Nervous System Anatomy and Function
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Questions and Answers

Which of the following functions is NOT directly associated with the actions of endogenous opioids?

  • Control of appetite and thirst.
  • Regulation of electrolyte balance in kidneys. (correct)
  • Modulation of the cardiovascular system.
  • Regulation of mood and emotions.
  • Nitric oxide (NO) exerts its effects in target cells by which of the following mechanisms?

  • Inhibiting adenylate cyclase, reducing cAMP production.
  • Directly binding to ligand-gated ion channels.
  • Stimulating the release of calcium from intracellular stores.
  • Activating guanylyl cyclase, leading to increased cGMP levels. (correct)
  • Which of the following best describes a 'nucleus' in the context of the nervous system?

  • A pathway of axons connecting different regions of the brain.
  • A group of neuron cell bodies clustered together in the central nervous system. (correct)
  • A bundle of nerve fibers in the peripheral nervous system.
  • A collection of ganglia located near the spinal cord.
  • What is the correct number of spinal and cranial nerve pairs in the peripheral nervous system (PNS)?

    <p>31 spinal nerve pairs and 12 cranial nerve pairs. (D)</p> Signup and view all the answers

    The limbic system is associated with a variety of functions. If a patient is experiencing difficulty in forming new memories, which area of the limbic system is MOST likely affected?

    <p>Hippocampus (C)</p> Signup and view all the answers

    Which of the following accurately describes the anatomical organization of the spinal cord?

    <p>Cervical, thoracic, lumbar, and sacral regions, arranged from superior to inferior. (A)</p> Signup and view all the answers

    Which of the following describes the primary functional role of the afferent division of the peripheral nervous system?

    <p>Carrying sensory information from the body to the CNS. (B)</p> Signup and view all the answers

    The somatic nervous system and the autonomic nervous system are divisions of the efferent division of the PNS. What is the key functional distinction between them?

    <p>Options A and C (C)</p> Signup and view all the answers

    Which of the following accurately describes the roles of neurons and glial cells in the central nervous system (CNS)?

    <p>Neurons generate electrical signals for communication, while glial cells support neurons and regulate the ECF composition. (D)</p> Signup and view all the answers

    How do sympathetic and parasympathetic divisions of the autonomic nervous system (ANS) differ in their functions?

    <p>The sympathetic division prepares the body for emergency situations, while the parasympathetic division is dominant during 'rest and digest.' (A)</p> Signup and view all the answers

    What is the functional significance of myelin in the nervous system?

    <p>Myelin insulates axons, increasing the speed of action potentials. (D)</p> Signup and view all the answers

    Which of the following describes the arrangement of the central nervous system?

    <p>Brain and spinal cord (C)</p> Signup and view all the answers

    How do oligodendrocytes and Schwann cells contribute to the function of the nervous system?

    <p>Oligodendrocytes form myelin in the CNS, while Schwann cells form myelin in the PNS. (A)</p> Signup and view all the answers

    How do axons and dendrites differ functionally in a neuron?

    <p>Axons deliver information, and dendrites receive information. (C)</p> Signup and view all the answers

    Which of the following is a primary function of Astroglia?

    <p>Supporting neurons metabolically (D)</p> Signup and view all the answers

    Which of the following best describes the role of microglia cells?

    <p>Serving immune function (B)</p> Signup and view all the answers

    Which of the following scenarios would MOST effectively lead to the initiation of an action potential in a postsynaptic neuron?

    <p>Numerous EPSPs from various presynaptic terminals causing a total depolarization of 15 mV at the initial segment. (A)</p> Signup and view all the answers

    A drug that increases synaptic effectiveness by reducing the degradation of a neurotransmitter in the synapse would MOST directly influence which process?

    <p>The duration of the neurotransmitter's action on the postsynaptic receptors. (C)</p> Signup and view all the answers

    How does axo-axonal communication between neuron A and neuron B influence the synaptic communication between neuron B and neuron C?

    <p>By modifying the amount of neurotransmitter released from neuron B, leading to either presynaptic inhibition or facilitation at the synapse with neuron C. (C)</p> Signup and view all the answers

    Which of the following mechanisms would NOT typically result in a graded hyperpolarization of a neuron's membrane potential?

    <p>Inward movement of sodium ions (Na+). (B)</p> Signup and view all the answers

    What is the MOST direct effect of acetylcholinesterase (AChE) on synaptic transmission?

    <p>It breaks down ACh in the synaptic cleft, reducing its availability to bind to postsynaptic receptors. (A)</p> Signup and view all the answers

    A postsynaptic neuron receives simultaneous EPSPs and IPSPs. Which combination of ion movements would MOST likely result in the neuron reaching its threshold for firing an action potential?

