NEURO 2020 COMBINED
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Questions and Answers

The blood brain barrier is not found in one of the following areas

  • The primary visual area in the occipital lobe
  • The cerebellum
  • The organum vasculosum of the lamina terminalis (OVLT) (correct)
  • The basal ganglia
  • The pons

A visual exam in an 80-year-old man shows he has a reduced ability to see objects in the upper and lower quadrants of the left visual fields of both eyes but some vision remains in the central regions of the visual field. The diagnosis is

  • lesion of the optic chiasm.
  • heteronymous hemianopia with macular sparing.
  • retinopathy.
  • central scotoma
  • homonymous hemianopia with macular sparing. (correct)

Higher motor commands originate in all the following centres, except:-

  • cerebral cortex
  • thalamus (correct)
  • caudate nucleus
  • None of the above
  • cerebellum

The following does not constitute motor innervations pathway to the muscle spindle

<p>Secondary type II fibres (C)</p> Signup and view all the answers

One of the following statements regarding language function is wrong

<p>The speech disorders are commoner in females than in males (A)</p> Signup and view all the answers

The upper motor neuron impairment produces the following change of muscles tone:

<p>spasticity (E)</p> Signup and view all the answers

Cerebellar ataxia is manifested by all the following, except :-

<p>static tremors (B)</p> Signup and view all the answers

One of the structures (named below) does not take part in the circulation of the cerebrospinal fluid (CSF) as outlined below

<p>30% of the CSF flows down following the olfactory receptor nerve sub arachnoid space to entre the lymphatics of the nasal mucosa which drain into the neck lymphatics (D)</p> Signup and view all the answers

Functions of basal ganglia include all the following, except :-

<p>initiation of reflex movement. (C)</p> Signup and view all the answers

In many elderly individuals

<p>Retrograde amnesia is a common memory system dysfunction (A)</p> Signup and view all the answers

Chief inhibitory neurotransmitter in the basal ganglia is:

<p>GABA (C)</p> Signup and view all the answers

One of the following listed areas is not in the frontal lobe of the brain

<p>The auditory association area (B)</p> Signup and view all the answers

Huntington's disease is a genetic disorder that is

<p>autosomal dominant (A)</p> Signup and view all the answers

Striatum sends stimulatory output to:

<p>None of the above (B)</p> Signup and view all the answers

A 45-year-old woman who had never needed to wear glasses had trouble reading a menu in a dimly-lit restaurant. She then recalled that as of late she needed to have the newspaper closer to her eyes to read it. Her ophthalmologist told her she was experiencing age-related loss of accommodation for near vision (presbyopis) that is due to

<p>the inability to increase the curvature of the lens. (C)</p> Signup and view all the answers

The correct sequence of events involved in phototransduction in rods and cones in response to light is:

<p>structural changes in rhodopsin, activation of transducin, decrease in intracellular cGMP, closure of cGMP-gated cation channels, and decreased release of glutamate. (C)</p> Signup and view all the answers

In relation to Parkinson's disease, all of the following happen except;

<p>broad based steps (A)</p> Signup and view all the answers

One of the following statements regarding the brain's hemispherical specialization is wrong

<p>Dysfunction of the non-dominant Broca's area make one speak in monotones (E)</p> Signup and view all the answers

Regarding corticospinal (corticobulbar) tract:

<p>30% of corticospinal (corticobulbar) tract is contributed by motor cortex. (C)</p> Signup and view all the answers

Saliva secretion is primarily a result of

<p>increased parasympathetic stimulation. (C)</p> Signup and view all the answers

Which of the following pairing of parts of cerebellum & its function is CORRECT?

<p>All of the above (D)</p> Signup and view all the answers

Higher CNS function does not include

<p>Thermoregulation (A)</p> Signup and view all the answers

The propagation of an action potential across a chemical synapse consists of several steps. Which of the following steps is the slowest?

<p>Diffusion of the neuro-transmitter. (A)</p> Signup and view all the answers

A medical student is studying neurons that are part of a descending pain modulating pathway. What brain region is correctly paired with the neurotransmitters it releases and the location where the neurotransmitter is released?

