Neoplasms and Tumor Characteristics Quiz
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Questions and Answers

What is the primary clinical distinction that influences therapy for neoplasms?

  • Benign vs malignant nature (correct)
  • Size of the neoplasm
  • Location of the neoplasm
  • Growth rate of the tumor
  • What characterizes benign neoplasms in terms of cellular differentiation?

  • Highly anaplastic
  • Moderately differentiated
  • Well-differentiated (correct)
  • Poorly differentiated
  • What does anaplasia refer to in tumor cells?

  • Uniform cell structure
  • Regular mitotic activity
  • Increased functionality of the cells
  • Lack of differentiation (correct)
  • Which of the following is a common characteristic of malignant tumors?

    <p>Marked pleomorphism and hyperchromatism (A)</p> Signup and view all the answers

    What is dysplasia most accurately described as?

    <p>Disorderly but non-neoplastic proliferation (D)</p> Signup and view all the answers

    Which characteristic differentiates in-situ malignancy from invasive malignancy?

    <p>Invasion through basement membrane (A)</p> Signup and view all the answers

    What is one feature that is NOT typically associated with a premalignant condition?

    <p>Invasion of surrounding tissues (A)</p> Signup and view all the answers

    Tumors are composed of two main components, what are they?

    <p>Stroma and parenchyma (C)</p> Signup and view all the answers

    Which of the following sites is commonly associated with premalignant changes?

    <p>Cervix (B)</p> Signup and view all the answers

    How are tumors typically named?

    <p>By their cellular origin (A)</p> Signup and view all the answers

    What stage occurs after the immune system initially detects and attempts to eliminate cancerous cells?

    <p>Equilibrium (C)</p> Signup and view all the answers

    Which theory of cancer suggests that specific genetic mutations are associated with specific types of cancer?

    <p>Somatic Mutation Theory (B)</p> Signup and view all the answers

    What does the term 'clonality' refer to in the context of neoplastic cells?

    <p>Non-lethal genetic changes passed onto daughter cells (C)</p> Signup and view all the answers

    What is a critical factor that distinguishes neoplastic cells from normal cells?

    <p>Their unregulated growth and division (C)</p> Signup and view all the answers

    In which condition do neoplastic cells typically exhibit loss of heterozygosity?

    <p>Mosaicism in heterozygous women (A)</p> Signup and view all the answers

    What defines the final step in the immunological theory of cancer?

    <p>Dominance of the tumor over the immune system (D)</p> Signup and view all the answers

    The Stem Cell Theory of Cancer describes cancer as arising from what?

    <p>An unregulated stem cell (A)</p> Signup and view all the answers

    Which feature is characteristic of malignant tumors compared to benign tumors?

    <p>Infiltration and invasion of surrounding tissues (B)</p> Signup and view all the answers

    What characterizes a benign neoplasm?

    <p>It remains at its site of origin. (A)</p> Signup and view all the answers

    Which of the following is true about malignant neoplasms?

    <p>They can spread to distant sites. (C)</p> Signup and view all the answers

    What is the primary cause of cancer as described?

    <p>Genetic mutations acquired from environmental insults. (B)</p> Signup and view all the answers

    What is meant by 'clonality' in the context of neoplasms?

    <p>Cells originate from a single ancestral cell. (A)</p> Signup and view all the answers

    Which of the following features is consistent with dysplasia?

    <p>Abnormal cell growth and organization. (C)</p> Signup and view all the answers

    How do genetic alterations contribute to cancer development?

    <p>They can cause aberrant cell behavior and growth. (B)</p> Signup and view all the answers

    How can neoplastic growth be distinguished from normal cell growth?

    <p>Neoplastic cells grow uncontrollably even after stimuli removal. (A)</p> Signup and view all the answers

    What role do oncogenes and tumor suppressor genes play in cancer?

    <p>They are responsible for modifications in cancer cells. (B)</p> Signup and view all the answers

    What suffix is used to denote benign tumors?

