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What is a major advantage of monoclonal antibodies in terms of their source?
Which type of antibody is best suited for large antigens with changing epitopes?
What is a limitation of polyclonal antibodies?
What is a major difference between monoclonal and polyclonal antibodies in terms of their production?
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What is a common application of monoclonal antibodies?
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What is a characteristic of monoclonal antibodies in terms of their growth?
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What is a limitation of using polyclonal antibodies from multiple animals?
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What is a benefit of using monoclonal antibodies in terms of purification?
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What is a characteristic of polyclonal antibodies in terms of their use?
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What is a difference between monoclonal and polyclonal antibodies in terms of their production?
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Study Notes
Monoclonal Antibodies
- Restricted to mouse cells
- Can be developed and grown in cell culture, which is quick and inexpensive
- Provides a lifelong source of antibodies with minimal purification needed
- Most commonly used in immunoassays
- Offers a constant source of antibodies
Polyclonal Antibodies
- Can be obtained from various animal species, as long as they are large enough
- Requires animal housing and strict regulations
- Provides a finite source of antibodies, as the animal will eventually die of old age
- The antibody source changes each time a new animal is used
- Requires purification of antibodies from other cell components
- Best suited for large antigens with changing epitopes, such as bacteria
Monoclonal Antibodies
- Restricted to mouse cells
- Can be developed and grown in cell culture, which is quick and inexpensive
- Provides a lifelong source of antibodies with minimal purification needed
- Most commonly used in immunoassays
- Offers a constant source of antibodies
Polyclonal Antibodies
- Can be obtained from various animal species, as long as they are large enough
- Requires animal housing and strict regulations
- Provides a finite source of antibodies, as the animal will eventually die of old age
- The antibody source changes each time a new animal is used
- Requires purification of antibodies from other cell components
- Best suited for large antigens with changing epitopes, such as bacteria
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Description
This quiz compares and contrasts monoclonal and polyclonal antibodies, including their development, advantages, and limitations. Learn about the differences in their production, purification, and uses in immunoassays.
