Podcast
Questions and Answers
As the brain initially matures, the number of neurons and their ______ increases.
As the brain initially matures, the number of neurons and their ______ increases.
complexity
Synaptic Plasticity refers to the ability of ______ to change.
Synaptic Plasticity refers to the ability of ______ to change.
synapses
Synapse strengthening is known as ______.
Synapse strengthening is known as ______.
Long Term Potentiation
Dendritic or Axonal Sprouting is an example of ______ restructuring.
Dendritic or Axonal Sprouting is an example of ______ restructuring.
Fragile X syndrome is an example of ______ Plasticity.
Fragile X syndrome is an example of ______ Plasticity.
Local synaptic activity initiates signaling cascades that affect ______ synthesis.
Local synaptic activity initiates signaling cascades that affect ______ synthesis.
Effectively translated into proteins in their local ______
Effectively translated into proteins in their local ______
Excitatory communication between neurons induces the post-translational modification of ______ molecules
Excitatory communication between neurons induces the post-translational modification of ______ molecules
Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature
Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature
Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks
Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks
Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors
Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors
Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu
Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu
CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.
CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.
CBP is targeted to ______ sites within the genome by the CREB transcription factor.
CBP is targeted to ______ sites within the genome by the CREB transcription factor.
When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.
When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.
The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.
The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.
The modification of histone proteins by CBP ______ the DNA-histone association.
The modification of histone proteins by CBP ______ the DNA-histone association.
CBP loss may also contribute to other ______ or neurodegenerative conditions.
CBP loss may also contribute to other ______ or neurodegenerative conditions.
The tail regions of histone proteins are rich in basic ______ Acids
The tail regions of histone proteins are rich in basic ______ Acids
When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA
When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA
The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery
The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery
Functionally, this ______ Gene Expression
Functionally, this ______ Gene Expression
The ______ of histone proteins are acetylated and thereby noncharged
The ______ of histone proteins are acetylated and thereby noncharged
MDBP stands for ______-DNA Binding Proteins
MDBP stands for ______-DNA Binding Proteins
Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.
Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.
Many ______ features are maintained in Rett Syndrome patients.
Many ______ features are maintained in Rett Syndrome patients.
X Chromosome Inactivation can skew the ______ of Rett Syndrome.
X Chromosome Inactivation can skew the ______ of Rett Syndrome.
Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.
Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.
Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.
Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.
The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.
The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.
