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Questions and Answers
Sensory nerves send information to the central nervous system about the internal and external environment.
Sensory nerves send information to the central nervous system about the internal and external environment.
True
Motor nerves primarily send information to sensory organs.
Motor nerves primarily send information to sensory organs.
False
A synapse is the junction between one neurone and the next cell.
A synapse is the junction between one neurone and the next cell.
True
Neuromuscular junctions are a type of synapse between nerve and gland cells.
Neuromuscular junctions are a type of synapse between nerve and gland cells.
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Motor response to sensory input depends on integration of information through reflex arcs.
Motor response to sensory input depends on integration of information through reflex arcs.
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Neurotransmitters are typically large, slow-acting molecules.
Neurotransmitters are typically large, slow-acting molecules.
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Electrical impulses are converted to chemical signals at synapses.
Electrical impulses are converted to chemical signals at synapses.
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Interconnections between nerves are not necessary for motor response.
Interconnections between nerves are not necessary for motor response.
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The central nervous system consists of the brain and spinal cord.
The central nervous system consists of the brain and spinal cord.
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Efferent neurons transmit information towards the central nervous system.
Efferent neurons transmit information towards the central nervous system.
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Acetylcholinesterase has a role in neurotransmission at the neuromuscular junction.
Acetylcholinesterase has a role in neurotransmission at the neuromuscular junction.
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Sensory nerves are also known as efferent nerves.
Sensory nerves are also known as efferent nerves.
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Nissl bodies are found in the presynaptic cell.
Nissl bodies are found in the presynaptic cell.
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The primary role of motor neurons is to transmit sensory stimuli.
The primary role of motor neurons is to transmit sensory stimuli.
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Dendrites receive input signals in a neuron.
Dendrites receive input signals in a neuron.
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Bi-polar neurons have multiple projections from the cell body.
Bi-polar neurons have multiple projections from the cell body.
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The role of the axon is to propagate output signals in the form of action potentials.
The role of the axon is to propagate output signals in the form of action potentials.
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Smooth muscle is primarily controlled by the somatic nervous system.
Smooth muscle is primarily controlled by the somatic nervous system.
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Binding of Ach opens Na+ channels in the synaptic cleft.
Binding of Ach opens Na+ channels in the synaptic cleft.
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Graded potentials can travel long distances without dying out.
Graded potentials can travel long distances without dying out.
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The resting membrane potential is typically around -70 mV.
The resting membrane potential is typically around -70 mV.
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Action potentials are triggered when graded potentials reach threshold voltage.
Action potentials are triggered when graded potentials reach threshold voltage.
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When sodium ions flood into the cell, it causes repolarization.
When sodium ions flood into the cell, it causes repolarization.
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Graded potentials have a magnitude that varies with the triggering event.
Graded potentials have a magnitude that varies with the triggering event.
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Voltage-gated channels open when the membrane potential is around -70 mV.
Voltage-gated channels open when the membrane potential is around -70 mV.
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Graded potentials can be integrated to generate an action potential.
Graded potentials can be integrated to generate an action potential.
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Action potentials involve large changes in membrane potential of about ≅100mV.
Action potentials involve large changes in membrane potential of about ≅100mV.
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Action potentials decrease in strength as they travel through the cell.
Action potentials decrease in strength as they travel through the cell.
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Voltage-gated Na+ channels allow Na+ to move out of the cell during an action potential.
Voltage-gated Na+ channels allow Na+ to move out of the cell during an action potential.
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The resting membrane potential is approximately -70mV.
The resting membrane potential is approximately -70mV.
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After the opening of voltage-gated Na+ channels, the membrane potential becomes more negative.
After the opening of voltage-gated Na+ channels, the membrane potential becomes more negative.
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Voltage-gated K+ channels open after Na+ channels to return the membrane potential towards resting level.
Voltage-gated K+ channels open after Na+ channels to return the membrane potential towards resting level.
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Action potentials involve only a small portion of the total excitable cell membrane at a time.
Action potentials involve only a small portion of the total excitable cell membrane at a time.
