Muscle Types and Control

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Questions and Answers

Which type of muscle is controlled via the somatic nervous system (SNS)?

  • Cardiac muscle
  • Visceral muscle
  • Smooth muscle
  • Skeletal muscle (correct)

Which characteristic distinguishes smooth muscle from skeletal and cardiac muscle?

  • Speed of contraction
  • Type of control (voluntary vs. involuntary)
  • Number of nuclei per cell
  • Presence of striations (correct)

What is the role of acetylcholine (ACh) in muscle function?

  • It inhibits muscle contraction.
  • It stimulates skeletal muscle contraction. (correct)
  • It regulates smooth muscle relaxation.
  • It stimulates cardiac muscle contraction.

How is cardiac muscle contraction primarily controlled?

<p>Spontaneous activity modulated by nerves (D)</p> Signup and view all the answers

Which of the following lists the muscle types in order from fastest to slowest contraction speed?

<p>Skeletal, cardiac, smooth (D)</p> Signup and view all the answers

If a muscle develops tension but does not shorten, what type of contraction is occurring?

<p>Isometric contraction (B)</p> Signup and view all the answers

What primarily controls the contraction of smooth muscle?

<p>Nerves, hormones, and stretch (C)</p> Signup and view all the answers

Why is the variation of resting length important in smooth muscle found in blood vessels?

<p>It helps regulate blood flow to the head. (A)</p> Signup and view all the answers

Which muscle type contains multiple nuclei per cell?

<p>Skeletal muscle (D)</p> Signup and view all the answers

What happens to passive tension when a muscle is stretched?

<p>Passive tension increases. (D)</p> Signup and view all the answers

What is the main function of skeletal muscle?

<p>Body movement (D)</p> Signup and view all the answers

How does the brain optimize force production in skeletal muscle?

<p>By regulating resting muscle length (A)</p> Signup and view all the answers

Which division of the nervous system modulates the spontaneous activity of cardiac muscle?

<p>Autonomic nervous system (B)</p> Signup and view all the answers

At what muscle length is active twitch tension maximized?

<p>At Lo (optimal length) (D)</p> Signup and view all the answers

What receptor type mediates the effect of acetylcholine (ACh) at the neuromuscular junction?

<p>Nicotinic ACh receptors (D)</p> Signup and view all the answers

In the context of muscle mechanics, what does 'Lo' typically represent?

<p>The optimal length for active tension (C)</p> Signup and view all the answers

Which of the following is true regarding the number of nuclei in cardiac muscle cells?

<p>Each cell has a single nucleus. (C)</p> Signup and view all the answers

What distinguishes cardiac muscle from skeletal muscle regarding voluntary control?

<p>Skeletal muscle is under voluntary control, while cardiac muscle is not. (C)</p> Signup and view all the answers

What is the primary function of smooth muscle in the viscera?

<p>Visceral and circulatory functions (A)</p> Signup and view all the answers

How does stretching a muscle affect its passive tension?

<p>It increases passive tension. (C)</p> Signup and view all the answers

During the cross-bridge cycle, what is the immediate consequence of ATP binding to myosin?

<p>Myosin detaches from actin. (A)</p> Signup and view all the answers

What triggers the binding of myosin to actin during muscle contraction?

<p>The exposure of actin-myosin binding sites due to calcium. (A)</p> Signup and view all the answers

During the power stroke of muscle contraction, what event directly causes the sliding of actin filaments?

<p>Conformational change in myosin. (D)</p> Signup and view all the answers

What is the role of ATP hydrolysis in the cross-bridge cycle?

<p>To recock and energize the myosin head. (C)</p> Signup and view all the answers

What is the functional unit of a striated muscle fiber?

<p>Sarcomere. (C)</p> Signup and view all the answers

Which of the following accurately describes the composition of myofilaments within a sarcomere?

<p>Made up of contractile proteins. (B)</p> Signup and view all the answers

What structural component defines the boundary of a sarcomere?

<p>Z discs. (A)</p> Signup and view all the answers

In skeletal muscle, what is the function of the T-tubules in excitation-contraction coupling?

<p>To propagate action potentials from the surface membrane into the cell. (B)</p> Signup and view all the answers

What regulatory proteins are directly associated with actin in the thin filament?

<p>Troponin and tropomyosin. (B)</p> Signup and view all the answers

What is the critical role of calcium ions ($Ca^{2+}$) in muscle contraction?

<p>Exposing the binding sites on actin for myosin attachment. (D)</p> Signup and view all the answers

During muscle contraction, what happens to the length of the A band?

<p>It remains constant. (D)</p> Signup and view all the answers

What describes the sliding filament hypothesis?

