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Questions and Answers
Which of the following functions is NOT directly associated with the actions of endogenous opioids?
Which of the following functions is NOT directly associated with the actions of endogenous opioids?
Nitric oxide (NO) exerts its effects in target cells by which of the following mechanisms?
Nitric oxide (NO) exerts its effects in target cells by which of the following mechanisms?
Which of the following best describes a 'nucleus' in the context of the nervous system?
Which of the following best describes a 'nucleus' in the context of the nervous system?
What is the correct number of spinal and cranial nerve pairs in the peripheral nervous system (PNS)?
What is the correct number of spinal and cranial nerve pairs in the peripheral nervous system (PNS)?
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The limbic system is associated with a variety of functions. If a patient is experiencing difficulty in forming new memories, which area of the limbic system is MOST likely affected?
The limbic system is associated with a variety of functions. If a patient is experiencing difficulty in forming new memories, which area of the limbic system is MOST likely affected?
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Which of the following accurately describes the anatomical organization of the spinal cord?
Which of the following accurately describes the anatomical organization of the spinal cord?
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Which of the following describes the primary functional role of the afferent division of the peripheral nervous system?
Which of the following describes the primary functional role of the afferent division of the peripheral nervous system?
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The somatic nervous system and the autonomic nervous system are divisions of the efferent division of the PNS. What is the key functional distinction between them?
The somatic nervous system and the autonomic nervous system are divisions of the efferent division of the PNS. What is the key functional distinction between them?
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Which of the following accurately describes the roles of neurons and glial cells in the central nervous system (CNS)?
Which of the following accurately describes the roles of neurons and glial cells in the central nervous system (CNS)?
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How do sympathetic and parasympathetic divisions of the autonomic nervous system (ANS) differ in their functions?
How do sympathetic and parasympathetic divisions of the autonomic nervous system (ANS) differ in their functions?
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What is the functional significance of myelin in the nervous system?
What is the functional significance of myelin in the nervous system?
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Which of the following describes the arrangement of the central nervous system?
Which of the following describes the arrangement of the central nervous system?
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How do oligodendrocytes and Schwann cells contribute to the function of the nervous system?
How do oligodendrocytes and Schwann cells contribute to the function of the nervous system?
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How do axons and dendrites differ functionally in a neuron?
How do axons and dendrites differ functionally in a neuron?
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Which of the following is a primary function of Astroglia?
Which of the following is a primary function of Astroglia?
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Which of the following best describes the role of microglia cells?
Which of the following best describes the role of microglia cells?
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Which of the following scenarios would MOST effectively lead to the initiation of an action potential in a postsynaptic neuron?
Which of the following scenarios would MOST effectively lead to the initiation of an action potential in a postsynaptic neuron?
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A drug that increases synaptic effectiveness by reducing the degradation of a neurotransmitter in the synapse would MOST directly influence which process?
A drug that increases synaptic effectiveness by reducing the degradation of a neurotransmitter in the synapse would MOST directly influence which process?
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How does axo-axonal communication between neuron A and neuron B influence the synaptic communication between neuron B and neuron C?
How does axo-axonal communication between neuron A and neuron B influence the synaptic communication between neuron B and neuron C?
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Which of the following mechanisms would NOT typically result in a graded hyperpolarization of a neuron's membrane potential?
Which of the following mechanisms would NOT typically result in a graded hyperpolarization of a neuron's membrane potential?
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What is the MOST direct effect of acetylcholinesterase (AChE) on synaptic transmission?
What is the MOST direct effect of acetylcholinesterase (AChE) on synaptic transmission?
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A postsynaptic neuron receives simultaneous EPSPs and IPSPs. Which combination of ion movements would MOST likely result in the neuron reaching its threshold for firing an action potential?
A postsynaptic neuron receives simultaneous EPSPs and IPSPs. Which combination of ion movements would MOST likely result in the neuron reaching its threshold for firing an action potential?
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A researcher discovers a new drug that prevents the reuptake of a specific neurotransmitter. What is the MOST likely effect of this drug on the postsynaptic neuron?
A researcher discovers a new drug that prevents the reuptake of a specific neurotransmitter. What is the MOST likely effect of this drug on the postsynaptic neuron?
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Which of the following scenarios would MOST likely result in presynaptic inhibition?
Which of the following scenarios would MOST likely result in presynaptic inhibition?
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How does the frequency of action potentials relate to the strength of a stimulus?
How does the frequency of action potentials relate to the strength of a stimulus?
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Why is it impossible to generate a second action potential during the absolute refractory period, regardless of stimulus intensity?
Why is it impossible to generate a second action potential during the absolute refractory period, regardless of stimulus intensity?
