6 Questions
What is the primary function of Natural Killer (NK) cells?
Initiating innate immune responses
Which process allows NK cells to kill IgG coated cells?
ADCC through Fc receptor interaction
Which of the following cytokines is NOT produced by NK cells?
IL-2
What are IL-2 activated NK cells called?
LAK cells
Dendritic cells are derived from which type of stem cells?
Myeloid stem cells
Where are mast cells typically found?
Connective tissues, skin, and airways
Study Notes
Natural Killer (NK) Cells
- Function primarily in innate immunity, exhibiting spontaneous, non-specific cytotoxic activity towards virus-infected cells, tumor cells, and graft cells.
- Mechanism of NK-mediated cytolysis is similar to Tc cells, but non-specific and MHC-unrestricted.
- Can interact with and kill IgG-coated cells through a receptor for the Fc portion of IgG, an acquired process.
- Produce cytokines, including INF-y, TNF alpha, and GM-CSF (Granulocyte-Monocyte Colony Stimulating Factor).
- IL-2-activated NK cells are called LAK cells (Lymphokine-Activated Natural Killer cells), with enhanced killing efficiency, showing promising results in metastatic cancer therapy.
Dendritic Cells
- Named for their long, narrow processes resembling neuronal dendrites.
- Derived from myeloid stem cells in the bone marrow.
Mast Cells
- Granulated cells that release histamine and other inflammatory mediators into the blood.
- Found in connective tissues, specifically in the skin and airways.
- Involved in hypersensitivity reactions.
Learn about the functions and mechanisms of Natural Killer (NK) cells, including their role in innate immunity, cytotoxic activity, and cytokine production.
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