<p>Actin and myosin filaments slide past each other, causing the sarcomere to shorten. (B)</p> Signup and view all the answers

How does optimal skeletal muscle length contribute to force generation?

<p>By maximizing the number of potential cross-bridges that can form. (C)</p> Signup and view all the answers

Which event occurs immediately before myosin binds to actin?

<p>Exposure of myosin binding sites on actin. (A)</p> Signup and view all the answers

During an isometric contraction, what is occurring at the level of the muscle?

<p>The muscle develops tension but does not change length. (A)</p> Signup and view all the answers

What triggers the detachment of myosin from actin during the cross-bridge cycle?

<p>Binding of ATP. (C)</p> Signup and view all the answers

What is the main characteristic of the thin filament in the sarcomere?

<p>Two strands of f-actin with regulatory proteins. (C)</p> Signup and view all the answers

What describes the role of ATP after the power stroke?

<p>Detaching the myosin head from actin. (B)</p> Signup and view all the answers

What event is directly powered by the hydrolysis of ATP during muscle contraction?

<p>Re-cocking of the myosin head. (C)</p> Signup and view all the answers

Why is sufficient blood flow crucial for the head musculature?

<p>To ensure adequate oxygen and nutrient delivery for muscle function. (D)</p> Signup and view all the answers

What is the direct effect of acetylcholine (ACh) binding to nicotinic receptors at the neuromuscular junction?

<p>Opening of ion channels, leading to membrane depolarization (B)</p> Signup and view all the answers

What structural component of muscle cells propagates action potentials from the surface membrane into the cell's interior?

<p>T-tubules (A)</p> Signup and view all the answers

What is the primary role of the motor end plate?

<p>To release acetylcholine (ACh), initiating muscle fiber activation. (D)</p> Signup and view all the answers

What initiates the excitation-contraction coupling process in muscle cells?

<p>The release of acetylcholine at the neuromuscular junction (A)</p> Signup and view all the answers

What is the function of the $Ca^{2+}$-ATPase pump in muscle relaxation?

<p>To transport $Ca^{2+}$ from the sarcoplasm back into the SR (B)</p> Signup and view all the answers

What event immediately follows the depolarization of the T-tubules during excitation-contraction coupling?

<p>Release of calcium ions from the sarcoplasmic reticulum (A)</p> Signup and view all the answers

How does calcium facilitate muscle contraction at the molecular level?

<p>By causing a conformational change in tropomyosin, exposing myosin-binding sites on actin (D)</p> Signup and view all the answers

How does the motor nerve action potential lead to muscle fiber contraction?

<p>By releasing acetylcholine (ACh) at the neuromuscular junction. (C)</p> Signup and view all the answers

What is the role of troponin in regulating muscle contraction?

<p>It prevents myosin from binding to actin when calcium levels are low. (A)</p> Signup and view all the answers

What happens to the concentration of calcium ions in the sarcoplasm immediately after depolarization opens calcium channels in the sarcoplasmic reticulum?

<p>It increases significantly, typically a tenfold increase. (C)</p> Signup and view all the answers

Where does the action potential propagate after reaching the surface membrane of the muscle cell?

<p>Along the T-tubules (D)</p> Signup and view all the answers

What is the functional significance of multiple branches of a motor nerve innervating individual muscle fibers?

<p>It allows for coordinated activation of multiple muscle fibers by a single motor neuron. (C)</p> Signup and view all the answers

What would happen if the $Ca^{2+}$-ATPase pump in the sarcoplasmic reticulum stopped functioning?

<p>The muscle would remain contracted due to high sarcoplasmic calcium levels. (C)</p> Signup and view all the answers

What structural change occurs in the actin filament when the myosin-binding site becomes available?

<p>Tropomyosin shifts position, exposing the binding site. (D)</p> Signup and view all the answers

What is the primary function of the lateral sacs (terminal cisternae) of the sarcoplasmic reticulum?

<p>To store and release calcium ions for muscle contraction. (C)</p> Signup and view all the answers

How is the action potential transferred from the motor neuron to the muscle fiber at the neuromuscular junction?

<p>Release of neurotransmitters, such as acetylcholine (ACh). (A)</p> Signup and view all the answers

What role do gap junctions play in muscle tissue, if any?

<p>Gap junctions facilitate rapid ion diffusion between cardiac muscle cells. (C)</p> Signup and view all the answers

How does the influx of $Ca^{2+}$ and $Na^+$ ions, after activation of the acetylcholine-gated cation channel, contribute to muscle cell excitability?

<p>It depolarizes the muscle cell membrane, increasing its excitability. (D)</p> Signup and view all the answers

What event directly causes myosin to bind to actin?

