5 Questions
What is the sequence of muscle paralysis observed with depolarizing blockers?
Rapidly moving muscles (eyes, jaw, larynx) relax first, followed by trunk muscles and intercostal muscles
What is the duration of action of succinylcholine?
5 minutes
Which type of neuromuscular blocker is Curare?
Competitive blocker
What effect does pancuronium have on the body?
Antimuscarinic effect
What is the clinical use of competitive neuromuscular blockers?
Muscle relaxation during surgery
Study Notes
Muscle Paralysis and Neuromuscular Blockers
- The sequence of muscle paralysis observed with depolarizing blockers is: small muscles (e.g., facial, finger), followed by larger muscles (e.g., arm, leg), and finally, the diaphragm and other respiratory muscles.
- Succinylcholine has a short duration of action, typically 4-6 minutes.
- Curare is a type of non-depolarizing (competitive) neuromuscular blocker.
- Pancuronium causes a increase in heart rate and blood pressure, as well as a decrease in gut motility and secretions.
- Competitive neuromuscular blockers, such as pancuronium, are clinically used to provide muscle relaxation during surgery, especially in conjunction with general anesthesia.
Test your knowledge about agents acting on the neuromuscular junction with this quiz. Learn about the history of Curare, its early medicinal uses, and its classification into competitive and depolarizer neuromuscular blockers.
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