chapter 4 Mixing #28

Why do pharmaceutical products rarely contain only one component?

What is needed to produce a tablet dosage form containing an active drug at a dose of 1 mg?

Which components are necessary for handling a tablet dosage form by the patient?

Why is mixing or blending required in the manufacturing process of pharmaceutical products?

What is the primary purpose of the unit operation of mixing in pharmaceutical preparations?

Why is control of mixing processes considered critical in pharmaceutical manufacturing?

pharmaceutical manufacturing, what role does mixing or blending play in dosage form release?

Which of the following is NOT a reason for mixing or blending in the manufacturing process?

Why is mixing used in the manufacturing process of tablets, capsules, and dry powder inhalers?

What is the primary purpose of mixing in the production of emulsions and creams?

What is the purpose of mixing in the unit operation of granulation?

Which of the following products require mixing processes?

What are pastes and suspensions?

Mixing and control are important in which of the following unit operations?

What is important when mixing potent drugs in a powder mix?

What is the potential consequence of over mixing lubricants with granules during tablet production?

Why is well-mixed product essential when dispersing two immiscible liquids or dispersing a solid in a liquid?

Which type of mixtures are formed from materials such as gases or miscible liquids, and tend to approach a perfect mix spontaneously and irreversibly?

What type of materials do positive mixtures require for spontaneous and irreversible mixing?

In general, do materials which mix by positive mixing present any problems during product manufacture?

Is an input of energy required with positive mixtures for spontaneous and irreversible mixing if the time available for mixing is unlimited?

What is a potential consequence of over mixing negative mixtures in pharmaceutical preparations?

All of the following is correct example Negative mixtures except ?

In which situation is an input of energy required to maintain the components adequately dispersed in a negative mixture?

What is generally a characteristic of negative mixtures compared to positive mixtures in terms of mixing efficiency?

What is a characteristic of neutral mixtures in terms of spontaneous mixing or segregation?

All of the following is FALSE considered an example of a neutral mixture except?

Which of the following best describes the behavior of neutral mixtures?

Which of the following example Neutral mixture ?

which of the following type of mixture ?

All of the following Correct factor can lead to a change in the mixture type except?

Which of the following is Correct characteristic of a mixture can cause it to change from a negative to a neutral mixture?

What is the definition of perfect mixing?

What are the terms commonly used interchangeably in the pharmaceutical industry?

Process that tends to result in a randomization of dissimilar particles within a system Defintion :

All of the following classification of mixing except ?

What may be added to the solids in order to coat or absorb coloring, flavoring, oils, or other solutions?

What contributes to the solid mixing process in terms of particle characteristics?

Which operation is performed to combine the active ingredient with binder, fillers, and additives in the manufacture of tablets?

What is the primary purpose of adding small amounts of liquid to solids in tablet formulation?

Which of the following is NOT an example of an additive used in dry blending?

How are solids divided based on their flow properties?

In which case is mixing considered a critical factor?

Which of the following is correct type of forces hold neighboring particles in fixed relative position except?

What results in surface-surface interactions that resist the movement of particles?

What type of charges produce particle-particle repulsions during mixing?

What should surface forces be during mixing?

Which forces hold neighboring particles in fixed relative position?

These depend on surface area, surface roughness, polarity, charge, moisture (Inertial forces)

During mixing, the particles develop surface charge which produce particle particle repulsions (monopolar charges, impossible to mix), which make random mixing impossible

What happens when heavy and light density powders are mixed together?

Why is well-mixed product essential when dispersing two immiscible liquids or dispersing a solid in a liquid?

Gravitational forces : happens when we have heavy and light density together in the same powder mixture.

What is the opposite effect to mixing, where components tend to separate out?

What does segregation cause?

How does segregation affect the quality of the mix?

Segregation arises because powder mixes encountered in practice are:

What happens to particles with similar properties in a powder bed?

When is segregation more likely to occur in a powder bed?

In what situations does segregation occur to a greater extent in powder beds?

What approach involves the selection of particular size fractions of drug and excipients to achieve a narrow particle size range?

Which method can be used to reduce the particle size range by milling components?

What is the particle size range at which segregation does not tend to cause serious problems?

What approach involves selecting excipients with a density similar to that of the active component(s)?

controlled crystallization during production of the drug/excipients to give components of a particular crystal shape or size range

What is another term for the production of an 'ordered' mix?

Which of the following is Correct equipment allows for multiple operations without transferring the mix?

How can segregation be minimized during the production of drug/excipients?

Which process involves size enlargement of the powder mix?

Which technique should be avoided to reduce vibration or movement?

What is convective mixing /Macro mixing?

How does shear mixing occur?

What is diffusion mixing/Micro mixing?

Which type of mixing contributes mainly to the macroscopic mixing of powder mixtures?

8. Which type of mixing requires extended mixing time to achieve a random mix?

All of the following Mechanisms of mixing of solids dosage forms except:

Which type of mixing tends to produce a large degree of mixing fairly quickly?

Macro mixing : Mixing does not, however occur without the group of particles moving together as a unit

What happens to the volume occupied by a powder bed when it is forced to move or flow?

Which type of mixing can occur under both gravitational forces and forced movement?

Which of the following is Correct In the solid solid mixing operations steps are involves:

Which of the following is an example of acceptable mixing?

Which of the following is an example of Ordered mixing:

Which of the following factors influences mixing?

What effect does the difference in particle sizes have on the mixing of solids?

How does the difference in densities among mixed particles affect the mixing process?

Which of the following is Correct one way to reduce the effect of electrostatic charges during mixing except?

What type of mixtures are powders and granulations that do not require substantial shear to be mixed?

Which process risk is often caused by segregation within the blender or after blender discharge when dealing with free flowing materials?

What factor limits the mixing rate of free flowing materials?

Free flowing materials :are powders and granulations in which interparticle cohesive forces are small enough for particles to move individually.( No electrostatic or hygroscopic No agglomeration)