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Questions and Answers
What was the early medicinal use of Curare?
What was the early medicinal use of Curare?
- Reversal of muscle paralysis
- Inducing muscle relaxation during surgery
- Treatment of tetanus and other spastic conditions (correct)
- Immobilization of animals for hunting
Which type of neuromuscular blocker is Curare?
Which type of neuromuscular blocker is Curare?
- Depolarizing blocker
- Competitive blocker (correct)
- Reversal blocker
- Intermediate blocker
What is the sequence of muscle paralysis caused by depolarizing blockers?
What is the sequence of muscle paralysis caused by depolarizing blockers?
- Muscles of the limbs and trunk relax first, followed by intercostal muscles and diaphragm (correct)
- Muscles recover in the opposite order
- Intermittent paralysis of various muscle groups
- Muscles of the limbs and trunk relax first, then small rapidly moving muscles
What is the clinical use of competitive neuromuscular blockers?
What is the clinical use of competitive neuromuscular blockers?
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Which effect is observed on the central nervous system (CNS) for competitive neuromuscular blockers?
Which effect is observed on the central nervous system (CNS) for competitive neuromuscular blockers?
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Study Notes
Curare: Early Medicinal Use and Characteristics
- Curare was initially used as a poison for arrows in South America, particularly in the Amazon rainforest.
- It is a type of neuromuscular blocker.
Sequence of Muscle Paralysis
- Depolarizing blockers, including Curare, cause muscle paralysis in the following sequence: • Small muscles (e.g., face, fingers) • Large muscles (e.g., arms, legs) • Diaphragm and other respiratory muscles
Clinical Use of Competitive Neuromuscular Blockers
- Competitive neuromuscular blockers are used clinically as muscle relaxants in surgical procedures.
Effects on the Central Nervous System (CNS)
- Competitive neuromuscular blockers do not affect the CNS because they act peripherally at the neuromuscular junction, rather than crossing the blood-brain barrier.
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