Neuronal Transmission & Reflexes Quiz
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Questions and Answers

What is the resting membrane potential (RMP) typically in mammalian neurons?

  • -40 to -75 mV (correct)
  • -20 to -40 mV
  • -75 to -90 mV
  • -100 to -120 mV
  • What is the resting membrane potential (RMP) primarily a measure of?

  • Electrically neutral charge across the membrane
  • Concentration of only cations inside the cell
  • Voltage difference between intracellular and extracellular fluids (correct)
  • Voltage difference between two intracellular compartments
  • Which ions are primarily moved by the Na+/K+ pump and in what ratio?

  • 3 K+ in and 2 Na+ out
  • 3 Na+ out and 2 K+ in (correct)
  • 2 Na+ out and 3 K+ in
  • 2 Na+ in and 3 K+ out
  • What occurs during depolarization?

    <p>The membrane potential becomes less negative than the resting potential (B)</p> Signup and view all the answers

    What is a characteristic feature of graded potentials (GP)?

    <p>They can vary in magnitude and duration. (D)</p> Signup and view all the answers

    Which statement best describes the ionic mechanisms of action potential?

    <p>Both sodium and potassium ions contribute to the creation of action potentials (D)</p> Signup and view all the answers

    What type of electrical signal serves as a long-distance signaling mechanism in neurons?

    <p>Action potentials (A)</p> Signup and view all the answers

    What is the primary characteristic of the threshold potential?

    <p>It is less than the resting potential by approximately 15 mV. (B)</p> Signup and view all the answers

    What is a key feature of synaptic transmission?

    <p>Neurotransmitters are released to propagate signals across synapses (B)</p> Signup and view all the answers

    Which type of potential can be either excitatory or inhibitory?

    <p>Graded potential (D)</p> Signup and view all the answers

    During which phase does the membrane potential become more negative than the resting state?

    <p>After-hyperpolarization (C)</p> Signup and view all the answers

    What defines a reflex arc?

    <p>A neural pathway that controls a reflex action via sensory and motor neurons (B)</p> Signup and view all the answers

    What primarily contributes to the negative charge inside the cell at resting membrane potential?

    <p>Presence of negatively charged proteins (A)</p> Signup and view all the answers

    What type of channel is always open and allows for the constant flow of ions?

    <p>Leak channels (A)</p> Signup and view all the answers

    What defines the concentration gradient maintained by the Na+/K+ pump?

    <p>Lower concentration of Na+ outside the cell compared to inside. (D)</p> Signup and view all the answers

    Which of the following describes the overshoot phase of an action potential?

    <p>The membrane potential becomes positive. (C)</p> Signup and view all the answers

    What is the principle of bulk electroneutrality in the context of RMP?

    <p>The overall charge balance extends to both intracellular and extracellular compartments (D)</p> Signup and view all the answers

    What type of proteins in the cell membrane actively transport ions?

    <p>Pumps (C)</p> Signup and view all the answers

    During repolarization, what primarily occurs?

    <p>The membrane potential becomes more negative again after depolarization (D)</p> Signup and view all the answers

    Which characteristic is true regarding the movement of anions across the plasma membrane?

    <p>Anions cannot diffuse due to being fixed within the cell. (C)</p> Signup and view all the answers

    What best describes the membrane's action potential property?

    <p>It follows an all-or-none principle. (D)</p> Signup and view all the answers

    Which condition correctly describes a graded potential?

    <p>Its magnitude decreases with distance from the stimulus site (B)</p> Signup and view all the answers

    What is the function of gated ion channels in the plasma membrane?

    <p>To control the flow of ions based on specific signals. (B)</p> Signup and view all the answers

    What happens during the repolarization phase of an action potential?

    <p>The membrane potential returns to a more negative state. (B)</p> Signup and view all the answers

    What occurs immediately after the threshold is reached during an action potential?

    <p>Voltage-gated Na+ channels open quickly. (A)</p> Signup and view all the answers

    During which phase of the action potential do Na+ channels have not yet returned to their resting state?

    <p>After-hyperpolarization phase. (B)</p> Signup and view all the answers

    In what condition does the membrane become most permeable to K+ ions during the action potential?

    <p>During the after-hyperpolarization phase. (A)</p> Signup and view all the answers

    What primarily causes repolarization during an action potential?

