6 Questions
What is the primary method by which the majority of DNA damage is repaired?
By excising the damaged bases and resynthesizing the removed area
What enzyme is involved in breaking down guanine bases in DNA?
06-Methylguanine DNA methyltransferase (MGMT)
Why might reversing the damage be a more effective method than excision for certain DNA lesions?
It avoids the need for resynthesis
What is the role of MGMT in DNA repair?
To reverse alkylation damage
What unique mechanism has the cell evolved for dealing with DNA damage?
Either repair the damage or get rid of the harmful chemical
Which of the following does MGMT NOT break down?
Thymine dimers
Study Notes
DNA Damage and Repair
- Most DNA damage is repaired by excising the damaged bases and then resynthesizing the removed area.
- Certain DNA lesions can be directly repaired by reversing the damage, which may be a more effective method for treating some common types of DNA damage.
Mechanisms of DNA Repair
- The cell has evolved a unique mechanism to either repair the damage or get rid of the harmful chemical for each form of DNA damage.
Enzymes Involved in DNA Repair
- MGMT (DNA alkyltransferase) breaks down guanine bases or the DNA structure into methyl and ethyl adducts.
This quiz covers the processes of DNA repair, including excision and resynthesis, and how it corrects different types of DNA damage.
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