Podcast
Questions and Answers
What is the primary role of kinesin in axoplasmic transport?
What is the primary role of kinesin in axoplasmic transport?
- It moves substances from the cell body to the terminal buttons. (correct)
- It regulates the shape of the neuron.
- It generates electrical impulses within the neuron.
- It moves substances from terminal buttons to the cell body.
Which part of the neuron is primarily associated with integrating signals?
Which part of the neuron is primarily associated with integrating signals?
- Axon hillock (correct)
- Terminal buttons
- Dendrites
- Cell nucleus
How do neurotransmitters interact with the postsynaptic neuron?
How do neurotransmitters interact with the postsynaptic neuron?
- They bind to receptors and then diffuse away. (correct)
- They trigger action potentials directly.
- They are absorbed by the postsynaptic neuron.
- They enter the postsynaptic neuron.
What is an example of retrograde axoplasmic transport?
What is an example of retrograde axoplasmic transport?
What structural component of the neuron contributes to its shape?
What structural component of the neuron contributes to its shape?
Which type of transport is primarily responsible for moving proteins produced in the cell body to the terminal buttons?
Which type of transport is primarily responsible for moving proteins produced in the cell body to the terminal buttons?
What happens to dendritic spines over time?
What happens to dendritic spines over time?
What is the function of channel proteins in the neuron's cell membrane?
What is the function of channel proteins in the neuron's cell membrane?
What triggers the action potential in a neuron?
What triggers the action potential in a neuron?
What force is responsible for the movement of molecules from regions of high concentration to low concentration?
What force is responsible for the movement of molecules from regions of high concentration to low concentration?
What type of ion is represented by Na+?
What type of ion is represented by Na+?
Which ion is predominantly found in the extracellular fluid?
Which ion is predominantly found in the extracellular fluid?
What balances the diffusion of potassium ions (K+) outside the axon?
What balances the diffusion of potassium ions (K+) outside the axon?
What is true about the A- ion in relation to the neuronal membrane?
What is true about the A- ion in relation to the neuronal membrane?
How does electrostatic pressure affect cations and anions in the neuron?
How does electrostatic pressure affect cations and anions in the neuron?
Which statement correctly describes the concentration of K+ ions in the axon?
Which statement correctly describes the concentration of K+ ions in the axon?
What characterizes a bipolar neuron?
What characterizes a bipolar neuron?
Which type of neuron is primarily responsible for transmitting sensory information?
Which type of neuron is primarily responsible for transmitting sensory information?
What is a primary role of motor neurons?
What is a primary role of motor neurons?
How do local interneurons differ from relay interneurons?
How do local interneurons differ from relay interneurons?
What structural components are essential for synapse function?
What structural components are essential for synapse function?
What initiates the release of neurotransmitters from synaptic vesicles?
What initiates the release of neurotransmitters from synaptic vesicles?
What is the function of postsynaptic receptors?
What is the function of postsynaptic receptors?
Which of the following best describes multipolar interneurons?
Which of the following best describes multipolar interneurons?
What role do sodium-potassium pumps play in the neuron?
What role do sodium-potassium pumps play in the neuron?
Which statement correctly explains the movement of Na+ ions across the neuronal membrane?
Which statement correctly explains the movement of Na+ ions across the neuronal membrane?
What is a significant characteristic of voltage-dependent ion channels?
What is a significant characteristic of voltage-dependent ion channels?
What effect does the influx of Na+ ions have on the membrane potential during an action potential?
What effect does the influx of Na+ ions have on the membrane potential during an action potential?
How does the sodium-potassium pump affect the concentration of K+ ions inside the neuron?
How does the sodium-potassium pump affect the concentration of K+ ions inside the neuron?
What is the primary reason why Na+ ions are more concentrated outside the axon?
What is the primary reason why Na+ ions are more concentrated outside the axon?
What occurs when the membrane potential reaches the threshold of excitation?