    <p>-oma (D)</p> Signup and view all the answers

    Which of the following is a malignant epithelial neoplasm?

    <p>Basal cell carcinoma (A)</p> Signup and view all the answers

    What type of benign tumor originates from adipose tissue?

    <p>Lipoma (B)</p> Signup and view all the answers

    Which of the following is NOT considered a malignant connective tissue neoplasm?

    <p>Fibroma (A)</p> Signup and view all the answers

    Which type of neoplasm is associated with germ cell tumors in the testis?

    <p>Seminoma (B)</p> Signup and view all the answers

    What is the term for a benign tumor of the muscle tissue?

    <p>Leiomyoma (B)</p> Signup and view all the answers

    Which is a characteristic feature of adenocarcinomas?

    <p>Derived from glandular tissue (C)</p> Signup and view all the answers

    Which type of lymphoma is specifically called Hodgkin's disease?

    <p>Malignant lymphoma (B)</p> Signup and view all the answers

    What happens to the rate of cell proliferation in cancerous tissues?

    <p>It increases as more cells enter the cell cycle. (B)</p> Signup and view all the answers

    What is one of the primary causes of disrupted balance between cell growth and death in cancer?

    <p>Loss of a cell's ability to undergo apoptosis. (A)</p> Signup and view all the answers

    How do alterations in growth control affect cell lifespan in cancer?

    <p>Cell lifespan is increased due to decreased apoptosis. (D)</p> Signup and view all the answers

    Which type of interaction is important for normal cell function and growth regulation?

    <p>Cell-cell interactions. (C)</p> Signup and view all the answers

    What is a characteristic feature of malignant neoplasms compared to benign neoplasms?

    <p>Higher mitotic count with abnormal mitosis. (D)</p> Signup and view all the answers

    What indicates the alteration of growth factors in cancer?

    <p>Autocrine or paracrine effects of growth factors. (A)</p> Signup and view all the answers

    What describes the effect of angiogenesis in cancer?

    <p>Formation of new blood vessels to support tumor growth. (B)</p> Signup and view all the answers

    What is a common alteration in receptors in cancer cells?

    <p>Increased expression of mutated receptors. (B)</p> Signup and view all the answers

    Flashcards

    What is a neoplasm?

    An abnormal growth of cells that continues to grow even after the initial stimulus is removed.

    What is a benign neoplasm?

    A benign tumor is a non-cancerous tumor. It is enclosed and does not spread to other areas.

    What is a malignant neoplasm?

    A malignant tumor is a cancerous tumor. It grows uncontrollably and can spread to other parts of the body.

    What is a tumor?

    A tumor is a swelling or lump, which can be caused by various factors.

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    What is cancer?

    Cancer is a disease caused by uncontrolled cell division and spread.

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    What is an oncogene?

    A genetic alteration that disrupts normal cell growth and behavior, leading to tumor formation.

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    What is a tumor suppressor gene?

    A gene that normally prevents uncontrolled cell growth, but when mutated can contribute to cancer development.

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    What is the sequence of gene alterations in cancer development?

    A process of gene alterations that can lead to the development of cancer from a normal cell to a benign tumor and then to a malignant tumor.

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    Monoclonal population

    A population of cells descended from a single mutated cell.

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    Tumor progression

    The process by which a normal cell develops into a cancerous cell through a series of genetic changes.

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    Somatic Mutation Theory

    The theory that cancer arises from a single cell that has undergone a series of mutations.

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    Stem Cell Theory

    The theory that cancer originates from a stem cell that has lost its normal regulation.

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    Immune system role in cancer

    The immune system is able to recognize and eliminate cancer cells.

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    Escape phase of cancer

    Cancer cells can evade the immune system and continue to grow.

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    Equilibrium phase of cancer

    The initial stages of cancer where the growth is limited and the immune system is able to control it.

