Nervous Tissue and Neurons
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Questions and Answers

What is the primary function of receptors in neurons?

  • To interact with extracellular signals and trigger intracellular effects (correct)
  • To synthesize neurotransmitter molecules
  • To transmit electrical impulses to other neurons
  • To maintain membrane polarization
  • Which type of channels in the axon membrane are responsible for membrane polarity reversal?

  • Voltage-gated Ca++ channels
  • Potassium ion channels
  • Calcium ion channels
  • Voltage-gated Na+ channels (correct)
  • What distinguishes unipolar neurons from multipolar neurons?

  • Multipolar neurons are only found in the peripheral nervous system.
  • Unipolar neurons have a single process emanating from the cell body. (correct)
  • Multipolar neurons have a single axonal branch.
  • Unipolar neurons have multiple dendrites.
  • What role do voltage-gated Ca++ channels play in neuron function?

    <p>Enabling the release of neurotransmitter molecules (A)</p> Signup and view all the answers

    Which type of neuron is most abundant in the central nervous system (CNS)?

    <p>Multipolar neurons (B)</p> Signup and view all the answers

    What constitutes the basis of nervous system function according to the neural circuits?

    <p>Excitation alterations communicated from one neuron to another (B)</p> Signup and view all the answers

    What is the main mechanism through which most neurons communicate?

    <p>Localized release of neurotransmitter molecules (D)</p> Signup and view all the answers

    What does the chromatophilic substance in neuronal cell bodies indicate?

    <p>Production of neurotransmitter proteins (A)</p> Signup and view all the answers

    What is the primary function of the cell body cytoplasm in neurons?

    <p>To synthesize and transport cellular constituents (B)</p> Signup and view all the answers

    Which type of proteins are synthesized in the cell body cytoplasm of neurons?

    <p>Enzymatic proteins and cytoskeletal proteins (A)</p> Signup and view all the answers

    Why are larger neurons more suited for conveying urgent information?

    <p>They conduct signals more rapidly (C)</p> Signup and view all the answers

    What is the axon hillock's role in a neuron?

    <p>It generates action potentials (B)</p> Signup and view all the answers

    Which of the following structures is absent in the axon of multipolar neurons?

    <p>Chromatophilic substance (C)</p> Signup and view all the answers

    What is the typical diameter range for cell bodies of neurons?

    <p>Less than 10 µm to more than 100 µm (B)</p> Signup and view all the answers

    What is the significance of the chromatophilic substance in neurons?

    <p>It represents aggregations of rough endoplasmic reticulum (C)</p> Signup and view all the answers

    In which area of a multipolar neuron is the cytoplasmic chromaticity relatively pale and diffuse?

    <p>Axon hillock (C)</p> Signup and view all the answers

    What type of neuron is characterized by a single axon that bifurcates into central and peripheral branches?

    <p>Unipolar neuron (D)</p> Signup and view all the answers

    Which type of synaptic vesicle is typically associated with inhibitory synapses and appears flattened under specific conditions?

    <p>Flattened electron-lucent synaptic vesicles (D)</p> Signup and view all the answers

    What is the primary purpose of transporter proteins in the vesicle membrane?

    <p>To load newly formed synaptic vesicles with neurotransmitters (A)</p> Signup and view all the answers

    What is the approximate diameter range of spherical synaptic vesicles?

    <p>40 to 60 nm (C)</p> Signup and view all the answers

    Where are neuronal cell bodies for unipolar neurons typically found?

    <p>In sensory ganglia located in cranial and spinal nerve roots (A)</p> Signup and view all the answers

    Which neurotransmitters are typically contained in electron-dense synaptic vesicles?

    <p>Dopamine and norepinephrine (C)</p> Signup and view all the answers

    What allows for neural plasticity, enabling learning and behavioral modification?

    <p>Mechanisms in synaptic vesicle function (A)</p> Signup and view all the answers

    What is a distinguishing feature of multipolar neurons compared to unipolar and bipolar neurons?

    <p>Multiple processes emanating from the cell body (C)</p> Signup and view all the answers

    What is the primary role of the postsynaptic density?

    <p>To stabilize and organize neurotransmitter receptors and signal transduction. (B)</p> Signup and view all the answers

    Which factor primarily determines whether a synapse is excitatory or inhibitory?

    <p>The nature of the receptor type coupled to the neurotransmitter. (D)</p> Signup and view all the answers

    What happens when calcium ions ($Ca^{++}$) influx into the presynaptic terminal?

    <p>It activates enzymes that phosphorylate synaptic vesicle proteins. (B)</p> Signup and view all the answers

    Which neurotransmitter is associated with excitatory synapses?

    <p>Glutamate (B)</p> Signup and view all the answers

    What is the immediate effect of an action potential at the axon terminal?

