Podcast
Questions and Answers
What is the primary cause of nephrotic syndrome in children aged 1-7 years old?
What is the primary cause of nephrotic syndrome in children aged 1-7 years old?
Which condition is characterized by an injury to podocytes leading to nephrotic syndrome?
Which condition is characterized by an injury to podocytes leading to nephrotic syndrome?
Which of the following is not a clinical feature related to nephritic syndrome?
Which of the following is not a clinical feature related to nephritic syndrome?
What is a common feature of Focal Segmental Glomerulosclerosis?
What is a common feature of Focal Segmental Glomerulosclerosis?
Signup and view all the answers
What percentage of nephrotic syndrome cases does Focal Segmental Glomerulosclerosis account for?
What percentage of nephrotic syndrome cases does Focal Segmental Glomerulosclerosis account for?
Signup and view all the answers
What mechanism primarily causes azotemia in nephritic syndrome?
What mechanism primarily causes azotemia in nephritic syndrome?
Signup and view all the answers
Which of the following is true about the renal function in cases of Minimal-Change Disease?
Which of the following is true about the renal function in cases of Minimal-Change Disease?
Signup and view all the answers
What is the primary treatment method for Minimal-Change Disease?
What is the primary treatment method for Minimal-Change Disease?
Signup and view all the answers
What are the main functions of the kidneys?
What are the main functions of the kidneys?
Signup and view all the answers
What are the two main clinical manifestations of glomerular diseases?
What are the two main clinical manifestations of glomerular diseases?
Signup and view all the answers
Which component of the glomerulus is responsible for forming a fenestrated endothelium?
Which component of the glomerulus is responsible for forming a fenestrated endothelium?
Signup and view all the answers
Which of the following is NOT a characteristic of nephrotic syndrome?
Which of the following is NOT a characteristic of nephrotic syndrome?
Signup and view all the answers
What causes the increased permeability to plasma proteins seen in nephrotic syndrome?
What causes the increased permeability to plasma proteins seen in nephrotic syndrome?
Signup and view all the answers
Which of the following indicates the presence of nephritic syndrome?
Which of the following indicates the presence of nephritic syndrome?
Signup and view all the answers
What do podocytes in the glomerulus do?
What do podocytes in the glomerulus do?
Signup and view all the answers
Which condition is associated with an increase in lipids in the blood?
Which condition is associated with an increase in lipids in the blood?
Signup and view all the answers
What is the most common type of kidney stone, accounting for 80% of cases?
What is the most common type of kidney stone, accounting for 80% of cases?
Signup and view all the answers
Which condition increases the risk of uric acid stone formation?
Which condition increases the risk of uric acid stone formation?
Signup and view all the answers
What percentage of individuals with urolithiasis may develop stones without any symptoms?
What percentage of individuals with urolithiasis may develop stones without any symptoms?
Signup and view all the answers
What urine pH level is typically associated with the formation of uric acid stones?
What urine pH level is typically associated with the formation of uric acid stones?
Signup and view all the answers
What factor does NOT contribute to the development of struvite stones?
What factor does NOT contribute to the development of struvite stones?
Signup and view all the answers
What is the primary characteristic of Membranous Nephropathy as observed under a light microscope?
What is the primary characteristic of Membranous Nephropathy as observed under a light microscope?
Signup and view all the answers
Which percentage of Membranous Nephropathy cases are classified as primary?
Which percentage of Membranous Nephropathy cases are classified as primary?
Signup and view all the answers
What is the typical initial event associated with hematuria in the context described?
What is the typical initial event associated with hematuria in the context described?
Signup and view all the answers
What is a notable clinical feature of Poststreptococcal Glomerulonephritis (PSGN)?
What is a notable clinical feature of Poststreptococcal Glomerulonephritis (PSGN)?
Signup and view all the answers
What percentage of cases may progress to end-stage renal disease within 20 years?
What percentage of cases may progress to end-stage renal disease within 20 years?
Signup and view all the answers
What triggers the podocyte injury in Membranous Nephropathy?
What triggers the podocyte injury in Membranous Nephropathy?
Signup and view all the answers
Which symptom is commonly associated with acute pyelonephritis?
Which symptom is commonly associated with acute pyelonephritis?
Signup and view all the answers
Which demographic is most commonly affected by IgA Nephropathy?
Which demographic is most commonly affected by IgA Nephropathy?
Signup and view all the answers
What is a common characteristic of simple cysts in the kidney?
What is a common characteristic of simple cysts in the kidney?
Signup and view all the answers
What is the typical age by which Polycystic Kidney Disease (PKD) usually produces symptoms?
What is the typical age by which Polycystic Kidney Disease (PKD) usually produces symptoms?
Signup and view all the answers
What is the underlying issue leading to immune complex formation in IgA Nephropathy?