    <p>Opening of voltage-gated K+ channels. (B)</p> Signup and view all the answers

    What describes the period during which no action potential can be generated regardless of stimulus strength?

    <p>Refractory period. (C)</p> Signup and view all the answers

    What is the main advantage of myelination in nerve fibers?

    <p>Decreased leak of current (D)</p> Signup and view all the answers

    Which type of conduction occurs in myelinated fibers?

    <p>Saltatory conduction (D)</p> Signup and view all the answers

    At resting membrane potential, which ion channel is primarily closed, contributing to the negative charge?

    <p>Voltage-gated Na+ channels (D)</p> Signup and view all the answers

    What is the role of the node of Ranvier in A-type fibers?

    <p>Only site where action potentials are evoked (A)</p> Signup and view all the answers

    What primarily causes the initial depolarization during an action potential?

    <p>Opening of non-selective cation channels (B)</p> Signup and view all the answers

    What is the typical resting membrane potential for neurons?

    <p>-70 mV (D)</p> Signup and view all the answers

    Which statement correctly describes EPSP and IPSP?

    <p>EPSP and IPSP can cancel each other out in synaptic integration. (B)</p> Signup and view all the answers

    Which of the following structures does NOT contribute to the propagation of electrical signals along neurons?

    <p>Neurotransmitter receptors (B)</p> Signup and view all the answers

    What type of postsynaptic potential is generated by an influx of sodium ions?

    <p>Excitatory postsynaptic potential (EPSP) (B)</p> Signup and view all the answers

    Which neurotransmitter deficiency is most commonly associated with Alzheimer's disease?

    <p>Acetylcholine (A)</p> Signup and view all the answers

    What causes an inhibitory postsynaptic potential (IPSP)?

    <p>Influx of Cl− (A)</p> Signup and view all the answers

    What impact does alpha-latrotoxin from the black widow spider have on neurotransmitter release?

    <p>Causes explosive release of acetylcholine (D)</p> Signup and view all the answers

    What does an excitatory postsynaptic potential (EPSP) typically lead to in a postsynaptic neuron?

    <p>Depolarization (D)</p> Signup and view all the answers

    Which part of the neuron is primarily responsible for synthesizing neurotransmitters?

    <p>Cell body (C)</p> Signup and view all the answers

    Which neurological disorder is characterized by a deficiency of dopamine in the basal nuclei?

    <p>Parkinson's Disease (B)</p> Signup and view all the answers

    What defines a spinal reflex?

    <p>An automatic response to a stimulus (A)</p> Signup and view all the answers

    Flashcards

    Resting Membrane Potential (RMP)

    The voltage difference between the inside and outside of a cell membrane when the cell is at rest.

    Depolarization

    A change in membrane potential that makes the inside of the cell less negative.

    Ionic Mechanisms of action potential (AP)

    The process of generating and propagating an action potential through the ion channels of the cell membrane.

    Membrane potential

    The difference in electrical charge across the cell membrane.

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    Extracellular fluid

    The fluid outside the cell.

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    Intracellular fluid

    The fluid inside the cell.

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    Graded potential

    A local change in the membrane potential that varies in size.

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    Action Potential (AP)

    A rapid and significant change in membrane potential that propagates along a nerve or muscle cell.

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    Na+/K+ pump

    A protein that actively transports sodium ions out and potassium ions into a cell, contributing to maintaining the resting membrane potential.

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    Graded Potential (GP)

    A local change in membrane potential that varies in size and duration according to the stimulus strength (local signal).

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    Receptor Potential

    A type of graded potential produced by sensory receptors in response to stimuli.

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    Postsynaptic Potential

    A type of graded potential that occurs in response to neurotransmitters at the synapse.

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    Ion Concentration Differences

    Differences in ion concentrations between the inside and outside of a cell are crucial for establishing and maintaining the resting membrane potential.

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    Voltage-gated channels

    Plasma membrane channel proteins whose permeability to ions changes in response to the membrane potential.

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    Resting Potential

    The stable electrical charge across a cell membrane when it's not firing an action potential.

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    Threshold Potential

    The membrane voltage at which an action potential is triggered.

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    Action Potential

    A rapid, large change in membrane potential, travelling down the axon.

