Questions and Answers
What is the primary cause of neuropathic pain?
Damage or injury to the nociceptive nerves
How would you describe the sensation of neuropathic pain?
A burning sensation
Where can damage or injury to the nociceptive nerves occur to cause neuropathic pain?
Both peripherally and centrally
What is a common characteristic of areas affected by neuropathic pain?
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What is NOT a characteristic of neuropathic pain?
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What is the primary function of ion channels present on nociceptor terminals?
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What is the effect of local anesthetics on nociceptors?
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What type of nerve endings are nociceptors?
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What is the outcome of the activation of ion channels on nociceptor terminals?
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What is the role of nociceptors in the pain pathway?
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Study Notes
Neuropathic Pain is caused by damage or injury to the nociceptive nerves – peripherally or centrally. The pain is usually described as a burning sensation and affected areas are often sensitive to the touch.
Nociceptors and Pain Pathways
- Nociceptors are free nerve endings found in the skin
- Various stimuli activate ion channels present on nociceptor terminals, acting as molecular transducers
- Activation of these ion channels leads to depolarization of nociceptor neurons, initiating nociceptive impulses
- Nociceptive impulses then propagate along pain pathways
- Local anaesthetics, such as lidocaine, can block nociceptor activity
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