What is the underlying issue leading to immune complex formation in IgA Nephropathy?
Signup and view all the answers
Which of the following clinical features is NOT typically associated with Membranous Nephropathy?
Which of the following clinical features is NOT typically associated with Membranous Nephropathy?
Signup and view all the answers
What is the most common type of renal stones formed in the urinary system?
What is the most common type of renal stones formed in the urinary system?
Signup and view all the answers
Which of the following is a risk factor for acute pyelonephritis?
Which of the following is a risk factor for acute pyelonephritis?
Signup and view all the answers
What is the primary type of immune complex involved in the pathogenesis of PSGN?
What is the primary type of immune complex involved in the pathogenesis of PSGN?
Signup and view all the answers
What is a significant outcome of Polycystic Kidney Disease?
What is a significant outcome of Polycystic Kidney Disease?
Signup and view all the answers
Flashcards
What is a nephron?
What is a nephron?
The functional and structural unit of the kidney, responsible for filtering waste products from the blood and producing urine.
What is a glomerulus?
What is a glomerulus?
A network of capillaries surrounded by two layers of epithelium in the kidney, responsible for filtering blood.
What are podocytes?
What are podocytes?
Cells that form the visceral layer of the glomerular capsule, responsible for filtering blood.
What is nephrotic syndrome?
What is nephrotic syndrome?
Signup and view all the flashcards
What is nephritic syndrome?
What is nephritic syndrome?
Signup and view all the flashcards
What is glomerulonephritis?
What is glomerulonephritis?
Signup and view all the flashcards
What is chronic kidney disease?
What is chronic kidney disease?
Signup and view all the flashcards
What is kidney failure?
What is kidney failure?
Signup and view all the flashcards
Azotemia
Azotemia
Signup and view all the flashcards
Oliguria
Oliguria
Signup and view all the flashcards
Nephritic Syndrome
Nephritic Syndrome
Signup and view all the flashcards
Primary Glomerular Disease
Primary Glomerular Disease
Signup and view all the flashcards
Secondary Glomerular Disease
Secondary Glomerular Disease
Signup and view all the flashcards
Minimal-Change Disease (MCD)
Minimal-Change Disease (MCD)
Signup and view all the flashcards
Focal Segmental Glomerulosclerosis (FSGS)
Focal Segmental Glomerulosclerosis (FSGS)
Signup and view all the flashcards
Primary FSGS
Primary FSGS
Signup and view all the flashcards
Membranous Nephropathy (MN)
Membranous Nephropathy (MN)
Signup and view all the flashcards
Spike and dome pattern
Spike and dome pattern
Signup and view all the flashcards
Primary Membranous Nephropathy
Primary Membranous Nephropathy
Signup and view all the flashcards
Secondary Membranous Nephropathy
Secondary Membranous Nephropathy
Signup and view all the flashcards
Poststreptococcal Glomerulonephritis (PSGN)
Poststreptococcal Glomerulonephritis (PSGN)
Signup and view all the flashcards
Abnormally glycosylated IgA1
Abnormally glycosylated IgA1
Signup and view all the flashcards
IgA Nephropathy
IgA Nephropathy
Signup and view all the flashcards
Recurrent hematuria
Recurrent hematuria
Signup and view all the flashcards
What is Urolithiasis?
What is Urolithiasis?
Signup and view all the flashcards
What is the main cause of kidney stones?
What is the main cause of kidney stones?
Signup and view all the flashcards
What is hypercalciuria?
What is hypercalciuria?
Signup and view all the flashcards
What are Struvite stones?
What are Struvite stones?
Signup and view all the flashcards
What are Uric Acid stones?
What are Uric Acid stones?
