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Questions and Answers
Which of the following is NOT a common location for contusions in the brain?
Which of the following is NOT a common location for contusions in the brain?
What is the most common cause of extradural hematomas?
What is the most common cause of extradural hematomas?
Which of the following is a characteristic of a closed head injury?
Which of the following is a characteristic of a closed head injury?
Subdural hematomas are most commonly associated with which of the following?
Subdural hematomas are most commonly associated with which of the following?
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Which of the following is NOT a symptom of a subdural hematoma?
Which of the following is NOT a symptom of a subdural hematoma?
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Intracerebral hematomas are most commonly located in which lobes of the brain?
Intracerebral hematomas are most commonly located in which lobes of the brain?
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Which of the following is a common sign of an intracerebral hematoma?
Which of the following is a common sign of an intracerebral hematoma?
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What is a concussion?
What is a concussion?
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What are the possible consequences of the autoimmune response in multiple sclerosis?
What are the possible consequences of the autoimmune response in multiple sclerosis?
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Which of the following is a risk factor for developing multiple sclerosis?
Which of the following is a risk factor for developing multiple sclerosis?
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Which clinical manifestation is considered the first sign of multiple sclerosis?
Which clinical manifestation is considered the first sign of multiple sclerosis?
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Which of the following is a characteristic of a clinically isolated syndrome (CIS) manifestation?
Which of the following is a characteristic of a clinically isolated syndrome (CIS) manifestation?
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What is the typical age range for the onset of multiple sclerosis?
What is the typical age range for the onset of multiple sclerosis?
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Which of the following is NOT a typical clinical manifestation of multiple sclerosis?
Which of the following is NOT a typical clinical manifestation of multiple sclerosis?
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What is the defining characteristic of multiple sclerosis in terms of its impact on the nervous system?
What is the defining characteristic of multiple sclerosis in terms of its impact on the nervous system?
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What is the primary reason for the development of multiple sclerosis, as currently understood?
What is the primary reason for the development of multiple sclerosis, as currently understood?
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Which of the following is a characteristic of mild TBI (mild concussion)?
Which of the following is a characteristic of mild TBI (mild concussion)?
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Which of the following is a potential diagnostic tool for mild TBI that is currently being studied?
Which of the following is a potential diagnostic tool for mild TBI that is currently being studied?
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Which of the following statements about the Glasgow Coma Scale (GCS) score is accurate in relation to mild TBI?
Which of the following statements about the Glasgow Coma Scale (GCS) score is accurate in relation to mild TBI?
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Which of the following is NOT a symptom of a mild concussion?
Which of the following is NOT a symptom of a mild concussion?
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What is the main cause of mild TBI?
What is the main cause of mild TBI?
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Which of the following explains the physiological effects of a mild concussion?
Which of the following explains the physiological effects of a mild concussion?
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Which biomarker is known to peak approximately 20 hours after a TBI and declines over 72 hours?
Which biomarker is known to peak approximately 20 hours after a TBI and declines over 72 hours?
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What is the key difference between Grade I and Grade II concussions?
What is the key difference between Grade I and Grade II concussions?
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What is the most common cause of a primary hemorrhagic stroke?
What is the most common cause of a primary hemorrhagic stroke?
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Which of the following arteries, if affected, can lead to contralateral hemiparesis or hemiplegia?
Which of the following arteries, if affected, can lead to contralateral hemiparesis or hemiplegia?
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What is a common symptom associated with a lacunar stroke?
What is a common symptom associated with a lacunar stroke?
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Which of the following is NOT a common site for a hemorrhagic stroke?
Which of the following is NOT a common site for a hemorrhagic stroke?
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Which of the following arteries, if affected, can lead to expressive aphasia (nonfluent aphasia) in the dominant hemisphere and dyarthria in the nondominant hemisphere?
Which of the following arteries, if affected, can lead to expressive aphasia (nonfluent aphasia) in the dominant hemisphere and dyarthria in the nondominant hemisphere?
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What is the term for a type of speech disorder characterized by difficulty in articulating words but with intact comprehension?
What is the term for a type of speech disorder characterized by difficulty in articulating words but with intact comprehension?
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Which of the following conditions is associated with an increased risk of embolic stroke?
Which of the following conditions is associated with an increased risk of embolic stroke?
