Neuroscience Chapter on Resting Membrane Potential

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Questions and Answers

What is the primary role of thermoreceptors in the body?

  • Detecting pressure changes
  • Detecting light intensity
  • Regulating blood pressure
  • Sensing heat and temperature variations (correct)

Which submodality of taste is primarily associated with hydrogen ions (H+)?

  • Salty
  • Umami
  • Sour (correct)
  • Bitter

Which type of afferent fiber is responsible for proprioception?

  • Ia and II fibers (correct)
  • Aß fibers
  • C fibers
  • Aδ fibers

What type of mechanoreceptor is primarily responsible for detecting sustained stretch?

<p>Ruffini ending (D)</p> Signup and view all the answers

Which mechanoreceptor is activated by light touch and phasic vibration?

<p>Meissner corpuscles (D)</p> Signup and view all the answers

Which type of receptor is primarily involved in pain perception?

<p>Nociceptors (D)</p> Signup and view all the answers

What is the common conduction velocity range for touch sensory afferents like Aß fibers?

<p>35-75 m/s (A)</p> Signup and view all the answers

What is the primary function of the stria vascularis in the cochlea?

<p>To maintain high potassium concentration in endolymph (D)</p> Signup and view all the answers

Which statement best describes the role of outer hair cells?

<p>They enhance sensitivity to sounds and sharpen frequency selectivity (D)</p> Signup and view all the answers

How do auditory nerve fibers encode sound intensity?

<p>Based on firing rate and number of activated fibers (C)</p> Signup and view all the answers

What is the function of the cochlear amplifier?

<p>To increase sensitivity to quiet sounds and sharpen frequency discrimination (C)</p> Signup and view all the answers

Which structure is NOT part of the auditory pathway from the cochlea to the auditory cortex?

<p>Basilar membrane (A)</p> Signup and view all the answers

What type of ions do salt stimuli primarily detect?

<p>Sodium ions (Na+) (A)</p> Signup and view all the answers

Which receptor type is primarily responsible for detecting temperature changes above 30°C?

<p>Warm receptors (A)</p> Signup and view all the answers

What is the function of Golgi tendon organs in the human body?

<p>Detect muscle tension (D)</p> Signup and view all the answers

How do both cold and warm receptors adapt to stimuli?

<p>They exhibit varying response frequencies to sustained stimuli. (C)</p> Signup and view all the answers

What neurotransmitters are primarily used by nociceptors to relay pain signals?

<p>Glutamate and substance P (B)</p> Signup and view all the answers

In stimulus intensity coding, what does frequency coding enable?

<p>Differentiation between stimuli intensities through action potential frequency (C)</p> Signup and view all the answers

What mechanism do acids (sour stimuli) primarily depend on for detection?

<p>Hydrogen ions (H+) (B)</p> Signup and view all the answers

What role do intrafusal fibers play in the muscular system?

<p>Provide proprioceptive information regarding body movement (C)</p> Signup and view all the answers

What triggers the activation of nociceptors?

<p>Intense mechanical pressure, excessive temperatures, and chemical signals (B)</p> Signup and view all the answers

What primarily determines the perception of spatial resolution in sensory coding?

<p>The distance between stimuli (D)</p> Signup and view all the answers

Which type of sensory receptor is best for detecting motion?

<p>Rapidly adapting receptors (B)</p> Signup and view all the answers

What role does lateral inhibition play in sensory perception?

<p>Enhances spatial localization of stimuli (D)</p> Signup and view all the answers

How is sensory information processed in the brain before reaching the cortex?

<p>Via thalamic relay points (A)</p> Signup and view all the answers

What is the purpose of 'descending pathways' in sensory information processing?

<p>To modulate and refine sensory information (A)</p> Signup and view all the answers

What is the main function of slowly adapting receptors in the sensory system?

<p>Maintaining constant sensation monitoring (C)</p> Signup and view all the answers

Which of the following best describes the anatomical components of the eye in relation to vision?

