Neuropharmacology: Drug Interactions and Nervous System

Study Notes

Study of the effects of drugs on the nervous system
Focuses on the interactions between drugs and neurotransmitters, receptors, and neural pathways
Examines the mechanisms of action of drugs on the brain, spinal cord, and peripheral nervous system
Key areas of study:
- Neurotransmitters: dopamine, serotonin, acetylcholine, GABA, glutamate
- Receptors: G-protein coupled receptors, ligand-gated ion channels
- Neurological disorders: Alzheimer's disease, Parkinson's disease, depression, anxiety

Study of the effects of drugs on the immune system
Focuses on the interactions between drugs and immune cells, cytokines, and immune responses
Examines the mechanisms of action of drugs on the immune system, including immunosuppression and immunostimulation
Key areas of study:
- Immune cells: T cells, B cells, macrophages, dendritic cells
- Cytokines: interleukins, interferons, tumor necrosis factor
- Immune-related disorders: autoimmune diseases, allergies, transplant rejection

Study of the adverse effects of chemicals on living organisms
Focuses on the detection, prevention, and treatment of poisoning
Examines the mechanisms of toxicity, including absorption, distribution, metabolism, and elimination
Key areas of study:
- Toxic agents: chemicals, pesticides, heavy metals, drugs of abuse
- Toxicity testing: in vitro, in vivo, and epidemiological studies
- Toxic effects: acute, chronic, and delayed effects on organs and systems

Study of the genetic factors that influence an individual's response to drugs
Focuses on the relationship between genetic variation and drug efficacy, safety, and toxicity
Examines the genetic differences in drug metabolism, transport, and target receptors
Key areas of study:
- Genetic variations: single nucleotide polymorphisms (SNPs), copy number variations
- Pharmacogenetic testing: genotyping, gene expression analysis
- Personalized medicine: tailoring drug therapy to an individual's genetic profile

Effects of drugs on the nervous system
Interactions between drugs and neurotransmitters (e.g. dopamine, serotonin, acetylcholine, GABA, glutamate)
Interactions between drugs and receptors (e.g. G-protein coupled receptors, ligand-gated ion channels)
Effects of drugs on brain, spinal cord, and peripheral nervous system
Study of neurological disorders (e.g. Alzheimer's disease, Parkinson's disease, depression, anxiety)

Effects of drugs on the immune system
Interactions between drugs and immune cells (e.g. T cells, B cells, macrophages, dendritic cells)
Interactions between drugs and cytokines (e.g. interleukins, interferons, tumor necrosis factor)
Effects of drugs on immune responses, including immunosuppression and immunostimulation
Study of immune-related disorders (e.g. autoimmune diseases, allergies, transplant rejection)

Adverse effects of chemicals on living organisms
Detection, prevention, and treatment of poisoning
Mechanisms of toxicity, including absorption, distribution, metabolism, and elimination
Study of toxic agents (e.g. chemicals, pesticides, heavy metals, drugs of abuse)
Toxicity testing methods (e.g. in vitro, in vivo, and epidemiological studies)
Acute, chronic, and delayed effects of toxic agents on organs and systems

Genetic factors that influence individual response to drugs
Relationship between genetic variation and drug efficacy, safety, and toxicity
Genetic differences in drug metabolism, transport, and target receptors
Study of genetic variations (e.g. single nucleotide polymorphisms, copy number variations)
Pharmacogenetic testing methods (e.g. genotyping, gene expression analysis)
Personalized medicine: tailoring drug therapy to individual genetic profile