Mucocutaneous Disease Treatment Options
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Questions and Answers

What type of disease is being referred to in the context?

  • Autoimmune disorder
  • Neurological disorder
  • Infectious disease
  • Mucocutaneous disease (correct)

    • What is the first-line treatment for mucocutaneous disease?

  • Colchicine (correct)
  • Topical antibiotics
  • Systemic steroids
  • Immunosuppressive therapy

    • What is an alternative treatment option for mucocutaneous disease?

  • Oral antivirals
  • Topical steroids (correct)
  • Topical antifungals
  • Systemic antihistamines

    • What is a common symptom of mucocutaneous disease?

    <p>All of the above</p> Signup and view all the answers

    What is the primary site of mucocutaneous disease?

    <p>Both skin and mucous membrane</p> Signup and view all the answers

    What is the treatment option for more severe cases of refractory disease?

    <p>TNF inhibitors</p> Signup and view all the answers

    What is the name of the disease characterized by recurrent episodes of fever with serosal, synovial, or cutaneous inflammation?

    <p>Familial Mediterranean fever</p> Signup and view all the answers

    What is used to treat CNS disease and uveitis?

    <p>Cyclophosphomide</p> Signup and view all the answers

    What is known as Recurrent polyserositis?

    <p>Familial Mediterranean fever</p> Signup and view all the answers

    What is NOT a treatment option for refractory disease?

    <p>Methotrexate</p> Signup and view all the answers

    At what age do 90% of patients experience their first febrile episode?

    <p>By age 20</p> Signup and view all the answers

    What is the typical duration of a febrile episode in this disease?

    <p>1-4 days</p> Signup and view all the answers

    What percentage of patients experience febrile episodes?

    <p>90%</p> Signup and view all the answers

    When do febrile episodes typically begin in this disease?

    <p>In early infancy</p> Signup and view all the answers

    What triggers febrile episodes in this disease?

    <p>Unknown triggers</p> Signup and view all the answers

    What is the most common side effect of colchicine?

    <p>Bloating, abdominal cramps, and diarrhea</p> Signup and view all the answers

    Which of the following is a serious side effect of colchicine?

    <p>Acute renal failure</p> Signup and view all the answers

    What is a common symptom of colchicine-induced neuromyopathy?

    <p>Proximal muscle weakness</p> Signup and view all the answers

    What is a laboratory finding that may be associated with colchicine-induced neuromyopathy?

    <p>Elevated creatinine kinase</p> Signup and view all the answers

    What is a serious muscle-related side effect of colchicine?

    <p>Rhabdomyolysis</p> Signup and view all the answers

    What are the two tracts through which colchicine and its metabolites are excreted?

    <p>Urinary and biliary tracts</p> Signup and view all the answers

    What is a potential side effect of using colchicine?

    <p>Neuropathy</p> Signup and view all the answers

    What is the term for a decrease in bone marrow activity, leading to decreased blood cell production?

    <p>Myelosuppression</p> Signup and view all the answers

    What two systems are affected by myelosuppression?

    <p>Hematopoietic and immune systems</p> Signup and view all the answers

    What is the result of decreased bone marrow activity?

    <p>Decreased blood cell production</p> Signup and view all the answers

    Study Notes

    Mucocutaneous Disease Treatment

    • First-line treatment: Colchicine
    • Topical steroids can be tried as an alternative

    Refractory Disease Treatment

    • Low dose systemic steroids
    • Azathioprine
    • TNF inhibitors

    CNS Disease and Uveitis Treatment

    • High dose systemic steroids
    • Cyclophosphamide

    Familial Mediterranean Fever (FMF)

    • Also known as Recurrent polyserositis
    • Characterized by recurrent episodes of fever with serosal, synovial, or cutaneous inflammation
    • Autosomal recessive disease

    Clinical Manifestations of FMF

    • Febrile episodes that may begin in early infancy
    • 90% of patients have their first attack by age 20
    • Attacks typically last 1-4 days

    Colchicine

    • Excreted through urinary and biliary tracts
    • Side effects:
      • Common: Bloating, abdominal cramps, diarrhea, nausea, and vomiting
      • Serious: Bone marrow suppression, acute renal failure, rhabdomyolysis, and neuromyopathy (proximal muscle weakness and elevation of creatinine kinase)

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    Description

    This quiz covers the treatment options for mucocutaneous diseases, including first-line and refractory treatments, as well as specific treatments for CNS disease and uveitis, and Familial Mediterranean Fever.

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