19 Questions
Which molecule is involved in down-regulating T cell activation by binding to B7.1/2 with higher affinity than CD28?
CTLA-4
What is the function of CTLA-4 in activated T cells?
Inhibit proliferation
Do effector T cells require costimulatory signals?
No, they never require costimulatory signals
Which pathway of cell death is triggered by the Fas-FasL pathway involving CTLs?
Extrinsic pathway
Which type of Tregs arise in the periphery from CD4+ T cells?
Induced (adaptive) Tregs
What is the role of ILC2 and TH2 cells in infections?
Producing a trio of cytokines
Which molecule is expressed on activated T cells and down-regulates T cell activation?
PD-1
What function do Treg cells serve in immune responses?
Inhibiting immune responses
What is the main function of Treg cells?
Negatively regulate immune responses
When does clonal contraction occur in the immune response?
After the antigen is cleared
Which molecule binds PDL-1 and PDL-2 to down-regulate T cell activation?
PD-1
Which cytokines are produced by ILC3 cells to defend against bacterial infection?
IL-17
What is the main function of IL-10 and TGF-b in the context of immune responses?
Suppress immune responses
What happens to most lymphocytes after an antigen is removed?
They undergo apoptosis
What happens to B7 molecules when CTLA-4 binds to them?
B7 molecules are sequestered and prevent binding to CD28
Which type of infection do ILC2 and TH2 cells assist in clearing?
Helminth infection
What contributes to the activation of ILCs?
Cytokines
What do effector T cells do once they have been activated, proliferated, and differentiated?
Require signals from APCs again
What happens to newly generated B and T cells at the end of the primary immune response?
They are lost
Refresh your understanding of Innate Lymphoid Cells (ILCs) and their role in the immune system. Explore how ILCs contribute to clearing infections, respond to cytokines, and target different pathogens. Dive into specific examples like ILC2 and ILC3 interactions with other immune cells.
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