T3 L6: Affective Disorders: Neurobiology and Treatment (AC)

Which neurotransmitters are implicated in the pathophysiology of depression?

What is the estimated heritability of major depression?

Which neurotransmitter system is dysfunctional in depression?

What is the primary pharmacological target for traditional antidepressants?

Which type of antidepressant is known to have rapid and striking antidepressant effects?

What is the concordance rate of bipolar disorder in monozygotic twins?

What is the estimated heritability of bipolar disorder?

Which gene has been associated with bipolar disorder in genome-wide association studies?

What is the overlap between risk alleles identified in genome-wide association studies for bipolar disorder and schizophrenia?

What is the primary pharmacological target for traditional antipsychotics?

Which neurotransmitter abnormality is associated with depression?

What is the main purpose of short-term treatment for Bipolar Disorder?

Which drug category is used for the prevention of depression in Bipolar Disorder?

What is a potential adverse effect of Lithium treatment?

Which drug category has a risk of inducing mania in Bipolar Disorder?

What is a disadvantage of stopping Lithium abruptly in Bipolar Disorder treatment?

What is a potential adverse effect of Valproate treatment in Bipolar Disorder?

What is a potential adverse effect of 2nd generation antipsychotics in Bipolar Disorder treatment?

What is a potential disadvantage of pharmacological treatments for Bipolar Disorder?

What is a cause of neurodevelopmental defects in pregnancy related to Bipolar Disorder treatment?

Which of the following is NOT a learning outcome for the module?

What is the current classification system for mood disorders?

According to the text, what are the factors involved in the etiology of depression?

What is the role of Dr. Alessandro Colasanti in relation to the module?

What is the main focus of the module?

What is the historical classification of mood disorders mentioned in the text?

What is the role of OpCourage TILS Veterans service in relation to the module?

What is the focus of the Immunopsychiatry Research clinic?

Which classification systems do not rely on the classification between reactive and endogenous depression?

What is the main focus of the module?

What is the concordance rate of bipolar disorder in monozygotic twins?

What is a potential adverse effect of Valproate treatment in Bipolar Disorder?

Which approach to understanding psychiatric syndromes was discussed in the previous lecture?

What is the main focus of today's lecture on affective disorders?

How were the treatments for psychiatric disorders historically chosen?

What is the emphasis when selecting medications for mood disorders?

Which factor is NOT considered a genetic cause of depression?

What is the main reason why no convincing loci have been identified in genetic studies of depression?

What is the interaction demonstrated by Caspi in the study mentioned in the text?

What is the function of the serotonin transporter gene polymorphism mentioned in the text?

What is the primary hormone involved in the negative feedback regulation of cortisol release?

What is the state of cortisol primarily observed in people with depression?

What is the condition characterized by an increase in cortisol levels?

What structural changes are observed in the brain of individuals with depression?

Which brain regions are important in emotional reward processing?

What is the main role of the dorsolateral prefrontal cortex and the ventral lateral frontal cortex?

What is the main function of the anterior cingulate cortex and the medial prefrontal cortex?

What is the rationale for focusing on serotonin in the treatment of depression?

Which imaging technique has molecular specificity and can be used to measure the density of the five H2 transporter in the brain?

What is the potential relationship between the reduction in 5G transport and depression?

What is the purpose of administering dexamethasone in the evening before going to bed?

What did the pet study using a particular ligand binding to the five H2 receptor demonstrate in people with depression?

Which treatment has a potentially drastic reduction of serious depressive symptoms in a matter of two days?

What is a concern when giving ketamine many times to a person with recurrent depression?

What is ketamine potentially replacing or being an alternative of?

What is a potential disadvantage of ketamine treatment?

What is the primary pharmacological target for traditional antidepressants?

What is the estimated heritability of major depression?