<p>Each component has a specific function in vision (D)</p> Signup and view all the answers

Which statement accurately reflects the characteristics of specific sensory receptors?

<p>They have a functional specialization for designated modalities (A)</p> Signup and view all the answers

What is a key feature of the crossed ascending pathways in sensory processing?

<p>They facilitate hemispheric balance in sensory information (A)</p> Signup and view all the answers

What do mechanoreceptors specifically respond to in the context of touch?

<p>Shape, texture, and vibration (D)</p> Signup and view all the answers

What does frequency, measured in Hertz (Hz), correspond to in sound perception?

<p>Pitch (D)</p> Signup and view all the answers

Which component of the ear is responsible for transmitting sound through the ossicles?

<p>Middle ear (C)</p> Signup and view all the answers

What is the primary function of inner hair cells (IHC) in the auditory system?

<p>Transducing sound into electrical signals (C)</p> Signup and view all the answers

How is the basilar membrane organized in terms of frequency sensitivity?

<p>Tonotopic organization (C)</p> Signup and view all the answers

What ion is predominantly found in endolymph, which influences hair cell function?

<p>Potassium (K+) (A)</p> Signup and view all the answers

What is the threshold of hearing measured in decibels (dB)?

<p>0 dB (C)</p> Signup and view all the answers

Which part of the ear includes the pinna and external auditory canal?

<p>Outer ear (C)</p> Signup and view all the answers

What sound characteristics are perceived as loudness?

<p>Amplitude (C)</p> Signup and view all the answers

What can sound levels exceeding 120 dB cause?

<p>Hearing loss (C)</p> Signup and view all the answers

Which part of the auditory system is involved in the activation of hair cells?

<p>Basilar membrane (C)</p> Signup and view all the answers

Flashcards

Thermoreceptors

Specialized sensory receptors that detect heat and temperature changes, essential for regulating body temperature.

Mechanoreceptors

Responsible for sensing touch, pressure, and vibrations. Various types exist, each with specific roles in tactile perception.

Chemoreceptors

Sensory receptors responsible for taste and smell, detecting chemical stimuli.

Free Nerve Endings

Free nerve endings located in the skin, responsible for detecting light touch and rapid changes in touch sensation.

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Meissner Corpuscles

Found in the dermis, these receptors detect vibrations and contribute to sensitivity in light touch.

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Merkel Cell-Neurite Complex

Slowly adapting receptors in the skin, essential for detailed perception of textures and edges.

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Ruffini Ending

Tonic receptors within the skin that respond to sustained stretch, providing proprioceptive feedback.

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Salt Taste

Sodium ions (Na+) are the primary trigger for activating salt receptors, triggering a taste sensation.

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Sour (Acid) Taste

Hydrogen ions (H+) are the main players in detecting acidity, leading to the sour taste perception.

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Umami Taste

Umami, a savory taste sensation, is triggered by the presence of monosodium glutamate.

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Proprioceptors

These receptors are specialized sensory cells found in muscles that provide information about body positioning and movement.

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Intrafusal Fibers

A type of proprioceptor found in muscle spindles, intrafusal fibers are central for monitoring muscle stretch and regulating reflexes.

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Golgi Tendon Organs

Golgi tendon organs are mechanoreceptors embedded in tendons that respond to muscle tension, contributing to coordination and injury prevention.

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Cold Receptors

Cold receptors are most active when exposed to temperatures below 30°C, playing a crucial role in thermoregulation and environmental response.

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Warm Receptors

Warm receptors are activated by increasing temperatures, peaking at around 45°C, and signaling the presence of potentially harmful temperatures.

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What is frequency in sound?

The measurement of how high or low a sound is, determined by the frequency of sound waves. It is perceived by humans as pitch.

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What is intensity in sound?

