Podcast
Questions and Answers
What effect does pancuronium have on the body?
What effect does pancuronium have on the body?
- Anticholinergic effect
- Partial blockade of ganglia and adrenal medulla (correct)
- Hypotension and bradycardia
- Stimulation of the CNS
What is the duration of action of succinylcholine?
What is the duration of action of succinylcholine?
- 5 minutes (correct)
- 10 minutes
- 15 minutes
- 20 minutes
Which type of neuromuscular blocker is Curare?
Which type of neuromuscular blocker is Curare?
- Competitive blocker (correct)
- Reversal blocker
- Non-competitive blocker
- Depolarizing blocker
What is the clinical use of competitive neuromuscular blockers?
What is the clinical use of competitive neuromuscular blockers?
Competitive antagonism can only occur through reversible binding of the antagonist to the receptor site
Competitive antagonism can only occur through reversible binding of the antagonist to the receptor site
Atropine competes with acetylcholine at muscarinic receptors, decreasing the stimulatory effect of acetylcholine on gastrointestinal motility
Atropine competes with acetylcholine at muscarinic receptors, decreasing the stimulatory effect of acetylcholine on gastrointestinal motility
Hexamethonium prevents the effect of acetylcholine on nicotinic receptors in autonomic ganglia by binding to the ligand binding domain
Hexamethonium prevents the effect of acetylcholine on nicotinic receptors in autonomic ganglia by binding to the ligand binding domain
Irreversible competitive antagonism occurs when the antagonist forms a strong bond with the receptor that dissociates very slowly or not at all
Irreversible competitive antagonism occurs when the antagonist forms a strong bond with the receptor that dissociates very slowly or not at all
Functional antagonism occurs when the antagonist reduces the physiological response of the agonist by inducing the opposite response at the same receptor site
Functional antagonism occurs when the antagonist reduces the physiological response of the agonist by inducing the opposite response at the same receptor site
Flashcards
What does Pancuronium do to the body?
What does Pancuronium do to the body?
Pancuronium partially blocks the transmission of nerve impulses at the neuromuscular junction, affecting both autonomic ganglia and the adrenal medulla. This leads to muscle paralysis, which can be helpful during surgery.
What is the duration of action of Succinylcholine?
What is the duration of action of Succinylcholine?
Succinylcholine has a short duration of action, typically lasting about 5 minutes. Its rapid onset and short duration make it suitable for rapid-sequence intubation.
What type of neuromuscular blocker is curare?
What type of neuromuscular blocker is curare?
Curare is a competitive neuromuscular blocker. It blocks the action of acetylcholine at the neuromuscular junction, preventing muscle contraction.
Clinical use of competitive neuromuscular blockers?
Clinical use of competitive neuromuscular blockers?
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Competitive antagonism only occurs through irreversible binding?
Competitive antagonism only occurs through irreversible binding?
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Atropine competes with acetylcholine at muscarinic receptors.
Atropine competes with acetylcholine at muscarinic receptors.
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Hexamethonium prevents acetylcholine by binding to the ligand binding domain.
Hexamethonium prevents acetylcholine by binding to the ligand binding domain.
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Irreversible antagonism is when the antagonist forms a strong bond.
Irreversible antagonism is when the antagonist forms a strong bond.
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Functional antagonism is when two drugs compete for the same receptor.
Functional antagonism is when two drugs compete for the same receptor.
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