Podcast
Questions and Answers
Which type of muscle is controlled via the somatic nervous system (SNS)?
Which type of muscle is controlled via the somatic nervous system (SNS)?
- Cardiac muscle
- Visceral muscle
- Smooth muscle
- Skeletal muscle (correct)
Which characteristic distinguishes smooth muscle from skeletal and cardiac muscle?
Which characteristic distinguishes smooth muscle from skeletal and cardiac muscle?
- Speed of contraction
- Type of control (voluntary vs. involuntary)
- Number of nuclei per cell
- Presence of striations (correct)
What is the role of acetylcholine (ACh) in muscle function?
What is the role of acetylcholine (ACh) in muscle function?
- It inhibits muscle contraction.
- It stimulates skeletal muscle contraction. (correct)
- It regulates smooth muscle relaxation.
- It stimulates cardiac muscle contraction.
How is cardiac muscle contraction primarily controlled?
How is cardiac muscle contraction primarily controlled?
Which of the following lists the muscle types in order from fastest to slowest contraction speed?
Which of the following lists the muscle types in order from fastest to slowest contraction speed?
If a muscle develops tension but does not shorten, what type of contraction is occurring?
If a muscle develops tension but does not shorten, what type of contraction is occurring?
What primarily controls the contraction of smooth muscle?
What primarily controls the contraction of smooth muscle?
Why is the variation of resting length important in smooth muscle found in blood vessels?
Why is the variation of resting length important in smooth muscle found in blood vessels?
Which muscle type contains multiple nuclei per cell?
Which muscle type contains multiple nuclei per cell?
What happens to passive tension when a muscle is stretched?
What happens to passive tension when a muscle is stretched?
What is the main function of skeletal muscle?
What is the main function of skeletal muscle?
How does the brain optimize force production in skeletal muscle?
How does the brain optimize force production in skeletal muscle?
Which division of the nervous system modulates the spontaneous activity of cardiac muscle?
Which division of the nervous system modulates the spontaneous activity of cardiac muscle?
At what muscle length is active twitch tension maximized?
At what muscle length is active twitch tension maximized?
What receptor type mediates the effect of acetylcholine (ACh) at the neuromuscular junction?
What receptor type mediates the effect of acetylcholine (ACh) at the neuromuscular junction?
In the context of muscle mechanics, what does 'Lo' typically represent?
In the context of muscle mechanics, what does 'Lo' typically represent?
Which of the following is true regarding the number of nuclei in cardiac muscle cells?
Which of the following is true regarding the number of nuclei in cardiac muscle cells?
What distinguishes cardiac muscle from skeletal muscle regarding voluntary control?
What distinguishes cardiac muscle from skeletal muscle regarding voluntary control?
What is the primary function of smooth muscle in the viscera?
What is the primary function of smooth muscle in the viscera?
How does stretching a muscle affect its passive tension?
How does stretching a muscle affect its passive tension?
During the cross-bridge cycle, what is the immediate consequence of ATP binding to myosin?
During the cross-bridge cycle, what is the immediate consequence of ATP binding to myosin?
What triggers the binding of myosin to actin during muscle contraction?
What triggers the binding of myosin to actin during muscle contraction?
During the power stroke of muscle contraction, what event directly causes the sliding of actin filaments?
During the power stroke of muscle contraction, what event directly causes the sliding of actin filaments?
What is the role of ATP hydrolysis in the cross-bridge cycle?
What is the role of ATP hydrolysis in the cross-bridge cycle?
What is the functional unit of a striated muscle fiber?
What is the functional unit of a striated muscle fiber?
Which of the following accurately describes the composition of myofilaments within a sarcomere?
Which of the following accurately describes the composition of myofilaments within a sarcomere?
What structural component defines the boundary of a sarcomere?
What structural component defines the boundary of a sarcomere?
In skeletal muscle, what is the function of the T-tubules in excitation-contraction coupling?
In skeletal muscle, what is the function of the T-tubules in excitation-contraction coupling?
