Nasopharynx Phase III Trial Question
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Nasopharynx Phase III Trial Question

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@PeacefulRhodonite

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Questions and Answers

What is the inferior border of the retropharyngeal lymph node level?

  • Cranial edge of the body of the hyoid bone (correct)
  • Caudal edge of the hyoid bone
  • Posterior edge of submandibular gland
  • Caudal edge of lateral process of C1

    • How does the systemic therapy agent lobaplatin work?

  • As an alkylating agent in the nitrogen mustard family
  • As a biosimilar of cetuximab
  • An EGFR inhibitor (tyrosine kinase inhibitor)
  • As an agent that generates DNA-drug adducts, mainly as intra-strand cross-links (correct)

    • What is the standard of care for a patient with locally advanced SCC of the oral cavity, post surgical resection demonstrating negative surgical margins, 1/13 LN +, PNI +, ECE – ve?

  • Post-operative radiation to 50-54 Gy
  • Post-operative radiation to 56-60 Gy (correct)
  • Post-operative chemoradiation to 60-06 Gy
  • Observation

    • In the phase III trial by You et al., what was the treatment option for metastatic NPC patients who were required to achieve complete or partial response to induction chemotherapy prior to randomization?

    <p>Chemotherapy + RT to the primary tumor and involved lymph nodes</p> Signup and view all the answers

    For patients with de novo mNPC in the phase III clinical trial, what did high-dose IMRT to the primary and nodal regions result in?

    <p>Significant improvement in 2-year OS</p> Signup and view all the answers

    What was the backbone of palliative chemotherapy in the phase III clinical trial by You et al.?

    <p>Cisplatin/fluorouracil (PF) for 3 cycles</p> Signup and view all the answers

    What defines the inferior border of the retropharyngeal lymph node level in the neck?

    <p>The hyoid bone</p> Signup and view all the answers

    What treatment option was associated with an improvement in OS, but also with unacceptable toxicity in the phase III trial by You et al.?

    <p>Chemotherapy + RT to the primary tumor and involved lymph nodes</p> Signup and view all the answers

    How many cycles of induction cisplatin/fluorouracil (PF) chemotherapy did the patients receive in the phase III clinical trial by You et al.?

    <p>3 cycles</p> Signup and view all the answers

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