The measurement of the intensity or strength of a sound wave, determined by the amplitude of the wave. It is perceived by humans as loudness.

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What is the function of the outer ear?

The outer ear includes the pinna, which collects sound waves, and the external auditory canal, which transmits sound to the middle ear.

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What is the function of the middle ear?

The middle ear contains three tiny bones called ossicles (malleus, incus, and stapes). These bones amplify and transmit sound vibrations from the eardrum to the inner ear.

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What is the function of the inner ear?

The innermost part of the ear, containing the cochlea and vestibular system. The cochlea converts sound vibrations into electrical signals, while the vestibular system helps with balance and spatial orientation.

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What is the role of the cochlea in hearing?

The cochlea is a fluid-filled, snail-shaped structure within the inner ear. It is lined with the basilar membrane, which vibrates in response to sound waves, triggering hair cells responsible for sound transduction.

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What is the function of the basilar membrane?

The basilar membrane is a flexible structure within the cochlea that vibrates in response to sound waves. Different regions of the membrane are sensitive to different frequencies, allowing for frequency discrimination.

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What role do hair cells play in hearing?

Hair cells are specialized sensory cells located in the cochlea. They are responsible for converting mechanical sound vibrations into electrical signals that the brain can interpret.

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What is the function of inner hair cells?

Inner hair cells (IHC) are primarily responsible for transducing sound vibrations into electrical signals, which are then transmitted to the brain via the auditory nerve.

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What is the function of outer hair cells?

Outer hair cells (OHC) help amplify sound and improve frequency resolution. They have a unique ability to change their length in response to electrical signals, enhancing the cochlea's response.

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What is the key function of the stria vascularis?

The stria vascularis is a specialized structure in the inner ear that plays a crucial role in generating and maintaining the endocochlear potential. It is responsible for the high potassium concentration in endolymph, which is essential for the proper functioning of hair cells, the sensory receptors of the inner ear.

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What is the endocochlear potential and why is it so important?

The endocochlear potential is a positive electrical potential that exists within the endolymph of the inner ear, primarily generated by the stria vascularis. This potential gradient is crucial for the transduction of sound waves into electrical signals that the brain can interpret.

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What are the roles of outer and inner hair cells?

Outer hair cells are responsible for amplifying sounds and improving frequency selectivity, while inner hair cells are responsible for sending auditory information to the brain via the auditory nerve.

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What does the cochlear amplifier do?

The cochlear amplifier, mainly attributed to the activity of outer hair cells, significantly enhances the sensitivity of the ear to quiet sounds and sharpens frequency discrimination. This mechanism is crucial for understanding complex sounds like speech.

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How do auditory nerve fibers encode sound intensity and frequency?

Sound intensity is encoded by the firing rate of auditory nerve fibers, which increases with louder sounds, and the number of activated fibers. Frequency encoding is more complex, with lower frequencies being encoded via phase locking and higher frequencies encoded spatially along the cochlea.

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Receptive Fields

Defined areas of skin that evoke responses from specific neurons, crucial for localizing stimuli.

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Spatial Resolution

Refers to the ability of the sensory system to distinguish between closely spaced stimuli. Closely spaced stimuli activate fewer neurons, while distant stimuli activate separate neurons, leading to better perception.

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Sensory Adaptation

A process where sensory receptors respond less to a constant stimulus over time.

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Rapidly Adapting Receptors

Receptors that respond quickly to changes in stimuli and then rapidly adapt. They are ideal for detecting movement and transitions in sensation.

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Slowly Adapting Receptors

Receptors that respond slowly to stimuli and maintain responsiveness for a longer duration. These receptors help you sense constant stimuli and keep track of ongoing sensations.

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Lateral Inhibition

The process of enhancing the perception of stimuli by suppressing activity in neighboring neurons. This helps to sharpen the contrast and make the stimulus location clearer.