    <p>Large Na+ influx and minimal K+ efflux. (B)</p> Signup and view all the answers

    A researcher discovers a new drug that prevents the reuptake of a specific neurotransmitter. What is the MOST likely effect of this drug on the postsynaptic neuron?

    <p>Prolonged stimulation due to increased neurotransmitter concentration in the synapse. (A)</p> Signup and view all the answers

    Which of the following scenarios would MOST likely result in presynaptic inhibition?

    <p>Neuron A releasing a neurotransmitter that blocks voltage-gated calcium channels on neuron B's axon terminal, reducing neurotransmitter release onto neuron C. (C)</p> Signup and view all the answers

    How does the frequency of action potentials relate to the strength of a stimulus?

    <p>A stronger stimulus results in a higher frequency of action potentials. (B)</p> Signup and view all the answers

    Why is it impossible to generate a second action potential during the absolute refractory period, regardless of stimulus intensity?

    <p>Voltage-gated $Na^+$ channels are inactivated and cannot be opened until the membrane potential is repolarized. (A)</p> Signup and view all the answers

    What is the primary mechanism by which local anesthetics prevent the generation of action potentials?

    <p>They block voltage-gated $Na^+$ channels, preventing depolarization. (C)</p> Signup and view all the answers

    In myelinated axons, action potentials propagate faster due to saltatory conduction. What is saltatory conduction?

    <p>Passive spread of depolarization under the myelin sheath, with action potentials generated only at the Nodes of Ranvier. (A)</p> Signup and view all the answers

    How does increasing the diameter of an axon affect the velocity of action potential propagation, and why?

    <p>Increases velocity, due to decreased axial resistance. (D)</p> Signup and view all the answers

    How do inhibitory synapses affect the likelihood of a postsynaptic neuron firing an action potential?

    <p>They drive the membrane potential farther from the threshold, decreasing the likelihood. (C)</p> Signup and view all the answers

    What determines the direction of action potential propagation along an axon?

    <p>Refractory periods of the membrane. (D)</p> Signup and view all the answers

    Compared to unmyelinated fibers, myelinated fibers propagate action potentials at a faster rate due to:

    <p>The ability to skip sections of the axon via saltatory conduction. (D)</p> Signup and view all the answers

    Which of the following statements accurately compares nicotinic and muscarinic acetylcholine (ACh) receptors?

    <p>Nicotinic receptors are permeable to both $Na^+$ and $K^+$, while muscarinic receptors primarily affect intracellular signaling cascades via G proteins. (C)</p> Signup and view all the answers

    What is the primary mechanism by which the concentration of catecholamines, such as norepinephrine and epinephrine, is reduced at the synapse?

    <p>Active reuptake by the axon terminal and enzymatic degradation (A)</p> Signup and view all the answers

    A researcher is studying the effects of a novel drug on adrenergic receptors. The drug selectively activates beta-adrenergic receptors. Which of the following effects would most likely be observed?

    <p>Increased heart rate and bronchodilation. (C)</p> Signup and view all the answers

    Serotonin's role as a neuromodulator implies that its effects are typically:

    <p>Slow in onset and diffuse, influencing multiple neural circuits. (A)</p> Signup and view all the answers

    Which of the following neurotransmitters is synthesized from tryptophan?

    <p>Serotonin (B)</p> Signup and view all the answers

    What distinguishes neurons described as 'peptidergic' from other types of neurons?

    <p>They release one or more neuropeptides, often alongside other neurotransmitters. (D)</p> Signup and view all the answers

    A patient is prescribed a drug that enhances the effects of GABA in the central nervous system. What is the likely therapeutic outcome of this medication?

    <p>Reduced anxiety and muscle relaxation. (D)</p> Signup and view all the answers

    What is the functional significance of AMPA and NMDA receptors working together in the context of learning and memory?

    <p>They mediate long-term potentiation (LTP), a cellular mechanism underlying learning and memory. (A)</p> Signup and view all the answers

    Which of the following accurately describes a key difference between the somatic and autonomic divisions of the peripheral nervous system (PNS)?

    <p>The somatic division controls voluntary movements and always leads to excitation, while the autonomic division can be either excitatory or inhibitory and innervates involuntary targets. (C)</p> Signup and view all the answers

    During an emergency, the sympathetic nervous system activates various involuntary targets. Which of the following is a typical response initiated by this activation?

