Podcast
Questions and Answers
What is the discrete probability distribution of the number of successes in a sequence of n independent experiments, each asking a yes–no question?
What is the discrete probability distribution of the number of successes in a sequence of n independent experiments, each asking a yes–no question?
What type of mutations alter the phenotype and kind of start the cancer?
What type of mutations alter the phenotype and kind of start the cancer?
What type of mutations have no impact on cancer and are not actionable?
What type of mutations have no impact on cancer and are not actionable?
What is the main source of errors in NGS machines resulting in noisy sequence reads?
What is the main source of errors in NGS machines resulting in noisy sequence reads?
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What process involves taking the information and converting it to insights?
What process involves taking the information and converting it to insights?
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What are variations of a gene called?
What are variations of a gene called?
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What is the term used to describe variations of a gene?
What is the term used to describe variations of a gene?
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What type of distribution can be used to model Normal-Tumour Allelic Count Data?
What type of distribution can be used to model Normal-Tumour Allelic Count Data?
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What does tertiary analysis involve?
What does tertiary analysis involve?
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What do driver mutations do in the context of cancer?
What do driver mutations do in the context of cancer?
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Flashcards
Binomial Distribution
Binomial Distribution
A probability distribution describing the number of 'successes' in a series of independent trials where each trial has only two possible outcomes and the probability of success is constant.
Driver Mutations
Driver Mutations
Mutations that directly contribute to the development of cancer by altering the function of genes involved in cell growth or regulation.
Passenger Mutations
Passenger Mutations
Mutations that occur in the genome but do not contribute to the development of cancer. They are essentially 'passengers' on the cancer journey.
Repetitive Sequences
Repetitive Sequences
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Tertiary Analysis
Tertiary Analysis
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Allele
Allele
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Tertiary Analysis
Tertiary Analysis
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Driver Mutations
Driver Mutations
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Passenger Mutations
Passenger Mutations
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Study Notes
Probability Distribution
- The discrete probability distribution of the number of successes in a sequence of n independent experiments, each asking a yes–no question, is called the binomial distribution.
Cancer and Mutations
- Driver mutations alter the phenotype and can start cancer.
- Passenger mutations have no impact on cancer and are not actionable.
Next Generation Sequencing (NGS)
- Errors in NGS machines, resulting in noisy sequence reads, are mainly due to sequencing errors.
Data Analysis
- Tertiary analysis involves taking the information and converting it to insights.
Genetics
- Variations of a gene are called alleles.
- The term used to describe variations of a gene is allelic variation.
Statistical Modeling
- The beta-binomial distribution can be used to model Normal-Tumour Allelic Count Data.
Cancer Biology
- Driver mutations promote cancer development and progression.
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Description
Test your knowledge on the cost of raw DNA sequencing, error sources in NGS machines, alignment procedures, gene variations, and allelic count data modeling. This quiz covers topics related to NGS machines, DNA sequencing, gene variations, and allele counting.