<p>Exposure of myosin-binding sites on actin (A)</p> Signup and view all the answers

What is the result of the wave of the action potential traveling along the T-tubules?

<p>Activation of voltage-gated calcium channels within the T-tubule membrane (D)</p> Signup and view all the answers

Flashcards

Acetylcholine (Ach)

The main neurotransmitter that controls muscle movement.

Striations in Skeletal Muscle

Skeletal muscles have visible striations, indicating their organized structure.

Function of Skeletal Muscle

Skeletal muscles enable body movement; controlled by the somatic nervous system (SNS).

Cardiac muscle contraction

Cardiac muscle contracts spontaneously, modulated by autonomic nerves.

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Smooth muscle contraction control

Smooth muscle contraction is influenced by nerves, hormones and stretch.

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Passive tension

Increasing passive tension when a muscle is stretched.

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Isometric contraction

Muscle develops tension without changing length.

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Brain regulates muscle length

Brain controls muscle length to optimize force production.

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Myosin Detachment

ATP binds to myosin, causing myosin to detach from actin.

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Myosin Head Activation

ATP hydrolysis leads to the myosin head being recocked and energized.

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Myosin-Actin Binding

Calcium exposure allows myosin to bind to actin.

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Power Stroke

Myosin pulls actin, ADP and Pi are released, causing the power stroke.

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Sarcomere Definition

The functional contractile unit of a striated muscle fibre

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Sarcomere Location

Region of the myofibril between two successive Z discs.

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Myofilaments Composition

Made up of contractile proteins.

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Thick Filament

Bundle of myosin molecules

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Thin Filament

Two strands of f-actin with regulatory proteins (troponin, tropomyosin).

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Sliding Filament Theory

Actin and myosin filaments slide along each other to cause muscle contraction.

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Action Potential (AP) Propagation

AP propagates along surface membrane and down the T-tubules.

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Motor End Plate

A structure where a motor nerve ending synapses onto a muscle fiber, activating the muscle fiber via acetylcholine release.

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T-tubules

Invaginations of the sarcolemma that allow action potentials to propagate deep inside the muscle fiber.

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Sarcoplasmic Reticulum (SR)

Specialized endoplasmic reticulum of muscle cells that stores and releases calcium ions.

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Excitation-Contraction Coupling

Excitation-contraction coupling: The process by which electrical signals are converted into muscle contraction.

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Calcium's Role in Contraction

Calcium ions bind to troponin, which causes tropomyosin to move, exposing myosin-binding sites on actin.

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Troponin

A complex of three regulatory proteins (troponin C, troponin I, and troponin T) that is integral to muscle contraction in skeletal and cardiac muscle.

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Tropomyosin

A protein involved in muscle contraction. It blocks the myosin-binding sites on actin molecules, preventing cross-bridge formation.

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Lateral Sacs

The region of the sarcoplasmic reticulum that is adjacent to the T-tubules.

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Calcium Re-uptake

Process where calcium ions are pumped back into the sarcoplasmic reticulum to end muscle contraction.

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Study Notes

  • Muscles convert electrical signals to excitation-contraction
  • Acetylcholine (ACh) and contraction are linked

Terminal Button and Muscle Cell Interaction

  • The terminal button is separated from the muscle cell by a gap
  • The surface membrane of the muscle cell contains T tubules and lateral sacs of the sarcoplasmic reticulum
  • Acetylcholine binds to nicotinic receptors on the muscle cell, opening ion channels
  • Calcium and sodium influx increases the membrane potential
  • Activated calcium channels release more calcium

Role of Calcium and Proteins in Muscle Contraction

  • Calcium binds to iron channels
  • Calcium also binds to troponin which is bound to tropomyosin
  • This binding induces a shape change in troponin
  • Tropomyosin then moves, which makes the actin-myosin binding site accessible
  • Myosin cross-bridges then bind to actin

Motor Nerve and Motor End Plate

  • A motor nerve (myelinated) branches at its terminal, with each branch (axon) ending on a separate muscle fiber
  • The ending is a motor end plate
  • At the motor end plate, the arrival of a nerve action potential triggers the muscle fiber to activate, which happens at the neuromuscular junction
  • The trigger is the release of acetylcholine (ACh) as a neurotransmitter

Muscle Contraction from Action Potential

  • Action potentials propagate along the muscle surface membrane and down the T-tubules
  • Depolarization opens calcium channels in the sarcoplasmic reticulum (SR), which are calcium stores
  • Calcium is released into the sarcoplasm, increasing its concentration tenfold
  • Calcium binds to troponin, initiating muscle contraction
  • Calcium is then re-accumulated by the SR via Ca2+-ATPase pumps, which leads to muscle relaxation

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