Podcast
Questions and Answers
What was the main objective of the NKF-ASN Taskforce formed in July 2020?
What was the main objective of the NKF-ASN Taskforce formed in July 2020?
Which variable did NOT play a significant role in the MDRD equation for estimating GFR?
Which variable did NOT play a significant role in the MDRD equation for estimating GFR?
What percentage of patients had African ancestry in the pooled data used for the original CKD-EPI with African Coefficient?
What percentage of patients had African ancestry in the pooled data used for the original CKD-EPI with African Coefficient?
Which statement accurately describes the impact of using the CKD-EPI equation without the African coefficient for individuals with African ancestry?
Which statement accurately describes the impact of using the CKD-EPI equation without the African coefficient for individuals with African ancestry?
Signup and view all the answers
Which equation is accurate for estimating the true GFR in individuals with African ancestry?
Which equation is accurate for estimating the true GFR in individuals with African ancestry?
Signup and view all the answers
Which statement accurately describes the limitations of using cystatin C as a biomarker for estimating kidney function?
Which statement accurately describes the limitations of using cystatin C as a biomarker for estimating kidney function?
Signup and view all the answers
Which equation is accurate for estimating the true GFR in people with African ancestry but NOT in people WITHOUT african ancestry
Which equation is accurate for estimating the true GFR in people with African ancestry but NOT in people WITHOUT african ancestry
Signup and view all the answers
The Cockcroft-Gault formula uses _____ instead of standard body surface area and is expressed in ml/min
The Cockcroft-Gault formula uses _____ instead of standard body surface area and is expressed in ml/min
Signup and view all the answers
The MDRD equation becomes inaccurate at GFR higher than ____ ml/min/1.73^2 and it was not developed with medication dosing in mind
The MDRD equation becomes inaccurate at GFR higher than ____ ml/min/1.73^2 and it was not developed with medication dosing in mind
Signup and view all the answers
The MDRD used pooled data from 1638 different patients and ___% of them had African ancestry
The MDRD used pooled data from 1638 different patients and ___% of them had African ancestry
Signup and view all the answers
The CKD-EPI without the African coefficient may make the GFR appear ________ than it really is
The CKD-EPI without the African coefficient may make the GFR appear ________ than it really is
Signup and view all the answers
Blended CKD-EPI with African coefficient is adjusted based on the ________ of patients with African ancestry in the area served by the hospital
Blended CKD-EPI with African coefficient is adjusted based on the ________ of patients with African ancestry in the area served by the hospital
Signup and view all the answers
CKD-EPI refit aims to maximize ________ in estimating GFR
CKD-EPI refit aims to maximize ________ in estimating GFR
Signup and view all the answers
______ is produced by all nucleated cells in the body and is not affected by race, gender, muscle mass, age, or disease
______ is produced by all nucleated cells in the body and is not affected by race, gender, muscle mass, age, or disease
Signup and view all the answers
______ (B2M) is a biomarker for estimating kidney function but is not yet ready for clinical practice
______ (B2M) is a biomarker for estimating kidney function but is not yet ready for clinical practice
Signup and view all the answers
NKF-ASN taskforce recommends using CKD-EPI Refit ____ the race variable
NKF-ASN taskforce recommends using CKD-EPI Refit ____ the race variable
Signup and view all the answers
CKD-EPIcr with race variable ____ true GFR in black adults
CKD-EPIcr with race variable ____ true GFR in black adults
Signup and view all the answers
In patients with African Ancestry, the SCr concentration is likely to decrease as the percentage of African ancestry increases.
In patients with African Ancestry, the SCr concentration is likely to decrease as the percentage of African ancestry increases.
Signup and view all the answers
The CKD-EPI with African coefficient weighted for demographics involves adjusting the coefficient based on genetic testing for each person.
The CKD-EPI with African coefficient weighted for demographics involves adjusting the coefficient based on genetic testing for each person.
Signup and view all the answers
CKD-EPIcys (cystatin) is not accurate to the true GFR in black adults but is in non-black patients.
