Neuroscience Quiz: Brain Development and Synaptic Plasticity

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As the brain initially matures, the number of neurons and their ______ increases.

complexity

Synaptic Plasticity refers to the ability of ______ to change.

synapses

Synapse strengthening is known as ______.

Long Term Potentiation

Dendritic or Axonal Sprouting is an example of ______ restructuring.

synapse Signup and view all the answers

Fragile X syndrome is an example of ______ Plasticity.

impaired Signup and view all the answers

Local synaptic activity initiates signaling cascades that affect ______ synthesis.

gene Signup and view all the answers

Effectively translated into proteins in their local ______

microdomains Signup and view all the answers

Excitatory communication between neurons induces the post-translational modification of ______ molecules

synaptic Signup and view all the answers

Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature

synaptic Signup and view all the answers

Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks

activity-dependent Signup and view all the answers

Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors

synaptic Signup and view all the answers

Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu

synaptic Signup and view all the answers

CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.

histone acetyltransferase Signup and view all the answers

CBP is targeted to ______ sites within the genome by the CREB transcription factor.

CRE Signup and view all the answers

When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.

mutation Signup and view all the answers

The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.

synaptic Signup and view all the answers

The modification of histone proteins by CBP ______ the DNA-histone association.

relaxes Signup and view all the answers

CBP loss may also contribute to other ______ or neurodegenerative conditions.

neurologic Signup and view all the answers

The tail regions of histone proteins are rich in basic ______ Acids

Amino Signup and view all the answers

When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA

charge Signup and view all the answers

The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery

diminished Signup and view all the answers

Functionally, this ______ Gene Expression

Regulates Signup and view all the answers

The ______ of histone proteins are acetylated and thereby noncharged

acetylation Signup and view all the answers

MDBP stands for ______-DNA Binding Proteins

Methyl Signup and view all the answers

Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.

brain Signup and view all the answers

Many ______ features are maintained in Rett Syndrome patients.

sensory Signup and view all the answers

X Chromosome Inactivation can skew the ______ of Rett Syndrome.

severity Signup and view all the answers

Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.

pattern Signup and view all the answers

Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.

mutations Signup and view all the answers

The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.

wild-type Signup and view all the answers

Neuroscience Quiz: Brain Development and Synaptic Plasticity

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Questions and Answers

As the brain initially matures, the number of neurons and their ______ increases.

Synaptic Plasticity refers to the ability of ______ to change.

Synapse strengthening is known as ______.

Dendritic or Axonal Sprouting is an example of ______ restructuring.

Fragile X syndrome is an example of ______ Plasticity.

Local synaptic activity initiates signaling cascades that affect ______ synthesis.

Effectively translated into proteins in their local ______

Excitatory communication between neurons induces the post-translational modification of ______ molecules

Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature

Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks

Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors

Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu

CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.

CBP is targeted to ______ sites within the genome by the CREB transcription factor.

When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.

The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.

The modification of histone proteins by CBP ______ the DNA-histone association.

CBP loss may also contribute to other ______ or neurodegenerative conditions.

The tail regions of histone proteins are rich in basic ______ Acids

When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA

The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery

Functionally, this ______ Gene Expression

The ______ of histone proteins are acetylated and thereby noncharged

MDBP stands for ______-DNA Binding Proteins

Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.

Many ______ features are maintained in Rett Syndrome patients.

X Chromosome Inactivation can skew the ______ of Rett Syndrome.

Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.

Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.

The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.

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