Podcast
Questions and Answers
Which polymorphic form of testosterone has the highest melting point?
Which polymorphic form of testosterone has the highest melting point?
- Form I (correct)
- Form IV
- Form II
- Form III
What is the advantage of having metastable polymorphic forms in drug delivery?
What is the advantage of having metastable polymorphic forms in drug delivery?
- They are more stable
- They have lower melting points
- They have better solubility (correct)
- They have higher bioavailability
What differentiates crystal hydrates from anhydrates in terms of solubility?
What differentiates crystal hydrates from anhydrates in terms of solubility?
- Crystal hydrates are more soluble (correct)
- Both have equal solubility
- Solubility is not affected by hydration state
- Anhydrates are more soluble
How do crystal hydrates and anhydrates of a drug differ in terms of stability?
How do crystal hydrates and anhydrates of a drug differ in terms of stability?
What type of crystal lattice defect can influence the physical properties of crystals by missing an atom?
What type of crystal lattice defect can influence the physical properties of crystals by missing an atom?
What knowledge is important for understanding crystal habit and polymorphism in the context of drug manufacturing?
What knowledge is important for understanding crystal habit and polymorphism in the context of drug manufacturing?
What is one of the effects of different polymorphs on molecules?
What is one of the effects of different polymorphs on molecules?
Which physical property can be significantly impacted by polymorphism?
Which physical property can be significantly impacted by polymorphism?
What type of transition involves a change from a metastable form to a stable form?
What type of transition involves a change from a metastable form to a stable form?
How can polymorphism impact the manufacture of dosage forms?
How can polymorphism impact the manufacture of dosage forms?
Which form of a polymorph typically has the lowest free energy?
Which form of a polymorph typically has the lowest free energy?
How does polymorphism influence the bioavailability of drugs?
How does polymorphism influence the bioavailability of drugs?
How does the presence of surfactants in the crystallisation solution impact crystal habit modification?
How does the presence of surfactants in the crystallisation solution impact crystal habit modification?
What is the primary impact of polymorphism on a substance?
What is the primary impact of polymorphism on a substance?
How do crystals with the same combinations of crystallographic forms but different crystal habits differ?
How do crystals with the same combinations of crystallographic forms but different crystal habits differ?
What effect does anionic surfactants have on crystal habit?
What effect does anionic surfactants have on crystal habit?
How does polymorphism affect the physical properties of a substance?
How does polymorphism affect the physical properties of a substance?
What is the role of impurities in modifying crystal habit?
What is the role of impurities in modifying crystal habit?
What is the key difference between crystalline and amorphous materials based on the text?
What is the key difference between crystalline and amorphous materials based on the text?
How does the text describe the crystallographic structure of crystals?
How does the text describe the crystallographic structure of crystals?
What is the role of the unit cell in crystallography?
What is the role of the unit cell in crystallography?
Which type of material shows a sharp transition from solid to liquid state upon heating?
Which type of material shows a sharp transition from solid to liquid state upon heating?
What are some examples of crystalline materials mentioned in the text?
What are some examples of crystalline materials mentioned in the text?
How do amorphous substances differ from crystalline substances upon heating?
How do amorphous substances differ from crystalline substances upon heating?
What are the three dimensions used to describe a unit cell?
What are the three dimensions used to describe a unit cell?
How many different basic crystal systems exist based on geometric descriptions?
How many different basic crystal systems exist based on geometric descriptions?
What term is used to describe the possibility of the presence of center atoms inside the unit cell or at edges of faces of the unit cell?
What term is used to describe the possibility of the presence of center atoms inside the unit cell or at edges of faces of the unit cell?
Which angles are used to describe a unit cell in crystallography?
Which angles are used to describe a unit cell in crystallography?
How many degrees of order do the seven basic crystal systems cover for atoms and molecules?
How many degrees of order do the seven basic crystal systems cover for atoms and molecules?
What role does a unit cell play in determining crystallinity?
What role does a unit cell play in determining crystallinity?
What term is used to describe crystal forms with different order of molecules or atoms but the same type of crystal lattice?
What term is used to describe crystal forms with different order of molecules or atoms but the same type of crystal lattice?
How can crystal habit be modified in the context of polymorphic forms?
How can crystal habit be modified in the context of polymorphic forms?
What is the impact of anionic surfactants on crystal habit modification?
What is the impact of anionic surfactants on crystal habit modification?
What is the result of cationic surfactants on crystal habit modification?
What is the result of cationic surfactants on crystal habit modification?
How do crystals with the same habit but different combinations of faces differ?
How do crystals with the same habit but different combinations of faces differ?