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    Metastasis

    A process where a tumor cell develops the ability to spread to other parts of the body.

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    Dysplasia

    A process where cells divide and grow in a disorganized way, but without the characteristics of cancer.

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    Differentiation in tumor cells

    The degree to which tumor cells resemble their normal counterparts in terms of structure and function.

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    Anaplasia

    The complete loss of differentiation in tumor cells, resulting in abnormal structure and function.

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    Malignant tumor characteristics

    The ability of tumor cells to invade surrounding tissues and spread to distant sites.

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    What is the key difference between normal cell growth and cancer?

    In normal tissues, the rates of new cell growth and old cell death are kept in balance. In cancer, this balance is disrupted. This disruption can result from 1) uncontrolled cell growth or 2) loss of a cell's ability to undergo apoptosis.

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    What is angiogenesis?

    The process by which new blood vessels are formed from pre-existing blood vessels.

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    What is a key characteristic of cancer cells in relation to their life span?

    Cells have changed life span. Decreased apoptosis.

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    What are cell-stromal interactions in relation to cancer?

    Interactions between cells and the surrounding extracellular matrix, which provides structural support and influences cell behavior.

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    What is a key characteristic of cancer cells in relation to their life span?

    Cells have changed life span. Decreased apoptosis

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    What are some ways that growth control can be altered in cancer?

    Altered synthesis of growth factors (autocrine or paracrine effect), altered receptors (increased, decreased, or mutated), and excess/modified growth control proteins

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    What is increased cell proliferation in cancer?

    Increased cell proliferation means more cells enter the cell cycle and the cell cycle speeds up, leading to a shorter doubling time.

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    What is cell proliferation?

    The process by which cells divide and form new cells.

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    Neoplasia

    An abnormal growth of cells that continues to grow even after the initial stimulus is removed.

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    Benign Tumor

    A tumor that is not cancerous and does not spread to other parts of the body.

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    Malignant Tumor

    A tumor that is cancerous and can spread to other parts of the body.

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    In-situ Malignancy

    A tumor that is confined to the area of origin and has not spread to other parts of the body. It's like a locked-down tumor that can't escape.

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    Papilloma

    A type of benign neoplasm characterized by finger-like projections.

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    Adenoma

    A benign epithelial tumor arising from glandular tissue.

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    Squamous cell carcinoma

    A malignant epithelial tumor originating from the skin.

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    Leiomyoma

    A benign connective tissue tumor derived from smooth muscle.

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    Leiomyosarcoma

    A malignant connective tissue tumor originating from smooth muscle.

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    Lymphoma

    A malignant tumor of lymphoid tissue.

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    Seminoma

    A malignant tumor of germ cells in the testes.

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    Mature cystic teratoma (Dermoid cyst)

    A benign germ cell tumor of the ovary, containing various tissue types.

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    Study Notes

    Neoplasia I - Session 9

    • Neoplasia is a general term for abnormal cellular growth
    • Tumors are a swelling resulting from any cause—inflammation, trauma or abnormal growth
    • Neoplasm specifically refers to abnormal cellular growth that persists after initiating stimulus is removed
    • Cell growth that does not respond to normal regulatory mechanisms is indicative of a neoplasm
    • There are benign and malignant neoplasms

    Benign Neoplasm

    • Cells grow in a compact mass
    • Remain at the site of origin
    • Example: colonic adenoma

    Malignant Neoplasm

    • Cell growth is uncontrolled
    • Cells can spread into surrounding tissue and to distant sites
    • Cancer is a malignant neoplasm

    Cancer Characteristics

    • Cancer is a genetic disorder due to DNA mutations
    • Mutations can be from spontaneous causes or environmental insults
    • These mutations are heritable and passed on during cell division
    • Cells with these alterations are subject to Darwinian selection
    • The changes in DNA cause an alteration in cell growth and behaviour
    • Oncogenes and tumor suppressor genes are altered
    • Gene alterations happen from normal to benign to malignant