What occurs when the membrane potential reaches the threshold of excitation?
What percentage of a neuron's metabolic resources is used by sodium-potassium transporters?
What percentage of a neuron's metabolic resources is used by sodium-potassium transporters?
What distinguishes action potentials from postsynaptic potentials?
What distinguishes action potentials from postsynaptic potentials?
What is spatial summation in neural integration?
What is spatial summation in neural integration?
How are postsynaptic potentials terminated?
How are postsynaptic potentials terminated?
What is presynaptic inhibition?
What is presynaptic inhibition?
Which type of synapse occurs between two terminal buttons?
Which type of synapse occurs between two terminal buttons?
What role do gap junctions play at dendrodendritic synapses?
What role do gap junctions play at dendrodendritic synapses?
Which of the following describes temporal summation?
Which of the following describes temporal summation?
What happens during the reuptake of neurotransmitters?
What happens during the reuptake of neurotransmitters?
What mechanism allows for faster conduction of action potentials in myelinated axons?
What mechanism allows for faster conduction of action potentials in myelinated axons?
What is the consequence of sodium channels being concentrated at the nodes of Ranvier?
What is the consequence of sodium channels being concentrated at the nodes of Ranvier?
Which feature of cerebral neurons is NOT accounted for in the Hodgkin-Huxley model?
Which feature of cerebral neurons is NOT accounted for in the Hodgkin-Huxley model?
What is the primary role of small synaptic vesicles in terminal buttons?
What is the primary role of small synaptic vesicles in terminal buttons?
How does myelination affect the sodium balance in an axon?
How does myelination affect the sodium balance in an axon?
What kind of conduction do non-myelinated axons primarily utilize?
What kind of conduction do non-myelinated axons primarily utilize?
How does the firing rate of an axon change in response to varying light intensities?
How does the firing rate of an axon change in response to varying light intensities?
In what way do some cerebral neurons differ from typical action potential behavior?
In what way do some cerebral neurons differ from typical action potential behavior?
Flashcards
Bipolar Neuron
Bipolar Neuron
A type of neuron with one dendrite and one axon, found in sensory systems such as vision.
Multipolar Interneuron
Multipolar Interneuron
A neuron with a short axon or no axon at all, found in the brain and responsible for integrating information within a single brain structure.
Sensory Neuron
Sensory Neuron
A neuron that gathers information from the environment, such as light, sound, touch, etc., and transmits it to the central nervous system (CNS).
Motor Neuron
Motor Neuron
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Relay Interneuron
Relay Interneuron
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Synapse
Synapse
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Neurotransmitters
Neurotransmitters
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Postsynaptic Receptors
Postsynaptic Receptors
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Axoplasmic transport
Axoplasmic transport
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Anterograde axoplasmic transport
Anterograde axoplasmic transport
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Retrograde axoplasmic transport
Retrograde axoplasmic transport
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Axon hillock
Axon hillock
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Dendritic spines
Dendritic spines
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Neural plasticity
Neural plasticity
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Ribosomes
Ribosomes
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Membrane Potential
Membrane Potential
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Diffusion
Diffusion
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Electrostatic Pressure
Electrostatic Pressure
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Threshold of Excitation
Threshold of Excitation
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Action Potential
Action Potential
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Ions
Ions
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Axon Initial Segment
Axon Initial Segment
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Sodium-potassium pump
Sodium-potassium pump
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Resting membrane potential
Resting membrane potential
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Ion channels
Ion channels
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Voltage-dependent ion channel
Voltage-dependent ion channel
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Membrane permeability
Membrane permeability
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Action Potential Frequency
Action Potential Frequency
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Saltatory Conduction
Saltatory Conduction
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Nodes of Ranvier
Nodes of Ranvier
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Decremental Conduction
Decremental Conduction
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Synaptic Vesicles
Synaptic Vesicles
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Synaptic Vesicle Production and Transport
Synaptic Vesicle Production and Transport
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Synaptic Vesicle Recycling
Synaptic Vesicle Recycling
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Postsynaptic Potential (PSP)
Postsynaptic Potential (PSP)
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Spatial Summation
Spatial Summation
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Temporal Summation
Temporal Summation
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Reuptake
Reuptake
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Enzymatic Deactivation
Enzymatic Deactivation
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Axodendritic Synapse
Axodendritic Synapse
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Axosomatic Synapse
Axosomatic Synapse
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Study Notes
Neurons and the Nervous System
- The nervous system is composed of neurons and glial cells.