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What is the primary mechanism by which local anesthetics prevent the generation of action potentials?
What is the primary mechanism by which local anesthetics prevent the generation of action potentials?
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In myelinated axons, action potentials propagate faster due to saltatory conduction. What is saltatory conduction?
In myelinated axons, action potentials propagate faster due to saltatory conduction. What is saltatory conduction?
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How does increasing the diameter of an axon affect the velocity of action potential propagation, and why?
How does increasing the diameter of an axon affect the velocity of action potential propagation, and why?
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How do inhibitory synapses affect the likelihood of a postsynaptic neuron firing an action potential?
How do inhibitory synapses affect the likelihood of a postsynaptic neuron firing an action potential?
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What determines the direction of action potential propagation along an axon?
What determines the direction of action potential propagation along an axon?
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Compared to unmyelinated fibers, myelinated fibers propagate action potentials at a faster rate due to:
Compared to unmyelinated fibers, myelinated fibers propagate action potentials at a faster rate due to:
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Which of the following statements accurately compares nicotinic and muscarinic acetylcholine (ACh) receptors?
Which of the following statements accurately compares nicotinic and muscarinic acetylcholine (ACh) receptors?
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What is the primary mechanism by which the concentration of catecholamines, such as norepinephrine and epinephrine, is reduced at the synapse?
What is the primary mechanism by which the concentration of catecholamines, such as norepinephrine and epinephrine, is reduced at the synapse?
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A researcher is studying the effects of a novel drug on adrenergic receptors. The drug selectively activates beta-adrenergic receptors. Which of the following effects would most likely be observed?
A researcher is studying the effects of a novel drug on adrenergic receptors. The drug selectively activates beta-adrenergic receptors. Which of the following effects would most likely be observed?
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Serotonin's role as a neuromodulator implies that its effects are typically:
Serotonin's role as a neuromodulator implies that its effects are typically:
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Which of the following neurotransmitters is synthesized from tryptophan?
Which of the following neurotransmitters is synthesized from tryptophan?
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What distinguishes neurons described as 'peptidergic' from other types of neurons?
What distinguishes neurons described as 'peptidergic' from other types of neurons?
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A patient is prescribed a drug that enhances the effects of GABA in the central nervous system. What is the likely therapeutic outcome of this medication?
A patient is prescribed a drug that enhances the effects of GABA in the central nervous system. What is the likely therapeutic outcome of this medication?
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What is the functional significance of AMPA and NMDA receptors working together in the context of learning and memory?
What is the functional significance of AMPA and NMDA receptors working together in the context of learning and memory?
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Which of the following accurately describes a key difference between the somatic and autonomic divisions of the peripheral nervous system (PNS)?
Which of the following accurately describes a key difference between the somatic and autonomic divisions of the peripheral nervous system (PNS)?
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During an emergency, the sympathetic nervous system activates various involuntary targets. Which of the following is a typical response initiated by this activation?
During an emergency, the sympathetic nervous system activates various involuntary targets. Which of the following is a typical response initiated by this activation?
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If a drug selectively blocked muscarinic receptors, which of the following physiological effects would be expected?
If a drug selectively blocked muscarinic receptors, which of the following physiological effects would be expected?
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A patient exhibits symptoms of skeletal muscle paralysis, and tests reveal an issue at the neuromuscular junction. Which receptor type is most likely affected?
A patient exhibits symptoms of skeletal muscle paralysis, and tests reveal an issue at the neuromuscular junction. Which receptor type is most likely affected?
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Cerebrospinal fluid (CSF) is crucial for brain function. What is its primary origin and major route of circulation?
Cerebrospinal fluid (CSF) is crucial for brain function. What is its primary origin and major route of circulation?
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A stroke interrupts the blood supply to a specific brain region. What immediate metabolic consequence would neurons in that region experience?
A stroke interrupts the blood supply to a specific brain region. What immediate metabolic consequence would neurons in that region experience?
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How does the blood-brain barrier protect the brain, and what critical substance is the brain absolutely dependent on from the blood supply under normal conditions?
How does the blood-brain barrier protect the brain, and what critical substance is the brain absolutely dependent on from the blood supply under normal conditions?
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Considering the anatomy of the sympathetic nervous system, what are the possible pathways a preganglionic fiber might take after entering the sympathetic trunk?
Considering the anatomy of the sympathetic nervous system, what are the possible pathways a preganglionic fiber might take after entering the sympathetic trunk?
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Flashcards
Nicotinic receptors
Nicotinic receptors
ACh receptors that are ligand-gated and allow Na+ & K+ to pass.
Muscarinic receptors
Muscarinic receptors
ACh receptors that couple with G proteins, affecting various cellular responses.
