Neurotransmitters in the Autonomic Nervous System

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Questions and Answers

What neurotransmitter is released by postganglionic neurons in the parasympathetic nervous system?

  • Norepinephrine
  • Epinephrine
  • Dopamine
  • Acetylcholine (correct)

Which term best describes neurons that release acetylcholine?

  • GABAergic
  • Noradrenergic
  • Adrenergic
  • Cholinergic (correct)

What is the primary neurotransmitter released by most postganglionic neurons in the sympathetic nervous system?

  • Serotonin
  • Norepinephrine (correct)
  • Epinephrine
  • Acetylcholine

If a neuron releases norepinephrine (NE), what term would be used to classify the neuron?

<p>Adrenergic (C)</p> Signup and view all the answers

What is the neurotransmitter released by preganglionic neurons in both the sympathetic and parasympathetic nervous systems?

<p>Acetylcholine (A)</p> Signup and view all the answers

How do acetylcholine (ACh) and norepinephrine (NE) typically affect target organs in the autonomic nervous system?

<p>They bind to different receptors to mediate different target organ responses. (C)</p> Signup and view all the answers

At the neuroeffector junction, what neurotransmitter is released by postganglionic neurons of the parasympathetic pathway?

<p>Acetylcholine (A)</p> Signup and view all the answers

Which neurotransmitter is NOT primarily associated with the autonomic nervous system?

<p>Glutamate (A)</p> Signup and view all the answers

What is the fundamental concept of the 'Neuron Doctrine'?

<p>The nervous system is made up of discrete individual cells. (B)</p> Signup and view all the answers

Which of the following best describes the Central Nervous System (CNS)?

<p>The brain and spinal cord. (C)</p> Signup and view all the answers

What is the primary role of motor nerves within the nervous system?

<p>Controlling movement and some functions. (D)</p> Signup and view all the answers

What is the main function of sensory nerves?

<p>Detecting external stimuli. (B)</p> Signup and view all the answers

According to the content, what are the two main divisions of the nervous system?

<p>Central and peripheral nervous systems. (D)</p> Signup and view all the answers

Which of the following is considered the minimal functional unit of the nervous system?

<p>The neuron. (C)</p> Signup and view all the answers

What is the primary function of a neuron?

<p>To conduct electrical signals (Action Potentials). (C)</p> Signup and view all the answers

Based on the content, what is a major reason for the close association between physiology and anatomy in the nervous system?

<p>Neurons conduct action potentials to control functions and detect stimuli. (D)</p> Signup and view all the answers

According to the provided diagram, what are the two main divisions of the nervous system?

<p>Central and Peripheral (D)</p> Signup and view all the answers

Which division of the nervous system includes the brain and spinal cord?

<p>Central Nervous System (D)</p> Signup and view all the answers

The Autonomic Nervous System is further divided into which two systems?

<p>Sympathetic and Parasympathetic (D)</p> Signup and view all the answers

What does the term 'chromothesia' refer to in the context of the text?

<p>A form of synesthesia where music is heard as colors (D)</p> Signup and view all the answers

What is the specific type of synesthesia where letters or numbers are perceived as being inherently colored?

<p>Grapheme-color synesthesia (B)</p> Signup and view all the answers

A musician experiencing different tastes in response to musical tones would be an example of:

<p>Auditory-gustatory synesthesia (A)</p> Signup and view all the answers

Which of the following is NOT directly mentioned as being included in the 'Efferent' division?

<p>Afferent Nervous System (B)</p> Signup and view all the answers

Based on the text provided, what processes are associated with the peripheral nervous system?

<p>Regulation of heart rate and blood pressure. (D)</p> Signup and view all the answers

What is one primary function of the blood-brain barrier?

<p>To prevent some substances, including antibodies, from easily entering the brain. (A)</p> Signup and view all the answers

What is the significance of rapid treatment with anti-rabies antibodies before symptom onset?

<p>It can help lessen the severity of the infection. (B)</p> Signup and view all the answers

Which of these components is described as influencing the structure and function of the blood-brain barrier?

<p>Astrocytes (C)</p> Signup and view all the answers

Based on the content, what is a direct effect of the rabies virus on the central nervous system?

