Podcast
Questions and Answers
As the brain initially matures, the number of neurons and their ______ increases.
As the brain initially matures, the number of neurons and their ______ increases.
complexity
Synaptic Plasticity refers to the ability of ______ to change.
Synaptic Plasticity refers to the ability of ______ to change.
synapses
Synapse strengthening is known as ______.
Synapse strengthening is known as ______.
Long Term Potentiation
Dendritic or Axonal Sprouting is an example of ______ restructuring.
Dendritic or Axonal Sprouting is an example of ______ restructuring.
Signup and view all the answers
Fragile X syndrome is an example of ______ Plasticity.
Fragile X syndrome is an example of ______ Plasticity.
Signup and view all the answers
Local synaptic activity initiates signaling cascades that affect ______ synthesis.
Local synaptic activity initiates signaling cascades that affect ______ synthesis.
Signup and view all the answers
Effectively translated into proteins in their local ______
Effectively translated into proteins in their local ______
Signup and view all the answers
Excitatory communication between neurons induces the post-translational modification of ______ molecules
Excitatory communication between neurons induces the post-translational modification of ______ molecules
Signup and view all the answers
Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature
Collectively, these cues regulate ______ function, select the synapses during development that will grow and mature
Signup and view all the answers
Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks
Many of the genes that are mutated in autism spectrum disorder encode for crucial components of the ______ signaling networks
Signup and view all the answers
Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors
Astrocytes Influence ______ Maturation and Function Directly By Releasing Soluble Neuroactive Factors
Signup and view all the answers
Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu
Astrocytes also influence ______ maturation indirectly by buffering the extracellular milieu
Signup and view all the answers
CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.
CBP possesses ______ activity, and can therefore shield the positive charges on histone proteins.
Signup and view all the answers
CBP is targeted to ______ sites within the genome by the CREB transcription factor.
CBP is targeted to ______ sites within the genome by the CREB transcription factor.
Signup and view all the answers
When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.
When CBP activity is lost due to ______ (as in Rubinstein-Taybi Syndrome), the nucleosome remodeling activity is lost.
Signup and view all the answers
The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.
The loss of CBP activity leads to deficiencies in ______ development and dendritic microdomain signaling reinforcement.
Signup and view all the answers
The modification of histone proteins by CBP ______ the DNA-histone association.
The modification of histone proteins by CBP ______ the DNA-histone association.
Signup and view all the answers
CBP loss may also contribute to other ______ or neurodegenerative conditions.
CBP loss may also contribute to other ______ or neurodegenerative conditions.
Signup and view all the answers
The tail regions of histone proteins are rich in basic ______ Acids
The tail regions of histone proteins are rich in basic ______ Acids
Signup and view all the answers
When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA
When deacetylated, the amino acids are highly positive in ______, and interact strongly with DNA
Signup and view all the answers
The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery
The ______ interactive force allows chromatin structure to be more relaxed, which makes the DNA around the nucleosome more accessible to transcriptional machinery
Signup and view all the answers
Functionally, this ______ Gene Expression
Functionally, this ______ Gene Expression
Signup and view all the answers
The ______ of histone proteins are acetylated and thereby noncharged
The ______ of histone proteins are acetylated and thereby noncharged
Signup and view all the answers
MDBP stands for ______-DNA Binding Proteins
MDBP stands for ______-DNA Binding Proteins
Signup and view all the answers
Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.
Physical Features of Rett Syndrome include ______ mass and size tend to be smaller.
Signup and view all the answers
Many ______ features are maintained in Rett Syndrome patients.
Many ______ features are maintained in Rett Syndrome patients.
Signup and view all the answers
X Chromosome Inactivation can skew the ______ of Rett Syndrome.
X Chromosome Inactivation can skew the ______ of Rett Syndrome.
Signup and view all the answers
Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.
Complements of Dr. Huda Zoghbi, Baylor College of Medicine, Howard Hughes Medical Institute, show the ______ of Rett Syndrome patients' brain.
Signup and view all the answers
Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.
Approximately one-third of all Rett Syndrome-causing ______ are nonsense mutations.
Signup and view all the answers
The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.
The Severity of Rett Syndrome can be dramatically influenced by whether key neuronal populations in the brain retain the ______ or mutant MeCP2 alleles.
Signup and view all the answers