    <p>Depolarization of the presynaptic element. (D)</p> Signup and view all the answers

    How do synaptic vesicles release neurotransmitters into the synaptic cleft?

    <p>By exocytosis after docking with the plasma membrane. (C)</p> Signup and view all the answers

    What types of synapses are primarily formed between neurons?

    <p>Axodendritic and axosomatic (C)</p> Signup and view all the answers

    What is the primary mechanism through which neurotransmitter receptors are rapidly removed from synaptic sites?

    <p>Endocytosis and degradation (D)</p> Signup and view all the answers

    What characterizes the glutamate receptors in the brain?

    <p>They mediate almost all excitatory communication between CNS neurons. (B)</p> Signup and view all the answers

    What role do cadherin-catenin complexes play in the synapse?

    <p>They provide structural support and organization. (D)</p> Signup and view all the answers

    Which cellular component plays a role in recycling neurotransmitter molecules?

    <p>Synaptic vesicles (D)</p> Signup and view all the answers

    What causes synaptic activity to cease?

    <p>Removal or degradation of neurotransmitter molecules (B)</p> Signup and view all the answers

    Which structural characteristic differentiates astrocytes in white matter versus gray matter?

    <p>Processes in white matter are long, slender, and moderately branched (D)</p> Signup and view all the answers

    What triggers the rapid immobilization and local accumulation of receptors on the neuronal surface?

    <p>Elevation in intracellular calcium concentration (B)</p> Signup and view all the answers

    What is one of the key functions of scaffolding proteins in neurons?

    <p>Regulating receptor endocytosis and exocytosis (B)</p> Signup and view all the answers

    What happens to excitatory and inhibitory synaptic effects at the cell body of a target neuron?

    <p>They are summated and integrated (C)</p> Signup and view all the answers

    What is suggested about the role of glial scarring in the CNS?

    <p>It helps restore homeostasis by isolating damaged regions. (B)</p> Signup and view all the answers

    Which of the following best describes the structure of ependymal cells?

    <p>They are cuboidal or columnar with motile cilia on their apical surfaces. (C)</p> Signup and view all the answers

    What barrier function do ependymal cells serve in the CNS?

    <p>They regulate the transport of ions and small molecules. (B)</p> Signup and view all the answers

    What are the primary types of gliocytes found in the peripheral nervous system (PNS)?

    <p>Ganglionic gliocytes and neurolemmocytes. (C)</p> Signup and view all the answers

    What is the role of ganglionic gliocytes in the PNS?

    <p>They encapsulate neuron cell bodies. (D)</p> Signup and view all the answers

    Which statement about ependymal cells in adults is accurate?

    <p>They form an epithelium that links gaps in the ventricular system. (B)</p> Signup and view all the answers

    How do ependymal cells contribute to the protection of neural tissue?

    <p>By regulating the movement of potentially harmful substances. (A)</p> Signup and view all the answers

    What feature distinguishes neurolemmocytes from other types of glial cells?

    <p>Their role in forming the myelin sheath around peripheral nerves. (B)</p> Signup and view all the answers

    Flashcards

    Axodendritic Synapse

    Synapses where the axon of one neuron connects to the dendrite of another neuron.

    Axosomatic Synapse

    Synapses where the axon of one neuron connects to the cell body of another neuron.

    Neurotransmitter Removal

    The process of removing neurotransmitter molecules from the synaptic cleft.

    Transporters

    Proteins that actively transport neurotransmitter molecules back into the presynaptic neuron.

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    Synaptic Vesicle Recycling

    The process by which membrane components are recycled.

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    Synaptic Integration

    The integration of excitatory and inhibitory synaptic signals at the cell body of a neuron.

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    Synaptic Plasticity

    Rapid changes in the number of receptor proteins on the neuronal membrane.

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    Astrocytes

    Glial cells that have numerous processes containing glial fibrils.

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    Pyramidal Neuron

    A specialized type of neuron in the cerebral cortex, characterized by a pyramid-shaped cell body and a single axon that emerges from its base.

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    Dendrites

    Branching extensions of a neuron that receive incoming signals from other neurons. They can be apical (top) or basal (bottom).

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    Axon

    The long, slender extension of a neuron that transmits signals to other neurons or effector cells.

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    Axonal Varicosities

    Specialized structures along the axon where neurotransmitters are stored and released.

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    Synaptic Vesicles

    Small, membrane-bound sacs within axonal varicosities or synaptic boutons that contain neurotransmitters.

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    Electron-Lucent Synaptic Vesicles

    A type of synaptic vesicle with a clear, electron-lucent interior, often associated with excitatory synapses.

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    Electron-Dense Synaptic Vesicles

    A type of synaptic vesicle with a dense, electron-dense core, usually containing dopamine or norepinephrine.

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    Vesicle Recycling

    The process by which synaptic vesicles are recycled and replenished with neurotransmitters, enabling the neuron to keep transmitting signals effectively.