CKD-EPIcys (cystatin) is not accurate to the true GFR in black adults but is in non-black patients.
Signup and view all the answers
CKD-EPIcr-cysNB (creatinine + cystatin.no race variable) underestimates true GFR in black adults and is accurate in non-black patients.
CKD-EPIcr-cysNB (creatinine + cystatin.no race variable) underestimates true GFR in black adults and is accurate in non-black patients.
Signup and view all the answers
CKD-EPIcr-cycR (refit.creatinine + cystatin) underestimates true GFR in black adults and overestimates in non-black patients.
CKD-EPIcr-cycR (refit.creatinine + cystatin) underestimates true GFR in black adults and overestimates in non-black patients.
Signup and view all the answers
In two patients with identical age, gender, and SCr, the patient with African Ancestry likely has a measured GFR that is ____ than that of the patients without African ancestry.
In two patients with identical age, gender, and SCr, the patient with African Ancestry likely has a measured GFR that is ____ than that of the patients without African ancestry.
Signup and view all the answers
in otherwise identical patients with the same measured GFR, the patient with African Ancestry will have a SCr value that is ____ than the patient who does not have African Ancestry
in otherwise identical patients with the same measured GFR, the patient with African Ancestry will have a SCr value that is ____ than the patient who does not have African Ancestry
Signup and view all the answers
Standardizing to _____ compensates for patients of different body sizes.
Standardizing to _____ compensates for patients of different body sizes.
Signup and view all the answers
If the package insert says use indexed MDRD, does Dr. Theilman think CKD-EPI Refit should be used and should it be de-indexed?
If the package insert says use indexed MDRD, does Dr. Theilman think CKD-EPI Refit should be used and should it be de-indexed?
Signup and view all the answers
If the package insert specifically says use mL/min for GFR, Theilman think it is reasonable to use CKD-EPI Refit approach and de-index mL/min/1.73m2 to mL/min.
If the package insert specifically says use mL/min for GFR, Theilman think it is reasonable to use CKD-EPI Refit approach and de-index mL/min/1.73m2 to mL/min.
Signup and view all the answers
A patient is 5'10 and a 150 pounds. Calculate their BSA
A patient is 5'10 and a 150 pounds. Calculate their BSA
Signup and view all the answers
The Mindikoglu Equation and the GRAIL equation are both equations that can be used to calculate GFR in ____ disease
The Mindikoglu Equation and the GRAIL equation are both equations that can be used to calculate GFR in ____ disease
Signup and view all the answers
Which process involves selectively filtering essential substances while retaining larger molecules and cells in the bloodstream?
Which process involves selectively filtering essential substances while retaining larger molecules and cells in the bloodstream?
Signup and view all the answers
T/F: In liver disease, it is best to estimate GFR using equation that use cystatin alone
T/F: In liver disease, it is best to estimate GFR using equation that use cystatin alone
Signup and view all the answers
Selective filtration of essential substances happens during tubular reabsorption in the kidney
Selective filtration of essential substances happens during tubular reabsorption in the kidney
Signup and view all the answers
The CKD-EPI with African coefficient adjusts GFR accurately in black adults but not in non-black patients
The CKD-EPI with African coefficient adjusts GFR accurately in black adults but not in non-black patients
Signup and view all the answers
T/F: When using the Cock croft-Gault equation, you should use actual body weight if a patient is more than 130% their IBW
T/F: When using the Cock croft-Gault equation, you should use actual body weight if a patient is more than 130% their IBW
Signup and view all the answers
a patient is 5'4 and 900 pounds. Calculate their IBW
a patient is 5'4 and 900 pounds. Calculate their IBW
Signup and view all the answers
a patient is 5'4 and 900 pounds. Calculate their ABW
a patient is 5'4 and 900 pounds. Calculate their ABW
Signup and view all the answers
Which biomarker for kidney function is endogenous?
Which biomarker for kidney function is endogenous?
Signup and view all the answers
T/F: If a patient is underweight, use their actual body weight in cockcroft-gault
T/F: If a patient is underweight, use their actual body weight in cockcroft-gault
Signup and view all the answers
