Neuroscience Exam 3 Overview

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Questions and Answers

What is one of the primary functions of the cerebellum?

  • Initiating motor activity
  • Coordinating and adjusting voluntary movement (correct)
  • Processing sensory information
  • Regulating heart rate

Which part of the brain is responsible for learning and memory of motor tasks?

  • Hippocampus
  • Cerebellum (correct)
  • Cerebral cortex
  • Basal ganglia

What structure separates the anterior lobe and posterior lobe of the cerebellum?

  • Primary fissure (correct)
  • Cerebral cortex
  • Vermis
  • Basal ganglia

Where is the cerebellum located?

<p>At the posterior cranial fossa in the cranial cavity (A)</p> Signup and view all the answers

Which of the following best describes the overall role of the cerebellum in motor activity?

<p>It creates motor plans based on current movements and positions. (B)</p> Signup and view all the answers

What neurotransmitter does the thalamus primarily use to project to the motor areas of the cortex?

<p>Glutamate (C)</p> Signup and view all the answers

What is the main function of the indirect pathway of the basal ganglia?

<p>Inhibition of motor cortex (C)</p> Signup and view all the answers

Which structure sends GABA projections to the thalamus?

<p>Globus Pallidus Internal (GPi) (A)</p> Signup and view all the answers

Which pathway is modulated by dopamine released from the substantia nigra pars compacta?

<p>Direct pathway (D)</p> Signup and view all the answers

What is the primary role of the basal ganglia pathways as a whole?

<p>Refinement of movement (D)</p> Signup and view all the answers

Where do the signals in the direct pathway begin?

<p>Cortex (B)</p> Signup and view all the answers

Which of the following describes the projection from the globus pallidus internal (GPi) to the thalamus?

<p>GABA projections (C)</p> Signup and view all the answers

What type of pathways are the direct and indirect pathways classified as?

<p>Excitatory and inhibitory pathways (D)</p> Signup and view all the answers

What function does the SNpc serve in relation to the caudate and putamen?

<p>It produces dopamine and sends information back to the striatum. (D)</p> Signup and view all the answers

Which motor symptom is NOT associated with Parkinson's disease?

<p>Full muscle paralysis (C)</p> Signup and view all the answers

How do the direct and indirect pathways of the basal ganglia contribute to motor control?

<p>They refine motor signals from the cortex. (D)</p> Signup and view all the answers

What is primarily impacted by the degeneration of SNpc cells in Parkinson's disease?

<p>Dopamine levels (B)</p> Signup and view all the answers

What type of movements result from dysfunction of the basal ganglia?

<p>Uneven and uncoordinated movements (D)</p> Signup and view all the answers

Which function is NOT attributed to the basal ganglia?

<p>Sensory processing (C)</p> Signup and view all the answers

What aspect is NOT typically affected by lesions in the basal ganglia?

<p>Muscle strength (C)</p> Signup and view all the answers

Which statement correctly describes the role of the cerebral cortex in movement production?

<p>It is involved in planning and executing voluntary movement. (C)</p> Signup and view all the answers

Which nucleus is primarily involved in goal-directed activity and cognitive functions like memory and sleep?

<p>Caudate nucleus (C)</p> Signup and view all the answers

What is the primary function of the putamen within the basal ganglia?

<p>Motor function preparation and execution (D)</p> Signup and view all the answers

What type of neurotransmitter does the globus pallidus predominantly release?

<p>GABA (C)</p> Signup and view all the answers

Which segment of the globus pallidus is primarily responsible for output to the thalamus?

<p>Globus pallidus internal (GPi) (D)</p> Signup and view all the answers

What type of input do glutamatergic projections provide to the striatum?

<p>Excitatory (D)</p> Signup and view all the answers

Which neurotransmitter plays a crucial role in the function of the basal ganglia, having both excitatory and inhibitory effects?

<p>Dopamine (B)</p> Signup and view all the answers

What role does the substantia nigra play regarding dopamine input in the basal ganglia?

<p>It provides the main source of dopaminergic input. (A)</p> Signup and view all the answers

Damage to the globus pallidus could lead to which of the following conditions?

<p>Movement disorders like tremors (C)</p> Signup and view all the answers

What is the primary function of the anterior lobe of the cerebellum?

<p>Regulation of muscle tone and adjusting movements (A)</p> Signup and view all the answers

Which lobe is the largest part of the cerebellum and is involved in planning and programming skilled movements?

<p>Cerebrocerebellum (C)</p> Signup and view all the answers

What anatomical feature separates the posterior lobe from the flocculonodular lobe?

<p>Posterolateral fissure (A)</p> Signup and view all the answers

What is the primary function of the flocculonodular lobe?

<p>Regulating balance and posture (D)</p> Signup and view all the answers

Which cerebellar peduncle connects the cerebellum to the midbrain and consists mainly of efferent pathways?

<p>Superior cerebellar peduncle (B)</p> Signup and view all the answers

What role does the cerebellar tonsils play in cerebellar function?

<p>Coordinating voluntary movements of distal limb parts (B)</p> Signup and view all the answers

Which type of input is primarily used by the spinocerebellum for regulating muscle tone?

