Podcast
Questions and Answers
Which artery primarily supplies blood to the internal capsule and most of the lateral hemispheres of the brain?
Which artery primarily supplies blood to the internal capsule and most of the lateral hemispheres of the brain?
A patient exhibits impaired motor control, difficulty with planning, and notable changes in personality. Which lobe of the brain is MOST likely affected?
A patient exhibits impaired motor control, difficulty with planning, and notable changes in personality. Which lobe of the brain is MOST likely affected?
Which of the following structures separates the precentral and postcentral gyrus?
Which of the following structures separates the precentral and postcentral gyrus?
What critical function is primarily associated with the brainstem, and loss of function may result in death?
What critical function is primarily associated with the brainstem, and loss of function may result in death?
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If a patient experiences sensory loss due to an injury of the cerebellum, which side of the body will the loss occur?
If a patient experiences sensory loss due to an injury of the cerebellum, which side of the body will the loss occur?
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Which of the following symptoms is NOT associated with Horner’s syndrome?
Which of the following symptoms is NOT associated with Horner’s syndrome?
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What is a common early indicator of autism spectrum disorders in infants?
What is a common early indicator of autism spectrum disorders in infants?
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What biological factor is significantly increased in the cerebrospinal fluid (CSF) of individuals with fibromyalgia?
What biological factor is significantly increased in the cerebrospinal fluid (CSF) of individuals with fibromyalgia?
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Which of the following correctly describes a key feature of Complex Regional Pain Syndrome (CRPS)?
Which of the following correctly describes a key feature of Complex Regional Pain Syndrome (CRPS)?
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Which type of nerve fiber has the slowest conduction velocity?
Which type of nerve fiber has the slowest conduction velocity?
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In a three-order neuron pathway, which of the following describes the location of the second-order neuron's cell body?
In a three-order neuron pathway, which of the following describes the location of the second-order neuron's cell body?
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Which of the following is NOT sensory information carried by the spinothalamic tract?
Which of the following is NOT sensory information carried by the spinothalamic tract?
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What is the primary function of dendrites in a neuron?
What is the primary function of dendrites in a neuron?
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What is the role of radial glia during cell migration in brain development?
What is the role of radial glia during cell migration in brain development?
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During which stage of development does gastrulation occur?
During which stage of development does gastrulation occur?
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Which structure does NOT arise from the mesoderm?
Which structure does NOT arise from the mesoderm?
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What is the neural crest responsible for forming?
What is the neural crest responsible for forming?
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Which primary brain vesicle gives rise to the cerebellum and pons?
Which primary brain vesicle gives rise to the cerebellum and pons?
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What event marks the beginning of the fetal stage of development?
What event marks the beginning of the fetal stage of development?
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What is the process by which a cell takes on the specific characteristics of a neuron termed?
What is the process by which a cell takes on the specific characteristics of a neuron termed?
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During neural development, when does myelination of axons begin?
During neural development, when does myelination of axons begin?
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Which of the following is a result of the failure of the anterior neural tube to close?
Which of the following is a result of the failure of the anterior neural tube to close?
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In spina bifida cystica, what is the difference between a meningocele and a myelomeningocele?
In spina bifida cystica, what is the difference between a meningocele and a myelomeningocele?
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Which of the following best describes the role of neuroglia?
Which of the following best describes the role of neuroglia?
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What is the primary function of the axon hillock?
What is the primary function of the axon hillock?
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What is the most severely affected sensation in demyelination?
What is the most severely affected sensation in demyelination?
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A nerve root lesion affects sensation in what pattern?
A nerve root lesion affects sensation in what pattern?
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What type of lesion results in contralateral pain and temperature loss below its level?
What type of lesion results in contralateral pain and temperature loss below its level?
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What is the primary function of an MRI?
What is the primary function of an MRI?
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Which sensory receptor responds to changes in temperature?
Which sensory receptor responds to changes in temperature?
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Which of the following accurately describes the role of the spinothalamic tract?
Which of the following accurately describes the role of the spinothalamic tract?
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In a complete transection of the spinal cord, what sensation will be lost below the level of the lesion?
In a complete transection of the spinal cord, what sensation will be lost below the level of the lesion?
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Which imaging technique is primarily used to assess blood flow and metabolic functions in the brain?
Which imaging technique is primarily used to assess blood flow and metabolic functions in the brain?
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What type of sensory receptor is primarily adapted for detecting rapid changes in stimuli?