    <p>Release of glucose to provide more energy. (B)</p> Signup and view all the answers

    If a drug selectively blocked muscarinic receptors, which of the following physiological effects would be expected?

    <p>Reduced gland secretion. (B)</p> Signup and view all the answers

    A patient exhibits symptoms of skeletal muscle paralysis, and tests reveal an issue at the neuromuscular junction. Which receptor type is most likely affected?

    <p>Nicotinic receptors. (D)</p> Signup and view all the answers

    Cerebrospinal fluid (CSF) is crucial for brain function. What is its primary origin and major route of circulation?

    <p>A filtrate of the blood, circulating through the ventricles and spinal cord before being reabsorbed. (D)</p> Signup and view all the answers

    A stroke interrupts the blood supply to a specific brain region. What immediate metabolic consequence would neurons in that region experience?

    <p>Cessation of function and eventual cell death due to lack of glucose and oxygen. (A)</p> Signup and view all the answers

    How does the blood-brain barrier protect the brain, and what critical substance is the brain absolutely dependent on from the blood supply under normal conditions?

    <p>It selectively allows essential nutrients to enter, while the brain depends on a constant supply of glucose. (B)</p> Signup and view all the answers

    Considering the anatomy of the sympathetic nervous system, what are the possible pathways a preganglionic fiber might take after entering the sympathetic trunk?

    <p>Synapse with a postganglionic neuron within the trunk at the same level, ascend or descend within the trunk to synapse at another level, or pass through the trunk to synapse in a collateral ganglion. (C)</p> Signup and view all the answers

    Flashcards

    Nicotinic receptors

    ACh receptors that are ligand-gated and allow Na+ & K+ to pass.

    Muscarinic receptors

    ACh receptors that couple with G proteins, affecting various cellular responses.

    Tyrosine hydroxylase

    Enzyme responsible for the rate-limiting step in catecholamine synthesis from tyrosine.

    Catecholamines

    Neurotransmitters made from tyrosine including dopamine, norepinephrine, and epinephrine.

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    Adrenergic fibers

    Neurons that release epinephrine (E) or norepinephrine (NE).

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    Serotonin

    A neuromodulator made from tryptophan, involved in mood and sleep regulation.

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    Excitatory amino acids

    Glutamate and aspartate, the major excitatory neurotransmitters in the CNS.

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    Endogenous opioids

    Neuropeptides like endorphins that bind to opioid receptors, providing pain relief.

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    Threshold

    Minimum depolarization needed to trigger an action potential.

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    EPSP

    Excitatory postsynaptic potential; causes depolarization in neurons.

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    IPSP

    Inhibitory postsynaptic potential; causes hyperpolarization in neurons.

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    Graded Depolarization

    A gradual increase in membrane potential toward the action potential threshold.

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    Axo-axonal Communication

    Interaction between axons that can enhance or inhibit synaptic transmission.

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    Acetylcholine (ACh)

    A major neurotransmitter in the PNS involved in muscle activation.

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    Acetylcholinesterase

    Enzyme that breaks down ACh in the synapse to terminate its action.

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    Synaptic Effectiveness Drugs

    Substances that alter neurotransmitter release or breakdown at synapses.

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    Central Nervous System (CNS)

    The brain and spinal cord, responsible for processing information.

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    Peripheral Nervous System (PNS)

    Nerves and nerve fibers that connect the CNS to the rest of the body.

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    Neurons

    Basic units of the nervous system that generate and transmit electrical signals.

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    Glial Cells

    Support cells in the CNS that assist and protect neurons, making up 90% of CNS cells.

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    Myelin

    A fatty substance formed by oligodendrocytes and Schwann cells that insulates axons and speeds up signal transmission.

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    Dendrites

    Part of a neuron that receives signals from other neurons.

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    Axons

    Long projections of neurons that carry action potentials away from the cell body.

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    Types of Glia

    CNS: Oligodendrocytes, Astroglia, Microglia; PNS: Schwann cells.

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    Threshold potential

    The membrane potential needed to trigger an action potential, typically about 15mV less negative than resting potential.

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    All-or-None response

    Action potentials either occur fully or not at all; there is no partial action potential.

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    Refractory period

    The period during which a second action potential cannot be generated, crucial for recovery.

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    Nitric Oxide (NO)

    A gas that acts as a neurotransmitter, influencing blood flow and neural signaling.

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    Guanylyl Cyclase

    An enzyme activated by NO that produces cGMP, influencing various cellular functions.

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    Absolute refractory period

    The time during an action potential when no second action potential can occur, regardless of stimulus strength.

