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Questions and Answers
What is the specific amino acid coded by the CAG repeat found in Huntington disease patients?
What is the specific amino acid coded by the CAG repeat found in Huntington disease patients?
- Glutamine (correct)
- Aspartate
- Alanine
- Glycine
Why is Huntington disease considered an autosomal dominant genetic disorder?
Why is Huntington disease considered an autosomal dominant genetic disorder?
- It can only affect males in each generation.
- It skips generations due to being recessive.
- It requires two affected copies of the gene to cause the disease.
- One affected copy of the gene is enough to cause the disease. (correct)
In a typical scenario, what is the chance that an affected individual with Huntington disease will pass on the affected gene to their child?
In a typical scenario, what is the chance that an affected individual with Huntington disease will pass on the affected gene to their child?
- 50% (correct)
- 25%
- 75%
- 100%
What part of the brain is notably affected by neuronal cell death in Huntington disease?
What part of the brain is notably affected by neuronal cell death in Huntington disease?
What is excitotoxicity believed to cause in neuronal cells in Huntington disease?
What is excitotoxicity believed to cause in neuronal cells in Huntington disease?
What makes Huntington disease more specifically classified as a 'polyglutamine' disease?
What makes Huntington disease more specifically classified as a 'polyglutamine' disease?
What is the term used to describe the phenomenon where Huntington disease families often show earlier symptom onset with each generation?
What is the term used to describe the phenomenon where Huntington disease families often show earlier symptom onset with each generation?
Why do individuals with 36-39 CAG repeats in the HTT gene show reduced penetrance?
Why do individuals with 36-39 CAG repeats in the HTT gene show reduced penetrance?
Which brain areas are most affected in Huntington disease due to neuronal death, leading to movement problems like chorea?
Which brain areas are most affected in Huntington disease due to neuronal death, leading to movement problems like chorea?
When does a person with 40+ CAG repeats in the HTT gene show 100% penetrance of Huntington disease?
When does a person with 40+ CAG repeats in the HTT gene show 100% penetrance of Huntington disease?
What is the term for the process of adding more CAG repeats in the HTT gene, which occurs more frequently during sperm production?
What is the term for the process of adding more CAG repeats in the HTT gene, which occurs more frequently during sperm production?
Why is the lateral ventricle expansion observed in Huntington disease?
Why is the lateral ventricle expansion observed in Huntington disease?
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