<p>It inhibits the function of natural neurotransmitters. (A)</p> Signup and view all the answers

What type of infection does the content primarily discuss in relation to the blood-brain barrier?

<p>Viral rabies (A)</p> Signup and view all the answers

Why is the blood-brain barrier a consideration in the treatment of neurological disorders?

<p>It can impede the delivery of therapeutic drugs to the brain. (D)</p> Signup and view all the answers

Which of the following diseases is mentioned in the text as associated with the blood-brain barrier?

<p>Parkinson's disease (B)</p> Signup and view all the answers

What can happen if the rabies virus is left untreated until after the onset of symptoms?

<p>There is no effective treatment for rabies after this point. (B)</p> Signup and view all the answers

What is the primary function of ion channels in the nervous system?

<p>To produce electrical impulses for rapid information transfer. (B)</p> Signup and view all the answers

How do voltage-gated ion channels contribute to electrical activity in axons?

<p>By altering the membrane potential when they open. (D)</p> Signup and view all the answers

What is the initial state of voltage-gated ion channels in axons?

<p>Initially closed, only opening to allow ions to move across the membrane. (A)</p> Signup and view all the answers

What type of signal transmission occurs in axons?

<p>Electrical signals via action potentials. (D)</p> Signup and view all the answers

What is the main function of action potentials?

<p>To transmit signals from one location to another within the nervous system. (B)</p> Signup and view all the answers

What causes a change in membrane potential in axons?

<p>The opening of voltage-gated ion channels. (C)</p> Signup and view all the answers

Where are sodium and potassium ions initially located at the start of an action potential?

<p>Sodium is outside and potassium is inside the axon (B)</p> Signup and view all the answers

Which specific ion channels are primarily responsible for electrical activity in axons?

<p>Voltage-sensitive ion channels (B)</p> Signup and view all the answers

What primarily stimulates the opening of voltage-gated ion channels in the axon membrane?

<p>Depolarization (C)</p> Signup and view all the answers

Why are the ion channels in the axon membrane described as voltage-gated?

<p>They are activated by changes in membrane potential. (C)</p> Signup and view all the answers

What mechanism prevents the membrane potential from becoming more positive than approximately 30 mV during an action potential?

<p>The inactivation of sodium channels and the opening of potassium channels. (B)</p> Signup and view all the answers

What does the 'all-or-none' principle of action potentials refer to?

<p>The action potential either reaches a consistent amplitude or it doesn't occur. (A)</p> Signup and view all the answers

Which of the following best describes how action potentials are propagated?

<p>By opening and closing of voltage-gated ion channels along the axon. (D)</p> Signup and view all the answers

What is the typical order of events that leads to action potential generation?

<p>Depolarization, opening of Na+ channels, opening of K+ channels (A)</p> Signup and view all the answers

Which statement correctly describes the function of voltage-gated channels during an action potential?

<p>They facilitate the rapid changes in membrane permeability to certain ions. (C)</p> Signup and view all the answers

If a neuron receives a stimulus that causes only a small depolarization, what will happen?

<p>A local potential will be generated. (B)</p> Signup and view all the answers

Flashcards

Central Nervous System (CNS)

The brain and spinal cord, responsible for processing information and controlling bodily functions.

Peripheral Nervous System (PNS)

The network of nerves and ganglia that connect the CNS to the rest of the body.

Neuron

The smallest functional unit of the nervous system, responsible for transmitting information.

Neuron Doctrine

The concept that the nervous system is composed of individual cells, not a continuous network.

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Neurophysiology

The study of how the nervous system functions.

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Neuroanatomy

The study of the structure of the nervous system.

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Motor Nerves

Nerves that carry signals from the CNS to muscles and glands, controlling movement and other functions.

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Sensory Nerves

Nerves that carry signals from sensory organs to the CNS, providing information about the external world.

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What is the blood-brain barrier?

A protective barrier that shields the brain from harmful substances in the bloodstream.

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What role do astrocytes play in the blood-brain barrier?

Astrocytes are star-shaped cells that play a crucial role in maintaining the structure and function of the blood-brain barrier.