What type of sensory receptor is primarily adapted for detecting rapid changes in stimuli?
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What kind of sensory loss is expected in an anterior cord lesion?
What kind of sensory loss is expected in an anterior cord lesion?
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Which of the following correctly describes the function of DTI in brain imaging?
Which of the following correctly describes the function of DTI in brain imaging?
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What is the role of the dorsal column in sensory information processing?
What is the role of the dorsal column in sensory information processing?
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Where does the spinal cord end in humans?
Where does the spinal cord end in humans?
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What characterizes the first-order neuron in the DCML pathway?
What characterizes the first-order neuron in the DCML pathway?
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What is the primary difference between recovery and compensation in the context of neural plasticity?
What is the primary difference between recovery and compensation in the context of neural plasticity?
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Which principle does NOT enhance experience-dependent neuroplasticity?
Which principle does NOT enhance experience-dependent neuroplasticity?
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What is a crucial critical period for visual development?
What is a crucial critical period for visual development?
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What neurotransmitter is primarily used by the parasympathetic nervous system?
What neurotransmitter is primarily used by the parasympathetic nervous system?
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Which statement best describes the function of the sympathetic nervous system?
Which statement best describes the function of the sympathetic nervous system?
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What role do endorphins play in relation to pain?
What role do endorphins play in relation to pain?
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What typically causes referred pain?
What typically causes referred pain?
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What is NOT a characteristic of the autonomic nervous system?
What is NOT a characteristic of the autonomic nervous system?
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What is an effect of high-intensity treadmill training in neuroplasticity?
What is an effect of high-intensity treadmill training in neuroplasticity?
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What distinguishes experience-expectant plasticity from experience-dependent plasticity?
What distinguishes experience-expectant plasticity from experience-dependent plasticity?
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Flashcards
Central Nervous System (CNS)
Central Nervous System (CNS)
The CNS consists of the brain, spinal cord, and cranial nerves 1 & 2.
Circle of Willis
Circle of Willis
A network of arteries that supplies blood to the cerebral hemispheres of the brain.
Frontal Lobe Functions
Frontal Lobe Functions
Responsible for motor control, executive functioning, planning, and personality traits.
Cerebellum Functions
Cerebellum Functions
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Action Potential
Action Potential
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Spina bifida prevention
Spina bifida prevention
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Cerebral palsy
Cerebral palsy
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Autism spectrum disorders
Autism spectrum disorders
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Horner’s syndrome
Horner’s syndrome
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Fibromyalgia
Fibromyalgia
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Three-order neuron pathway
Three-order neuron pathway
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First order neuron
First order neuron
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Second order neuron
Second order neuron
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Third order neuron
Third order neuron
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Spinothalamic tract
Spinothalamic tract
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Neuron
Neuron
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Axon
Axon
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Dendrites
Dendrites
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Soma (Cell Body)
Soma (Cell Body)
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Neuroglia
Neuroglia
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Myotome
Myotome
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Dermatome
Dermatome
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Neurulation
Neurulation
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Spina Bifida
Spina Bifida
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Anencephaly
Anencephaly
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Contralateral
Contralateral
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Compression effects
Compression effects
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Demyelination
Demyelination
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Nerve root lesion
Nerve root lesion
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Complete transection
Complete transection
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Brown-Sequard syndrome
Brown-Sequard syndrome
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Posterior column lesions
Posterior column lesions
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Anterior cord lesion
Anterior cord lesion
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Lesion of thalamus
Lesion of thalamus
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fMRI
fMRI
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Proprioceptors
Proprioceptors
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DCML pathway
DCML pathway
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EEG
EEG
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Sensory receptors types
Sensory receptors types
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Neural Plasticity
Neural Plasticity
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Recovery vs Compensation
Recovery vs Compensation
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Experience-Expectant Plasticity
Experience-Expectant Plasticity
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Experience-Dependent Plasticity
Experience-Dependent Plasticity
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Critical Period
Critical Period
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Sympathetic Nervous System (SNS)
Sympathetic Nervous System (SNS)
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Parasympathetic Nervous System (PSNS)
Parasympathetic Nervous System (PSNS)
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Nociceptors
Nociceptors
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Endorphins
Endorphins
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Study Notes
Central Nervous System (CNS) Anatomy and Function
- CNS comprises the brain, spinal cord, and cranial nerves 1 & 2. Major regions include the spinal cord, brainstem, cerebellum, and cerebrum.
