10 Questions
What is the role of the Nernst equation in determining membrane potential?
It tells us that EK is -80 mV when K+ is concentrated twentyfold on the inside of a cell.
Explain how ionic concentration gradients are established in a neuronal membrane.
Ionic concentration gradients are established by the actions of ion pumps, particularly the sodium-potassium pump and the calcium pump.
Which ion is more concentrated on the inside of a cell, potassium (K+) or sodium (Na+)?
Potassium (K+) is more concentrated on the inside of a cell.
What is the ratio of K+ concentration inside to outside the cell?
1:20
How does the sodium-potassium pump function in maintaining ionic balance?
The pump exchanges internal Na+ for external K+ by breaking down ATP in the presence of internal Na+.
What is the membrane potential achieved for Na+ at body temperature?
62 mV
Explain the significance of the calcium pump in cellular neurophysiology.
The calcium pump helps establish the concentration gradient for Ca2+ across the membrane.
What is the ratio of Cl- concentration outside to inside the cell?
11.5:1
What is the membrane potential achieved for Cl- at body temperature?
-65 mV
How does the sodium-potassium pump utilize the energy released from ATP breakdown?
The energy released from ATP breakdown is used to drive the pump that exchanges Na+ and K+ across the membrane.
Explore the concept of resting membrane potential in neuronal cells, focusing on the role of electrically charged ions, protein channels, concentration gradient, and electrical potential difference across the membrane. Understand how ions move through selective channels and contribute to establishing the membrane's voltage.
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