13 Questions
What causes transmitter release?
Synaptic vesicle
What does a rise in calcium do?
Promotes actin-myosin interaction and cell shortening
What is the main difference between skeletal and smooth muscle contraction?
Skeletal muscle has striations, while smooth muscle does not
What leads to a rise in calcium during skeletal muscle activation?
Opening of voltage-sensitive calcium channels
What is the primary event following acetylcholine release at the neuromuscular junction?
Activation of nicotinic AchR
What is the role of SERCA in skeletal muscle contraction?
Pumping calcium ions out of the cytoplasm into the sarcoplasmic reticulum
What triggers calcium-induced calcium release (CICR) in cardiac muscle contraction?
Membrane depolarization through T-tubules
What is the function of Troponin-T?
Binds to tropomyosin
How does calcium influx affect smooth muscle contraction?
Activates Myosin Light Chain Kinase (MLCK)
What differentiates the myosin isoform in smooth muscle from that in skeletal muscle?
Lower ATPase activity
What is the role of Myosin Light Chain Kinase (MLCK) in smooth muscle cells?
Activates myosin light chains by phosphorylation
What is the function of Troponin-C?
Calcium binding
What initiates the depolarization process in a skeletal muscle cell?
Neuronal Action Potential (AP)
Test your knowledge of muscle contraction mechanisms including transmitter release, calcium rise in skeletal muscle activation, myosin interaction with actin, and differences between skeletal and smooth muscle contraction.
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