What regulatory proteins are directly associated with actin in the thin filament?
What regulatory proteins are directly associated with actin in the thin filament?
What is the critical role of calcium ions ($Ca^{2+}$) in muscle contraction?
What is the critical role of calcium ions ($Ca^{2+}$) in muscle contraction?
During muscle contraction, what happens to the length of the A band?
During muscle contraction, what happens to the length of the A band?
What describes the sliding filament hypothesis?
What describes the sliding filament hypothesis?
How does optimal skeletal muscle length contribute to force generation?
How does optimal skeletal muscle length contribute to force generation?
Which event occurs immediately before myosin binds to actin?
Which event occurs immediately before myosin binds to actin?
During an isometric contraction, what is occurring at the level of the muscle?
During an isometric contraction, what is occurring at the level of the muscle?
What triggers the detachment of myosin from actin during the cross-bridge cycle?
What triggers the detachment of myosin from actin during the cross-bridge cycle?
What is the main characteristic of the thin filament in the sarcomere?
What is the main characteristic of the thin filament in the sarcomere?
What describes the role of ATP after the power stroke?
What describes the role of ATP after the power stroke?
What event is directly powered by the hydrolysis of ATP during muscle contraction?
What event is directly powered by the hydrolysis of ATP during muscle contraction?
Why is sufficient blood flow crucial for the head musculature?
Why is sufficient blood flow crucial for the head musculature?
What is the direct effect of acetylcholine (ACh) binding to nicotinic receptors at the neuromuscular junction?
What is the direct effect of acetylcholine (ACh) binding to nicotinic receptors at the neuromuscular junction?
What structural component of muscle cells propagates action potentials from the surface membrane into the cell's interior?
What structural component of muscle cells propagates action potentials from the surface membrane into the cell's interior?
What is the primary role of the motor end plate?
What is the primary role of the motor end plate?
What initiates the excitation-contraction coupling process in muscle cells?
What initiates the excitation-contraction coupling process in muscle cells?
What is the function of the $Ca^{2+}$-ATPase pump in muscle relaxation?
What is the function of the $Ca^{2+}$-ATPase pump in muscle relaxation?
What event immediately follows the depolarization of the T-tubules during excitation-contraction coupling?
What event immediately follows the depolarization of the T-tubules during excitation-contraction coupling?
How does calcium facilitate muscle contraction at the molecular level?
How does calcium facilitate muscle contraction at the molecular level?
How does the motor nerve action potential lead to muscle fiber contraction?
How does the motor nerve action potential lead to muscle fiber contraction?
What is the role of troponin in regulating muscle contraction?
What is the role of troponin in regulating muscle contraction?
What happens to the concentration of calcium ions in the sarcoplasm immediately after depolarization opens calcium channels in the sarcoplasmic reticulum?
What happens to the concentration of calcium ions in the sarcoplasm immediately after depolarization opens calcium channels in the sarcoplasmic reticulum?
Where does the action potential propagate after reaching the surface membrane of the muscle cell?
Where does the action potential propagate after reaching the surface membrane of the muscle cell?
What is the functional significance of multiple branches of a motor nerve innervating individual muscle fibers?
What is the functional significance of multiple branches of a motor nerve innervating individual muscle fibers?
What would happen if the $Ca^{2+}$-ATPase pump in the sarcoplasmic reticulum stopped functioning?
What would happen if the $Ca^{2+}$-ATPase pump in the sarcoplasmic reticulum stopped functioning?
What structural change occurs in the actin filament when the myosin-binding site becomes available?
What structural change occurs in the actin filament when the myosin-binding site becomes available?
What is the primary function of the lateral sacs (terminal cisternae) of the sarcoplasmic reticulum?
What is the primary function of the lateral sacs (terminal cisternae) of the sarcoplasmic reticulum?
How is the action potential transferred from the motor neuron to the muscle fiber at the neuromuscular junction?
How is the action potential transferred from the motor neuron to the muscle fiber at the neuromuscular junction?