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The process of action potential generation requires the influx of Ca2+ ions.
The process of action potential generation requires the influx of Ca2+ ions.
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Acetylcholinesterase breaks down the neurotransmitter ACh at the neuromuscular junction.
Acetylcholinesterase breaks down the neurotransmitter ACh at the neuromuscular junction.
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Curare is known to enhance the binding of ACh to nicotinic receptors.
Curare is known to enhance the binding of ACh to nicotinic receptors.
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Botulinum toxin prevents muscles from responding to nerve impulses.
Botulinum toxin prevents muscles from responding to nerve impulses.
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Myasthenia gravis is a condition where there is an excess of ACh at the neuromuscular junction.
Myasthenia gravis is a condition where there is an excess of ACh at the neuromuscular junction.
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Ingesting a small amount of botulinum toxin can be lethal to an adult.
Ingesting a small amount of botulinum toxin can be lethal to an adult.
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Acidic food products are a primary source of botulinum toxin poisoning.
Acidic food products are a primary source of botulinum toxin poisoning.
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AChE inhibitors increase the duration of ACh action at the neuromuscular junction.
AChE inhibitors increase the duration of ACh action at the neuromuscular junction.
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D-Tubocurarine is used to block neuromuscular junction activity.
D-Tubocurarine is used to block neuromuscular junction activity.
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Dopamine is an example of a neurotransmitter that depolarises the postsynaptic membrane.
Dopamine is an example of a neurotransmitter that depolarises the postsynaptic membrane.
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The binding of acetylcholine to its receptors causes the efflux of Na+ ions from the postsynaptic cell.
The binding of acetylcholine to its receptors causes the efflux of Na+ ions from the postsynaptic cell.
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Acetylcholine serves as a neurotransmitter at both excitatory and inhibitory synapses.
Acetylcholine serves as a neurotransmitter at both excitatory and inhibitory synapses.
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The end plate potential is created by hyperpolarization of the muscle fiber.
The end plate potential is created by hyperpolarization of the muscle fiber.
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Acetylcholine (ACh) binds to receptors on the muscle fiber to initiate contraction.
Acetylcholine (ACh) binds to receptors on the muscle fiber to initiate contraction.
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When the postsynaptic membrane reaches a threshold due to depolarisation, an action potential is generated.
When the postsynaptic membrane reaches a threshold due to depolarisation, an action potential is generated.
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Voltage-gated Na+ channels are triggered to open by the resting membrane potential of -80 mV.
Voltage-gated Na+ channels are triggered to open by the resting membrane potential of -80 mV.
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Neurons release more than one type of major neurotransmitter at a synapse.
Neurons release more than one type of major neurotransmitter at a synapse.
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The action potential in a muscle fiber travels down the axon towards the neuromuscular junction.
The action potential in a muscle fiber travels down the axon towards the neuromuscular junction.
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Acetylcholinesterase is responsible for stopping the action of ACh in the synaptic cleft.
Acetylcholinesterase is responsible for stopping the action of ACh in the synaptic cleft.
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Motor nerves primarily control the activity of the body by managing muscle and gland functions.
Motor nerves primarily control the activity of the body by managing muscle and gland functions.
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Sensory nerves do not send information to the central nervous system.
Sensory nerves do not send information to the central nervous system.
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A synapse is the junction where an electrical impulse becomes a chemical signal for communication between cells.
A synapse is the junction where an electrical impulse becomes a chemical signal for communication between cells.
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Neuromuscular junctions are specialized connections between nerve cells and other nerve cells.
Neuromuscular junctions are specialized connections between nerve cells and other nerve cells.
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Neurotransmitters are typically large, slow-acting molecules.
Neurotransmitters are typically large, slow-acting molecules.
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Interconnections between nerves are essential for reflex actions.
Interconnections between nerves are essential for reflex actions.
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Efferent neurons carry information away from the central nervous system.
Efferent neurons carry information away from the central nervous system.
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The synaptic terminal is involved in converting chemical signals back into electrical impulses.
The synaptic terminal is involved in converting chemical signals back into electrical impulses.
