Mediators of inflammation.

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Questions and Answers

,&__are 3 types of neropeptides.

Substance P , vasoactive intestinal polypeptide (VIP) and Neurokinin A.

Match the mediators with their functions.

Histamine = Vasodilation, increased vascular permeability, itching and pain. Neuropeptides = Increased vascular permeability, transmission of pain stimuli and mast cell degranulation. PG D2 and PGE2 = Increased vascular permeability, vasodilation, bronchodilation. Prostacycline = VD, bronchodilation, inhibit platelet aggregation.

Match with their actions.

Theomboxane A2 = Platelet aggregation, vasoconstriction, bronchoconstriction. PGF2 -alpha = Uterine and bronchial smooth muscle contraction, vasoconstriction. LT B4 = Chemotactic for leukocytes LT C4, D4 ,E4 = Increased vascular permeability, vasoconstriction and bronchoconstriction.

Enzyme involved in formation of arachidonic acid from phospholipid membrane is ....

Phospholipase A2. Signup and view all the answers

COX pathway gives which 2 intermediates ?

PGG2 ( prostaglandin endoperoxidase ), PGH2 . Signup and view all the answers

1st product of lipoxygenase pathway.

5- Hydroxyperoxy eicosatetraenoic acid. ( HETE). Signup and view all the answers

Match.

IL1,6 = mediate acute inflammation. IL-12,17 = Chronic inflammation TNF-aplha = Retraction of endothelial cells, expression of endothelial adhesion molecules. IFN-gamma = Activation of macrophages, secretion of IG by B cells, antiviral. Signup and view all the answers

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