35 Questions
Which type of granules in neutrophils contain proteinases, acid phosphatase, myeloperoxidase, and β-glucuronidase?
Azurophilic granules
What causes neutrophilia and changes in neutrophil morphology?
Bacterial infection
What is the term used to describe the presence of neutrophil precursors like band cells and metamyelocytes in peripheral blood?
Left shift
What is the term used to describe the dark blue, coarse granules seen in neutrophils?
Toxic granulation
What is the term used to describe the light blue, peripheral inclusions seen in neutrophils?
Döhle bodies
Which of the following is NOT a neutrophil chemotactic agent?
C6
What is the term used to describe neutrophils with a nucleus that has 6+ lobes?
Hypersegmented neutrophils
What does a left shift in peripheral blood suggest?
Inflammation, CML
What does a leukoerythroblastic reaction suggest?
Bone marrow infiltration
Which of the following is the primary source of energy for erythrocytes?
Carbohydrate
What is the average lifespan of erythrocytes in healthy adults?
90-120 days
What is the term used to describe the condition of having an increased RBCs?
Erythrocytosis
What does the presence of varying shapes of erythrocytes indicate?
Poikilocytosis
Which of the following is true about thrombocytes (platelets)?
They have a life span of 8-10 days.
Which of the following is a function of thrombocytes (platelets)?
Form platelet plug.
Where is approximately 1/3 of the platelet pool stored?
Spleen
Which receptor is responsible for vWF binding on thrombocytes (platelets)?
GpIb
Which of the following is a component of thrombocytes (platelets) alpha granules?
vWF
Which of the following is a characteristic of monocytes?
Extensive cytoplasm
Where do monocytes differentiate into macrophages?
In the tissues
What does the term 'mono' in monocytes refer to?
One nucleus
Which of the following is true about macrophages?
They differentiate from circulating blood monocytes
Which of the following is a function of macrophages?
Presenting antigens via MHC II
Where are macrophages an important cellular component?
Liver
What initiates septic shock by binding to macrophages?
Lipid A from bacterial LPS
Which molecule from bacterial LPS binds to CD14 on macrophages?
Lipid A
What is the role of CD14 in the initiation of septic shock?
It binds to Lipid A on macrophages
Which immune cells are primarily targeted by Lipid A from bacterial LPS?
Macrophages
Which cells function as a link between the innate and adaptive immune systems?
Dendritic cells
Which receptors are expressed on the surface of dendritic cells?
MHC class II and Fc receptors
What is the term used to describe the presentation of exogenous antigens on MHC class I by dendritic cells?
Cross-presentation
Which of the following is a function of eosinophils?
Phagocytosis of antigen-antibody complexes
What is the major basic protein (MBP) produced by eosinophils?
Eosinophil-derived neurotoxin
What is the cause of eosinophilia known as PACMAN Eats?
Myeloproliferative disorders
What does eosinophilic granulomatosis with polyangiitis cause?
Eosinophilia
Test your knowledge on neutrophils in the acute inflammatory response and their role as phagocytic cells. Learn about the specific and azurophilic granules found in neutrophils, as well as the changes in neutrophil morphology during inflammatory states.
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