10 Questions
Which of the following cell types is primarily responsible for antigen presentation in D-MALT?
Dendritic cells
What is the primary mechanism by which D-MALT induces tolerance to commensal microorganisms?
By promoting the differentiation of Tregs
What is the primary function of D-MALT in the mucosal immune system?
To induce the production of secretory IgA antibodies
Which of the following cytokines is primarily involved in the development of D-MALT?
IL-7
What is the primary function of the organized lymphoid structures in D-MALT?
To provide a site for the interaction between T cells and antigen-presenting cells
What is the primary mechanism by which keratinocytes regulate the immune response in the mucosal immune system?
Producing antimicrobial peptides that modulate the microbiota
How do keratinocytes contribute to the development of mucosal tolerance?
By producing TGF-β to induce regulatory T-cell differentiation
What is the primary function of keratinocyte-derived cytokines in the mucosal immune system?
Modulating the activity of immune cells
How do keratinocytes interact with dendritic cells in the mucosal immune system?
By producing chemokines that attract dendritic cells
What is the consequence of keratinocyte dysfunction in the mucosal immune system?
Impaired immune tolerance to commensal microorganisms
Delve into the intricacies of mucosal immunity and explore the role of D-MALT in the immune system. Test your knowledge of this complex topic and discover the intricacies of immune responses in the mucosal layer. Are you up for the challenge?
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