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How does the blood-brain barrier make treating neurological disorders difficult?

The blood-brain barrier is a challenge for drug delivery to the brain, especially when treating neurological disorders like Parkinson's disease, Alzheimer's disease, and brain cancer.

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What is rabies?

Rabies is a deadly viral infection that affects the brain. It is typically transmitted through the bite of an infected animal.

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What is the treatment for rabies?

After symptoms appear, there is no cure for rabies. However, rapid treatment with anti-rabies antibodies before symptoms show can help fight the infection.

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How does the blood-brain barrier affect rabies treatment?

The blood-brain barrier prevents immune cells and antibodies from entering the brain, making it difficult to fight infections like rabies.

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How does nitric oxide (NO) affect the blood-brain barrier?

Nitric oxide (NO) is a signaling molecule that can be inhibited through various neurotransmitter receptors, including NMDA and substance P. This inhibition can impact the function of the blood-brain barrier.

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Why is it hard for drugs to reach the brain?

Drugs that target the brain often face challenges in crossing the blood-brain barrier due to its protective nature.

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Autonomic Nerve Classification

Nerves in the autonomic nervous system are categorized based on the primary neurotransmitter released at their synapses.

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Cholinergic Neuron

ACh stands for acetylcholine. Neurons that release ACh are called cholinergic neurons.

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Adrenergic Neuron

NE stands for norepinephrine. Neurons that release NE are called adrenergic neurons.

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Parasympathetic Outflow

The parasympathetic nervous system uses acetylcholine as its primary neurotransmitter at both preganglionic and postganglionic synapses.

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Sympathetic Outflow

The sympathetic nervous system uses acetylcholine at its preganglionic synapse and norepinephrine at its postganglionic synapse.

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Neuroeffector Junction

The interface between a neuron and its target cell, where neurotransmitters are released.

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Neurotransmitter Receptor Specificity

ACh and NE bind to different receptors on target cells, leading to distinct responses.

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Autonomic Nervous System

The Autonomic Nervous System (ANS) is a control system that operates largely unconsciously, regulating functions like heart rate, digestion, breathing, and blood pressure.

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What is the CNS?

The central nervous system (CNS) is the control center of the body, consisting of the brain and spinal cord. It receives information from the peripheral nervous system (PNS) and sends out commands to the body.

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What is the PNS?

The peripheral nervous system (PNS) is the network of nerves that connect the CNS to the rest of the body. It acts as a messenger, carrying information to and from the CNS.

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What do afferent nerves do?

Afferent nerves carry sensory information from the body to the CNS, like feeling pain or warmth.

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What do efferent nerves do?

Efferent nerves carry motor commands from the CNS to the body, telling muscles to move.

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What is the SNS?

The somatic nervous system (SNS) controls voluntary movements, like walking or typing.

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What is the ANS?

The autonomic nervous system (ANS) controls involuntary actions, like breathing or heartbeat.

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What is the SNS?

The sympathetic nervous system (SNS), a branch of the ANS, prepares the body for 'fight or flight' responses, like increased heart rate or breathing.

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What is the PSNS?

The parasympathetic nervous system (PSNS), another branch of the ANS, helps the body relax and conserve energy after a stressful situation.

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Membrane potential

The difference in electrical charge between the inside and outside of a cell membrane.

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Ion channels

Specialized proteins embedded in the cell membrane that allow ions to pass through.

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Electrical impulse

The movement of ions across a cell membrane, creating an electrical signal.

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Voltage-gated ion channels

Ion channels that open or close in response to changes in the membrane potential.

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Polarization

The process of changing the membrane potential of a cell by opening or closing ion channels.

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Action potential

A rapid, short-lasting change in membrane potential that travels along an axon.

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Signal transmission

The movement of ions across the cell membrane, creating an electrical signal that is transmitted along the axon.

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Nervous system communication

The process of sending information from one part of the nervous system to another using electrical signals.

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Voltage-gated channels

Voltage-gated channels are ion channels that open or close in response to changes in the membrane potential.

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Action Potential Propagation

The process by which an action potential travels along the length of an axon.

