Sossin 4: Synaptic Plasticity
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Questions and Answers

What is the consequence of a higher probability of release on the depression of the synapse?

  • It leads to a longer post-tetanic potentiation
  • It leads to a more pronounced facilitation
  • It leads to a more pronounced depression (correct)
  • It has no effect on the depression

What is the primary role of Syt3 in the process of synaptic release?

  • To increase the calcium-dependent increase in the RRP
  • To phosphorylate Munc18 to increase priming
  • To act as a calcium sensor during prolonged release (correct)
  • To bind to calmodulin to accelerate Munc13's ability to disrupt Munc18

What is the effect of Munc13 lacking calmodulin binding on post-tetanic potentiation?

  • It increases the post-tetanic potentiation
  • It reduces the post-tetanic potentiation (correct)
  • It abolishes the post-tetanic potentiation
  • It has no effect on post-tetanic potentiation

What is the role of DAG in the regulation of synaptic release?

<p>It binds to Unc13 to increase the phosphorylation of Munc18 (A)</p> Signup and view all the answers

What is the characteristic of PPF and PTP in terms of memory?

<p>They are not forms of memory (D)</p> Signup and view all the answers

What is the mechanism underlying behavioral habituation in Aplysia?

<p>Repeated touches lead to a decrease of withdrawal (A)</p> Signup and view all the answers

What is the effect of depressive synaptic plasticity on the RRP?

<p>It has no effect on the RRP (C)</p> Signup and view all the answers

What is the primary characteristic of the readily releasable pool (RRP) in terms of synaptic release?

<p>It is a probe for priming (C)</p> Signup and view all the answers

What is the effect of calcium-dependent PKCs on synaptic release?

<p>They increase the probability of release (A)</p> Signup and view all the answers

What is the role of the C1 domain in Unc13 in terms of synaptic regulation?

<p>It is required for modulation by DAG (B)</p> Signup and view all the answers

What is the primary function of synaptic plasticity in neurons?

<p>Crucial for learning, memory, homeostasis, and behavior (D)</p> Signup and view all the answers

Which of the following factors influences the strength of a synapse?

<p>Recent firing patterns of both pre and post-synaptic neurons (C)</p> Signup and view all the answers

What is the role of calcium entry in synaptic plasticity?

<p>Enhancing vesicle fusion (D)</p> Signup and view all the answers

What is the function of the readily releasable pool (RRP) in synaptic plasticity?

<p>Releasing neurotransmitters in response to action potentials (C)</p> Signup and view all the answers

What is the effect of paired pulse facilitation on synaptic strength?

<p>Increases synaptic strength if P is low (D)</p> Signup and view all the answers

What is the role of Syt3 and Syt7 in paired pulse facilitation?

<p>Required for vesicle fusion, but not sufficient (A)</p> Signup and view all the answers

What is the effect of a decrease in paired pulse facilitation on P?

<p>Increase in P (D)</p> Signup and view all the answers

What is the primary cause of post-tetanic depression (PTD)?

<p>Depletion of readily releasable vesicles (D)</p> Signup and view all the answers

What is the effect of hypertonic shock on neurotransmitter release?

<p>Disrupts the membrane, releasing all primed vesicles (C)</p> Signup and view all the answers

What is the primary function of Syt3 and Syt7 in vesicle fusion?

<p>Required for vesicle fusion, but not sufficient (A)</p> Signup and view all the answers

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