Podcast
Questions and Answers
Which neurotransmitter is released by the enterochromaffin cells of the small intestine in response to blood-borne emetics and local irritants?
Which neurotransmitter is released by the enterochromaffin cells of the small intestine in response to blood-borne emetics and local irritants?
- Dopamine
- Histamine
- Acetylcholine
- Serotonin (correct)
Which receptor is stimulated by serotonin to initiate the vomiting reflex?
Which receptor is stimulated by serotonin to initiate the vomiting reflex?
- H1 (histamine)
- Muscarinic (acetylcholine)
- D2 (dopamine)
- 5HT3 (serotonin) (correct)
Which neurotransmitter's receptors may mediate signaling in the emetic center?
Which neurotransmitter's receptors may mediate signaling in the emetic center?
- Acetylcholine
- Dopamine
- Histamine
- Serotonin (correct)
Which neurotransmitter is associated with 5HT3 receptors?
Which neurotransmitter is associated with 5HT3 receptors?
Which neurotransmitter is responsible for stimulating vagal afferents in the vomiting reflex?
Which neurotransmitter is responsible for stimulating vagal afferents in the vomiting reflex?
Which neurotransmitter is released in response to blood-borne emetics and local irritants?
Which neurotransmitter is released in response to blood-borne emetics and local irritants?
Which medication has the highest receptor-binding affinity to 5-HT3R and a longer half-life?
Which medication has the highest receptor-binding affinity to 5-HT3R and a longer half-life?
Which medication is metabolized by CYP2D6 and to a lesser extent, CYP3A4 and CYP1A2?
Which medication is metabolized by CYP2D6 and to a lesser extent, CYP3A4 and CYP1A2?
Which medication is a pro-drug that is converted in vivo by carbonyl reductase to its active metabolite, hydrodolasetron?
Which medication is a pro-drug that is converted in vivo by carbonyl reductase to its active metabolite, hydrodolasetron?
Which medication has the highest bioavailability but is rapidly absorbed after oral administration?
Which medication has the highest bioavailability but is rapidly absorbed after oral administration?
Which medication has the longest half-life after intravenous injection?
Which medication has the longest half-life after intravenous injection?
Which medication is extensively metabolized by liver CPY3A4 enzyme with extensive inter-subject variability?
Which medication is extensively metabolized by liver CPY3A4 enzyme with extensive inter-subject variability?
Which of the following is a common side effect of antihistamines and anticholinergics?
Which of the following is a common side effect of antihistamines and anticholinergics?
Where are the serotonin receptors localized and how do they influence the emetic center?
Where are the serotonin receptors localized and how do they influence the emetic center?
What are the names of the 5-HT3 receptor antagonists?
What are the names of the 5-HT3 receptor antagonists?
Why should metoclopramide not be given at high doses or used long-term?
Why should metoclopramide not be given at high doses or used long-term?
Name some antihistamine drugs.
Name some antihistamine drugs.
What event in the body results most often as a side effect of 5-HT3 use?
What event in the body results most often as a side effect of 5-HT3 use?
Which areas in the CNS would be most associated with motion sickness?
Which areas in the CNS would be most associated with motion sickness?
What are some side effects of antihistamines and anticholinergics?
What are some side effects of antihistamines and anticholinergics?
Which medication is a selective 5-HT3 receptor antagonist?
Which medication is a selective 5-HT3 receptor antagonist?
What is the mechanism of action of Aprepitant?
What is the mechanism of action of Aprepitant?
Which medication has the longest half-life after intravenous injection?
Which medication has the longest half-life after intravenous injection?
What is the most common side effect of Dronabinol?
What is the most common side effect of Dronabinol?
How is scopolamine primarily excreted from the body?
How is scopolamine primarily excreted from the body?
What is the main concern associated with metoclopramide use at high doses or long-term?
What is the main concern associated with metoclopramide use at high doses or long-term?
Which medication is metabolized by CYP2D6 and to a lesser extent, CYP3A4?
Which medication is metabolized by CYP2D6 and to a lesser extent, CYP3A4?
What is the primary receptor targeted by Palonosetron?
What is the primary receptor targeted by Palonosetron?
What is the primary mechanism of action of glucocorticoids like dexamethasone in preventing nausea and vomiting?
What is the primary mechanism of action of glucocorticoids like dexamethasone in preventing nausea and vomiting?
What is the most common side effect of ondansetron?
What is the most common side effect of ondansetron?
Which of the following is a common side effect of anticholinergic agents?
Which of the following is a common side effect of anticholinergic agents?
Which of the following is a side effect most frequently associated with antihistamines?
Which of the following is a side effect most frequently associated with antihistamines?
What area in the body are H1R antagonists well absorbed from?
What area in the body are H1R antagonists well absorbed from?
Which neurotransmitter's receptors may mediate signaling in the emetic center?
Which neurotransmitter's receptors may mediate signaling in the emetic center?
Where are the serotonin receptors localized and how do they influence the emetic center?
Where are the serotonin receptors localized and how do they influence the emetic center?
What are some side effects of antihistamines and anticholinergics?
What are some side effects of antihistamines and anticholinergics?
Which area in the central nervous system could be most associated with motion sickness?
Which area in the central nervous system could be most associated with motion sickness?
What event in the body results most often as a side effect of 5-HT3 receptor antagonist use?
What event in the body results most often as a side effect of 5-HT3 receptor antagonist use?
Why should metoclopramide not be given at high doses or used long-term?
Why should metoclopramide not be given at high doses or used long-term?
Which medication has the highest receptor-binding affinity to 5-HT3 receptors and a longer half-life?
Which medication has the highest receptor-binding affinity to 5-HT3 receptors and a longer half-life?
What is the main neurotransmitter responsible for stimulating vagal afferents in the vomiting reflex?
What is the main neurotransmitter responsible for stimulating vagal afferents in the vomiting reflex?
Which medication is a pro-drug converted in vivo by carbonyl reductase to its active metabolite, hydrodolasetron?
Which medication is a pro-drug converted in vivo by carbonyl reductase to its active metabolite, hydrodolasetron?
Which medication has the highest receptor-binding affinity to 5-HT3R and a longer half-life?
Which medication has the highest receptor-binding affinity to 5-HT3R and a longer half-life?
What is a common side effect of antihistamines and anticholinergics?
What is a common side effect of antihistamines and anticholinergics?
What event in the body most often results as a side effect of 5-HT3 use?
What event in the body most often results as a side effect of 5-HT3 use?
Which areas in the CNS are most associated with motion sickness?
Which areas in the CNS are most associated with motion sickness?
Why should metoclopramide not be given at high doses or used long-term?
Why should metoclopramide not be given at high doses or used long-term?
Which medication is extensively metabolized by liver CPY3A4 enzyme with extensive inter-subject variability?
Which medication is extensively metabolized by liver CPY3A4 enzyme with extensive inter-subject variability?
Which medication has the longest half-life after intravenous injection?
Which medication has the longest half-life after intravenous injection?
Which receptor is stimulated by serotonin to initiate the vomiting reflex?
Which receptor is stimulated by serotonin to initiate the vomiting reflex?