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    Relative refractory period

    A brief period after the absolute refractory period when a stronger stimulus can trigger a second action potential.

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    CNS

    Central Nervous System, consisting of the brain and spinal cord.

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    Myelinated fibers

    Nerve fibers covered with myelin, allowing faster propagation of action potentials via saltatory conduction.

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    PNS

    Peripheral Nervous System, which includes spinal and cranial nerves.

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    Ganglion

    A cluster of neuron cell bodies in the PNS, acting as relay points.

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    Synapse

    A specialized junction where neurons communicate; can excite or inhibit postsynaptic neurons.

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    Excitatory synapse

    A type of synapse that increases the likelihood of an action potential in the postsynaptic neuron.

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    Nucleus (in CNS)

    A group of neuron cell bodies located in the CNS, involved in processing information.

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    Limbic System Functions

    Involved in emotion, learning, appetite, sex, and endocrine integration.

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    Enteric Nervous System

    Part of the autonomic nervous system that controls gastrointestinal functions.

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    Somatic Nervous System

    Controls voluntary movements via single neurons from the CNS to skeletal muscles.

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    Autonomic Nervous System

    Regulates involuntary actions through a two-neuron chain to effector organs.

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    Sympathetic Nervous System

    Part of the autonomic system that prepares the body for 'fight or flight' responses.

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    Parasympathetic Nervous System

    Part of the autonomic system that promotes 'rest and digest' functions.

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    Acetylcholine (ACh) Receptors

    Receptors for ACh include nicotinic and muscarinic types affecting muscles and neurons.

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    Blood-Brain Barrier

    A selective permeability barrier that protects the brain from potentially harmful substances in the blood.

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    Cerebrospinal Fluid (CSF)

    Fluid that cushions the brain, flows through ventricles and spinal cord, and is reabsorbed into blood.

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    Study Notes

    Neuronal Signaling and Structure of the Nervous System

    • The central nervous system (CNS) includes the brain and spinal cord. Terminologies include tracts/pathways/commissures and nuclei.
    • The peripheral nervous system (PNS) includes nerves and nerve fibers (afferent and efferent). Terminologies include nerves and ganglia.
    • The CNS controls skeletal muscles, and the autonomic nervous system (ANS) controls visceral organs. The ANS is divided into sympathetic (emergency) and parasympathetic (rest & digest) divisions.
    • Neurons are the basic units of the CNS, comprising 10% of the cell count and 50% of the CNS volume They generate electrical signals and are integrators.
    • Glial cells (neuroglia) support neurons, physically and metabolically. Account for 90% of CNS cells. Form myelin. Regulate extracellular fluid (ECF) composition in CNS. Contribute to the blood-brain barrier (BBB). Provide fuel (glucose) to neurons and remove waste (ammonia). Play a potential role in information signaling. Support immune defense in CNS. Regulate cerebrospinal fluid (CSF) production and flow. Support embryonic cells and are a source of growth factors.
    • Types of Glia in CNS: Oligodendrocytes (myelin-forming cells). Astroglia (metabolically support neurons). Microglia (serve immune function).
    • Types of Glia in PNS: Schwann cells (myelin-forming).
    • Dendrites receive information, typically neurotransmitters, and undergo graded potentials.
    • Axons undergo action potentials to deliver information, typically neurotransmitters, from the axon terminals.
    • Myelinated neurons conduct action potentials most rapidly. Myelin sheath is a collection of Schwann cells and oligodendrocytes associated with the neuron.
    • Axonal Transport: Important for maintenance of axonal structure and function. Involves transport of material between soma and axon terminal. Carried out by microtubules and motor proteins (kinesins & dyneins). Consists of anterograde (kinasin-powered) and retrograde (dynein-powered) types.
    • Functional Classes of Neurons: Afferent neurons transmit information from tissues/organs to the CNS. Efferent neurons transmit information from the CNS to effector cells. Interneurons are the majority of neuron types, transmitting information within the CNS.
    • Sensory receptors are specialized portions of the cell membrane or specialized cell types associated with afferent neurons.
    • Neural pathways have long axons between brain regions/spinal cord with few synapses, leading to minimal information processing. Multineural (multisynaptic) pathways utilize many synapses, leading to significant information processing alterations.
    • Neural development involves generation, axonal guidance, synapse formation, and fine-tuning of synapses.
    • Axonal generation takes place primarily before birth.
    • Axonal regeneration can occur outside the CNS.
    • Membrane potentials in excitable cells: Basic principles of electricity. Resting membrane potential.
    • Factors that determine resting membrane potential involve passive (electrochemical gradients) and active (membrane pumps) forces
    • Active factors, such as the Na+/K+-pump, counteract passive forces.
    • Action potentials, which involve transient changes in transmembrane potential, signify rapid alterations in membrane potential. They are important for long-distance communication, mainly mediated by voltage-gated Na+ & K+ channels.
    • Voltage-gated Na+ channels open rapidly during depolarization, allowing rapid Na+ entry. Voltage-gated K+ channels open more slowly, causing K+ exit and repolarization.
    • Refractory periods limit the frequency of action potential generation.
    • Factors determining action potential propagation velocity include fiber diameter and myelination.