    Immunological Theory of Cancer

    • Immune system surveys and destroys cancerous cells
    • Tumorous cells may remain undetected and dormant during a period of “equilibrium”
    • In the escape phase, tumors overpower immune system and spread

    Somatic Mutation Theory of Cancer

    • Analysis of cancer development through genetic factors
    • Specific mutations directly correlate with specific cancers

    Stem Cell Theory of Cancer

    • Cancer is a result of unregulated stem cell growth

    Tumor Progression

    • Multiple mutations lead to colon cancer
    • Genetic changes result in tumor changes

    Clonality

    • The change must be non-lethal and passed to daughter cells
    • Therefore, genetic alterations exist in every cell of a monoclonal population
    • Initially demonstrated using enzyme G6PD encoded on the X chromosome

    Neoplastic vs Normal Cells

    • Growth control is altered: Proliferation is stimulated while cell death is suppressed
    • Factors which regulate growth, including receptors, are altered
    • Cellular interactions between cells, and with stroma, are also altered

    Growth Control

    • Increased cell proliferation: more cells enter cell cycle, cycle is speeded up

    • Cells have changed life span due to decreased apoptosis

    • Modifications in cell metabolism

    • Angiogenesis is altered

    • In normal tissues, the rates of new cell growth and old cell death are in balance

    • In cancer, this balance is disrupted

    • This disruption can lead to uncontrolled cell growth or loss of a cells’ ability to undergo apoptosis

    Growth Control (Altered synthesis of growth factors)

    • Autocrine or paracrine effect altered
    • Altered receptors—increased, decreased, mutated
    • Excess/modified growth control proteins

    Cellular Interactions

    • Cell-cell interactions
    • Cell-stromal interactions (e.g., with the basement membrane)
    • Important for differentiation, embryogenesis, and growth regulation in normal cells

    Differences Between Benign and Malignant Neoplasms

    • Size
    • Growth characteristics
    • Vascularity/necrosis
    • Function
    • Invasion/metastasis

    Differentiation

    • How close the parenchymal cells resemble the normal cells of the type
      • more differentiated cells retain more functional capabilities of the normal counterparts, benign tumors usually have well-differentiated cells.
      • Lack of differentiation is designated as anaplasia,
        • anaplasia includes bizarre nuclei, atypical mitoses, loss of polarity,
        • more rapidly growing tumors that are more anaplastic less likely to have specialized function activity

    In-situ Malignancy

    • Epithelial neoplasm shows evidence of malignancy—altered cell growth, cytological atypia, altered differentiation
    • BUT no basement membrane invasion

    Possible Events

    • Benign to Benign
    • Benign to Dysplasia
    • Benign to Dysplasia to In-situ
    • Benign to Dysplasia to In-situ to Invasive
    • Dysplasia to In-Situ to Invasive
    • In-situ to Invasive
    • Invasive to Invasive

    Nomenclature

    • Tumors composed of stroma (supporting connective tissue, blood supply) and parenchyma (neoplastic cells, which determine biologic behavior)
    • Named according to parenchyma, organ, or cell type (e.g., Hepatoma- liver, Osteoma-bone)
    • Named according to pattern or structure (e.g., Fluid-filled → CYST, Glandular → ADENO, Finger-like → PAPILLO, Stalk → POLYP)

    Types of Neoplasms (Benign vs Malignant)

    • Benign: Epithelial, Connective tissue, Lymphoid/haemopoietic, Germ cell
    • Malignant: Epithelial, Connective tissue, Lymphoid/haemopoietic, Germ cell

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    Related Documents

    Neoplasia I L 9 PDF

    Description

    Test your knowledge on the clinical distinctions of neoplasms and their characteristics. This quiz covers topics such as cellular differentiation, anaplasia, dysplasia, and the classification of tumors. Perfect for students studying oncology or pathology.

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