Podcast
Questions and Answers
Which neurotransmitter is not mentioned in the text as being a major neurotransmitter related to mood?
Which neurotransmitter is not mentioned in the text as being a major neurotransmitter related to mood?
Which disorder is characterized by at least 2 years of consistent depressed mood?
Which disorder is characterized by at least 2 years of consistent depressed mood?
Which part of the brain is associated with reward in the context of mood?
Which part of the brain is associated with reward in the context of mood?
What percentage of Australians (16 – 85) experience at least one anxiety, mood or substance use disorder?
What percentage of Australians (16 – 85) experience at least one anxiety, mood or substance use disorder?
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Which hormone has a negative modulatory effect on the hippocampus and hypothalamic PVN in the context of the HPA axis?
Which hormone has a negative modulatory effect on the hippocampus and hypothalamic PVN in the context of the HPA axis?
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Which factor is NOT associated with stress and depression in the context of neuroplasticity/neurotrophic hypothesis?
Which factor is NOT associated with stress and depression in the context of neuroplasticity/neurotrophic hypothesis?
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Which class of drugs strongly potentiates the effects of alcohol and can cause death via respiratory depression?
Which class of drugs strongly potentiates the effects of alcohol and can cause death via respiratory depression?
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Which class of drugs is 50-fold selective for SERT over NAT?
Which class of drugs is 50-fold selective for SERT over NAT?
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Which class of drugs inhibits the degradation of 5HT, NA, and DA?
Which class of drugs inhibits the degradation of 5HT, NA, and DA?
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Which class of drugs blocks presynaptic α2 receptors and increases 5HT, NA release?
Which class of drugs blocks presynaptic α2 receptors and increases 5HT, NA release?
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Which class of drugs is considered the gold standard for treating moderate to severe depression, although newer drugs have reduced side effects?
Which class of drugs is considered the gold standard for treating moderate to severe depression, although newer drugs have reduced side effects?
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Which effect is associated with the use of antidepressants according to the Neuroplasticity Hypothesis?
Which effect is associated with the use of antidepressants according to the Neuroplasticity Hypothesis?
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Which neurotransmitter is mentioned as promoting neurogenesis via specific receptors?
Which neurotransmitter is mentioned as promoting neurogenesis via specific receptors?
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Which effect is associated with the use of MAOIs according to the Monoamine Hypothesis?
Which effect is associated with the use of MAOIs according to the Monoamine Hypothesis?
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Study Notes
Neurotransmitters and Mood Disorders
- Dopamine is not mentioned as a major neurotransmitter related to mood.
- Major depressive disorder is characterized by experiencing a consistent depressed mood for at least 2 years.
Brain Regions and Disorders
- The ventral striatum is associated with reward processing in the context of mood.
- Approximately 20% of Australians aged 16 to 85 experience at least one anxiety, mood, or substance use disorder.
Hormones and Neuroplasticity
- Cortisol has a negative modulatory effect on the hippocampus and hypothalamic paraventricular nucleus (PVN) within the HPA axis.
- Factors like genetics and environmental stressors are associated with stress and depression, while social support is not typically linked to neuroplasticity/neurotrophic hypothesis.
Pharmacological Classes
- Benzodiazepines strongly potentiate the effects of alcohol and can lead to respiratory depression fatalities.
- Selective Serotonin Reuptake Inhibitors (SSRIs) demonstrate a 50-fold selectivity for the serotonin transporter (SERT) over the norepinephrine transporter (NAT).
- Monoamine Oxidase Inhibitors (MAOIs) inhibit the degradation of serotonin (5HT), norepinephrine (NA), and dopamine (DA).
- α2 adrenergic antagonists block presynaptic α2 receptors and increase the release of 5HT and NA.
- SSRIs are considered the gold standard for treating moderate to severe depression despite newer drugs aiming to reduce side effects.
Effects of Antidepressants
- The use of antidepressants is associated with promoting neurogenesis as per the Neuroplasticity Hypothesis.
- The use of MAOIs aligns with the Monoamine Hypothesis, which suggests their effects relate to increased monoamine levels in the brain.
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Description
Test your knowledge about antidepressants and depressive disorders with this quiz. Explore key facts about depression, including its prevalence and genetic factors. Learn about the symptoms of major depression and persistent depressive disorder.
