Neurodegenerative Disorders
40 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary characteristic of Niemann-Pick's Disease?

  • Chorean-style movements
  • Early language impairment and behavioral disorders (correct)
  • Macroscopic atrophy in the corpus striatum
  • Forgetfulness and stagnation
  • What is the typical age of onset for Huntington's disease?

  • Old age
  • Adulthood (correct)
  • Teenage years
  • Childhood
  • What is the mode of inheritance for Huntington's disease?

  • Autosomal recessive
  • Mitochondrial inheritance
  • X-linked dominant
  • Autosomal dominant (correct)
  • What are the characteristic pathological findings of Alzheimer's disease?

    <p>Extracellular senile plaques, neurofibrillary tangles, and synapse loss</p> Signup and view all the answers

    What is the main cause of amnesia and loss of cognitive function in Alzheimer's disease?

    <p>Loss of cholinergic neurons in the basal nuclei</p> Signup and view all the answers

    What is the most common cause of dementia?

    <p>Alzheimer's disease</p> Signup and view all the answers

    What is the effect of Alzheimer's disease on a person's abilities?

    <p>Gradual destruction of memory and the ability to learn</p> Signup and view all the answers

    Who is credited with the description of Alzheimer's disease?

    <p>Alois Alzheimer</p> Signup and view all the answers

    What is donepezil used to treat?

    <p>Mild and moderate Alzheimer's disease</p> Signup and view all the answers

    What is the effect of ketoconazole on donepezil concentrations?

    <p>Increases average concentrations by 30%</p> Signup and view all the answers

    What happens when donepezil is combined with enzyme inducers?

    <p>Donepezil levels decrease</p> Signup and view all the answers

    What is similar between donepezil and rivastigmine?

    <p>Side effects</p> Signup and view all the answers

    What is a contraindication for donepezil?

    <p>Pregnancy and lactation</p> Signup and view all the answers

    What is the main way rivastigmine is metabolized?

    <p>By hydrolysis by esterases</p> Signup and view all the answers

    What is the primary objective of the treatment approach for Alzheimer's disease?

    <p>To maximize functional performance by improving cognition, mood, and behavior</p> Signup and view all the answers

    What is a potential interaction with donepezil?

    <p>Synergistic effect with cholinergic agonists</p> Signup and view all the answers

    What is the effect of stimulating glutamate NMDA receptors in nerve cells?

    <p>It causes excess calcium entry into the nerve cell and cell destruction</p> Signup and view all the answers

    What is a side effect of rivastigmine?

    <p>Angina pectoris</p> Signup and view all the answers

    What is the Mini-mental status review (MMSE) used for?

    <p>To score cognitive and behavioral status</p> Signup and view all the answers

    What is the goal of nonpharmacological treatment approaches for Alzheimer's disease?

    <p>To create an environment that will provide trust and emotional intimacy</p> Signup and view all the answers

    What is included in the diagnostic methods of Alzheimer's disease?

    <p>History, blood tests, physical and neurological examination, mental status examination, neuropsychological tests, MRI, tomography, and autopsy</p> Signup and view all the answers

    What is recommended when interacting with Alzheimer's patients?

    <p>Be friendly, witty, and physically close</p> Signup and view all the answers

    What is the purpose of cognitive therapies in nonpharmacological treatment approaches?

    <p>Cognitive enhancement</p> Signup and view all the answers

    What is included in nonpharmacological treatment approaches for Alzheimer's disease?

    <p>Regular appointments, family and carers' contact, and landscaping modifications</p> Signup and view all the answers

    What is the mechanism of action of memantine in Alzheimer's disease?

    <p>Blockage of NMDA receptors</p> Signup and view all the answers

    What is the relationship between memantine and epilepsy?

    <p>Memantine should be used with caution in epilepsy</p> Signup and view all the answers

    What is the primary action of riluzole in Amyotrophic Lateral Sclerosis (ALS)?

    <p>Inhibition of glutamate release</p> Signup and view all the answers

    What is the indication for memantine?

    <p>Moderate to severe Alzheimer's disease</p> Signup and view all the answers

    What is the characteristic of memantine that distinguishes it from other Alzheimer's disease treatments?

    <p>It is a noncompetitive receptor antagonist</p> Signup and view all the answers

    What is the side effect profile of memantine?

    <p>Headache, dizziness, lightheadedness, and confusion</p> Signup and view all the answers

    What is the contraindication for memantine in renal impairment?

    <p>Advanced renal impairment</p> Signup and view all the answers

    What is the effect of riluzole on voltage-dependent Na channels?

    <p>Blockage of voltage-dependent Na channels</p> Signup and view all the answers

    What is a potential consequence of combining rivastigmine with succinylcholine-type muscle relaxants during anesthesia?

    <p>Exacerbated effects of muscle relaxants</p> Signup and view all the answers

    What is the recommended action in cases of asymptomatic overdose of rivastigmine?

    <p>Remove all EXELON PATCH transdermal patches immediately and wait for 24 hours before reinserting</p> Signup and view all the answers

    What is the primary mechanism of rivastigmine's metabolism?

    <p>Unknown, but considered unlikely</p> Signup and view all the answers

    What is the recommended treatment for severe nausea and vomiting associated with rivastigmine overdose?

    <p>Use antiemetics to alleviate nausea and vomiting</p> Signup and view all the answers

    What is the approximate duration of acetylcholinesterase inhibition caused by rivastigmine?

    <p>9 hours</p> Signup and view all the answers

    What is the recommended initial dose of atropine sulfate for treating severe rivastigmine overdose?

    <p>0.03 mg/kg i.v.</p> Signup and view all the answers

    What is the primary enzyme responsible for the metabolism of galantamine?

    <p>Both CYP2D6 and CYP3A4</p> Signup and view all the answers

    What is a potential consequence of combining rivastigmine with anticholinergic drugs?

    <p>Interference with the activity of anticholinergic drugs</p> Signup and view all the answers

    More Like This

    Alzheimer Disease Overview
    12 questions
    Alzheimer's Disease Overview
    39 questions
    Enfermedades Neurodegenerativas y Alzheimer
    7 questions
    Huntington's Disease Overview
    21 questions
    Use Quizgecko on...
    Browser
    Browser