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Questions and Answers
What is the function of chromosomal mutations such as deletions and duplications?
Which type of chromosome has its centromere located at the middle?
What is achieved through the process of meiosis in humans?
What term describes a segment of a chromosome that has a change in direction?
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In Mendel's laws of inheritance, what is the definition of a dominant trait?
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What stage during meiosis allows for genetic diversity through crossover?
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What are gametes in terms of chromosomal composition?
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Which of the following best describes the advantage of sexual reproduction?
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What is the role of the Ames test in assessing chemical safety?
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How do pyrimidine dimers affect DNA functionality?
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What distinguishes a benign tumor from a malignant tumor?
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What role do oncogenes play in cancer development?
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What is xeroderma pigmentosum caused by?
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Which statement about proto-oncogenes is true?
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What is metastasis in the context of cancer?
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Which of the following correctly describes a tumor's development in cancer?
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What occurs during anaphase in mitosis?
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How does cytokinesis differ in animal and plant cells?
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What is formed during prophase I of meiosis?
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What is the major function of crossing over during meiosis?
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Which phase involves the segregation of homologs during meiosis?
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What is the significance of the synaptonemal complex during meiosis?
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What structure forms between two daughter cells during plant cell cytokinesis?
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What is the end result of meiosis in terms of chromosome number?
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What is one way HIV can be transmitted?
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What role do helper T cells play in the immune system?
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What is a consequence of HIV destroying T cells?
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Why is it difficult to create a vaccine for HIV?
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What is a characteristic of viroids?
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What do prions do to normal proteins?
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What are resistance plasmids (R factors) primarily used for?
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What biological process requires the compaction of the bacterial chromosome?
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What can be inferred about the gametes in terms of chromosome transmission during fertilization?
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How does Mendel's Law of Segregation relate to meiosis?
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What distinguishes an autosomal dominant disease from an autosomal recessive disease?
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What is true about the Law of Independent Assortment?
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What is the role of locus in genetics?
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In which inheritance pattern is Huntington disease categorized?
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Which of the following statements about sex chromosomes is correct?
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What characterizes the haplo-diploid system in bees?
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Study Notes
Ames Test
- Detects the mutagenic potential of chemicals
- Uses Salmonella typhimurium strains with a mutation preventing histidine synthesis
- Detects mutations that allow the bacteria to regain the ability to synthesize histidine
DNA Repair and Xeroderma Pigmentosum
- Inherited disease caused by a defect in the UV repair pathway
- Individuals with XP are highly sensitive to UV radiation
Cancer
- Develops from a single cell that accumulates genetic changes
- Benign tumors are non-invasive and do not metastasize
- Malignant tumors invade surrounding tissues and metastasize
Oncogenes and Proto-oncogenes
- Oncogenes promote uncontrolled cell growth by being overactive
- Proto-oncogenes are normal genes that can become oncogenes when mutated
- Examples of oncogene mutations involve growth factors and receptors
Mitosis
- Cell division that produces two daughter cells genetically identical to the parent cell
- Includes the stages: prophase, metaphase, anaphase, telophase, and cytokinesis
- Involves the separation of sister chromatids, reformation of nuclear membranes, and division of the cytoplasm
Meiosis
- Cell division that produces four haploid daughter cells from a diploid parent cell
- Involves two rounds of division: meiosis I and meiosis II
- Includes the processes of synapsis, crossing over, and segregation of homologous chromosomes
Chromosome Identification
- Chromosomes are identified based on size, centromere location, and banding patterns
- Centromere location is described as metacentric, submetacentric, acrocentric, or telocentric
- Banding patterns are observed under a light microscope after staining
Chromosomal Mutations
- Deletions: loss of a chromosome segment
- Duplications: repeated segment of chromosome
- Inversions: segment is flipped in direction
- Translocations: segment attaches to another chromosome
Sex Chromosomes
- Sex chromosomes determine an individual's sex
- X-Y system: males XY, females XX
- X-O system: females XX, males X or XO
- Z-W system: males ZZ, females ZW
HIV
- Human immunodeficiency virus, causes AIDS
- Targets and destroys helper T cells, weakening the immune system
- Can be spread through sexual contact, blood transfusions, sharing of needles, and mother-to-child transmission
- Reverse transcriptase lacks proofreading function, leading to rapid mutation and making vaccine development difficult
Viroids
- Single-stranded circular RNA molecules infecting plant cells
- Replicate in the nucleus or chloroplast
- Do not encode proteins
Prions
- Infectious proteins that cause neurodegenerative diseases
- PrP protein in a different conformation causes disease
- Prions convert other normal PrP proteins to the abnormal form
- Can cause transmissible spongiform encephalopathies (TSE)
Bacterial Chromosome Compaction
- Bacterial chromosomes are supercoiled to fit within the cell
- Topoisomerases control the degree of supercoiling
Plasmids
- Small, circular pieces of DNA independent of the bacterial chromosome
- Can replicate independently and provide growth advantages
- Episomes can integrate into the bacterial chromosome
- Include resistance plasmids, degradative plasmids, virulence plasmids, and fertility plasmids
Bacterial Reproduction
- Bacteria reproduce asexually through binary fission.
- The bacterial chromosome is replicated and the cell divides into two daughter cells.
- This process is rapid and allows bacteria to quickly populate a suitable environment.
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Description
Test your knowledge on key topics in molecular biology, including the Ames Test, DNA repair mechanisms, cancer biology, and the role of oncogenes. This quiz covers essential concepts related to genetics and cell division, providing insights into how genetic changes lead to diseases like cancer.