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Voltage-gated Na+ and K+ Channels

Sodium (Na+) and potassium (K+) channels in the axon membrane are voltage-gated, meaning they open and close based on changes in the membrane potential.

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All-or-None Principle

The amplitude of an action potential is always the same, regardless of the strength of the stimulus.

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Maximum Membrane Potential

The membrane potential does not become more positive than 30 mV during an action potential because the sodium channels close and the potassium channels open.

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Conduction Velocity

The ability of a neuron to rapidly conduct action potentials across long distances.

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Threshold Potential

Action potentials are triggered by a stimulus that depolarizes the membrane to the threshold potential.

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Study Notes

Learning Outcomes

  • Neurophysiology covers the nervous system (161-169, 239-249, 256, 163-171, 243-252 & 258-260)
  • Functional classifications of neurons
  • Structural classifications of brain cells
  • Blood-brain barrier
  • Organization of the nervous system
  • Critical thinking skills

Introduction to Neurophysiology

  • Nervous system structure = Anatomy
  • Nervous system function = Physiology
  • Understanding physiology requires knowledge of neuroanatomy and microanatomy
  • Neurons have 2 (or 3) functions:
    • Conduct electrical signals (action potentials)
    • Release chemical signals (neurotransmitters)
  • Neurophysiology is closely related to anatomy in the nervous system.

Neurons and Synapses

  • Neurons are the basic functional units of the nervous system
  • Dendrites receive information from sensory receptors and send it to the cell body
  • Axons deliver electrical signals from the cell body to another neuron or an effector
  • Neurons move "information" rapidly by conducting action potentials.
  • Action potentials (Electrical impulses) move from one part of the neuron to another.
  • Once at the Axon terminal, action potentials are converted to a chemical signal at the Synapse

Functional Classification of Neurons

  • Sensory (afferent) neurons carry impulses into the CNS from sensory receptors.
  • Association (interneurons) neurons are located entirely within the CNS, helping to integrate CNS functions
  • Motor (efferent) neurons carry impulses out of the CNS to effector organs like muscles or glands.
  • Somatic motor control skeletal muscles (reflexes and voluntary)
  • Autonomic motor control smooth muscles, cardiac muscles, glands (involuntary)
  • Sympathetic and parasympathetic are subdivisions of autonomic neurons

STRUCTURAL Classification of Neurons

  • Four types of neurons:

    • Pseudopolar (unipolar) - sensory, 1 process that splits (e.g., sensory receptors)
    • Bipolar - retinal/cochlear, 2 processes (e.g., retinal neurons)
    • Multipolar - most common, motor, and association, many dendrites, but one axon (e.g., motor neurons)
    • Anaxonic - some CNS neurons, no obvious axon (e.g., some interneurons)
  • Supporting cells (glial cells) help support neuron function

    • Supporting Cells in the PNS : Schwann Cells, Satellite Cells
    • Supporting Cells in the CNS : Oligodendrocytes, Microglia, Astrocytes, Ependymal cells

Functional/Classification of Neurons: Simple Neural Circuit

  • Sensory neurons carry signals to the CNS
  • Motor neurons carry signals from the CNS
  • Interneurons transmit signals between neurons
  • Sensory neurons carry information to the integration centre (CNS)
  • The integration centre processes information and sends signals to the motor neurons.
  • Motor neurons initiate a response in an effector

The Synapse

  • Axons end near other cells
  • Action potentials reach the end of the axon
    • Stimulate the next cell
  • Chemicals (neurotransmitters) carry the signal to the next cell
  • In the CNS, the 2nd cell is also a neuron
  • In the PNS, it might be a neuron or an effector cell (muscle/gland)

Blood Brain Barrier

  • The brain’s capillaries differ in structure compared to capillaries in other organ systems
  • Capillaries in the brain have tight junctions, limiting what can pass between the blood and brain
  • Nonpolar molecules like O2 and CO2 can pass
  • Other molecules need specific transport mechanisms
  • Astrocytes play a supportive role in the blood-brain barrier.

Action Potentials

Critical Thinking

  • Evaluating information critically
  • Assessing accuracy, validity, and relevance of information
  • Applying knowledge to new situations
  • Identifying biases

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