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Curare is a drug that enhances the binding of ACh to nicotinic receptors.
Curare is a drug that enhances the binding of ACh to nicotinic receptors.
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Botulinum toxin can lead to muscle paralysis by blocking the release of ACh.
Botulinum toxin can lead to muscle paralysis by blocking the release of ACh.
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Myasthenia gravis is caused by an overproduction of ACh at the neuromuscular junction.
Myasthenia gravis is caused by an overproduction of ACh at the neuromuscular junction.
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D-Tubocurarine is a neuromuscular blocking agent used to induce muscle relaxation.
D-Tubocurarine is a neuromuscular blocking agent used to induce muscle relaxation.
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Acetylcholinesterase inhibitors are used to shorten the effects of ACh on muscles.
Acetylcholinesterase inhibitors are used to shorten the effects of ACh on muscles.
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Ingesting a large amount of botulinum toxin can be lethal to an adult.
Ingesting a large amount of botulinum toxin can be lethal to an adult.
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The primary treatment for myasthenia gravis involves increasing the production of ACh.
The primary treatment for myasthenia gravis involves increasing the production of ACh.
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Nicotinic cholinergic receptors are found exclusively at the neuromuscular junction.
Nicotinic cholinergic receptors are found exclusively at the neuromuscular junction.
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The peripheral nervous system includes both sensory and motor nerves.
The peripheral nervous system includes both sensory and motor nerves.
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Neurons that transmit information away from the central nervous system are called afferent neurons.
Neurons that transmit information away from the central nervous system are called afferent neurons.
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The action potential is primarily propagated along the axon by the influx of potassium ions.
The action potential is primarily propagated along the axon by the influx of potassium ions.
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Acetylcholine (ACh) is released at the neuromuscular junction to stimulate muscle contraction.
Acetylcholine (ACh) is released at the neuromuscular junction to stimulate muscle contraction.
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Dendrites are responsible for sending signals away from the neuron.
Dendrites are responsible for sending signals away from the neuron.
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Botulinum toxin causes muscles to contract more strongly.
Botulinum toxin causes muscles to contract more strongly.
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Acetylcholinesterase (AChE) breaks down acetylcholine after its release at the neuromuscular junction.
Acetylcholinesterase (AChE) breaks down acetylcholine after its release at the neuromuscular junction.
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Myasthenia gravis is caused by an excess of acetylcholine at the neuromuscular junction.
Myasthenia gravis is caused by an excess of acetylcholine at the neuromuscular junction.
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Nissl bodies are composed of rough endoplasmic reticulum and are found in the postsynaptic cell.
Nissl bodies are composed of rough endoplasmic reticulum and are found in the postsynaptic cell.
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Graded potentials can travel short distances and can vary in magnitude.
Graded potentials can travel short distances and can vary in magnitude.
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Sensory nerves primarily activate gland functions by sending information to muscles.
Sensory nerves primarily activate gland functions by sending information to muscles.
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Synapses facilitate communication between nerves and muscles by converting electrical impulses into chemical signals.
Synapses facilitate communication between nerves and muscles by converting electrical impulses into chemical signals.
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Neuromuscular junctions are specifically required for nerve-nerves communication.
Neuromuscular junctions are specifically required for nerve-nerves communication.
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The integration of information in the nervous system does not involve interconnections between neurons.
The integration of information in the nervous system does not involve interconnections between neurons.
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Acetylcholine is the only neurotransmitter involved in synaptic transmission at neuromuscular junctions.
Acetylcholine is the only neurotransmitter involved in synaptic transmission at neuromuscular junctions.
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Chemical signals transmitted at synapses are typically slow-acting molecules.
Chemical signals transmitted at synapses are typically slow-acting molecules.
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Efferent nerves are responsible for sending information towards the sensory organs.
Efferent nerves are responsible for sending information towards the sensory organs.
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Repolarization occurs when sodium ions leave the cell, restoring the membrane potential.
Repolarization occurs when sodium ions leave the cell, restoring the membrane potential.
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Graded potentials die out quickly over short distances within excitable cell membranes.