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What term describes the syndrome characterized by contralateral hemiparesis, ipsilateral lower motor neuron facial palsy, and the inability to move voluntarily, with preserved consciousness?
What term describes the syndrome characterized by contralateral hemiparesis, ipsilateral lower motor neuron facial palsy, and the inability to move voluntarily, with preserved consciousness?
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Which of the following is NOT a common risk factor for lacunar stroke?
Which of the following is NOT a common risk factor for lacunar stroke?
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What is the term for a condition that involves focal neurologic deficits in 80% of people experiencing hemorrhagic stroke?
What is the term for a condition that involves focal neurologic deficits in 80% of people experiencing hemorrhagic stroke?
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What is the primary challenge facing chemotherapeutic treatment for gliomas?
What is the primary challenge facing chemotherapeutic treatment for gliomas?
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Which of the following is NOT a clinical manifestation of gliomas?
Which of the following is NOT a clinical manifestation of gliomas?
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Which of the following is a type of primary extracerebral brain tumor?
Which of the following is a type of primary extracerebral brain tumor?
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What is the most common type of primary central nervous system (CNS) tumor?
What is the most common type of primary central nervous system (CNS) tumor?
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Which of the following is a common early symptom of an astrocytoma?
Which of the following is a common early symptom of an astrocytoma?
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What is the primary mechanism by which Landry-Guillain-Barré syndrome (GBS) develops?
What is the primary mechanism by which Landry-Guillain-Barré syndrome (GBS) develops?
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Which of the following is a common clinical manifestation of GBS?
Which of the following is a common clinical manifestation of GBS?
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What is the underlying cause of myasthenia gravis?
What is the underlying cause of myasthenia gravis?
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Which of the following is a characteristic symptom of myasthenia gravis?
Which of the following is a characteristic symptom of myasthenia gravis?
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What is the primary target of autoantibodies in myasthenia gravis?
What is the primary target of autoantibodies in myasthenia gravis?
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What is a key difference between the pathophysiology of GBS and myasthenia gravis?
What is a key difference between the pathophysiology of GBS and myasthenia gravis?
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Which of the following is a potential trigger for GBS?
Which of the following is a potential trigger for GBS?
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In myasthenia gravis, the autoantibodies that contribute to the disease are predominantly of which immunoglobulin class?
In myasthenia gravis, the autoantibodies that contribute to the disease are predominantly of which immunoglobulin class?
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Flashcards
What causes mild TBI?
What causes mild TBI?
Damage to axonal fibers and white matter tracts affecting the cerebral cortex.
GCS range for mild TBI
GCS range for mild TBI
The Glasgow Coma Scale (GCS) for mild TBI is 13 to 15.
What are GFAP and UCH-L1?
What are GFAP and UCH-L1?
Biomarkers used to diagnose TBI and mild concussions.
Peak time for GFAP after TBI
Peak time for GFAP after TBI
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Grade I concussion
Grade I concussion
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Symptoms of mild TBI
Symptoms of mild TBI
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Post-Traumatic Amnesia
Post-Traumatic Amnesia
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Grade IV concussion
Grade IV concussion
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Closed Head Injury
Closed Head Injury
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Focal Brain Injury
Focal Brain Injury
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Contusion
Contusion
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Epidural Hematoma
Epidural Hematoma
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Subdural Hematoma
Subdural Hematoma
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Intracerebral Hematoma
Intracerebral Hematoma
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Concussion
Concussion
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Graded Concussions
Graded Concussions
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Myasthenia Gravis Symptoms
Myasthenia Gravis Symptoms
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Primary Intracerebral Tumors
Primary Intracerebral Tumors
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Metastatic Carcinoma
Metastatic Carcinoma
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Glial Tumors
Glial Tumors
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Astrocytoma
Astrocytoma
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Multiple Sclerosis (MS)
Multiple Sclerosis (MS)
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Etiology of MS
Etiology of MS
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Embolic stroke
Embolic stroke
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Lacunar stroke
Lacunar stroke
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Clinical Isolated Syndrome (CIS)
Clinical Isolated Syndrome (CIS)
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Paresthesia
Paresthesia
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Main causes of lacunar stroke
Main causes of lacunar stroke
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Optic Neuritis
Optic Neuritis
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Hemorrhagic stroke
Hemorrhagic stroke
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Cerebellar Syndromes
Cerebellar Syndromes
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Affected artery in MCA stroke
Affected artery in MCA stroke
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Contralateral paralysis in ACA stroke
Contralateral paralysis in ACA stroke
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Cognitive Deficits in MS
Cognitive Deficits in MS
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Relapsing-Remitting MS
Relapsing-Remitting MS
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Basilar artery stroke
Basilar artery stroke
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Symptoms of hemorrhagic stroke
Symptoms of hemorrhagic stroke
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Pure motor and sensory deficits
Pure motor and sensory deficits
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Data processing deficits
Data processing deficits
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Guillain-Barré Syndrome (GBS)
Guillain-Barré Syndrome (GBS)
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Pathophysiology of GBS
Pathophysiology of GBS
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Molecular mimicry
Molecular mimicry
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Clinical manifestations of GBS
Clinical manifestations of GBS
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Myasthenia Gravis (MG)
Myasthenia Gravis (MG)
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Pathophysiology of MG
Pathophysiology of MG
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Hallmark symptom of MG
Hallmark symptom of MG
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Study Notes
Closed Head Injury
- Involves head striking a hard surface or a rapidly moving object hitting the head.