Tyrosine hydroxylase
Tyrosine hydroxylase
Enzyme responsible for the rate-limiting step in catecholamine synthesis from tyrosine.
Catecholamines
Catecholamines
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Adrenergic fibers
Adrenergic fibers
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Serotonin
Serotonin
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Excitatory amino acids
Excitatory amino acids
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Endogenous opioids
Endogenous opioids
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Threshold
Threshold
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EPSP
EPSP
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IPSP
IPSP
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Graded Depolarization
Graded Depolarization
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Axo-axonal Communication
Axo-axonal Communication
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Acetylcholine (ACh)
Acetylcholine (ACh)
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Acetylcholinesterase
Acetylcholinesterase
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Synaptic Effectiveness Drugs
Synaptic Effectiveness Drugs
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Central Nervous System (CNS)
Central Nervous System (CNS)
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Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
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Neurons
Neurons
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Glial Cells
Glial Cells
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Myelin
Myelin
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Dendrites
Dendrites
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Axons
Axons
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Types of Glia
Types of Glia
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Threshold potential
Threshold potential
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All-or-None response
All-or-None response
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Refractory period
Refractory period
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Nitric Oxide (NO)
Nitric Oxide (NO)
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Guanylyl Cyclase
Guanylyl Cyclase
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Absolute refractory period
Absolute refractory period
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Relative refractory period
Relative refractory period
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CNS
CNS
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Myelinated fibers
Myelinated fibers
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PNS
PNS
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Ganglion
Ganglion
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Synapse
Synapse
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Excitatory synapse
Excitatory synapse
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Nucleus (in CNS)
Nucleus (in CNS)
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Limbic System Functions
Limbic System Functions
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Enteric Nervous System
Enteric Nervous System
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Somatic Nervous System
Somatic Nervous System
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Autonomic Nervous System
Autonomic Nervous System
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Sympathetic Nervous System
Sympathetic Nervous System
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Parasympathetic Nervous System
Parasympathetic Nervous System
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Acetylcholine (ACh) Receptors
Acetylcholine (ACh) Receptors
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Blood-Brain Barrier
Blood-Brain Barrier
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Cerebrospinal Fluid (CSF)
Cerebrospinal Fluid (CSF)
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Study Notes
Neuronal Signaling and Structure of the Nervous System
- The central nervous system (CNS) includes the brain and spinal cord. Terminologies include tracts/pathways/commissures and nuclei.
- The peripheral nervous system (PNS) includes nerves and nerve fibers (afferent and efferent). Terminologies include nerves and ganglia.
- The CNS controls skeletal muscles, and the autonomic nervous system (ANS) controls visceral organs. The ANS is divided into sympathetic (emergency) and parasympathetic (rest & digest) divisions.
- Neurons are the basic units of the CNS, comprising 10% of the cell count and 50% of the CNS volume They generate electrical signals and are integrators.
- Glial cells (neuroglia) support neurons, physically and metabolically. Account for 90% of CNS cells. Form myelin. Regulate extracellular fluid (ECF) composition in CNS. Contribute to the blood-brain barrier (BBB). Provide fuel (glucose) to neurons and remove waste (ammonia). Play a potential role in information signaling. Support immune defense in CNS. Regulate cerebrospinal fluid (CSF) production and flow. Support embryonic cells and are a source of growth factors.
- Types of Glia in CNS: Oligodendrocytes (myelin-forming cells). Astroglia (metabolically support neurons). Microglia (serve immune function).
- Types of Glia in PNS: Schwann cells (myelin-forming).
- Dendrites receive information, typically neurotransmitters, and undergo graded potentials.
- Axons undergo action potentials to deliver information, typically neurotransmitters, from the axon terminals.
- Myelinated neurons conduct action potentials most rapidly. Myelin sheath is a collection of Schwann cells and oligodendrocytes associated with the neuron.
- Axonal Transport: Important for maintenance of axonal structure and function. Involves transport of material between soma and axon terminal. Carried out by microtubules and motor proteins (kinesins & dyneins). Consists of anterograde (kinasin-powered) and retrograde (dynein-powered) types.
- Functional Classes of Neurons: Afferent neurons transmit information from tissues/organs to the CNS. Efferent neurons transmit information from the CNS to effector cells. Interneurons are the majority of neuron types, transmitting information within the CNS.
- Sensory receptors are specialized portions of the cell membrane or specialized cell types associated with afferent neurons.
- Neural pathways have long axons between brain regions/spinal cord with few synapses, leading to minimal information processing. Multineural (multisynaptic) pathways utilize many synapses, leading to significant information processing alterations.
- Neural development involves generation, axonal guidance, synapse formation, and fine-tuning of synapses.
