9 Questions
What is the inferior border of the retropharyngeal lymph node level?
Cranial edge of the body of the hyoid bone
How does the systemic therapy agent lobaplatin work?
As an agent that generates DNA-drug adducts, mainly as intra-strand cross-links
What is the standard of care for a patient with locally advanced SCC of the oral cavity, post surgical resection demonstrating negative surgical margins, 1/13 LN +, PNI +, ECE – ve?
Post-operative radiation to 56-60 Gy
In the phase III trial by You et al., what was the treatment option for metastatic NPC patients who were required to achieve complete or partial response to induction chemotherapy prior to randomization?
Chemotherapy + RT to the primary tumor and involved lymph nodes
For patients with de novo mNPC in the phase III clinical trial, what did high-dose IMRT to the primary and nodal regions result in?
Significant improvement in 2-year OS
What was the backbone of palliative chemotherapy in the phase III clinical trial by You et al.?
Cisplatin/fluorouracil (PF) for 3 cycles
What defines the inferior border of the retropharyngeal lymph node level in the neck?
The hyoid bone
What treatment option was associated with an improvement in OS, but also with unacceptable toxicity in the phase III trial by You et al.?
Chemotherapy + RT to the primary tumor and involved lymph nodes
How many cycles of induction cisplatin/fluorouracil (PF) chemotherapy did the patients receive in the phase III clinical trial by You et al.?
3 cycles
Test your knowledge about the phase III trial conducted by You et al. (JAMA Oncology, 2020) regarding the treatment of metastatic nasopharyngeal carcinoma patients. This quiz focuses on the randomized treatment options and their outcomes in the trial.
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