<p>Locus coeruleus neurons release norepinephrine in the spinal dorsal horn. (E)</p> Signup and view all the answers

Regarding motor lesions;

<p>Upper motor neuron lesions may produce atrophy in long standing cases (D)</p> Signup and view all the answers

The magnocellular units where posterior pituitary nanopeptides are synthesized are found in

<p>Preoptic and paraventricular nuclei (B)</p> Signup and view all the answers

The crista ampullaris is sensitive to :-

<p>angular acceleration (E)</p> Signup and view all the answers

The gross barriers that protect the brain from damage are

<p>The dura mater (E)</p> Signup and view all the answers

Cerebellum receives input from the following sites EXCEPT:

<p>All of the above (A)</p> Signup and view all the answers

The following areas in the brain have no Blood Brain Barrier EXCEPT

<p>The posterior lobe of the cerebellum (A)</p> Signup and view all the answers

One of the following statements regarding the electroencephalogram (EEG) is wrong

<p>Can be used for studying the activity of single neurons (C)</p> Signup and view all the answers

One of the following is not an EEG wave

<p>T (C)</p> Signup and view all the answers

Destruction of cerebellum leads to the following EXCEPT:

<p>Hypertonia (E)</p> Signup and view all the answers

Actions of Cortisol include

<p>inhibiting mast cells response and allergic response (A)</p> Signup and view all the answers

One of the steps regarding the way in which the brain executes voluntary movements is incorrect

<p>Nerve impulses are sent to the pre motor cortex and the visual cortex (C)</p> Signup and view all the answers

Neural transplantation in Parkinson's disease has been found to be generally effective:

<p>If the patient is under 60 yrs of age and immunosuppressant treatment is given (C)</p> Signup and view all the answers

One of the sequential processes, listed below, which the brain executes in learning new verbal facts and committing them to memory, is incorrect

<p>The sensory memory holds all the information and noise coming from the ears for seconds (A)</p> Signup and view all the answers

Pain Sensation: -

<p>occurs when the stimulus causes damage of the sensory receptors (B)</p> Signup and view all the answers

One of the following terms is not used for classifying human memory

<p>Retroactive (C)</p> Signup and view all the answers

Which of the following parts of the eye has the greatest concentration of rods?

<p>Parafoveal region (D)</p> Signup and view all the answers

The following areas in the central nervous system are not involved in the direct control of higher CNS functions

<p>The lumbar spinal cord (C)</p> Signup and view all the answers

Vertigo :-

<p>is a post-rotational sense of being rotated toward opposite side of original rotation (B)</p> Signup and view all the answers

Polysynaptic reflexes does not serve to

<p>translocate the entire organism from danger spot (C)</p> Signup and view all the answers

The EEG has the following waves forms EXCEPT

<p>T (B)</p> Signup and view all the answers

Which of the following statement regarding vision is FALSE?

<p>Lesions in the lateral geniculate nuclei result in contralateral heteronymous hemianopia with normal pupillary reflex. (A)</p> Signup and view all the answers

Huntington's disease and Parkinson's disease are examples of;

<p>Extrapyramidal disorders (A)</p> Signup and view all the answers

A 62-year-old man went to his ophthalmologist for his routine eye exam. It included ophthalmoscopy to visualize the interior surface of his eye, opposite to the lens. This portion of the eye is called

<p>the fundus. (B)</p> Signup and view all the answers

One of the following structures is not part of the Papez emotion circuit

<p>The primary visual cortex (E)</p> Signup and view all the answers

With relation to lesions in the basal ganglia'

<p>tremor may be present during movement (intentional tremor) (D)</p> Signup and view all the answers

Flashcards

Where is the blood-brain barrier NOT present?

The organum vasculosum of the lamina terminalis (OVLT) is a circumventricular organ (CVO) that lacks a blood-brain barrier. It is involved in osmoregulation, thirst, and blood pressure control.

What is the visual field defect called when half of the visual field is lost in both eyes, but central vision is spared?

Homonymous hemianopia with macular sparing is a visual field defect where the same half of the visual field is lost in both eyes, but central vision is spared. This is typically caused by a lesion in the optic tract or the visual cortex.

Which of these is NOT a higher motor command center?

The thalamus is a relay center for sensory information and not a motor control center.

Which motor neuron is NOT part of the muscle spindle innervation pathway?

Beta motor neurons are not involved in the innervation of muscle spindles. Muscle spindles are innervated by alpha and gamma motor neurons.

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Which statement about language function is incorrect?

Speech disorders are more common in males than females. This is likely due to the fact that males are more prone to certain neurological conditions that can affect speech, such as stroke and traumatic brain injury.

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What is the muscle tone change produced by upper motor neuron impairment?

Upper motor neuron impairment results in spasticity, which is an increase in muscle tone and stiffness.

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Which symptom is NOT a manifestation of cerebellar ataxia?

Resting tremors are characteristic of Parkinson's disease, not cerebellar ataxia.

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Which statement about CSF circulation is incorrect?

The cerebrospinal fluid (CSF) does not flow down the olfactory receptor nerve subarachnoid space to enter lymphatics of the nasal mucosa. The majority of CSF is reabsorbed into the blood via arachnoid granulations.

