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Monoclonal vs Polyclonal Antibodies

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Questions and Answers

What is the purpose of using monoclonal antibodies (mAbs) as diagnostic tools?

To produce hybridoma technology

To treat bacterial infections

To stimulate the immune system

To identify the presence of specific proteins (correct)

How are monoclonal antibodies (mAbs) produced by hybridoma technology?

By injecting mice with antigens

By directly extracting them from animals that have been immunized

By transforming human B-cells with Epstein-Barr virus

By fusing un-dividing B lymphocytes producing specific antibodies with myeloma cells (correct)

Which method is an alternative way to produce monoclonal antibodies using human B-cells?

By transforming human B-cells with Epstein-Barr virus (correct)

By injecting mice with antigens

By directly extracting them from animals that have been immunized

By fusing B lymphocytes with myeloma cells

What is the basis of hybridoma technology for producing monoclonal antibodies?

<p>Fusion of un-dividing B lymphocytes producing specific antibodies with myeloma cells</p> Signup and view all the answers

What is the main benefit of using monoclonal antibodies (mAbs) for therapeutic purposes?

<p>High specificity and recognition of only one epitope on the antigen</p> Signup and view all the answers

Study Notes

Antibody Types

Polyclonal Antibodies: Generated from the immune response to an antigen injected into an animal, leading to a mix of antibodies from multiple lymphocyte clones.
Polyclonal Antisera: Serum collected post-immunization that contains a diverse range of antibodies that target the original antigen.

Monoclonal Antibodies

Defined as antibodies produced by a single clone of B-cells, resulting in identical heavy and light chain structures.
Advantages:
- High specificity towards the target antigen.
- More consistent efficacy in research and therapeutic applications.
- Predictable toxicity profiles in vivo.

Historical Development

Monoclonal antibodies (mAbs) were first created in 1970.
Hybridoma Technology: This method enabled the expansion and immortalization of individual B-cell clones, establishing a foundation for producing mAbs.

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Description

Learn about the differences between monoclonal and polyclonal antibodies and how they are produced in the immune response. Understand the enrichment process of antibodies specific to antigens.