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Questions and Answers
What is the sequence of muscle paralysis observed with depolarizing blockers?
What is the sequence of muscle paralysis observed with depolarizing blockers?
- Rapidly moving muscles (eyes, jaw, larynx) relax first, followed by trunk muscles and intercostal muscles (correct)
- Diaphragm muscles cease respiration first, followed by limb muscles
- Limbs and trunk muscles relax first, followed by eye and jaw muscles
- Muscles recover in a random order
What is the duration of action of succinylcholine?
What is the duration of action of succinylcholine?
- 1 hour
- 1 day
- 5 minutes (correct)
- 30 minutes
Which type of neuromuscular blocker is Curare?
Which type of neuromuscular blocker is Curare?
- Non-competitive blocker
- Depolarizing blocker
- Competitive blocker (correct)
- Reversal blocker
What effect does pancuronium have on the body?
What effect does pancuronium have on the body?
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What is the clinical use of competitive neuromuscular blockers?
What is the clinical use of competitive neuromuscular blockers?
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Study Notes
Muscle Paralysis and Neuromuscular Blockers
- The sequence of muscle paralysis observed with depolarizing blockers is: small muscles (e.g., facial, finger), followed by larger muscles (e.g., arm, leg), and finally, the diaphragm and other respiratory muscles.
- Succinylcholine has a short duration of action, typically 4-6 minutes.
- Curare is a type of non-depolarizing (competitive) neuromuscular blocker.
- Pancuronium causes a increase in heart rate and blood pressure, as well as a decrease in gut motility and secretions.
- Competitive neuromuscular blockers, such as pancuronium, are clinically used to provide muscle relaxation during surgery, especially in conjunction with general anesthesia.
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