- Circle of Willis: A network of arteries supplying blood to the cerebral hemispheres.
- Anterior Cerebral Artery (ACA): Branches supply the medial surface of frontal and parietal lobes.
- Middle Cerebral Artery (MCA): Supplies internal capsule, globus pallidus, putamen, caudate, and most of the lateral hemispheres.
- Posterior Cerebral Artery (PCA): Supplies midbrain, occipital lobe, and parts of medial and inferior temporal lobe.
- Brain Lobes and Functions:
- Frontal Lobe: Motor functions, executive functions, planning, and personality.
- Parietal Lobe: Sensation processing.
- Temporal Lobe: Language and hearing.
- Occipital Lobe: Vision.
- Brainstem Functions: Vital functions, cardiovascular activity, respiration, conveying information from cerebrum and spinal cord, cranial nerve nuclei, and consciousness.
- Brain Structure and Sulci/Gyri:
- Deep Longitudinal Fissure: Separates right and left hemispheres.
- Central Sulcus: Separates precentral and postcentral gyri, both part of the frontal lobe.
- Parieto-occipital Sulcus: Separates parietal and occipital lobes.
- Communication Between Brain Areas: Presynaptic neuron transmits information to the postsynaptic neuron via action potentials (nerve impulses).
- Cerebellum Function and Sensory Input:
- Motor and nonmotor domains.
- Comparator function (coordination, regulation, and modulation of motor behavior).
- Sensory function: Unconscious proprioception, regulating balance and coordination of movement, quality control of movement.
- Sensory loss with injury is ipsilateral for cerebellum.
- Sensory losses include proprioception, light touch, fast nociception, heat, and slow nociception.
- Demyelination: Affects proprioception and vibratory sense (most heavily myelinated).
- Nerve Root Lesion: Impaired sensation in dermatomal pattern and loss of motor function in myotomal pattern.
- Complete Transection: All sensation lost 1-2 levels below lesion level.
- Hemi-section/Brown-Sequard Syndrome:
- Pain and temperature interrupted below lesion contralaterally.
- Pain and temperature interrupted at lesion ipsilaterally.
- Discriminative touch and conscious proprioception lost below lesion ipsilaterally.
- Posterior Column Lesions: Loss of conscious proprioception, vibration, and 2-point discrimination below lesion level.
- Anterior Cord Lesion: Loss of pain, temperature, and crude touch below lesion level.
- Brainstem Lesions: Contralateral or ipsilateral signs, depending on lesion location.
- Thalamus Lesion: Contralateral decrease or loss of sensation.
- Somatosensory Cortex: Contralateral impairments; discriminative sensations include stereognosis, conscious proprioception, 2-point discrimination, localization of touch, and fast nociception.
- Spinal Cord Anatomy: Extends from foramen magnum to L1 vertebra (ends at conus medullaris). Blood supply via 3 spinal arteries: 1 anterior (⅔), 2 posterior (⅓). Dorsal (sensory) and ventral (motor) roots join to form nerve roots.
- Imaging Techniques:
- PET: Shows metabolic functions, blood flow (radioactive material).
- CT: Detailed images of bones/fractures (X-rays).
- MRI: Shows soft tissue detail (magnetic field).
- MRA: Visualizes blood vessels in detail (contrast medium).
- BOLD MRI: Detects areas of oxygen consumption; assesses brain function.
- DTI: Detailed white matter tract imaging; detects ischemic stroke (water diffusion).
- EEG: Records electrical impulses from brain cortex; detects seizures.
Sensory Receptors and Functions
- Exteroreceptors: Respond to external environment.
- Interoreceptors: Respond to internal environment.
- Proprioceptors: Internal sense of movement; joint position sense.
- Tonic Receptors: Slowly adapting receptors.
- Phasic Receptors: Fast adapting receptors.
- Mechanoreceptors: Respond to mechanical deformation.
- Thermoreceptors: Respond to temperature gradients across the skin.
- Nociceptors: Respond to tissue-damaging stimuli.
- Chemoreceptors: Respond to chemical constituents.
Dorsal Column-Medial Lemniscus (DCML) Pathway
- Discriminative tactile sensation, kinesthesia/proprioception and stereognosis.
- Heavily myelinated.
- Three-neuron pathway:
- First order: Enters dorsal column, ascends ipsilaterally to medulla; cell body in DRG.