Graded potentials die out quickly over short distances within excitable cell membranes.
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If graded potentials summate and reach a threshold voltage, it results in the opening of voltage-gated calcium channels.
If graded potentials summate and reach a threshold voltage, it results in the opening of voltage-gated calcium channels.
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A nerve impulse constitutes an action potential that moves down the axon.
A nerve impulse constitutes an action potential that moves down the axon.
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During depolarization, potassium ions flood into the cell.
During depolarization, potassium ions flood into the cell.
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The magnitude of a graded potential is independent of the magnitude of the triggering event.
The magnitude of a graded potential is independent of the magnitude of the triggering event.
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The resting membrane potential is typically less negative than -80 mV.
The resting membrane potential is typically less negative than -80 mV.
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Action potentials involve only a small and localized change in membrane potential.
Action potentials involve only a small and localized change in membrane potential.
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After the activation of voltage-gated Na+ channels, the influx of K+ ions initiates depolarization.
After the activation of voltage-gated Na+ channels, the influx of K+ ions initiates depolarization.
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Action potentials involve a change in membrane potential of approximately ≅150mV.
Action potentials involve a change in membrane potential of approximately ≅150mV.
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During an action potential, Na+ channels open due to hyperpolarization.
During an action potential, Na+ channels open due to hyperpolarization.
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Voltage-gated K+ channels close immediately after action potentials, leading to sustained depolarization.
Voltage-gated K+ channels close immediately after action potentials, leading to sustained depolarization.
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The resting membrane potential is less negative than the threshold potential required for action potential initiation.
The resting membrane potential is less negative than the threshold potential required for action potential initiation.
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The influx of Na+ ions during an action potential is a key factor that contributes to depolarization.
The influx of Na+ ions during an action potential is a key factor that contributes to depolarization.
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Action potentials decrease in strength as they propagate along the axon.
Action potentials decrease in strength as they propagate along the axon.
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After opening voltage-gated Na+ channels, Ca2+ influx is responsible for repolarization of the membrane potential.
After opening voltage-gated Na+ channels, Ca2+ influx is responsible for repolarization of the membrane potential.
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The threshold potential is the membrane potential level at which voltage-gated sodium channels are triggered to open.
The threshold potential is the membrane potential level at which voltage-gated sodium channels are triggered to open.
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Ingestion of 0.001 mg of botulinum toxin can cause death in adults.
Ingestion of 0.001 mg of botulinum toxin can cause death in adults.
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Myasthenia gravis leads to an excess of ACh at the neuromuscular junction.
Myasthenia gravis leads to an excess of ACh at the neuromuscular junction.
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Curare is a drug that enhances the binding of ACh to nicotinic receptors.
Curare is a drug that enhances the binding of ACh to nicotinic receptors.
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Neostigmine is used to prolong the effect of ACh at the neuromuscular junction.
Neostigmine is used to prolong the effect of ACh at the neuromuscular junction.
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Botulinum toxin prevents the release of neurotransmitters from synaptic vesicles.
Botulinum toxin prevents the release of neurotransmitters from synaptic vesicles.
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D-Tubocurarine is effective in enhancing neuromuscular transmission.
D-Tubocurarine is effective in enhancing neuromuscular transmission.
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The muscle contraction process is initiated by the decrease of ACh in the synaptic cleft.
The muscle contraction process is initiated by the decrease of ACh in the synaptic cleft.
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Curare is derived from the skins of South American frogs.
Curare is derived from the skins of South American frogs.
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Nicotinic receptors are ionotropic and mediate slow responses in muscle fibers.
Nicotinic receptors are ionotropic and mediate slow responses in muscle fibers.
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The receptors for ACh at the neuromuscular junction are known as NM or N2 receptors.
The receptors for ACh at the neuromuscular junction are known as NM or N2 receptors.
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ACh can be taken up by the muscle fiber when it is attached to its receptor.
ACh can be taken up by the muscle fiber when it is attached to its receptor.
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Calcium ions (Ca2+) play a crucial role in muscle contraction following excitation-contraction coupling.