What role do gap junctions play in muscle tissue, if any?
What role do gap junctions play in muscle tissue, if any?
How does the influx of $Ca^{2+}$ and $Na^+$ ions, after activation of the acetylcholine-gated cation channel, contribute to muscle cell excitability?
How does the influx of $Ca^{2+}$ and $Na^+$ ions, after activation of the acetylcholine-gated cation channel, contribute to muscle cell excitability?
What event directly causes myosin to bind to actin?
What event directly causes myosin to bind to actin?
What is the result of the wave of the action potential traveling along the T-tubules?
What is the result of the wave of the action potential traveling along the T-tubules?
Flashcards
Acetylcholine (Ach)
Acetylcholine (Ach)
The main neurotransmitter that controls muscle movement.
Striations in Skeletal Muscle
Striations in Skeletal Muscle
Skeletal muscles have visible striations, indicating their organized structure.
Function of Skeletal Muscle
Function of Skeletal Muscle
Skeletal muscles enable body movement; controlled by the somatic nervous system (SNS).
Cardiac muscle contraction
Cardiac muscle contraction
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Smooth muscle contraction control
Smooth muscle contraction control
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Passive tension
Passive tension
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Isometric contraction
Isometric contraction
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Brain regulates muscle length
Brain regulates muscle length
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Myosin Detachment
Myosin Detachment
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Myosin Head Activation
Myosin Head Activation
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Myosin-Actin Binding
Myosin-Actin Binding
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Power Stroke
Power Stroke
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Sarcomere Definition
Sarcomere Definition
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Sarcomere Location
Sarcomere Location
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Myofilaments Composition
Myofilaments Composition
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Thick Filament
Thick Filament
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Thin Filament
Thin Filament
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Sliding Filament Theory
Sliding Filament Theory
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Action Potential (AP) Propagation
Action Potential (AP) Propagation
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Motor End Plate
Motor End Plate
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T-tubules
T-tubules
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Sarcoplasmic Reticulum (SR)
Sarcoplasmic Reticulum (SR)
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Excitation-Contraction Coupling
Excitation-Contraction Coupling
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Calcium's Role in Contraction
Calcium's Role in Contraction
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Troponin
Troponin
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Tropomyosin
Tropomyosin
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Lateral Sacs
Lateral Sacs
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Calcium Re-uptake
Calcium Re-uptake
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Study Notes
- Muscles convert electrical signals to excitation-contraction
- Acetylcholine (ACh) and contraction are linked
Terminal Button and Muscle Cell Interaction
- The terminal button is separated from the muscle cell by a gap
- The surface membrane of the muscle cell contains T tubules and lateral sacs of the sarcoplasmic reticulum
- Acetylcholine binds to nicotinic receptors on the muscle cell, opening ion channels
- Calcium and sodium influx increases the membrane potential
- Activated calcium channels release more calcium
Role of Calcium and Proteins in Muscle Contraction
- Calcium binds to iron channels
- Calcium also binds to troponin which is bound to tropomyosin
- This binding induces a shape change in troponin
- Tropomyosin then moves, which makes the actin-myosin binding site accessible
- Myosin cross-bridges then bind to actin
Motor Nerve and Motor End Plate
- A motor nerve (myelinated) branches at its terminal, with each branch (axon) ending on a separate muscle fiber
- The ending is a motor end plate
- At the motor end plate, the arrival of a nerve action potential triggers the muscle fiber to activate, which happens at the neuromuscular junction
- The trigger is the release of acetylcholine (ACh) as a neurotransmitter
Muscle Contraction from Action Potential
- Action potentials propagate along the muscle surface membrane and down the T-tubules
- Depolarization opens calcium channels in the sarcoplasmic reticulum (SR), which are calcium stores
- Calcium is released into the sarcoplasm, increasing its concentration tenfold
- Calcium binds to troponin, initiating muscle contraction
- Calcium is then re-accumulated by the SR via Ca2+-ATPase pumps, which leads to muscle relaxation
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