20 Questions
What is the consequence of a higher probability of release on the depression of the synapse?
It leads to a more pronounced depression
What is the primary role of Syt3 in the process of synaptic release?
To act as a calcium sensor during prolonged release
What is the effect of Munc13 lacking calmodulin binding on post-tetanic potentiation?
It reduces the post-tetanic potentiation
What is the role of DAG in the regulation of synaptic release?
It binds to Unc13 to increase the phosphorylation of Munc18
What is the characteristic of PPF and PTP in terms of memory?
They are not forms of memory
What is the mechanism underlying behavioral habituation in Aplysia?
Repeated touches lead to a decrease of withdrawal
What is the effect of depressive synaptic plasticity on the RRP?
It has no effect on the RRP
What is the primary characteristic of the readily releasable pool (RRP) in terms of synaptic release?
It is a probe for priming
What is the effect of calcium-dependent PKCs on synaptic release?
They increase the probability of release
What is the role of the C1 domain in Unc13 in terms of synaptic regulation?
It is required for modulation by DAG
What is the primary function of synaptic plasticity in neurons?
Crucial for learning, memory, homeostasis, and behavior
Which of the following factors influences the strength of a synapse?
Recent firing patterns of both pre and post-synaptic neurons
What is the role of calcium entry in synaptic plasticity?
Enhancing vesicle fusion
What is the function of the readily releasable pool (RRP) in synaptic plasticity?
Releasing neurotransmitters in response to action potentials
What is the effect of paired pulse facilitation on synaptic strength?
Increases synaptic strength if P is low
What is the role of Syt3 and Syt7 in paired pulse facilitation?
Required for vesicle fusion, but not sufficient
What is the effect of a decrease in paired pulse facilitation on P?
Increase in P
What is the primary cause of post-tetanic depression (PTD)?
Depletion of readily releasable vesicles
What is the effect of hypertonic shock on neurotransmitter release?
Disrupts the membrane, releasing all primed vesicles
What is the primary function of Syt3 and Syt7 in vesicle fusion?
Required for vesicle fusion, but not sufficient
Test your understanding of synaptic plasticity, a crucial mechanism in learning, memory, and behavior, involving dynamic changes in the strength of connections between neurons. Learn how modulatory transmitters and recent firing patterns of neurons influence synaptic strength. Explore the role of calcium entry and other factors in modulating synaptic plasticity.
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