Podcast
Questions and Answers
What can lead to systemic organ dysfunction and disease, including inflammation, cancer, diabetes, cardiovascular disease, obesity, and reproductive disorders?
What can lead to systemic organ dysfunction and disease, including inflammation, cancer, diabetes, cardiovascular disease, obesity, and reproductive disorders?
- Bone growth abnormalities
- Lipid metabolism disruption
- Apoptosis dysfunction
- Mutations, misfolding, or alteration of signaling pathways (correct)
Which nuclear receptor is essential for male sexual differentiation, bone growth, muscle homeostasis, and development?
Which nuclear receptor is essential for male sexual differentiation, bone growth, muscle homeostasis, and development?
- Progesterone Receptor (PR)
- Oestrogen Receptor (ER)
- Retinoid X Receptor (RXR)
- Androgen Receptor (AR) (correct)
What role does the Progesterone Receptor (PR) play in the body?
What role does the Progesterone Receptor (PR) play in the body?
- Muscle homeostasis maintenance
- Female reproduction
- Development of mammary glands & other female reproductive organs (correct)
- Bone growth regulation
Which nuclear receptor is associated with breast cancer development & metastasis when dysregulated?
Which nuclear receptor is associated with breast cancer development & metastasis when dysregulated?
What functions are promoted by downregulation or loss of RXR signaling?
What functions are promoted by downregulation or loss of RXR signaling?
Which nuclear receptor plays a key role in lipid metabolism, apoptosis, and the immune system?
Which nuclear receptor plays a key role in lipid metabolism, apoptosis, and the immune system?
What is a common consequence of dysregulation of nuclear receptor signaling in the body?
What is a common consequence of dysregulation of nuclear receptor signaling in the body?
What is the initial event in the activation of Class I nuclear receptors?
What is the initial event in the activation of Class I nuclear receptors?
What is the final step in the activation pathway of Class I nuclear receptors?
What is the final step in the activation pathway of Class I nuclear receptors?
Which subclassification of nuclear receptors generally requires ligand binding for both partners to activate?
Which subclassification of nuclear receptors generally requires ligand binding for both partners to activate?
What is the role of co-repressor complexes like NCoR and SMRT in Class II nuclear receptor signaling?
What is the role of co-repressor complexes like NCoR and SMRT in Class II nuclear receptor signaling?
Which nuclear receptor superfamily plays a significant role in lipid metabolism and inflammatory signaling?
Which nuclear receptor superfamily plays a significant role in lipid metabolism and inflammatory signaling?
How do Class II nuclear receptors like PPAR-RXR and LXR-RXR differ in their ligand binding requirements?
How do Class II nuclear receptors like PPAR-RXR and LXR-RXR differ in their ligand binding requirements?
Why are Class I nuclear receptors crucial in embryogenesis and tissue development?
Why are Class I nuclear receptors crucial in embryogenesis and tissue development?
Which nuclear receptor is associated with cell growth reduction or increased susceptibility to apoptosis in prostate cancer cells?
Which nuclear receptor is associated with cell growth reduction or increased susceptibility to apoptosis in prostate cancer cells?
Which type of nuclear receptors are involved in the modulation of cellular differentiation, development, and metabolism?
Which type of nuclear receptors are involved in the modulation of cellular differentiation, development, and metabolism?
Which drug is an AR antagonist used in the treatment of metastatic prostate cancer?
Which drug is an AR antagonist used in the treatment of metastatic prostate cancer?
What is the approved indication for Bexarotene, a RXR modulator?
What is the approved indication for Bexarotene, a RXR modulator?
Which nuclear receptor drug is used for the treatment of non-metastatic CRPC?
Which nuclear receptor drug is used for the treatment of non-metastatic CRPC?
Which nuclear receptor drug is known for its reduction in the risk of breast cancer?
Which nuclear receptor drug is known for its reduction in the risk of breast cancer?
Which class of nuclear receptors enhances peripheral insulin sensitivity and is used in Type II diabetes treatment?
Which class of nuclear receptors enhances peripheral insulin sensitivity and is used in Type II diabetes treatment?
'Ligands of PPARα are clinically effective at lowering TG & LDL and increasing HDL' - This statement refers to the action of which type of drugs?
'Ligands of PPARα are clinically effective at lowering TG & LDL and increasing HDL' - This statement refers to the action of which type of drugs?
Which nuclear receptor drug is used for the treatment of metastatic breast cancer and reducing the risk of breast cancer?
Which nuclear receptor drug is used for the treatment of metastatic breast cancer and reducing the risk of breast cancer?
What is the main function of nuclear receptors within the cell?
What is the main function of nuclear receptors within the cell?
How many members are there in the human nuclear receptor superfamily?
How many members are there in the human nuclear receptor superfamily?
Which class of nuclear receptors functions as endocrine receptors that bind to specific DNA elements as homo-dimers?
Which class of nuclear receptors functions as endocrine receptors that bind to specific DNA elements as homo-dimers?
What is the main role of Class II (RXR Heterodimers) nuclear receptors?
What is the main role of Class II (RXR Heterodimers) nuclear receptors?
Which statement best describes the role of nuclear receptor signalling in health and disease?
Which statement best describes the role of nuclear receptor signalling in health and disease?
Which domain of nuclear receptors harbors the ligand-binding site and modulates co-activator & co-repressor binding?
Which domain of nuclear receptors harbors the ligand-binding site and modulates co-activator & co-repressor binding?
What does the hinge region of nuclear receptors primarily do?
What does the hinge region of nuclear receptors primarily do?
What role does the Retinoid X Receptor (RXR) play in the body?
What role does the Retinoid X Receptor (RXR) play in the body?
How is the Progesterone Receptor (PR) involved in the development of the body?
How is the Progesterone Receptor (PR) involved in the development of the body?
What are the essential functions of the Androgen Receptor (AR) in the male body?
What are the essential functions of the Androgen Receptor (AR) in the male body?
How does dysregulation of the Oestrogen Receptor (ER) impact health?
How does dysregulation of the Oestrogen Receptor (ER) impact health?
What are the consequences of mutations, misfolding, or alteration of signaling pathways involving Nuclear Receptors?
What are the consequences of mutations, misfolding, or alteration of signaling pathways involving Nuclear Receptors?
