Molecular Modelling and Drug Designing Lecture Online
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Questions and Answers

What is the definition of a drug?

A drug is any chemical or biological substance, synthetic or non-synthetic, intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in man or other animals.

Give an example of a source of synthetic drugs.

Propranolol

Name one source of biological drugs.

Penicillin

Why are new drugs needed?

<p>New drugs are needed for the diagnosis, cure, mitigation, treatment, or prevention of disease in man or other animals.</p> Signup and view all the answers

What are some examples of unmet medical needs mentioned in the text?

<p>Corona Virus, Swine flu, AIDS, Alzheimer’s, obesity</p> Signup and view all the answers

What are the downstream health costs mentioned in the text?

<p>Alzheimer’s, spinal injury</p> Signup and view all the answers

What are some factors contributing to the cost of therapy according to the text?

<p>Interleukins</p> Signup and view all the answers

What is the term used for the occasional discovery of new drugs by luck?

<p>Serendipity</p> Signup and view all the answers

Who discovered the antibiotic penicillin by accident?

<p>Fleming</p> Signup and view all the answers

What drug was considered just a better tolerable prodrug of salicylic acid but turned out to have a unique mechanism?

<p>Acetylsalicylic acid</p> Signup and view all the answers

What use was initially thought for phenolphthalein before its drastic diarrheal activity was discovered?

<p>Useful dye for cheap wines</p> Signup and view all the answers

What was warfarin originally used for before its current medical use?

<p>Rat poison</p> Signup and view all the answers

What was the basis for preparing nitro derivatives used in angina treatment?

<p>TNT</p> Signup and view all the answers

What led to the discovery of drugs used in leukemia to inhibit excessive proliferation of white blood cells?

<p>Destruction of white blood cells due to mustard gas exposure</p> Signup and view all the answers

What is the approach of screening a large number of chemical compounds or natural products for a desired effect called?

<p>Random Screening</p> Signup and view all the answers

What are some drawbacks of the random screening approach for drug development?

<p>Time consuming, Trial &amp; error approach</p> Signup and view all the answers

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