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Final T cell lecture: negative regulation

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Final T cell lecture: negative regulation

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Questions and Answers

Which molecule is involved in down-regulating T cell activation by binding to B7.1/2 with higher affinity than CD28?

TGF-b

CTLA-4 (correct)

PD-1

IL-10

What is the function of CTLA-4 in activated T cells?

Promote cell growth

Enhance IL-2 production

Activate APCs

Inhibit proliferation (correct)

Do effector T cells require costimulatory signals?

Effector T cells require costimulatory signals only in the presence of APCs

Yes, they always require costimulatory signals

Effector T cells sometimes require costimulatory signals

No, they never require costimulatory signals (correct)

Which pathway of cell death is triggered by the Fas-FasL pathway involving CTLs?

Extrinsic pathway Signup and view all the answers

Which type of Tregs arise in the periphery from CD4+ T cells?

Induced (adaptive) Tregs Signup and view all the answers

What is the role of ILC2 and TH2 cells in infections?

Producing a trio of cytokines Signup and view all the answers

Which molecule is expressed on activated T cells and down-regulates T cell activation?

PD-1 Signup and view all the answers

What function do Treg cells serve in immune responses?

Inhibiting immune responses Signup and view all the answers

What is the main function of Treg cells?

Negatively regulate immune responses Signup and view all the answers

When does clonal contraction occur in the immune response?

After the antigen is cleared Signup and view all the answers

Which molecule binds PDL-1 and PDL-2 to down-regulate T cell activation?

PD-1 Signup and view all the answers

Which cytokines are produced by ILC3 cells to defend against bacterial infection?

IL-17 Signup and view all the answers

What is the main function of IL-10 and TGF-b in the context of immune responses?

Suppress immune responses Signup and view all the answers

What happens to most lymphocytes after an antigen is removed?

They undergo apoptosis Signup and view all the answers

What happens to B7 molecules when CTLA-4 binds to them?

B7 molecules are sequestered and prevent binding to CD28 Signup and view all the answers

Which type of infection do ILC2 and TH2 cells assist in clearing?

Helminth infection Signup and view all the answers

What contributes to the activation of ILCs?

Cytokines Signup and view all the answers

What do effector T cells do once they have been activated, proliferated, and differentiated?

Require signals from APCs again Signup and view all the answers

What happens to newly generated B and T cells at the end of the primary immune response?

They are lost Signup and view all the answers