Podcast
Questions and Answers
Which enzyme is responsible for the formation of nitric oxide?
Which enzyme is responsible for the formation of nitric oxide?
What is the primary precursor for the synthesis of nitric oxide?
What is the primary precursor for the synthesis of nitric oxide?
Which molecule can move through the cell membrane fairly easily due to its gaseous nature?
Which molecule can move through the cell membrane fairly easily due to its gaseous nature?
What happens to the enzyme responsible for nitric oxide synthesis as a person ages and develops certain diseases?
What happens to the enzyme responsible for nitric oxide synthesis as a person ages and develops certain diseases?
Signup and view all the answers
What is the role of nitric oxide in blood vessels?
What is the role of nitric oxide in blood vessels?
Signup and view all the answers
How does increased production of nitric oxide affect blood pressure?
How does increased production of nitric oxide affect blood pressure?
Signup and view all the answers
Which individuals are likely to have increased plasma nitric oxide biomarkers?
Which individuals are likely to have increased plasma nitric oxide biomarkers?
Signup and view all the answers
What is the impact of nitric oxide on muscle force production?
What is the impact of nitric oxide on muscle force production?
Signup and view all the answers
What is the impact of exercise on nitric oxide production and glucose uptake?
What is the impact of exercise on nitric oxide production and glucose uptake?
Signup and view all the answers
How is L-arginine related to nitric oxide production?
How is L-arginine related to nitric oxide production?
Signup and view all the answers
What is the effect of oral L-arginine supplementation at low doses?
What is the effect of oral L-arginine supplementation at low doses?
Signup and view all the answers
What was observed in a study on the effect of acute ingestion of 6 g L-arginine for severe-intensity running?
What was observed in a study on the effect of acute ingestion of 6 g L-arginine for severe-intensity running?
Signup and view all the answers
What was the outcome of a study with 6 g of L-arginine or placebo for 3 days on peak or mean power output during cycling exercise?
What was the outcome of a study with 6 g of L-arginine or placebo for 3 days on peak or mean power output during cycling exercise?
Signup and view all the answers
Nitric oxide is formed through an enzyme called nitric oxide synthase and is ______ dependent
Nitric oxide is formed through an enzyme called nitric oxide synthase and is ______ dependent
Signup and view all the answers
The enzyme responsible for the formation of nitric oxide starts to become dysfunctional as one ages and starts to develop certain ______
The enzyme responsible for the formation of nitric oxide starts to become dysfunctional as one ages and starts to develop certain ______
Signup and view all the answers
L-arginine + O2 → (nitric oxide synthase) → nitric oxide + ______
L-arginine + O2 → (nitric oxide synthase) → nitric oxide + ______
Signup and view all the answers
Nitric oxide can move through the membrane fairly easily because it is a ______ molecule
Nitric oxide can move through the membrane fairly easily because it is a ______ molecule
Signup and view all the answers
When a blood vessel is exposed to sheer stressed, it activates nitric oxide synthase, which leads to the production of ______, which can diffuse into the smooth muscle cells and cause the process of relaxation
When a blood vessel is exposed to sheer stressed, it activates nitric oxide synthase, which leads to the production of ______, which can diffuse into the smooth muscle cells and cause the process of relaxation
Signup and view all the answers
Increased production of nitric oxide = reduction in blood pressure + may increases blood flow to the organs. Exercise context → opening up the blood vessels (vasodilation) has implications in blood flow (important for oxygen and nutrient delivery, removal of waste products), removal of metabolites that cause fatigue (better recovery). Individuals with cardiovascular issues will often take drugs that will stimulate ______ production
Increased production of nitric oxide = reduction in blood pressure + may increases blood flow to the organs. Exercise context → opening up the blood vessels (vasodilation) has implications in blood flow (important for oxygen and nutrient delivery, removal of waste products), removal of metabolites that cause fatigue (better recovery). Individuals with cardiovascular issues will often take drugs that will stimulate ______ production
Signup and view all the answers
Plasma nitric oxide biomarkers are lowered with ageing and several diseases. Increased in individuals with high aerobic fitness. Muscle force production → excitation-contraction coupling. Can help glucose uptake in an insulin dependant pathway. If you exercise you produce more ______ and hence helps clear some of the glucose into the muscle. Implications for athletes and diabetes
