient based on genetic testing for each person.

CKD-EPIcys (cystatin) is not accurate to the true GFR in black adults but is in non-black patients.

CKD-EPIcr-cysNB (creatinine + cystatin.no race variable) underestimates true GFR in black adults and is accurate in non-black patients.

CKD-EPIcr-cycR (refit.creatinine + cystatin) underestimates true GFR in black adults and overestimates in non-black patients.

In two patients with identical age, gender, and SCr, the patient with African Ancestry likely has a measured GFR that is ____ than that of the patients without African ancestry.

in otherwise identical patients with the same measured GFR, the patient with African Ancestry will have a SCr value that is ____ than the patient who does not have African Ancestry

Standardizing to _____ compensates for patients of different body sizes.

If the package insert says use indexed MDRD, does Dr. Theilman think CKD-EPI Refit should be used and should it be de-indexed?

If the package insert specifically says use mL/min for GFR, Theilman think it is reasonable to use CKD-EPI Refit approach and de-index mL/min/1.73m2 to mL/min.

A patient is 5'10 and a 150 pounds. Calculate their BSA

The Mindikoglu Equation and the GRAIL equation are both equations that can be used to calculate GFR in ____ disease

Which process involves selectively filtering essential substances while retaining larger molecules and cells in the bloodstream?

T/F: In liver disease, it is best to estimate GFR using equation that use cystatin alone

Selective filtration of essential substances happens during tubular reabsorption in the kidney

The CKD-EPI with African coefficient adjusts GFR accurately in black adults but not in non-black patients

T/F: When using the Cock croft-Gault equation, you should use actual body weight if a patient is more than 130% their IBW

a patient is 5'4 and 900 pounds. Calculate their IBW

a patient is 5'4 and 900 pounds. Calculate their ABW

Which biomarker for kidney function is endogenous?

T/F: If a patient is underweight, use their actual body weight in cockcroft-gault

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