Resting Membrane Potential Overview
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Questions and Answers

What is the primary role of phospholipids in the membrane?

  • To facilitate enzymatic reactions
  • To form a lipid bilayer that provides structural integrity (correct)
  • To transport ions across the membrane
  • To act as a signal transducer
  • How does the distribution of cholesterol in the phospholipid bilayer affect the cell?

  • It increases the permeability of all ions
  • It aids in the formation of a rigid membrane
  • It prevents the formation of integral proteins
  • It regulates fluidity and permeability (correct)
  • What does the resting membrane potential represent?

  • The maximum potential reached during an action potential
  • The membrane potential at which there is no ion movement (correct)
  • The average potential created by all ions in the cell
  • The charge difference that promotes ion flow out of the cell
  • Which of the following statements best describes equilibrium potential?

    <p>It occurs when chemical and electrical driving forces are equal and opposite (D)</p> Signup and view all the answers

    What does Bernstein’s suggestion about intracellular and extracellular potassium concentrations imply?

    <p>Intracellular potassium concentrations exceed extracellular concentrations (A)</p> Signup and view all the answers

    What characterizes the equilibrium potential of a cell?

    <p>The concentration gradient and electrical force are equal and opposite. (A)</p> Signup and view all the answers

    Which role of the Na/K pump is critical in cellular function?

    <p>It directly utilizes ATP to pump ions against their gradients. (C)</p> Signup and view all the answers

    In secondary active transport, what is utilized to drive the transport of solutes?

    <p>The electrochemical gradient of another ion. (C)</p> Signup and view all the answers

    How does osmosis contribute to cell dynamics?

    <p>It can cause cells to either swell or shrivel depending on solute concentrations. (A)</p> Signup and view all the answers

    What is the primary function of aquaporins in the cell membrane?

    <p>To facilitate the movement of water molecules. (B)</p> Signup and view all the answers

    What is a consequence of deleting the gene for Aquaporin4 in mice?

    <p>Sevenfold reduction in water permeability of cell membranes. (C)</p> Signup and view all the answers

    How does the capacitative current relate to ionic current in a membrane?

    <p>Higher capacitative current corresponds with higher ionic current, maintaining membrane potential. (B)</p> Signup and view all the answers

    What distinguishes exchange (antiport) and cotransport (symport) in secondary active transport?

    <p>Antiport involves the movement of one solute against its gradient while another is moved down its gradient, whereas symport moves both against their gradients. (D)</p> Signup and view all the answers

    Flashcards

    Fluid Mosaic Model

    A model describing the cell membrane as a fluid structure with a phospholipid bilayer and embedded proteins. The phospholipids form a barrier to ions and molecules, while proteins provide channels for transport and communication.

    Resting Membrane Potential

    The difference in electrical charge between the inside and outside of a cell membrane. It is determined by the distribution of charged ions across the membrane.

    Membrane Capacitance

    The ability of a membrane to store electrical charge. This property is essential for cell signaling and communication.

    Equilibrium Potential

    The electrical potential at which the chemical and electrical forces driving ion movement across a membrane are equal and opposite.

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    K+ Concentration Gradient

    The difference in concentration of potassium ions (K+) across the cell membrane, with a higher concentration inside the cell than outside.

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    What is equilibrium potential?

    The equilibrium potential is reached when the concentration gradient and the electrical force acting on an ion are equal and opposite, resulting in no net movement of the ion across the membrane.

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    How does the Na/K pump work?

    The Na/K pump actively transports sodium ions out of the cell and potassium ions into the cell, using energy from ATP. This creates an imbalance in cation movement, making the pump electrogenic and contributing to the resting membrane potential.

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    What is secondary active transport?

    Secondary active transport uses the energy stored in the electrochemical gradient of one ion to drive the transport of another solute against its concentration or electrochemical gradient.

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    What is exchange (antiport)?

    Exchange, also known as antiport, is a type of secondary active transport where two molecules move in opposite directions across the membrane.

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    What is cotransport (symport)?

    Cotransport, also known as symport, is a type of secondary active transport where two molecules move in the same direction across the membrane.

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    What is osmosis?

    Osmosis is the net movement of solvent molecules, such as water, through a semi-permeable membrane into a region of higher solute concentration. This movement can cause cells to shrivel or swell due to osmotic pressure.

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    What are aquaporins?

    Aquaporins are channels that facilitate water movement across the membrane, and they are expressed in the nervous system.

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    How can the membrane be considered as an RC circuit?

    The membrane can be considered as an RC circuit, where the capacitance represents the cell membrane and the resistance represents the ionic channels. As capacitative current increases, ionic current also increases, maintaining membrane potential.

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    Study Notes

    Resting Membrane Potential

    • The cell membrane is a lipid bilayer with embedded proteins, forming a selectively permeable barrier.
    • Phospholipids are amphiphilic, with hydrophobic tails and hydrophilic heads, spontaneously forming a bilayer in aqueous solutions.
    • Integral and peripheral proteins facilitate transport and communication across the membrane.
    • Cholesterol regulates membrane fluidity and permeability.

    Bernstein's Model

    • Intracellular potassium concentration ([K+]in) is greater than extracellular potassium concentration ([K+]out).
    • Potassium permeability (PK) is significantly higher than the permeability of other ions (Pall).
    • Resting membrane potential (Vm) is approximately equal to the potassium equilibrium potential (EK).

    Electrochemical Equilibrium

    • Equilibrium potential is the membrane potential at which the chemical and electrical driving forces for an ion are equal and opposite, resulting in no net ion movement.

    Maintaining Transmembrane Ion Gradients

    • The Na+/K+ pump actively transports sodium ions out of the cell and potassium ions into the cell, using ATP.
    • This pump is electrogenic, contributing a small but significant voltage to the resting membrane potential.
    • Secondary active transport utilizes the electrochemical gradient of one ion to drive the transport of another. This includes exchange (antiport) and cotransport (symport).
    • Osmosis is the movement of water across a semi-permeable membrane from an area of high water concentration to low water concentration.
    • Aquaporins are channels that facilitate water movement across membranes. Their deletion in mice affects water permeability, although other water transport can maintain normal function under normal conditions.

    The Membrane as an RC Circuit

    • The cell membrane acts as both a capacitor and a resistor, influencing how rapidly membrane voltage changes.
    • Changes in ionic current affect capacitive current and vice-versa, influencing the overall membrane potential.

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    Description

    Explore the concepts of resting membrane potential, Bernstein's model, and electrochemical equilibrium in this quiz. Understand the roles of cell membrane structure, ion concentrations, and transport mechanisms in maintaining membrane potential. Test your knowledge on how these factors influence cellular functions.

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