Plasma nitric oxide biomarkers are lowered with ageing and several diseases. Increased in individuals with high aerobic fitness. Muscle force production → excitation-contraction coupling. Can help glucose uptake in an insulin dependant pathway. If you exercise you produce more ______ and hence helps clear some of the glucose into the muscle. Implications for athletes and diabetes
Signup and view all the answers
It is a free radical gas → has a short half-life → it is hard to measure → its oxidation products are measured to asses ______ (e.g., in saliva)
It is a free radical gas → has a short half-life → it is hard to measure → its oxidation products are measured to asses ______ (e.g., in saliva)
Signup and view all the answers
Logic → L-arginine is the precursor of ______ hence it will lead to an increased NO which leads to improved performance - Claimed to improve muscle blood flow and hence performance. It is not as simple as it seems
Logic → L-arginine is the precursor of ______ hence it will lead to an increased NO which leads to improved performance - Claimed to improve muscle blood flow and hence performance. It is not as simple as it seems
Signup and view all the answers
Low doses (< 20 g) of L-arginine are well tolerated with no side effects. Plasma ______ peaks 60-120 min post oral ingestion of 6 g L-arginine (pharmacokinetics) → coincides with the higher levels of l-arginine in the blood
Low doses (< 20 g) of L-arginine are well tolerated with no side effects. Plasma ______ peaks 60-120 min post oral ingestion of 6 g L-arginine (pharmacokinetics) → coincides with the higher levels of l-arginine in the blood
Signup and view all the answers
Study → Acute ingestion of 6 g ______ (substrate for NO) ○ Severe-intensity running ○ No changes in time-to-exhaustion with ______ supplementation. Most studies do not observe changes in NO biomarkers following ______ supplementation → mostly looked at single dose, maybe longer supplementation will improve. It is not because ______ is a substrate for an enzyme that you will get an increased flux through the enzyme
Study → Acute ingestion of 6 g ______ (substrate for NO) ○ Severe-intensity running ○ No changes in time-to-exhaustion with ______ supplementation. Most studies do not observe changes in NO biomarkers following ______ supplementation → mostly looked at single dose, maybe longer supplementation will improve. It is not because ______ is a substrate for an enzyme that you will get an increased flux through the enzyme
Signup and view all the answers
Study → 6 g of ______ or placebo for 3 days → expanding the supplementation window to 3 days sis not ○ No effect of ______ on peak or mean power output during 13 repetitions of 20 s all-out cycling, 15 s recovery
Study → 6 g of ______ or placebo for 3 days → expanding the supplementation window to 3 days sis not ○ No effect of ______ on peak or mean power output during 13 repetitions of 20 s all-out cycling, 15 s recovery
Signup and view all the answers
Study → 6 g of ______ or placebo for 7 days → No effect of ______ on time-to-exhaustion during severe-intensity cycling exercise. Most studies that have found positive effects of ______ supplementation have Assessed power/strength based exercise ○ Administered ______ with L-glycine → a lot of performance enhanc.
Study → 6 g of ______ or placebo for 7 days → No effect of ______ on time-to-exhaustion during severe-intensity cycling exercise. Most studies that have found positive effects of ______ supplementation have Assessed power/strength based exercise ○ Administered ______ with L-glycine → a lot of performance enhanc.
Signup and view all the answers
What was observed in a study on the effect of acute ingestion of 6 g ______ for severe-intensity running? No changes in time-to-exhaustion with ______ supplementation
What was observed in a study on the effect of acute ingestion of 6 g ______ for severe-intensity running? No changes in time-to-exhaustion with ______ supplementation
Signup and view all the answers
What is the impact of nitric oxide on muscle force production? Can help glucose uptake in an insulin dependant pathway. If you exercise you produce more ______ and hence helps clear some of the glucose into the muscle. Implications for athletes and diabetes
What is the impact of nitric oxide on muscle force production? Can help glucose uptake in an insulin dependant pathway. If you exercise you produce more ______ and hence helps clear some of the glucose into the muscle. Implications for athletes and diabetes
Signup and view all the answers
Which individuals are likely to have increased plasma ______ biomarkers? Increased in individuals with high aerobic fitness
Which individuals are likely to have increased plasma ______ biomarkers? Increased in individuals with high aerobic fitness
Signup and view all the answers