Calcium ions (Ca2+) play a crucial role in muscle contraction following excitation-contraction coupling.
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ACh is always cleared from the synaptic cleft by slowly diffusing away.
ACh is always cleared from the synaptic cleft by slowly diffusing away.
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Voltage-gated sodium channels (VGSCs) open in response to depolarization at the postsynaptic membrane.
Voltage-gated sodium channels (VGSCs) open in response to depolarization at the postsynaptic membrane.
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Nicotine inhibits the activation of nicotinic receptors at the neuromuscular junction.
Nicotine inhibits the activation of nicotinic receptors at the neuromuscular junction.
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Excitation-contraction coupling involves the binding of ACh at the presynaptic membrane.
Excitation-contraction coupling involves the binding of ACh at the presynaptic membrane.
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Study Notes
The Nervous System
- The nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS).
- The CNS consists of the brain and spinal cord.
- The PNS contains the sensory and motor nerves.
- Sensory nerves (afferent nerves) transmit information to the CNS.
- Motor nerves (efferent nerves) transmit information from the CNS to the body.
- The PNS is further divided into the somatic nervous system and the autonomic nervous system.
Somatic vs Autonomic Nervous System
- The somatic nervous system controls voluntary movement of skeletal muscles.
- The autonomic nervous system controls involuntary actions (e.g., heart rate, digestion, breathing).
- The autonomic nervous system is further divided into the sympathetic, parasympathetic, and enteric nervous system.
Neuron Structure
- Neurons are the structural unit of the nervous system.
- They consist of a cell body (soma), dendrites, and an axon.
- Dendrites receive input signals and transmit them to the cell body.
- The axon transmits output signals from the cell body to other neurons or target cells.
Neurotransmission
- Neurotransmission is the process of communication between neurons.
- This occurs at specialized junctions called synapses.
- Synapses can be between nerve-nerve, nerve-organ, nerve-muscle, and nerve-gland.
- The synapse between a nerve and muscle cell is called a neuromuscular junction or motor end plate.
Neurotransmitters
- Neurotransmitters are chemical messengers released by neurons to transmit signals across synapses.
- Common neurotransmitters include acetylcholine, dopamine, glutamate, noradrenaline, and GABA.
- Neurons typically release one main type of neurotransmitter.
The Chemical Synapse
- At a chemical synapse, the presynaptic neuron releases a neurotransmitter.
- The neurotransmitter diffuses across the synaptic cleft and binds to receptors on the postsynaptic cell.
- Binding of the neurotransmitter alters the postsynaptic cell's membrane potential, either depolarizing or hyperpolarizing it.
Excitatory Synapses
- Excitatory synapses depolarize the postsynaptic membrane, increasing the likelihood of an action potential.
- For example, acetylcholine (ACh) is an excitatory neurotransmitter at the neuromuscular junction.
- ACh binds to receptors on the postsynaptic cell, opening ligand-gated sodium channels and allowing an influx of Na+ ions.
- This reduces the membrane potential and can trigger an action potential.
End Plate Potential
- Muscle fibers have a resting membrane potential of -80 mV.
- When ACh binds to receptors, sodium ions enter, reducing the membrane potential and creating an end plate potential (EPP).
- The magnitude of the EPP depends on the amount and duration of ACh.
- The EPP can trigger an action potential in the muscle fiber, leading to muscle contraction.
Acetylcholinesterase (AChE)
- AChE is an enzyme that breaks down ACh in the synaptic cleft.
- It's concentrated on the external surface of the postsynaptic membrane.
- After ACh is broken down, the sodium channels close, preparing the synapse for another signal.
Neuromuscular Blocking Agents
- These drugs block the action of ACh at the neuromuscular junction, causing paralysis.
- Examples include:
- Curare: blocks ACh binding to receptors.
- Botulinum toxin: prevents the release of ACh from the presynaptic terminal.
Myasthenia Gravis
- Myasthenia gravis is a disease where the immune system attacks ACh receptors at the neuromuscular junction.
- It leads to muscle weakness and fatigue.
- It's treated with AChE inhibitors (to prolong the effect of ACh) or immunosuppressants.
