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Questions and Answers
What is the primary method by which the majority of DNA damage is repaired?
What is the primary method by which the majority of DNA damage is repaired?
- By using chemical antioxidants
- By summoning immune cells
- By excising the damaged bases and resynthesizing the removed area (correct)
- By employing RNA interference
What enzyme is involved in breaking down guanine bases in DNA?
What enzyme is involved in breaking down guanine bases in DNA?
- DNA ligase
- DNA polymerase
- Endonuclease
- 06-Methylguanine DNA methyltransferase (MGMT) (correct)
Why might reversing the damage be a more effective method than excision for certain DNA lesions?
Why might reversing the damage be a more effective method than excision for certain DNA lesions?
- It speeds up the process
- It avoids the need for resynthesis (correct)
- It enhances the fidelity of repair
- It consumes less cellular energy
What is the role of MGMT in DNA repair?
What is the role of MGMT in DNA repair?
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What unique mechanism has the cell evolved for dealing with DNA damage?
What unique mechanism has the cell evolved for dealing with DNA damage?
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Which of the following does MGMT NOT break down?
Which of the following does MGMT NOT break down?
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Study Notes
DNA Damage and Repair
- Most DNA damage is repaired by excising the damaged bases and then resynthesizing the removed area.
- Certain DNA lesions can be directly repaired by reversing the damage, which may be a more effective method for treating some common types of DNA damage.
Mechanisms of DNA Repair
- The cell has evolved a unique mechanism to either repair the damage or get rid of the harmful chemical for each form of DNA damage.
Enzymes Involved in DNA Repair
- MGMT (DNA alkyltransferase) breaks down guanine bases or the DNA structure into methyl and ethyl adducts.
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Description
This quiz covers the processes of DNA repair, including excision and resynthesis, and how it corrects different types of DNA damage.