    Synapses

    • Synapses are anatomically specialized junctions in the CNS. Synapses can increase/decrease the likelihood of postsynaptic neuron action potentials by eliciting graded potentials.
    • Excitatory synapses bring postsynaptic neuron membrane potential closer to threshold.
    • Inhibitory synapses drive postsynaptic neuron membrane potential farther from threshold or stabilize at its present level.
    • Types of Synapses: Electrical synapse – signals are transmitted via gap junctions, leading to rapid communication but being rare in the mammalian nervous system. Chemical synapse – signals are transmitted by chemical messengers (neurotransmitters).
    • Presynaptic neuron releases neurotransmitters into the synaptic cleft.
    • Postsynaptic neuron receives neurotransmitters, leading to changes in ion permeability.
    • Removal of neurotransmitters from the synaptic cleft terminates the response of the postsynaptic cell, including active transport back into the axon terminal, diffusion away from the synapse, or transformation by enzymes into ineffective substances.
    • An excitatory postsynaptic potential (EPSP) is a graded depolarization that moves the membrane potential closer to the threshold for an action potential. An inhibitory postsynaptic potential (IPSP) is a graded hyperpolarization that moves the membrane potential further from the threshold.
    • The level of postsynaptic cell excitability is determined by the number of active synapses and the type of active synapses.
    • Axo-axonal communication can modify synaptic communication, resulting in either presynaptic inhibition or facilitation.
    • Several factors determine synaptic strength in terms of presynaptic, postsynaptic and general factors.

    Brain Blood Supply & the Blood Brain Barrier

    • Glucose is the sole brain energy substrate. Blood supply is vital for glucose and oxygen to brain; cessation results in neuron death, known as stroke
    • The blood-brain barrier (formed by tightly sealed endothelial cells of brain capillaries) regulates the brain extracellular fluid (ECF) chemical composition and minimizes harmful substance access.

    Divisions of the Peripheral Nervous System (PNS)

    • The PNS is divided into afferent and efferent divisions.
    • The somatic nervous system consists of a single neuron connecting the CNS to skeletal muscles, causing excitation.
    • The autonomic nervous system has a two-neuron chain connecting the CNS to smooth and cardiac muscles, glands, and GI neurons. This system can mediate excitation or inhibition.
    • Afferent division conveys sensory information from the periphery and internal organs to the CNS.
    • The autonomic nervous system (ANS) is part of the efferent division, innervating smooth muscle, cardiac muscle, glands, and GI neurons.
    • The ANS has 3 subdivisions:
    • The sympathetic nervous system involves energy expenditure and reaction to emergencies.
    • The parasympathetic nervous system facilitates rest and digestion.
    • The enteric nervous system controls the gastrointestinal system.

    Ventricular System & Cerebrospinal Fluid (CSF)

    • The ventricular system is a network of interconnected cavities filled with CSF.
    • The CSF is a filtrate of the blood that flows through the ventricles and spinal cord before being absorbed back into the blood.

    The Brain

    • The four interconnected ventricles of the brain are fluid-filled cavities.
    • The brain is segmented into several parts with specific functions, including the cerebral cortex, thalamus, hypothalamus, and limbic system. The four main lobes of the cerebral cortex are frontal, parietal, temporal, and occipital lobes. The layers of the cerebral cortex integrate afferent and efferent signals.

    Spinal cord

    • The spinal cord is a component of the central nervous system. (CNS) with two main types of neurons (afferent & efferent).
    • Afferent neurons carry sensory information, and efferent neurons carry motor commands.

    Cranial Nerves

    • Cranial nerves are part of the peripheral nervous system (PNS) connecting the brain to the head and neck.
    • They perform various functions, including sensory perception, motor control, and glandular secretion.

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    Test your knowledge of the nervous system. Questions cover the functions of endogenous opioids, nitric oxide, nuclei, spinal and cranial nerves. Also includes the the limbic system, spinal cord and divisions of the peripheral nervous system.

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