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    Hyperpolarization

    A phase where the membrane potential becomes more negative than its resting state, following repolarization.

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    Overshoot

    Part of an action potential where the membrane potential becomes positive

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    After-hyperpolarization/Undershoot

    The phase after repolarization where the membrane potential dips below the resting potential.

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    Action Potential (AP) Propagation

    How electrical signals travel along neurons, using both passive and active current flow.

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    Temporal Summation

    Adding up EPSPs (excitatory) or IPSPs (inhibitory) from repeated signals at a rapid rate.

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    Spatial Summation

    Adding up EPSPs or IPSPs from different synaptic inputs.

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    Myelinated Nerve Fibers

    Nerve fibers with a fatty coating (myelin), speeding up action potential transmission.

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    Saltatory Conduction

    Action potentials "jumping" between gaps (nodes of Ranvier) in myelinated fibers.

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    Ionic Basis of AP

    Action potentials are generated by the movement of ions (Na+ and K+) through voltage-gated channels.

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    Resting Membrane Potential

    The stable electrical difference across a neuron's membrane when it's not transmitting a signal.

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    Threshold

    The minimum level of depolarization required to trigger an action potential (AP).

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    Voltage-gated Na+ Channels

    These channels open quickly during depolarization, allowing a massive influx of Na+ ions into the cell, causing the rapid rise of the AP.

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    Repolarization (Falling Phase)

    The phase where the membrane potential returns to its resting state after the AP peak.

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    After-hyperpolarization (AHP)

    The phase where the membrane potential dips below the resting membrane potential.

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    Refractory Period

    A period during and after an AP when it is difficult or impossible to generate another AP.

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    Neurotransmitters

    Chemical messengers released from presynaptic neurons that excite or inhibit postsynaptic neurons. They are synthesized in the cytoplasm of the cell body and stored in vesicles in axon terminals.

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    EPSP

    Excitatory Postsynaptic Potential. A depolarizing change in the postsynaptic membrane potential that makes it more likely for the neuron to fire an action potential.

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    IPSP

    Inhibitory Postsynaptic Potential. A hyperpolarizing change in the postsynaptic membrane potential that makes it less likely for the neuron to fire an action potential.

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    What causes EPSP?

    An influx of Na+ (sodium) ions into the postsynaptic neuron. This means sodium ions move into the cell, making the inside more positive.

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    What causes IPSP?

    An influx of Cl- (chloride) ions or efflux of K+ (potassium) ions from the postsynaptic neuron.

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    Parkinson's disease

    A neurological disorder characterized by dopamine deficiency in the basal nuclei. This leads to tremors, rigidity, and slow movements.

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    Alzheimer's disease

    A neurodegenerative disease characterized by acetylcholine deficiency. This leads to memory loss, confusion, and impaired thinking.

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    Spinal reflex

    A rapid, automatic (involuntary) response to a stimulus, such as a pinprick. Reflexes are important for defending against harmful stimuli and maintaining body support.

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    Study Notes

    Neuronal Transmission & Reflexes

    • Neuronal transmission involves the passing of signals between neurons.
    • Reflexes are automatic responses to stimuli.
    • Neuron types include sensory neurons, interneurons (or association neurons), and motor neurons.
    • Sensory neurons transmit signals from sensory receptors to the central nervous system (CNS).
    • Interneurons connect sensory and motor neurons within the CNS.
    • Motor neurons transmit signals from the CNS to effectors (muscles and glands).
    • Reflex arcs are the pathways followed by nerve impulses during reflexes.

    Membrane Potentials

    • Resting membrane potential (RMP) is a voltage difference across a cell membrane.
    • RMP is typically -70 mV in animal nerve cells.
    • Depolarization is a change that makes the membrane potential less negative.
    • Repolarization occurs when the ion movement changes to return the potential to its resting level.
    • Action potential (AP) is a rapid, large change in membrane potential.

    Synaptic Transmission

    • Neurotransmitters are chemical messengers released from neurons.
    • Neurotransmitters can stimulate (excitatory) or inhibit (inhibitory) neurons.
    • Ion channels on the postsynaptic cell are involved in transmitting the signal.

    Properties of the Cell Plasma Membrane

    • The plasma membrane is a thin, non-conducting bilayer of phospholipids.
    • It has important proteins that help in ion transport.
    • Ion channels are important in regulating ion movement across the plasma membrane. These channels can be leak channels (always open) or gated channels (open or close in response to stimuli).

