Podcast
Questions and Answers
Which protein is associated with the formation of amyloid plaques in Alzheimer's disease?
Which protein is associated with the formation of amyloid plaques in Alzheimer's disease?
False
True or False: According to the amyloid cascade hypothesis, abnormal genes lead to the deposition of amyloid plaques in the brain.
True or False: According to the amyloid cascade hypothesis, abnormal genes lead to the deposition of amyloid plaques in the brain.
True
Which area of the brain experiences initial plaque and tangle formation in Alzheimer's disease?
Which area of the brain experiences initial plaque and tangle formation in Alzheimer's disease?
False
True or False: The cholinergic deficiency hypothesis states that loss of cholinergic neurons leads to an excess of cholinergic neurotransmitters.
True or False: The cholinergic deficiency hypothesis states that loss of cholinergic neurons leads to an excess of cholinergic neurotransmitters.
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What is the major effect of kinases on Tau proteins in Alzheimer's disease?
What is the major effect of kinases on Tau proteins in Alzheimer's disease?
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Excess amounts of glutamate lead to the activation of which receptors?
Excess amounts of glutamate lead to the activation of which receptors?
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Which drug is an example of an NMDA receptor antagonist used in the treatment of Alzheimer's disease?
Which drug is an example of an NMDA receptor antagonist used in the treatment of Alzheimer's disease?
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What is the dosing recommendation for Memantine in the treatment of moderate to severe Alzheimer's disease?
What is the dosing recommendation for Memantine in the treatment of moderate to severe Alzheimer's disease?
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What are some examples of behavioral and psychological symptoms of dementia (BPSD)?
What are some examples of behavioral and psychological symptoms of dementia (BPSD)?
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Which pharmacological treatment is indicated for managing aggression in dementia?
Which pharmacological treatment is indicated for managing aggression in dementia?
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Study Notes
Alzheimer's Disease
- Amyloid-β protein is associated with the formation of amyloid plaques in Alzheimer's disease.
Amyloid Cascade Hypothesis
- According to the amyloid cascade hypothesis, abnormal genes lead to the deposition of amyloid plaques in the brain.
Brain Regions Affected
- The entorhinal cortex is the area of the brain that experiences initial plaque and tangle formation in Alzheimer's disease.
Cholinergic Deficiency Hypothesis
- The cholinergic deficiency hypothesis states that loss of cholinergic neurons leads to a decrease in cholinergic neurotransmitters.
Tau Proteins
- Kinases phosphorylate Tau proteins in Alzheimer's disease, leading to their abnormal accumulation.
Glutamate and NMDA Receptors
- Excess amounts of glutamate lead to the activation of N-methyl-D-aspartate (NMDA) receptors.
Pharmacological Treatment of Alzheimer's Disease
- Memantine is an example of an NMDA receptor antagonist used in the treatment of Alzheimer's disease.
- The dosing recommendation for Memantine in the treatment of moderate to severe Alzheimer's disease is 5-20 mg/day.
Behavioral and Psychological Symptoms of Dementia (BPSD)
- Examples of BPSD include aggression, agitation, depression, anxiety, and psychosis.
Managing Aggression in Dementia
- Antipsychotics are indicated for managing aggression in dementia.
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Description
Test your knowledge of the neurobiology of dementia and Alzheimer’s disease with this quiz. Explore the hallmarks in the AD brain, aetiology, major theories, and more.