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Which function is NOT performed by the basal ganglia?

Basal ganglia are involved in the initiation of movements, not reflex movements. Reflex movements are controlled by spinal cord reflexes.

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What is a common age-related memory dysfunction observed in the elderly?

The hippocampus, a brain structure involved in memory formation, often shows dysfunction in the elderly. This can lead to difficulties with forming new memories (anterograde amnesia) and remembering past events (retrograde amnesia).

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What is the chief inhibitory neurotransmitter in the basal ganglia?

GABA is the main inhibitory neurotransmitter in the basal ganglia. This plays a crucial role in modulating and controlling movement.

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Which area is NOT located in the frontal lobe of the brain?

The auditory association area is located in the temporal lobe, not the frontal lobe.

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What is the genetic inheritance pattern of Huntington's Disease?

Huntington's disease is an autosomal dominant genetic disorder that is caused by a mutation in the huntingtin gene. There is no cure or effective treatment for the disorder.

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Where does the striatum send stimulatory output?

The striatum sends stimulatory output to the external segment of the globus pallidus. This is part of the direct pathway in the basal ganglia, which facilitates movement.

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What is the underlying cause of presbyopia?

Presbyopia, the age-related loss of accommodation for near vision, is caused by the inability to increase the curvature of the lens. This occurs because the lens becomes less flexible with age.

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What is the correct sequence of events in phototransduction?

The correct sequence of events involved in phototransduction in rods and cones in response to light involves structural changes in rhodopsin, activation of transducin, decrease in intracellular cGMP, closure of cGMP-gated cation channels, and decreased release of glutamate.

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Which statement about Parkinson's disease is incorrect?

In Parkinson's disease, the resting tremor is present, not a static tremor. Static tremor refers to a tremor that is present even during rest.

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Which statement regarding language function is incorrect?

Broca's area in the non-dominant hemisphere is involved in humor and storytelling, not just monotone speech. The non-dominant hemisphere contributes to prosody, which involves the emotional and rhythmic aspects of language.

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Which statement regarding the corticospinal (corticobulbar) tract is correct?

Only about 30% of corticospinal (corticobulbar) tract fibers originate from the motor cortex. Other areas like the premotor cortex also contribute to this important pathway.

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What primarily drives saliva secretion?

Saliva secretion is primarily driven by increased parasympathetic stimulation. This leads to increased activity of salivary glands, producing more saliva.

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Which cerebellum part and function pairing is correct?

The spinocerebellum is involved in motor execution, while the vestibulocerebellum is responsible for balance and eye movement, and the cerebrocerebellum is involved in motor planning.

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What is NOT a higher CNS function?

Thermoregulation is not considered a higher CNS function. It is primarily controlled by the hypothalamus in the brain.

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Which step in chemical synaptic transmission is the slowest?

Diffusion of the neurotransmitter across the synaptic cleft is the slowest step in the propagation of an action potential across a chemical synapse.

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Which brain region is correctly paired with its neurotransmitter and release location in the descending pain modulating pathway?

The periaqueductal gray neurons release endorphins in the spinal dorsal horn. This is part of the descending pain modulating pathway, which helps to reduce pain perception.

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Which statement about motor lesions is incorrect?

Upper motor neuron lesions can produce weakness and paralysis, not just flaccidity, and may cause atrophy in long-standing cases. Lower motor neuron lesions do not produce hyperreflexia. Upper motor neuron lesions show a positive Babinski sign.

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Where are the magnocellular units that synthesize posterior pituitary nanopeptides located?

The magnocellular units where posterior pituitary nanopeptides are synthesized are found in the paraventricular and preoptic nuclei of the hypothalamus. These neurohormones are then released from the posterior pituitary.

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What is the crista ampullaris sensitive to?

The crista ampullaris is sensitive to angular acceleration. It is a sensory structure located within the semicircular canals of the inner ear that detects changes in rotational movement.

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Which area of the brain DOES have a blood-brain barrier?

The blood-brain barrier is NOT present in the following areas: * The infundibulum that connects the hypothalamus to the pituitary gland * The Organum Vasculosum Lamina Terminalis * The Sub-fornical Organ of the third ventricle * The Area Postrema which overlies the vomiting centre

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Which statement about the EEG is incorrect?

The EEG can be used to diagnose different types of epilepsy and assess brain activity in intensive care units, but it does not measure the activity of single neurons. It records the summed electrical activity of large groups of neurons.

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Which of the following is NOT an EEG wave form?