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Cognitive Control of Sensory Perception

Sensory information is not just passively received but can be influenced by descending pathways in the brain. For example, pain can be modulated by factors like stress or expectation.

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Thalamus: Sensory Relay Station

The thalamus acts as a central relay station for most sensory pathways before they reach the cortex. This allows the brain to process and integrate information from different senses in a coordinated way.

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Distinct Cortical Processing of Sensory Information

Different sensory modalities are processed in specialized regions of the cortex, allowing for distinct and detailed perception of each type of sensory information.

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Descending Controls for Sensory Information

Descending pathways from higher brain regions can regulate the flow of sensory information, influencing how we perceive and respond to sensory stimuli.

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Study Notes

Resting Membrane Potential (RMP)

  • RMP is the difference in charged particle distribution across the cell membrane when it's not stimulated.
  • A typical RMP is around -70 mV.
  • Maintenance factors include: diffusion of ions via concentration gradients, electrostatic interactions between charged particles, and ion transport via the Na+/K+ pump.
  • The Na+/K+ pump actively transports 3 sodium ions out of the cell for every 2 potassium ions brought in, contributing to the intracellular negative charge.
  • The presence of negatively charged ions (Cl⁻) and proteins inside the cell also establishes the RMP.
  • The 'salty banana' analogy illustrates the difference in Na⁺ concentration between inside and outside the cell, crucial for understanding RMP.

Ion Transport

  • The Na+/K+ pump is vital for maintaining RMP.
  • It utilizes ATP and conformational changes to transport ions against their concentration gradient.

Ion Permeability

  • The Goldman-Katz equation predicts equilibrium potential for ions when the membrane is permeable to multiple ions.
  • Typical permeability ratios at rest: PK:PCl:PNa = 1.0 : 0.45 : 0.04.
  • K⁺ ions have a more substantial effect on RMP due to higher permeability compared to Na⁺.

Factors Influencing Membrane Potential

  • K⁺ diffusion results in a loss of net positive charge inside the cell.
  • Active transport of ions (Na+/K+ pump) contributes to a net loss of positive charge.
  • Electrochemical gradients influence K⁺ movement into the cell.
  • Changes in voltage across the membrane initiate changes and affect the signaling pathways in neurons.

Action Potentials

  • Action potentials are crucial for signal propagation in the neuron.
  • The threshold for firing an action potential is typically around -55mV.
  • Action potential phases:
    • Rest: Neurons are in a steady state with resting membrane potential established.
    • Depolarization: Rapid influx of Na⁺ ions, creating a more positive charge.
    • Repolarization: K⁺ channels open, driving the membrane potential back to a negative value.
    • Refractory Period: The neuron is temporarily less excitable.
    • In the absolute refractory period, the cell cannot fire another action potential due to Na⁺ channel inactivation.
    • In the relative refractory period, a stronger-than-normal stimulus is required before firing another action potential.

Refractory Periods

  • Absolute and Relative Refractory periods are key phases that allow neurons to regulate and control actions potentials.
  • Absolute period: No new action potentials can fire during this phase.
  • Relative period: A stronger stimulus is required to fire an action potential.

Factors Influencing Membrane Potential, Including Action Potential Phases and Characteristics

  • The interplay of graded and action potentials sets the stage for neuron communication.
  • The combined impact of positive and negative charges on a neuron leads to changes in membrane potential.
  • Action potentials serve as critical signaling units, ensuring information transmission and action through neurons along the axon.

Summary of Membrane and Action Potential Changes

  •  Graded potentials are summed at the axon hillock to trigger action potentials.
  •  Action potentials are generated if the threshold is reached.

Phases of Action Potentials

  • Rest: Neuron is at a steady state with the resting membrane potential established.
  • Depolarization: The influx of Na⁺ ions causes the neuron to become less polarized.
  • Repolarization: K⁺ channels open, facilitating the return to a more negative resting state.
  • Refractory period: The neuron is temporarily less excitable following an action potential.

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