Sossin 4: Synaptic Plasticity

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What is the consequence of a higher probability of release on the depression of the synapse?

It leads to a longer post-tetanic potentiation

It leads to a more pronounced facilitation

It leads to a more pronounced depression (correct)

It has no effect on the depression

What is the primary role of Syt3 in the process of synaptic release?

To increase the calcium-dependent increase in the RRP

To phosphorylate Munc18 to increase priming

To act as a calcium sensor during prolonged release (correct)

To bind to calmodulin to accelerate Munc13's ability to disrupt Munc18

What is the effect of Munc13 lacking calmodulin binding on post-tetanic potentiation?

It increases the post-tetanic potentiation

It reduces the post-tetanic potentiation (correct)

It abolishes the post-tetanic potentiation

It has no effect on post-tetanic potentiation

What is the role of DAG in the regulation of synaptic release?

It binds to Unc13 to increase the phosphorylation of Munc18 Signup and view all the answers

What is the characteristic of PPF and PTP in terms of memory?

They are not forms of memory Signup and view all the answers

What is the mechanism underlying behavioral habituation in Aplysia?

Repeated touches lead to a decrease of withdrawal Signup and view all the answers

What is the effect of depressive synaptic plasticity on the RRP?

It has no effect on the RRP Signup and view all the answers

What is the primary characteristic of the readily releasable pool (RRP) in terms of synaptic release?

It is a probe for priming Signup and view all the answers

What is the effect of calcium-dependent PKCs on synaptic release?

They increase the probability of release Signup and view all the answers

What is the role of the C1 domain in Unc13 in terms of synaptic regulation?

It is required for modulation by DAG Signup and view all the answers

What is the primary function of synaptic plasticity in neurons?

Crucial for learning, memory, homeostasis, and behavior Signup and view all the answers

Which of the following factors influences the strength of a synapse?

Recent firing patterns of both pre and post-synaptic neurons Signup and view all the answers

What is the role of calcium entry in synaptic plasticity?

Enhancing vesicle fusion Signup and view all the answers

What is the function of the readily releasable pool (RRP) in synaptic plasticity?

Releasing neurotransmitters in response to action potentials Signup and view all the answers

What is the effect of paired pulse facilitation on synaptic strength?

Increases synaptic strength if P is low Signup and view all the answers

What is the role of Syt3 and Syt7 in paired pulse facilitation?

Required for vesicle fusion, but not sufficient Signup and view all the answers

What is the effect of a decrease in paired pulse facilitation on P?

Increase in P Signup and view all the answers

What is the primary cause of post-tetanic depression (PTD)?

Depletion of readily releasable vesicles Signup and view all the answers

What is the effect of hypertonic shock on neurotransmitter release?

Disrupts the membrane, releasing all primed vesicles Signup and view all the answers

What is the primary function of Syt3 and Syt7 in vesicle fusion?