Signup and view all the flashcards
Acute Pyelonephritis
Acute Pyelonephritis
Signup and view all the flashcards
Simple Kidney Cysts
Simple Kidney Cysts
Signup and view all the flashcards
Adult Polycystic Kidney Disease (PKD)
Adult Polycystic Kidney Disease (PKD)
Signup and view all the flashcards
Renal Stones (Urolithiasis)
Renal Stones (Urolithiasis)
Signup and view all the flashcards
Calcium Oxalate Kidney Stone
Calcium Oxalate Kidney Stone
Signup and view all the flashcards
Urinary Outflow Obstruction
Urinary Outflow Obstruction
Signup and view all the flashcards
Kidney Failure
Kidney Failure
Signup and view all the flashcards
Study Notes
Kidney Pathology
- Kidneys are bean-shaped organs with multiple functions
- Key functions include: waste excretion (urea, uric acid, bilirubin), water and salt regulation (normal range PH 7.35-7.45), acid balance maintenance, and hormone secretion
- Nephrons are the structural and functional units of the kidney
- Kidney diseases are categorized based on their effect on different components: glomeruli, tubules, interstitium, and blood vessels
Glomerular Diseases
- Glomeruli are the filtering units of the kidneys
- The glomerulus has two layers of epithelium, namely visceral and parietal epithelium
- The GBM, endothelial cells, and podocytes are key components of the glomerulus
- Two well-defined glomerular disease syndromes are nephrotic and nephritic syndromes
Nephrotic Syndrome
- Characterized by proteinuria, hypoalbuminemia, generalized edema, hyperlipidemia, and lipiduria
- Caused by abnormal capillary walls in glomeruli, leading to increased permeability to plasma proteins
- Common causes include Minimal change disease, Focal segmental glomerulosclerosis, and systemic diseases like diabetes mellitus
Nephritic Syndrome
- Characterized by hematuria, less severe proteinuria than nephrotic syndrome (with or without edema), azotemia, oliguria, and hypertension
- Caused by inflammatory lesions in glomeruli
- Inflammation causes injury to capillary walls, allowing red blood cells to pass into the urine and changes in hemodynamics that result in oliguria, azotemia, fluid retention, and hypertension
Mechanisms of Glomerular Injury and Disease
- Primary glomerular diseases affect the kidney only or predominantly
- Secondary glomerular diseases are secondary to systemic diseases, where glomerular injury occurs
- Most primary and secondary glomerular diseases are immune-mediated
Minimal-Change Disease (MCD)
- One of the most common causes of nephrotic syndrome in children (1-7 years old)
- Light microscopy shows normal glomeruli
- Electron microscopy reveals diffuse effacement or fusion of podocyte foot processes
- Pathogenesis is unknown
- Usually responsive to corticosteroid treatment
Focal Segmental Glomerulosclerosis (FSGS)
- Characterized by sclerosis of some glomeruli, affecting only parts of each glomerulus
- A common cause of nephrotic syndrome, especially in adults
- Pathogenesis is due to podocyte injury, but the exact cause is unknown
- Poorly responsive to corticosteroid treatment, and end-stage renal disease in 50% of cases within 10 years
Membranous Nephropathy (MN)
- Also known as membranous glomerulopathy
- Causes nephrotic syndrome
- Characterized by subepithelial deposits of immune complexes along the GBM
- Morphology shows diffuse thickening of the GBM, podocyte foot process effacement, and subepithelial deposits separated by spike-like projections (spike and dome pattern)
- Usually affects adults (30–60 years) and not responsive to corticosteroid treatment
Poststreptococcal Glomerulonephritis (PSGN)
- Develops in children (or rarely in adults) 2–4 weeks after recovery from infection with certain group A streptococci strains
- An immune complex disease where immune complexes deposit in the glomerular basement membrane (GBM)
- Deposition of immune complexes causes acute injury to the glomeruli; leading to an inflammatory reaction
- Symptoms of acute nephritic syndrome include edema, hypertension, mild to moderate azotemia, hematuria (cola-colored urine), and potential chronic renal disease
IgA Nephropathy
- One of the most common causes of recurrent gross or microscopic hematuria
- Caused by IgA immune complexes in the mesangium
- Pathogenesis involves abnormally glycosylated IgA1 eliciting an immune response and forming complexes that deposit in the mesangium inducing inflammation, injuring the glomerulus and leading to the release of red blood cells into the urine
- Symptoms usually start with an episode of hematuria that often recurs after a respiratory infection
Acute Pyelonephritis
- A common suppurative inflammation of the kidney and renal pelvis caused primarily by bacterial infections (typically enteric gram-negative bacilli)
- Bacteria reach kidneys through the urinary tract (ascending infection) or bloodstream (hematogenous infection)
- Symptoms include pain in the costovertebral angle, chills, fever, nausea, malaise, dysuria, frequency, urgency, and turbid urine
Cystic Diseases of the Kidney
- Simple cysts are fluid-filled sacs, commonly found in the kidney cortex, usually asymptomatic, occurring in 25% of adults over 40
- Adults Polycystic Kidneys Disease (PKD) is characterized by multiple expanding cysts in both kidneys, progressive enlargement, and loss of kidney function; often asymptomatic until the fourth decade; common cause of chronic kidney disease.
Urinary Outflow Obstruction
- Includes various conditions that block urine flow
- Renal stones (Urolithiasis) can be caused by multiple factors (supersaturation of urine constituents, predisposing conditions). These stone types vary including calcium oxalate, struvite, uric acid, and cysteine. Symptoms include severe pain (renal colic) and hematuria
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge on nephrotic syndrome, particularly focusing on its causes, clinical features, and treatment in children aged 1-7 years. This quiz covers essential topics like Minimal-Change Disease and Focal Segmental Glomerulosclerosis. Perfect for students and healthcare professionals looking to deepen their understanding of pediatric nephrology.