Functional Classification of Neurons
- Sensory Neurons: Send information to the Central Nervous System (CNS) about the internal and external environment.
- Motor Neurons: Control bodily activity through muscle and gland functions (contraction, relaxation, secretion).
- Interneurons: Integrate information between nerves, enabling motor responses to sensory input, e.g., reflex arcs.
Synapses
- Definition: Junction between one neuron and the next cell.
- Function: Converts electrical impulses into chemical signals for communication between cells.
-
Communication Types:
- Nerve-Nerve
- Nerve-Organ / Organ-Nerve
- Nerve-Muscle
- Nerve-Gland
- Neuromuscular Junction: Synapse between nerve and muscle cells.
Neurotransmitters
- Properties: Small, rapid-acting molecules.
- Mechanism: Binding opens Na+ channels, leading to depolarization.
Graded Potentials
- Definition: Local changes in membrane potential that do not reach threshold.
-
Characteristics:
- Die out over short distances.
- Can be integrated to generate an action potential.
- Serve as long-distance signals.
- Current Flow: Occurs in small, specialized regions of excitable cell membranes.
- Magnitude: Varies directly with the magnitude of the triggering event.
Action Potentials
- Definition: Brief, rapid, large changes in membrane potential where potential reverses.
- Involvement: Small portion of the excitable cell membrane at a specific time.
- Strength: Do not decrease in strength during travel throughout the cell.
-
Process:
- Depolarization: Voltage-gated Na+ channels open, allowing Na+ influx.
- Repolarization: Voltage-gated K+ channels open, allowing K+ efflux.
- Sodium Influx: Responsible for the rapid rise in membrane potential during an action potential.
- Potassium Efflux: Responsible for the return of membrane potential to resting levels.
Nicotinic Receptors
- Location: Postsynaptic membrane of skeletal neuromuscular junction.
- Mechanism: Ionotropic receptors: ion channel is part of the receptor.
- Effect: Mediate rapid responses.
-
Types:
- NM or N1: found at the neuromuscular junction of skeletal muscles.
- Ganglion: found in the autonomic nervous system and the central nervous system.
ACh Clearance from the Synaptic Cleft
-
Mechanism:
- Breakdown by AChE: Enzyme breaks down ACh.
- Reuptake by muscle: Muscle takes up ACh when attached to the receptor.
- Diffusion: ACh slowly diffuses away.
Acetylcholinesterase (AChE)
- Location: Concentrated on the external surface of the postsynaptic membrane and the synaptic cleft.
- Function: Rapidly breaks down ACh.
- Result: Sodium channels close, clearing the field for another nerve impulse.
Neuromuscular Blocking Agents
- Effect: Inhibit ACh binding to nAChR, leading to paralysis of skeletal muscles.
-
Examples:
- Curare: Found in plants, used by South American Indians for poison darts.
- Tubocurarine: Used as a neuromuscular blocking agent.
- Mechanism: Block the nicotinic cholinergic receptors at the neuromuscular junction.
Botulinum Toxin (Botox)
- Effect: Blocks release of ACh, preventing muscle response to nerve impulses.
- Mechanism: Cleaves synaptic proteins required for vesicle release.
- Toxicity: Ingesting 0.0001 mg can be fatal.
- Treatment: Caused by improperly canned food, used to treat dystonias, spasms, and involuntary twitches.
- Cosmetic Applications: Reduces wrinkles by temporarily paralyzing muscles.
Myasthenia Gravis
- Definition: Autoimmune disease where the immune system attacks ACh receptors.
- Symptoms: Muscle weakness.
- Treatment: AChE inhibitors (neostigmine) to prolong ACh effect, immunosuppressants to suppress the immune system.
Effect of AChE Inhibitor on Neuromuscular Transmission
- Mechanism: Prevents the breakdown of ACh, leading to prolonged muscle contraction.
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Explore the fascinating world of the nervous system through this quiz. Test your knowledge on sensory and motor nerves, synapses, neurotransmitters, and the central nervous system's structure and function. Challenge yourself with questions about how different neural components interact.