- Dura mater remains intact; brain tissue is not exposed.
- Most are mild (75-90%); causes mild concussion.
- Brief periods of bradycardia and decreased blood pressure, lasting 30 seconds or less, are possible.
- Vital signs stabilize rapidly.
- Can result from blunt or open trauma.
- Associated with skull fractures sometimes.
- Focal brain injuries occur precisely (e.g., cortical contusions, epidural hemorrhage, subdural hemorrhage, intracerebral hematoma).
- Coup or contrecoup injuries are possible.
Contusions
- Bleeding from injured vessels
- Most common areas:
- Frontal lobes (particularly at poles and along inferior orbital surfaces)
- Temporal lobes
- Frontotemporal junction
- Extradural hematomas:
- Bleeding between dura mater and skull
- Often caused by MVAs (85% of cases)
- Subdural hematomas:
- Often caused by MVAs, or falls, especially in older adults or those with alcohol abuse.
- Acute forms develop rapidly (within 48 hours), often located at the top of the skull.
- 10-20% of TBIs.
- Symptoms include headache, drowsiness, restlessness, and agitation (80% of people).
- Intracerebral hematomas:
- Common in MVAs and falls
- Often located in frontal and temporal lobes
- 2-3% of TBIs
- Symptoms include decreasing LOC, contralateral hemiplegia, and a positive Babinski reflex.
Mild TBI (Mild Concussion)
- Immediate, transitory clinical manifestations.
- Loss of consciousness (LOC) is momentary or less than 30 minutes.
- Post-traumatic anterograde amnesia is possible (transient, less than 24 hours).
- GCS: 13-15
- Often no findings on CT/MRI (lesions may show up with advanced MRI).
- Symptoms include headaches, nausea/vomiting, confusion, disorientation, attention deficits, dizziness.
- May require increased vigilance for a period after injury due to risk of diffuse axonal injury, metabolic impairment, altered neural activation and cerebral blood flow issues.
Moderate TBI
- LOC lasting more than 30 minutes.
- Post-traumatic anterograde amnesia lasting 24 hours or more.
- GCS: 8-13.
Severe TBI
- LOC lasting more than 24 hours.
- Immediate autonomic dysfunction.
- Increased intracranial pressure (ICP) 4-6 days post injury.
- GCS: less than 8, with brainstem signs (pupillary reaction, cardiac/respiratory symptoms).
- Severe sensorimotor and cognitive deficits.
- Up to 14% vegetative state and 20-40% mortality.
Concussion Grades
- Grade I: Transient confusion/disorientation, no LOC, amnesia resolving within 15 minutes.
- Grade II: Transient confusion/retrograde amnesia, lasting no more than 15 minutes, and possible LOC (5-10 minutes).
- Grade III: Any LOC, confusion, and amnesia persisting longer than several minutes after impact, often from the moment of the injury.
- Grade IV: LOC lasting up to 6 hours, with retrograde and anterograde amnesia.
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Description
Test your knowledge on brain injuries including contusions, hematomas, and concussions, as well as the characteristics and symptoms of multiple sclerosis. This quiz covers key concepts and clinical manifestations related to these neurological conditions.