<p>Proprioceptive input (D)</p> Signup and view all the answers

What does the term vestibulocerebellum refer to in relation to the cerebellum?

<p>Maintaining equilibrium and coordinating eye movements (C)</p> Signup and view all the answers

What is the main function of the vermis in the cerebellum?

<p>Coordinates movements of the central body (D)</p> Signup and view all the answers

Which region of the cerebellum is responsible for coordinating distal limb movements?

<p>Lateral hemisphere (B)</p> Signup and view all the answers

Which of the following represents the deep cerebellar nuclei and their functions?

<p>Dentate - involved in planning limb movements (A), Fastigial - coordination of axial muscles (D)</p> Signup and view all the answers

What is the role of the granular layer in the cerebellar cortex?

<p>Contains excitatory neurons involved in signal transmission (D)</p> Signup and view all the answers

Which layer of the cerebellum is primarily composed of the dendrites of Purkinje cells?

<p>Molecular layer (D)</p> Signup and view all the answers

What type of neurons are the Purkinje cells classified as?

<p>Inhibitory neurons (C)</p> Signup and view all the answers

Which nucleus is associated with the lateral hemispheres of the cerebellum?

<p>Dentate nucleus (C)</p> Signup and view all the answers

Which part of the cerebellum projects upon the vestibular nuclei?

<p>Floccular-nodular lobe (B)</p> Signup and view all the answers

Flashcards

Basal Ganglia Nuclei

Structures in the brain that play a key role in movement, cognition, and emotions.

Caudate Nucleus

A basal ganglia structure involved in goal-directed actions, memory, and sleep.

Putamen

A structure in the basal ganglia, crucial for motor functions, like preparing and performing movements.

Globus Pallidus

A basal ganglia structure that controls conscious movement and posture; divided into internal (GPi) and external (GPe) segments.

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Subthalamic Nucleus

A basal ganglia structure involved in motor control.

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Substantia Nigra

A basal ganglia structure that provides dopamine input, affecting movement.

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Striatum

A part of the basal ganglia (caudate + putamen) that receives input from the cortex and substantia nigra.

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Basal Ganglia Input

Information flowing into the basal ganglia from the cortex, primarily via glutamate.

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Basal Ganglia Output

Information leaving the basal ganglia through the globus pallidus internal segment (GPi), targeting inhibitory projections to thalamus.

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GPi

Internal segment of the globus pallidus, a primary output area of the basal ganglia.

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GPe

External Segment of the Globus Pallidus, involved in the indirect pathway

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Dopamine

A neurotransmitter that plays a crucial role in basal ganglia function. Its effects can be excitatory or inhibitory.

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Basal Ganglia Direct Pathway

A neural pathway that initiates movement by exciting thalamic projections to the cortex, ultimately increasing motor activity.

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Basal Ganglia Indirect Pathway

A neural pathway that inhibits motor activity by suppressing thalamic projections to the cortex.

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Globus Pallidus Internal (GPi)

A brain structure involved in the basal ganglia pathways, sending inhibitory signals to the thalamus, thus refining movement.

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Substantia Nigra pars compacta (SNc)

A brain region that influences the basal ganglia's direct pathway by releasing dopamine to the striatum, facilitating movement.

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Thalamus

A relay station in the brain, receiving signals from the basal ganglia and projecting them to the cortex, crucial for motor control.

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Dopamine

A neurochemical that modulates basal ganglia activity, influencing movement through its effects on the direct pathway.

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Striatum

A part of the basal ganglia, receiving input from the cortex and influencing the activity of the basal ganglia pathways.

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Glutamate

An excitatory neurotransmitter crucial for communication between the thalamus and cerebral cortex during movement.

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GABA

An inhibitory neurotransmitter, used in the basal ganglia to refine movement by inhibiting unwanted outputs.

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Motor Cortex

Region of the cortex that directly controls movement.

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Cortex refining movement

The brain's outer layer where signals from the basal ganglia are further processed and refined for precise movement.

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Substantia Nigra pars compacta (SNpc)

Part of the basal ganglia that produces dopamine, crucial for movement.

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Substantia Nigra pars reticulata (SNpr)

Basal ganglia part sending signals outside the basal ganglia to control eye and head movements.

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Parkinson's Disease

A neurological disorder causing dopamine depletion in the SNpc.

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Basal Ganglia Function

Refines and coordinates movement signals, crucial for smooth and balanced movement.

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Basal Ganglia Involvement in Motor Disorders

Disruption can result in uncoordinated/rough movements, excessive or insufficient, NOT paralysis or weakness.

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Basal Ganglia and Emotion/Behavior

Crucial role in regulating emotions and behavioral restraint.

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Cerebral Cortex and Movement

Plans and executes voluntary movements.

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Cerebellum and Movement

Part of movement production, interacting with the cerebral cortex and basal ganglia.

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Dopamine Depletion (Parkinson's)

Causes motor symptoms such as tremor at rest, rigidity, slow movement, postural instability, and fenestrated gait.

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Cerebellum Function

Coordinates and adjusts voluntary movements, posture, balance, muscle tone, and skilled motor activities. Also involved in learning and remembering motor tasks.