- Axonal generation takes place primarily before birth.
- Axonal regeneration can occur outside the CNS.
- Membrane potentials in excitable cells: Basic principles of electricity. Resting membrane potential.
- Factors that determine resting membrane potential involve passive (electrochemical gradients) and active (membrane pumps) forces
- Active factors, such as the Na+/K+-pump, counteract passive forces.
- Action potentials, which involve transient changes in transmembrane potential, signify rapid alterations in membrane potential. They are important for long-distance communication, mainly mediated by voltage-gated Na+ & K+ channels.
- Voltage-gated Na+ channels open rapidly during depolarization, allowing rapid Na+ entry. Voltage-gated K+ channels open more slowly, causing K+ exit and repolarization.
- Refractory periods limit the frequency of action potential generation.
- Factors determining action potential propagation velocity include fiber diameter and myelination.
Synapses
- Synapses are anatomically specialized junctions in the CNS. Synapses can increase/decrease the likelihood of postsynaptic neuron action potentials by eliciting graded potentials.
- Excitatory synapses bring postsynaptic neuron membrane potential closer to threshold.
- Inhibitory synapses drive postsynaptic neuron membrane potential farther from threshold or stabilize at its present level.
- Types of Synapses: Electrical synapse – signals are transmitted via gap junctions, leading to rapid communication but being rare in the mammalian nervous system. Chemical synapse – signals are transmitted by chemical messengers (neurotransmitters).
- Presynaptic neuron releases neurotransmitters into the synaptic cleft.
- Postsynaptic neuron receives neurotransmitters, leading to changes in ion permeability.
- Removal of neurotransmitters from the synaptic cleft terminates the response of the postsynaptic cell, including active transport back into the axon terminal, diffusion away from the synapse, or transformation by enzymes into ineffective substances.
- An excitatory postsynaptic potential (EPSP) is a graded depolarization that moves the membrane potential closer to the threshold for an action potential. An inhibitory postsynaptic potential (IPSP) is a graded hyperpolarization that moves the membrane potential further from the threshold.
- The level of postsynaptic cell excitability is determined by the number of active synapses and the type of active synapses.
- Axo-axonal communication can modify synaptic communication, resulting in either presynaptic inhibition or facilitation.
- Several factors determine synaptic strength in terms of presynaptic, postsynaptic and general factors.
Brain Blood Supply & the Blood Brain Barrier
- Glucose is the sole brain energy substrate. Blood supply is vital for glucose and oxygen to brain; cessation results in neuron death, known as stroke
- The blood-brain barrier (formed by tightly sealed endothelial cells of brain capillaries) regulates the brain extracellular fluid (ECF) chemical composition and minimizes harmful substance access.
Divisions of the Peripheral Nervous System (PNS)
- The PNS is divided into afferent and efferent divisions.
- The somatic nervous system consists of a single neuron connecting the CNS to skeletal muscles, causing excitation.
- The autonomic nervous system has a two-neuron chain connecting the CNS to smooth and cardiac muscles, glands, and GI neurons. This system can mediate excitation or inhibition.
- Afferent division conveys sensory information from the periphery and internal organs to the CNS.
- The autonomic nervous system (ANS) is part of the efferent division, innervating smooth muscle, cardiac muscle, glands, and GI neurons.
- The ANS has 3 subdivisions:
- The sympathetic nervous system involves energy expenditure and reaction to emergencies.
- The parasympathetic nervous system facilitates rest and digestion.
- The enteric nervous system controls the gastrointestinal system.
Ventricular System & Cerebrospinal Fluid (CSF)
- The ventricular system is a network of interconnected cavities filled with CSF.
- The CSF is a filtrate of the blood that flows through the ventricles and spinal cord before being absorbed back into the blood.
The Brain
- The four interconnected ventricles of the brain are fluid-filled cavities.
- The brain is segmented into several parts with specific functions, including the cerebral cortex, thalamus, hypothalamus, and limbic system. The four main lobes of the cerebral cortex are frontal, parietal, temporal, and occipital lobes. The layers of the cerebral cortex integrate afferent and efferent signals.
Spinal cord
- The spinal cord is a component of the central nervous system. (CNS) with two main types of neurons (afferent & efferent).
- Afferent neurons carry sensory information, and efferent neurons carry motor commands.
Cranial Nerves
- Cranial nerves are part of the peripheral nervous system (PNS) connecting the brain to the head and neck.
- They perform various functions, including sensory perception, motor control, and glandular secretion.
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Description
Test your knowledge of the nervous system. Questions cover the functions of endogenous opioids, nitric oxide, nuclei, spinal and cranial nerves. Also includes the the limbic system, spinal cord and divisions of the peripheral nervous system.