The EEG wave forms include: Alpha, Beta, Delta, Theta, and Gamma. There is no T wave in the EEG.

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Which symptom is NOT a consequence of cerebellar destruction?

Hypertonia is not a consequence of cerebellar destruction. Cerebellar lesions typically cause ataxia, dysmetria, dysdiadochokinesia, and impaired learning of coordinated movements.

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Which action is NOT associated with Cortisol?

Cortisol has various functions including increasing fibroblast activity and accelerating wound healing, inhibiting mast cells response and allergic response. However, it does not have a diuretic effect and does not synergize with insulin to promote glucose entry into cells.

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Which statement about the brain execution of voluntary movements is incorrect?

The decision to carry out a voluntary movement is made in the emotion and motivation brain, specifically the cingulate gyrus and prefrontal lobe.

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When is neural transplantation generally effective in Parkinson's disease?

Neural transplantation in Parkinson's disease is not generally effective. While some promising research is ongoing, current techniques have limited success and are considered experimental.

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Which statement about the brain's processing of verbal facts is incorrect?

The information is transferred to the short-term memory systems in the hippocampus, the prefrontal, and temporal lobes, not the occipital lobe. The occipital lobe primarily processes visual information.

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What is the correct explanation for pain sensation?

Pain sensation is evoked by strong stimulation of specific receptors, which can be either free nerve endings or encapsulated receptors. It does not necessarily involve damage to sensory receptors.

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Which term is NOT used for classifying human memory?

Retroactive interference is not a type of memory, but a phenomenon that can affect memory. It refers to the interference of newly learned information with the retrieval of previously learned information.

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Which part of the eye has the greatest concentration of rods?

The parafoveal region, which surrounds the fovea, has a higher concentration of rods than the fovea. The fovea has a high concentration of cones, specialized for color vision and sharp detail.

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Which area is NOT directly involved in controlling higher CNS functions?

The lumbar spinal cord is not directly involved in the control of higher CNS functions. It primarily relays sensory information from the lower body and controls motor functions of the legs and feet.

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What is Vertigo?

Vertigo is a rotational sense of being rotated toward the opposite side of the original rotation. This is caused by a mismatch between the signals from the vestibular system and the visual system.

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Which statement about language function is incorrect?

The statement that 'allowing children to be fluent in their mother tongue enables them to learn foreign languages better' is incorrect. While fluency in the first language is beneficial, it does not guarantee better foreign language acquisition.

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What does polysynaptic reflex NOT do?

Polysynaptic reflexes serve various functions, including withdrawing the affected part of the body from danger, translocating the entire organism away from danger, and maintaining the posture of the body. However, they do not directly regulate the rate of change of muscle fiber length.

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Which of the following is NOT an EEG wave form?

Gamma waves are also present in the EEG. They are associated with higher cognitive processing and information processing.

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Which statement regarding vision is false?

Binocular vision does not rely on fusion of images from the central visual field of both eyes at a cortical level. It relies on the fusion of images from both eyes at the subcortical level, specifically in the brain stem.

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What are Huntington's disease and Parkinson's disease examples of?

Huntington's disease and Parkinson's disease are examples of extrapyramidal disorders. These disorders are characterized by movement abnormalities that affect the basal ganglia.

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What is the name for the interior surface of the eye opposite to the lens?

The fundus is the interior surface of the eye opposite to the lens. It includes the retina, optic disc, macula, and blood vessels.

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Which structure is NOT part of the Papez emotion circuit?

The primary visual cortex is not part of the Papez emotion circuit. The Papez circuit involves the cingulate gyrus, hippocampal gyrus, anterior thalamus, and hypothalamus, which play roles in emotional processing and memory.

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With relation to lesions in the basal ganglia, what is a true statement?

Lesions in the basal ganglia can lead to changes in muscle tone, both hypertonia and hypotonia, depending on the location and specific pathways affected. However, lesions in the basal ganglia can cause involuntary movements like tremors and chorea.

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Study Notes

Blood Brain Barrier

  • The blood brain barrier is not found in the primary visual area of the occipital lobe.
  • It is present in the cerebellum, pons, and basal ganglia.
  • The organum vasculosum of the lamina terminalis (OVLT) lacks the barrier.

Visual Exam in 80-Year-Old Man

  • A visual exam on an 80-year-old man revealed reduced vision in the upper and lower quadrants of the left visual field, but central vision remained.
  • The diagnosis is heteronymous hemianopia with macular sparing.

Higher Motor Commands

  • Higher motor commands originate in the cerebral cortex, thalamus, and caudate nucleus.
  • The cerebellum is not involved in the origin of these commands.