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    Membrane Receptor

    Protein on a cell membrane that binds to specific molecules, often signaling molecules, and triggers a response inside the cell.

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    Unipolar Neuron

    Specialized type of neuron with a single axon and dendrites extending from the cell body. They are involved in sensory functions.

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    Bipolar Neuron

    Specialized type of neuron with one axon and one dendrite extending from the cell body. They are involved in sensory functions.

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    Multipolar Neuron

    Specialized type of neuron with one axon and multiple dendrites extending from the cell body. They are responsible for transmitting information throughout the nervous system.

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    Synaptic Boutons

    Specialized structures at the end of axons that release neurotransmitters into the synapse.

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    Voltage-Gated Sodium Channels

    Specialized channels in the axon membrane that open in response to an electrical signal, allowing sodium ions (Na+) to flow into the cell, causing depolarization.

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    Voltage-Gated Calcium Channels

    Specialized channels located in the synaptic boutons that open in response to an electrical signal. They allow calcium ions (Ca++) to flow into the cell, triggering the release of neurotransmitters.

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    Neurotransmitter Release

    The process by which the neuron releases neurotransmitters into the synapse.

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    What is the cell body of a neuron?

    The cell body of a neuron, containing the nucleus and surrounding cytoplasm, is responsible for synthesizing cellular components.

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    How does cell body size relate to neuron size?

    The size of a neuron's cell body is related to the total volume of the neuron, with larger cell bodies indicating longer processes.

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    Why do neurons with long processes need larger cell bodies?

    Neurons with long processes require a larger cell body to accommodate the synthesis of proteins for those processes.

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    What is chromatophilic substance?

    The cell body cytoplasm contains structures like rough endoplasmic reticulum, ribosomes, and polyribosomes, forming chromatophilic substance responsible for protein synthesis.

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    What's special about the axon hillock?

    The axon hillock, a region where the axon originates, is devoid of chromatophilic substance but contains neurofilaments and microtubules.

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    How does process size impact conduction speed?

    The size of a neuron's processes influences its speed of conduction, with larger processes conducting signals more quickly.

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    Why are neurons conveying urgent information larger?

    Neurons responsible for urgent communication, like those involved in reflexes, tend to be larger due to their faster conduction speed.

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    How does cell body size relate to synaptic integration?

    The cell body plasma membrane in multipolar neurons integrates synaptic input, and smaller cell bodies can be more efficient in this function.

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    Oligodendrocytes

    Glial cells in the CNS that myelinate axons, forming a sheath that increases the speed of nerve impulse conduction.

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    Ependymal Cells

    A type of glial cell found in the CNS that forms a protective barrier between the brain and spinal cord and the cerebrospinal fluid.

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    Glial Scarring

    The formation of a scar in the CNS, composed mainly of astrocytes, that occurs after injury.

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    Neurolemmocytes (Schwann Cells)

    Glial cells found in the peripheral nervous system (PNS) that wrap around axons to form myelin sheaths.

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    Ganglionic Gliocytes (Satellite Cells)

    Glial cells found in the PNS that surround and support neuron cell bodies in ganglia.

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    Blood-Brain Barrier

    A barrier function that prevents the passage of harmful substances from the blood into the central nervous system.

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    Cerebrospinal Fluid (CSF)

    The fluid that fills the ventricles of the brain and the central canal of the spinal cord.

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    Synapse

    A specialized structure that allows communication between neurons, involving the release and reception of chemical messengers called neurotransmitters.

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    Neurotransmitter Receptors

    Proteins that bind to neurotransmitters, triggering a change in the receiving neuron's activity. They can be excitatory or inhibitory, influencing whether the neuron is more or less likely to fire.

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    Postsynaptic Density

    The area on the receiving neuron where neurotransmitter receptors are concentrated, facilitating efficient signal transmission.

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    Exocytosis

    The process of releasing neurotransmitters from the sending neuron into the synaptic cleft.

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    Calcium Influx

    The arrival of an action potential at the end of an axon triggers the release of calcium ions (Ca++) into the presynaptic terminal.

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    Neurotransmitter Reuptake

    The process of re-uptake occurs when excess neurotransmitters in the synaptic cleft are taken back up by the presynaptic neuron or other cells. This removes the neurotransmitter from the synapse, preventing overstimulation and regulating the signal.