- Second order: Crosses, travels to contralateral dorsal column nuclei, ascends to thalamus; cell body in medulla.
- Third order: Thalamus to parietal lobe; cell body in thalamus.
- Carries discriminative touch, conscious proprioception, and vibration.
Spinothalamic Tract
- Part of the anterolateral system; for nociception, temperature, and crude touch.
- Lightly myelinated.
- Three-neuron pathway:
- First order: Enters spinal cord, synapses in dorsal horn; cell body in DRG.
- Second order: Crosses midline, ascends in anterolateral white matter to thalamus; cell body in dorsal horn.
- Third order: Thalamus to parietal lobe; cell body in thalamus.
- Carries nociception (fast), temperature, and crude touch.
Nerve Structure and Function
- Neurons: Nerve cells; receive and transmit signals; responsible for control, integration, and responses of body functions.
- Parts: Axon (conducting), dendrites (receptive), soma (cell body).
- Neuroglia: Supporting cells; protect and supply metabolic support to neurons.
- Information Transmission: Axons (nerve fibers) forming bundles (tracts/pathways).
Nerve Damage
- Description of damage effects not provided.
CNS Development
- Zygote: Fertilized egg; divides into cells.
- Morula: Collection of blastomeres (cells).
- Blastocyst: Spheres of cells; outer layer becomes placenta, inner layer embryo.
- Embryo: Until 8 weeks; Fetus: After 8 weeks.
- Gastrulation: Single-layered blastula reorganized into trilaminar gastrula (ectoderm, mesoderm, endoderm).
- Neurulation: Formation of neural tube (3rd week gestation).
- Neural Plate: Thickening of ectoderm.
- Neural Tube: Forms CNS.
- Neurocele: Forms ventricles and spinal cord.
- Neural Crest: Forms PNS.
- Somite Development: Develop from mesoderm (day 20-30).
- Myotome: Embryonic part of somite that becomes muscle.
- Dermatome: Embryonic part of somite that becomes dermis.
- Brain Formation (primary vesicles): 4 weeks.
- Prosencephalon (forebrain), Mesencephalon (midbrain), Rhombencephalon (hindbrain).
- Brain Formation (secondary vesicles): 5 weeks.
- Telencephalon → cerebral hemispheres (lateral ventricles)
- Diencephalon → thalamus, hypothalamus, optic vesicles
- Mesencephalon → midbrain
- Rhombencephalon → cerebellum, pons, medulla
- Fetal Stage (8 weeks-birth): More nervous system development, myelination begins.
- Cellular Development: Proliferation, migration, differentiation (growth cones, synaptogenesis).
- Myelination: Begins 4th month, most sheaths complete by 3 years.
- Clinical Conditions: Descriptions and causes of anencephaly, spina bifida, cerebral palsy, autism spectrum disorders, Horner's syndrome, fibromyalgia, complex regional pain syndrome, listed.
Neurotransmitters
- General descriptions of neurotransmitters (e.g., acetylcholine, norepinephrine, dopamine, GABA).
Neurological Plasticity
- Neural plasticity: Ability of NS to change functions, chemical profiles, or structure.
- Recovery vs. compensation.
- Experience-expectant plasticity: Changes during development.
- Experience-dependent plasticity: Cellular structure changes.
- Critical periods: Specific times for development.
- Treatments: Examples of treatment approaches.
Autonomic Nervous System (ANS)
- SNS: Increase energy utilization; fight-or-flight (stress, exercise).
- Efferent pathway, innervates adrenal medulla, vasculature, etc.
- Paravertebral ganglia, short preganglionic, long postganglionic fibers; uses ACh (pre) & EPI/NE/ACh (post).
- PSNS: Most active at rest; energy conservation, increases digestion, promotes relaxation.
- Efferent pathway, PS fibers innervate pupil, salivary glands, etc.
- Long preganglionic, short postganglionic fibers, ganglia near/in organ.
- Uses ACh for both pre and post.
- SNS vs PSNS: Comparison table of functions.
Pain
- Nociceptors: Signal injury.
- Referred pain: Perceived as coming from different origin due to shared secondary neuron in spinal cord; thalamus.
- Spinothalamic tract mediates pain.
- Antinociception: Suppression of pain.
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Description
Test your knowledge on key aspects of neuroscience including understanding brain structures, their functions, and related neurological conditions. This quiz covers essential topics such as blood supply to the brain, brain damage effects, and syndromes associated with nerve conditions.