Motor Innervations Pathway to the Muscle Spindle

  • The final common pathway is part of the motor innervations pathway to the muscle spindle.
  • Secondary type II fibers, alpha motor neurons, and beta motor neurons are also part of the pathway.
  • Descending gamma fibers are not part of the pathway.

Language Function

  • Destruction of Broca's area (anterior speech area) leads to non-fluent aphasia (motor aphasia)
  • Broca's area controls the motor aspects of speech, such as word production.
  • Destruction of Wernicke's area (posterior speech area) causes fluent aphasia (jargon aphasia).
  • Speech disorders are not more common in females than males
  • Wernicke's area is responsible for the comprehension of speech, written language or sign language

Upper Motor Neuron Impairment

  • Upper motor neuron impairment results in spasticity.

Cerebellar Ataxia

  • Cerebellar ataxia is characterized by resting tremors.
  • Also includes dysdiadochokinesia and dysmetria
  • Staccato speech is a symptom.

Cerebrospinal Fluid Circulation

  • Several structures are not part of the cerebrospinal fluid circulation.

Basal Ganglia Functions

  • Basal ganglia functions include planning voluntary movements, executing learned movement patterns, programming voluntary movements, and postural regulation.

Memory

  • Elderly individuals may exhibit dysfunction in the hippocampus, leading to retrograde amnesia, difficulty recalling past events, and impaired long-term memory.
  • Inhibitory neurotransmitter for basal ganglia is GABA

Brain Regions in Frontal Lobe

  • The premotor cortex, pre-frontal cortex, and primary motor cortex are within the frontal lobe of the brain.
  • The auditory association area is not found within the frontal lobe.

Huntington's Disease

  • Huntington's disease is an autosomal dominant genetic disorder.
  • The condition is not treatable, and symptoms are not typically identified until after 50 years of age.

Striatum Output

  • The striatum sends stimulatory output to the substantia nigra, external segment of globus pallidus, internal segment of globus pallidus, and subthalamic nuclei

Presbyopia:

  • Presbyopia is age-related loss of accommodation for near vision.
  • Symptoms include the need to hold reading material closer to the eyes to see clearly.
  • The inability to increase the curvature of the eye's lens results in presbyopia.

Phototransduction

  • The correct sequence of phototransduction events involves structural changes in rhodopsin, activation of transducin, a decrease in intracellular cGMP, closure of cGMP-gated cation channels, and a decreased release of glutamate.

Parkinson's Disease

  • Symptoms from Parkinson's disease include Facial masking, rigidity in both flexors and extensors, and static tremors.
  • Absence of arm swinging during walking and broad-based steps occur in Parkinsons patients.

Brain Hemispheric Specialization

  • Broca's area in the non-dominant hemisphere is not involved in telling jokes and stories.
  • Language function is primarily controlled by the left hemisphere.
  • The right hemisphere is responsible for spatio-temporal brain functions.

Corticospinal Tract

  • 30% of the corticospinal tract is composed of the motor cortex.
  • The corticospinal tract also has contributions from the premotor and somatosensory cortices.

Saliva Secretion

  • Increased parasympathetic stimulation primarily results in saliva secretion.

Cerebellar Function

  • Cerebrocerebellum is involved in motor planning.
  • Spinocerebellum is involved in motor execution.
  • Vestibulocerebellum plays a role in balance and eye movement.

Higher CNS Function

  • Thermoregulation is not considered a higher CNS function.

Polysynaptic Reflexes

  • Polysynaptic reflexes are involved in relocating the affected part of the body from dangers.
  • They regulate muscle fiber length changes.

EEG Waves

  • The EEG does not have T waves.
  • EEG waves include Beta, Delta, Gamma, and Theta.

Visual System

  • Binocular vision combines images from both eyes in the cortex, essential for depth perception.
  • Monocular vision alone can be sufficient for perceiving some aspects of depth.
  • Bilateral occipital cortex damage may result in subjective blindness but preserve responses to visual stimuli.

Neurological Disorders

  • Huntington's disease and Parkinson's disease are examples of extrapyramidal disorders (specifically, of dopaminergic disorders) and should not be confused with dementia or gabaergic disorders.

Ophthalmoscopy

  • The fundus—the interior surface of the eye behind the lens—is visualized during ophthalmoscopy.

Papez Emotion Circuit

  • The primary visual cortex is not part of the Papez emotion circuit; the limbic system is involved in the emotion circuit.

Basal Ganglia Lesions

  • Lesions to the basal ganglia can cause involuntary movements, including intentional tremors, or changes in muscle tone (hypertonia).

Human Memory

  • Retroactive interference is not a standard method for classifying human memory.

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