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    Study Notes

    Nervous Tissue

    • Nervous tissue is composed of neurons and neuroglia
    • The nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS)
    • The CNS includes the brain and spinal cord
    • The PNS includes cranial and spinal nerves, plus associated nerve roots and ganglia

    Neurons

    • Neurons are the structural and functional units of the nervous system
    • Neurons are trophic units, transforming and sustaining the structure and function of innervated cells.
    • Neurons typically live a lifetime; most are incapable of mitosis. Recent evidence shows new neuron formation in some brain regions
    • The cell body (perikaryon or soma) contains the nucleus and surrounding cytoplasm.
    • The cytoplasm of large neurons contains chromatophilic substance (Nissl substance), made of aggregated rough endoplasmic reticulum, free ribosomes, and polyribosomes.
    • Cell bodies range in size from less than 10 µm to more than 100 µm in diameter
    • The nucleus is typically spherical or ovoid and relatively euchromatic.
    • Neurons have processes called dendrites and axons; dendrites extend out to receive input; axons conduct signals outwards.
    • The axon hillock is a pale-staining region of the cell body where the axon originates.

    Neuronal Structure

    • Axon: Relatively long, cylindrical process arising from the axon hillock. Contains microtubules, neurofilaments, mitochondria, and smooth endoplasmic reticulum (sER)
    • Dendrites: Highly branched, tree-like processes that receive synaptic input from other neurons. Contain microtubules, neurofilaments, mitochondria, and smooth endoplasmic reticulum (sER).
    • Synaptic vesicles: Concentrated in axon terminals; contain neurotransmitters that are released into the synaptic cleft.
    • Synaptic cleft: Space between two neurons across which neurotransmitters diffuse between presynaptic and postsynaptic neurons.

    Neuroglia

    • Neuroglia comprise over 90% of the cells in the nervous system.
    • Neuroglia in the CNS include astrocytes, oligodendrocytes, microglia, and ependymal cells.
    • Neuroglia in the PNS include ganglionic gliocytes and neurolemmocytes (Schwann cells)

    Astrocytes

    • Pale, ovoid nuclei
    • Numerous processes containing glial fibrils
    • White matter: Fibrous astrocytes (long, slender processes)
    • Gray matter: Protoplasmic astrocytes (shorter, highly branched processes)
    • Astrocyte processes form a glial limiting membrane
    • Play vital roles in brain function.

    Oligodendrocytes

    • Small, spherical, densely stained nuclei
    • Relatively few branches
    • Form myelin sheaths around axons in white matter of the CNS

    Microglia

    • Small, elongated, chromophilic nuclei
    • Act as macrophages, have phagocytic capabilities.

    Ependymal Cells

    • Line the central canal of the spinal cord and ventricles of the brain
    • Cuboidal or columnar cells with cilia
    • Involved in cerebrospinal fluid production

    Ganglionic Gliocytes

    • Encapsulate neuron cell bodies in the PNS.
    • Form a tight capsule around sensory neuron cell bodies in sensory ganglia.

    Neurolemmocytes

    • Envelop and myelinate axons in the PNS
    • Myelin sheath: Multiple layers of neurolemmocyte plasma membrane that surround and insulate axons.
    • Nodes of Ranvier: Gaps in the myelin sheath.
    • Saltatory conduction: Action potentials jump between nodes, resulting in faster transmission speed.

    Nerves

    • Bundles of axons and supporting cells (endoneurium, perineurium, and epineurium)
    • Fascicles: Bundles of axons. Perineurium sheathes fascicles
    • Epineurium: Sheaths the entire nerve.
    • Endoneurium: surrounds individual axons

    Ganglia

    • Localized swellings in nerves containing neuron cell bodies.
    • Sensory ganglia: Contain cell bodies of sensory neurons. Typically unipolar neurons except in sense organs.
    • Autonomic ganglia: Contain multipolar neurons.

    Efferent Neurons

    • Convey signals from the CNS to muscles and glands (motor neurons)
    • Somatic efferent neurons: Innervate skeletal muscle; each neuron with fibers is a motor unit.
    • Visceral efferent neurons: innervate smooth and cardiac muscle and glands (autonomic nervous system)

    Receptors

    • Specialized cells or structures that detect stimuli.
    • Nonencapsulated receptors: Free nerve endings, detect pain, temperature, touch, and pressure.
    • Encapsulated receptors: Lamellar corpuscles (Pacini's corpuscles) are sensitive to transient pressures; they are widely distributed in the skin. Other examples include tactile corpuscles (Meissner's corpuscles), neurotendinous spindles, and muscle spindles (used for proprioception).

    Meninges, Blood Vessels, and Cerebrospinal Fluid (CSF)

    • The brain and spinal cord are covered by layers of connective tissue called meninges.
    • Dura mater, arachnoid mater, and pia mater from superficial to deep.
    • Arachnoid villi: Projections of arachnoid mater through which CSF is absorbed by blood vessels.
    • Blood-brain barrier: A selective barrier between blood and brain tissue, composed of tight junctions between endothelial cells of brain capillaries. This barrier limits the passage of certain substances.
    • CSF: Fluid produced by choroid plexuses of ventricles, circulating in the subarachnoid space, serving both cushioning and buffering functions.

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