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Cerebellum Location

Located in the posterior cranial fossa of the skull.

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Cerebellum Anatomy (Structure)

Two hemispheres separated by a vermis and divided into anterior, posterior, and flocculonodular lobes.

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Cerebellum Function (Communication)

Communicates extensively with the cerebral cortex and spinal cord, processing information about movement and position to refine and correct actions.

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Cerebellar Motor Planning

Determines the timing, initiation, speed, direction, precision, and required muscle groups for a movement.

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Anterior Cerebellar Lobe Function

Regulates muscle tone and adjusts movements based on proprioceptive input (muscle stretch receptors).

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Vermis function

Coordinates the movements of the central body (trunk, head, proximal limbs).

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Paravermis function

Coordinates movement of the distal limbs (arms, legs, fingers, toes).

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Posterior Cerebellar Lobe (Cerebrocerebellum)

Assists in planning and executing skilled movements; the largest part of the cerebellum.

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Cerebrocerebellum function

Coordinates and plans limb movements, working with the basal ganglia.

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Posterior Lobe Bounded by?

Bounded by the posterolateral fissure, separating it from the flocculonodular lobe.

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Cerebellar Cortex layers

Molecular, Purkinje, and Granular layers, with distinct cell types and functions.

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Flocculonodular Lobe Function

Controls posture, balance, and coordinates eye movements using vestibular system input.

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Fastigial Nucleus

A deep cerebellar nucleus associated with the vermis.

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Flocculonodular Lobe Contains

Contains a part of the vermis (nodule) and two lateral flocculi.

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Cerebellar Tonsils

Hemispheric structures involved in coordinating voluntary movements of distal limbs.

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Interpositus Nuclei

Globose and Emboliform nuclei, collectively associated with the intermediate zone.

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Dentate Nucleus

Associated with the lateral hemispheres, involved in fine motor control.

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Superior Cerebellar Peduncle

Connects the cerebellum to the midbrain, primarily carrying efferent pathways.

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Middle Cerebellar Peduncle

Connects the cerebellum to the pons and carries mostly afferent signals.

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Floccular-nodular lobe

Projects to the vestibular nuclei (in the medulla), involved in balance.

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Inferior Cerebellar Peduncle

Connects the cerebellum to the medulla, carrying afferent signals from the spinal cord and brainstem.

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Study Notes

Exam 3 Breakdown

  • Exam 3 will be held on Friday, November 15th at 10:00 AM.
  • The exam will consist of 40 questions.
  • The exam duration is 80 minutes.
  • The exam will cover four topics
  • Topic 1: Basal Ganglia and Cerebellum (10 questions)
  • Topic 2: Brainstem sensory systems (10 questions)
  • Topic 3: Lab images (fill-in-the-blank) (10 questions)
  • Topic 4: Thalamus/Hypothalamus (10 questions)

Basal Ganglia

  • The basal ganglia are masses of grey matter in the telencephalon.
  • They are a group of subcortical nuclei below the cerebral cortex.
  • They are responsible for coordinating/regulating voluntary movement.
  • Learning objectives: discuss function, describe anatomical components, compare input vs. output, and discuss pathways.
  • Structures: Caudate nuclei, Putamen, Globus pallidus (externus and internus), Subthalamic nucleus, Substantia nigra.
  • Striatum = caudate nuclei + putamen.
  • Lentiform=globus pallidus + putamen.
  • Function: Initial signal from the motor cortex in frontal lobe is modified as it travels to the muscles. Different parts of the basal ganglia amplify or diminish(excite/inhibit) the signal.
  • Parkinson's and Huntington's disease arise from dysfunction within basal ganglia neurons.
  • Functions also include emotional and cognitive processing.
  • The basal ganglia act as an intermediary between higher thought, sensations, and reflexes.

Cerebellum

  • Part of the brain that translates to "little brain".
  • Located at the posterior cranial fossa.
  • Assists in coordinating movement, posture, balance, maintaining muscle tone, and coordinated skilled motor tasks.
  • Learning Objectives: Identity the lobes, explain functions of each lobe and related fibers/peduncles, describe deep nuclei and functional regions, and discuss layers of cerebellar cortex and related cells.
  • Cerebellum Anatomy consists of three lobes(anterior, posterior, flocculonodular).
  • Anterior Lobe: spinocerebellum, responsible for regulation of muscle tone, and adjusting movements through proprioception input.
  • Posterior Lobe: cerebrocerebellum or pontocerebellum, is the largest part, involved in planning and programming skilled or fine motor movements.
  • Flocculonodular Lobe: vestibulocerebellum, responsible for maintenance of posture and balance(eye movements).
  • Cerebellar nuclei- deep gray matter clusters (fastigial, globose, emboliform, and dentate).
  • Cerebellar peduncles: bundles of white matter connect the cerebellum to the brainstem, containing both afferent and efferent axons. (superior, middle, and inferior)
  • Cerebellar cortex- folded into folia, three layers (molecular, purkinje, and granular).

Additional Notes

  • Specific exam questions are part of the learning material.
  • GABA, Glutamate, Dopamine are neurotransmitters involved

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