- Neurons are specialized cells for receiving, conducting, and transmitting electrochemical signals.
- Glial cells provide support and contribute to information processing.
- The neuron doctrine proposes that information is transmitted from one neuron to the next across synapses.
- Neurons are 80-90 billion in the adult human brain and roughly equal numbers to glial cells.
- External features of neurons include dendrites, cell body, axon, and axon terminals.
Anatomy of Neurons
- Dendrites: Receive information from other neurons across synapses.
- Cell body (soma): Contains the cell nucleus and processes the received information to determine if there is a need to send a signal.
- Axon: A long, thin tube that leaves the cell body and serves as a conduction zone. It is covered by a myelin sheath.
- Myelin sheath: Insulating substance that speeds the conduction of electrical signals.
- Axon terminals (terminal buttons): Transmit signals across synapses to other cells.
- Nodes of Ranvier: Gaps between sections of myelin in the axon.
Classifications of Neurons
- Multipolar neuron: Many dendrites and a single axon (most common type).
- Unipolar neuron: Only 1 process extending from the cell body, branching into input and output zones.
- Bipolar neuron: 1 dendrite and 1 axon, common in sensory systems (e.g., vision).
- Multipolar interneuron: Short axon or no axon, connecting circuits of neurons within a brain region.
Synapses
- Synapses consist of a presynaptic membrane, synaptic cleft, and postsynaptic membrane.
- Presynaptic membrane (axon terminal): Contains synaptic vesicles with neurotransmitters.
- Synaptic cleft: A gap between presynaptic and postsynaptic neurons.
- Postsynaptic membrane: Contains receptors for neurotransmitters.
Synaptic Transmission
- Electrical activity in the axon causes vesicles to fuse with the presynaptic membrane and release neurotransmitters into the synaptic cleft.
- Neurotransmitters bind to receptors on the postsynaptic membrane, causing changes in membrane potential.
Types of Neurotransmitters
- Neurotransmitters are molecules that transmit signals across synapses. Examples are not provided.
Neuron Classifications by Function
- Sensory neurons: Gather information from the environment (light, sound, touch etc).
- Motor neurons: Control the contraction of muscles (facilitate movements).
- Interneurons: Connect circuits of neurons in different parts of the CNS or within a region.
Action Potentials
- Action potentials are bursts of rapid depolarization and hyperpolarization.
- They begin at the axon initial segment and travel down the axon.
- This process is all-or-none (always the same size), but rate of firing varies with the intensity of the stimulus.
Membrane Potential
- Membrane potential is the difference in charge across the membrane.
- Resting potential is -70 mV.
- Action potentials are caused by changes in the movement of ions (sodium, potassium, chloride) across the membrane, driven by diffusion and electrostatic pressure.
Axoplasmic Transport
- Anterograde transport: Movement of substances from cell body to axon terminals.
- Retrograde transport: Movement of substances from axon terminals to cell body.
Glial Cells
- Astrocytes are the largest glial cells. They form functional networks and control blood flow.
- Microglia respond to damage and remove debris.
- Oligodendrocytes myelinate axons in the CNS and Schwann cells myelinate axons in the PNS.
Neurotransmission: Direct and Indirect
- Direct method: neurotransmitter directly opens ion channels.
- Indirect method: neurotransmitter activates a second messenger system to open ion channels.
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