    Types of Gated Ion Channels

    • Voltage-gated channels open in response to a change in voltage across a membrane.
    • Ligand-gated channels open in response to a ligand binding to the channel protein.
    • Mechanically-gated channels open in response to physical deformation of the membrane.

    Ion Concentrations

    • Ion concentrations differ inside and outside a nerve cell.
    • Na+, K+, Ca2+, and Cl- are important ions in transmitting nerve impulses.
    • These ions have differing concentrations inside and outside the cell.

    Na+/K+ Pump (Na+/K+ ATPase)

    • This transmembrane protein is important in establishing and maintaining the resting membrane potential.
    • This pump moves three sodium ions outside and two potassium ions inside the cell, against their concentration gradients.
    • The pump is an important part of electrochemical gradients.

    Types of Electrical Neuronal Signals

    • Graded potentials are local changes in the membrane potential and can be positive or negative.
    • Action potentials are large, rapid changes in membrane potential that are "all-or-none."

    Types of Graded Potentials

    • Receptor potentials.
    • Postsynaptic potentials.

    Propagation of Electrical Signals

    • Electrical signals can be propagated through neurons through passive and active current flow.
    • Active current is the movement of ions through ion channels, while passive current is the movement of charge along a neuronal process.

    Synaptic Integration

    • Temporal summation is summing of postsynaptic potentials generated at the same synapse in rapid succession.
    • Spatial summation is summing of postsynaptic potentials originating from different synapses.

    Conduction of APs along Nerve Fibers

    • Myelinated fibers conduct impulses more rapidly than unmyelinated fibers due to saltatory conduction.
    • The nodes of Ranvier are gaps in the myelin sheath where action potentials are generated.

    Ionic Basis of Action Potential

    • Initial depolarization is caused by opening of some non-selective cation channels and influx of Na+.
    • During the rising phase of the action potential, voltage-gated Na+ channels open quickly; voltage-gated K+ channels are still closed.
    • During the falling phase, Na+ channels inactivate and voltage-gated K+ channels open, repolarizing the membrane.
    • The undershoot (after-hyperpolarization) occurs when the membrane potential becomes more negative than the resting potential.

    Depolarization (Na+ Influx) & Repolarization (K+ Efflux)

    • Depolarization occurs when voltage-gated Na+ channels open and Na+ ions rush into the cell.
    • Repolarization occurs when voltage-gated K+ channels open and K+ ions rush out of the cell, returning the membrane to its resting potential.

    Chemical Messengers/Neurotransmitters

    • Chemical messengers are released from neurons and act on receptors.
    • They include amino acids, cholinergic esters, and monoamines.

    Neuronal Communication at a Synapse

    • Neurotransmitters are released into the synaptic cleft and bind to receptors.
    • This creates post-synaptic potentials, which are graded potentials that can be excitatory or inhibitory.

    Excitatory & Inhibitory Postsynaptic Potentials

    • An influx of Na+ causes an EPSP; the influx of CI- or the efflux of K+ causes an IPSP.

    Clinical Significance of Neurotransmitters

    • Changes in neurotransmitter levels are associated with several neurological disorders.
    • Parkinson's disease is associated with dopamine deficiency.
    • Alzheimer's disease is associated with acetylcholine deficiency.
    • Schizophrenia is associated with dopamine excess.
    • Depression is associated with decreased release of serotonin or norepinephrine.

    What is a Spinal Reflex?

    • A spinal reflex is a rapid, involuntary response to a stimulus.
    • The reflex arc is the pathway followed by nerve impulses during a reflex.
    • The reflex arc involves five components: receptor, sensory neuron, integrating center, motor neuron, and effector.

    Example: Withdrawal Reflex (Polysynaptic)

    • The withdrawal reflex is a protective response to noxious stimuli.
    • It involves the activation of nociceptors, a sensory neuron, and excitatory interneurons; a motor neuron is stimulated.

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    Description

    Test your knowledge on neuronal transmission and reflexes with this quiz. Explore key concepts such as neuron types, resting membrane potentials, and the mechanisms of reflex arcs. Assess your understanding of how signals are transmitted in the nervous system.

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